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Rare Metals 2021年第3期40卷 600-606页

作者： Shun Guo Rui-Tang Wu Yu-Lu Shi yan-Pin Hou Wen Ma Guang-Lei Liu Hai-Xia Liu xiao-Nong Cheng School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China Youke Publishing Co. Ltd.GRINM Group Co.Ltd.Beijing 100088China

The deformation behavior involved in Nb/NiTi composite for biomedical applications within a large macroscopic strain range was investigated by tensile loading-unloading test and in situ synchrotron X-ray diffraction(SXRD).Experimental results show that during loading,the Nb/NiTi composite experiences the elastic elongation of B2-NiTi austenitic,B19’-NiTi martensitic and β-Nb phases,B2→ B19’ stress-induced martensitic(SIM) transformation and tensile plastic deformation of β-Nb *** unloading,the deformation behavior involved in Nb/NiTi composite includes the elastic recovery of B2-NiTi austenitic,B19’-NiTi martensitic and β-Nb phases,reverse phase transformation B19’→B2 and compressive deformation of p-Nb *** martensitic transformation in this composite is almost reversible and occurs in a localized *** results might contribute to a comprehensive understanding of the deformation mechanism involved in Nb/NiTi composite and shed some light on design and development of novel composites with a combination of good biocompatibility and excellent superelasticity for biomedical applications.

关键词： Nb/NiTi composite Deformation behavior Superelasticity Localized martensitic transformation

^(13)C NMR Study of Ethylene/propylene/octene-1 Terpolymers Synthesized with TiCl_4/MgCl_2/ i -Bu_3Al as the Catalyst

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Chemical Research in Chinese Universities 2000年第3期16卷 236-245页

作者： LI San xi ZHOU Zi nan xiao yan wen JING Feng ying PANG De ren HUANG Bao tong Department of Materials Science and Engineering Shenyang Institute of Chemical TechnologyShenyang 110021P.R.China Changchun Institute of Applied Chemistry Academia SinicaChangchun 130022P.R.China

The theory of chemical shift effect of substituent was applied to the assignment of the 13 C NMR spectra of the ethylene/propylene and ethylene/octene 1 copolymers. Using the parameters derived above and the DEPT technique, we then entirely assigned the 13 C NMR spectra of the ethylene/propylene/octene 1 terpolymers synthesized in the presence of the same heterogeneous supported Ziegler Natta catalyst, TiCl 4/MgCl 2/ i Bu 3Al. The present paper also covers the terpolymer composition and the monomer sequence distributions of a series of ethylene/propylene/octene 1 terpolymers.

关键词： Chemical shift effect ^(13)C NMR Ethylene/propylene/octene^(-1) terpolymer

Elementary school comprehensive intervention and myopia development:the Wenzhou Epidemiology of Refraction Error Study

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1363-1369页

作者： Dan-Dan Jiang Jie Chen Frank Thorn Guang-Yun Mao Chun-Chun Li Zhong Lin Balamurali Vasudevan xiao-Qiong Huang yan-yan Chen The Eye Hospital of Wenzhou Medical University Wenzhou 325000Zhejiang ProvinceChina Deptartment of Brain&Cognitive Sciences MIT CambridgeCambridgeMA 02139USA School of Public Health Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina College of Optometry MidWestern UniversityGlendaleAZ 84729USA

AIM:To investigate the effects of school-basedcomprehensive intervention on myopia development inelementary school ***:As a part of the Wenzhou Epidemiologyof Refraction Error Study,there were 1524 participatingelementary students(730 girls,47.9%)in grades 1 to3 from three campuses of one school,aged 7.3±0.9y,who were examined twice every year for a 2.5y follow *** intervention and other reminderswere given at school every semester for the *** control group did not receive comprehensiveintervention and did not have reminders of ***:There were 651 students in the interventiongroup[mean age 7.3±0.9y;294(45.2%)girls]and 737students in the control group[mean age 7.2±0.9y;346(46.9%)girls].Overall mean myopia progression duringthe 2.5y follow-up was-0.49±1.04 diopters(D)in theintervention group and-0.65±1.08 D in the control group(P=0.004).The majority that not get myopia at baselinespherical equivalent(SE≤-1.0 D).Their mean myopiaprogression during the 2.5y follow-up was-0.37±0.89 Din the intervention group and-0.51±0.93 D in the controlgroup(27.5%reduction,P=0.009);Overall,mean axiallength elongation was less in the intervention group(0.56±0.32 mm)than in the control group(0.61±0.38 mm,10.5%reduction,P=0.009).The percentage of close reading distance(<30 cm)in the intervention group was less than in the control group(73.4%vs 76.2%,P<0.001),the percentage of everyday perform eye exercises in the intervention group was more than in the control group(27.8%vs 20.7%,P<0.001)30mo ***:The comprehensive intervention program at elementary school has a significant alleviating effect on myopia progression for children during the 2.5y follow-up,especially for those non-myopia at baseline.

关键词： myopia progression axial length comprehensive intervention school children

Whole Genome Sequencing and Comparisons of Different Chinese Rabies Virus Lineages Including the First Complete Genome of an Arctic-like Strain in China

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Biomedical and Environmental Sciences 2016年第5期29卷 340-346页

作者： LI Hao GUO Zhen yang ZHANG Jian TAO xiao yan ZHU Wu yang TANG Qing LIU Hong Tu Key Laboratory for Medical Virology Ministry of Health National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention

Objective To learn the rabies genome molecular characteristics and compare the difference of China rabies lineages. Methods The complete genomes of 12 strains from different China rabies lineages were amplified and sequenced, and all the China street strain genomes （total 43）, Arctic and Arctic-like genomes were aligned using ClustalX2, the genome homologies were analyzed using MegAlign software, and the phylogenetic trees were constructed by MEGA 5. Results First Arctic-like rabies genome in China （CO, H1202D） was reported, and we supplemented the rabies genome data of China, ensuring at least one genome was available in each China lineage. The genome size of China V （11908nt） is obviously shorter than other lineages＇（11923-11925nt） for the difference of N-P non-coding regions. Among different lineages, the genome homologies are almost under 90%. CQH1202D （China IV lineage） has close relationship with strains from South Korea and they share about 95% genome similarities. Conclusion The molecular characteristics of 6 different China rabies lineages were compared and analyzed from genome level, which benefits for continued comprehensive rabies surveillance, rabies prevention and control in China.

关键词： Rabies virus Genome Lineage

Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats

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World Journal of Gastroenterology 2012年第20期18卷 2481-2492页

作者： Hong-yan Qin Hai-Tao xiao Justin CY Wu Brian M Berman Joseph JY Sung Zhao-Xiang Bian School of Chinese Medicine Hong Kong Baptist University Hong Kong 999077 China Faculty of Medicine The Chinese University of Hong Kong.Hong Kong 999077 China Center for Integrative Medicine University of Maryland School of Medicine Baltimore MD 21201 United States

AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHODS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from *** 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were *** 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation *** 5 d post TNBS,the pathological score and myeloperoxidase(MPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,P<0.05).At 4 wk post TNBS,the pathological score in high and median dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,P<0.05);(2)Intracolonic TNBS administration position affected the persistence of visceral *** 4 wk post TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,P<0.05).At 8 wk post TNBS,AWR threshold pressure in 8 cm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,P<0.05);(3)Ethanol percentage affected the TNBS-induced inflammation severity and visceral *** TNBS-25%ethanol-treated group,the pathological score and MPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR thres

关键词： Post-inflammatory Irritable bowel syndrome Rat model Trinitrobenzene sulfonic acid Key factors

Highly conductive and transparent carbon nanotube-based electrodes for ultrathin and stretchable organic solar cells

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Chinese Physics B 2017年第2期26卷 516-522页

作者： Qingxia Fan qiang Zhang Wenbin Zhou Feng yangl, Nan Zhang Shiqi xiao xiaogang Gu Zhuojian xiao Huiliang Chen yanchun Wang Huaping Liu Weiya Zhou Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Beijing Key Laboratory for Advanced Functional Materials and Structure Research Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

In this work, we have presented a freestanding and flexible CNT-based film with sheet resistance of 60 ？/ and transmittance of 82% treated by nitric acid and chloroauric acid in sequence. Based on modified CNT film as a transparent electrode, we have demonstrated an ultrathin, flexible organic solar cell（OSC） fabricated on 2.5-μm PET substrate. The efficiency of OSC, combined with a composite film of poly（3-hexylthiophene）（P3HT） and phenyl-C61 butyric acid methyl ester（PCBM） as an active layer and with a thin layer of methanol soluble biuret inserted between the photoactive layer and the cathode, can be up to 2.74% which is approximate to that of the reference solar cell fabricated with ITO-coated glass（2.93%）. Incorporating the as-fabricated ITO-free OSC with pre-stretched elastomer, 50% compressive deformation can apply to the solar cells. The results show that the as-prepared CNT-based hybrid film with outstanding electrical and optical properties could serve as a promising transparent electrode for low cost, flexible and stretchable OSCs, which will broaden the applications of OSC and generate more solar power than it now does.

关键词： carbon nanotube transparent electrode organic solar cells stretchability

Long Noncoding RNA Expression Signatures of Abdominal Aortic Aneurysm Revealed by Microarray

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Biomedical and Environmental Sciences 2016年第10期29卷 713-723页

作者： yanG Yao Guo LI Mei Xia KOU Lei ZHOU You QIN yan Wen LIU xiao Jun CHEN Zhong The Department of Vascular Surgery Beijing Anzhen Hospital Capital Medical University Beijing 100029 China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences ＆ School of Basic Medicine Peking Union Medical College Beijing 100005 China

Objective This study is aimed at observing the role of long noncoding RNAs（lncR NAs） in the pathogenesis of abdominal aortic aneurysm（AAA）.Methods Lnc RNA and m RNA expression signatures of AAA tissues and normal abdominal aortic tissues（NT） were analyzed by microarray and further verified by Real-time quantitative reverse-transcription PCR（q RT-PCR）.The lnc RNAs-m RNAs targeting relationships were identified using computational *** effect of lnc-ARG on 5-lipoxygenase（ALOX5） expression was tested in HeL a *** Differential expressions of 3,688 lncR NAs and 3,007 m RNAs were identified between AAA and NT ***,1,284 differentially expressed long intergenic noncoding RNAs and 206 differentially expressed enhancer-like lnc RNAs adjacent to protein-coding genes were discerned by bioinformatics *** differentially expressed lncR NAs and m RNAs between AAA and normal tissue samples were further verified using q RT-PCR.A co-expression network of coding and noncoding genes was constructed based on the correlation analysis between the differentially expressed lnc RNAs and mR *** addition,the lnc-ARG located within the upstream of ALOX5 was sorted as a noncoding transcript by analyzing the protein-coding potential using computational ***,we found that lnc-ARG can decrease the m RNA level of ALOX5 and reactive oxygen species production in He La *** This study revealed new lnc RNA candidates are related to the pathogenesis of AAA.

关键词： IncRNA Abdominal aortic aneurysm Inc-ARG ALOX5

Bystander effect and abscopal effect in recurrent thymic carcinoma treated with carbon-ion radiation therapy:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6538-6543页

作者： yan-Shan Zhang Yi-He Zhang xiao-Jun Li Ting-Chao Hu Wei-Zuo Chen Xin Pan Hong-Yu Chai yan-Cheng Ye Department of Heavy Ion Center Wuwei Cancer HospitalWuwei 733000Gansu ProvinceChina

BACKGROUND Although the bystander effect and abscopal effect are familiar in medicine,they are relatively rare in clinical ***,we report the case of a patient who demonstrated an obvious bystander effect and abscopal effect response following carbon-ion irradiation for recurrent thymic *** SUMMARY A 44-year-old female presented with shortness of *** years prior,she was diagnosed with athymic tumor located in the anterosuperior *** underwent extensive tumor resection,and the postoperative pathologic diagnosis was thymic *** was administered 50 Gy/25 Fx of postoperative *** 2019,she was diagnosed with a recurrence of thymic carcinoma,with multiple recurrent nodules and masses in the left thoracic chest and peritoneal cavity,the largest of which was in the diaphragm pleura proximal to the pericardium,with a size of 6.7 cm×5.3 cm×4.8 *** received carbonion *** carbon-ion radiotherapy treatment,the treated masses and the untreated masses were observed to have noticeably shrunk on the day of carbon-ion radiotherapy completion and on follow-up *** followed the CARE Guidelines for consensus-based clinical case reporting guideline development and completed the CARE Checklist of information to report this *** This report is the first of obvious abscopal and bystander effects following carbonion irradiation in a human patient,and further research is needed to better elucidate the mechanisms of bystander and abscopal effects.

关键词： Bystander effect Abscopal effect Recurrent thymic carcinoma Carbon-ion radiation therapy Case report

MiR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer

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World Journal of Gastroenterology 2015年第31期21卷 9337-9347页

作者： Shu-Bo Tian Jian-Chun Yu Yu-Qin Liu Wei-Ming Kang Zhi-qiang Ma Xin Ye Chao yan Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Cell Centre Institute of Basic Medical SciencesChinese Academy of Medical Sciences

AIM: To elucidate the potential biological role of mi R-30 b in gastric cancer and investigate the underlying molecular mechanisms of mi R-30 b to inhibit metastasis of gastric cancer ***: The expression of mi R-30 b was detected in gastric cancer cell lines and samples by reverse transcription-polymerase chain reaction. CCK-8 assays were conducted to explore the impact of mi R-30 b overexpression on the proliferation of gastric cancer cells. Flow cytometry was used to examine the effect of mi R-30 b on the apoptosis. Transwell test was used for the migration and invasion assays. Luciferase reporter assays and Western blot were employed to validate regulation of putative target of mi R-30 ***: The results showed that mi R-30 b was downregulated in gastric cancer tissues and cancer cell lines and functioned as a tumor suppressor. Overexpression of mi R-30 b promoted cell apoptosis,and suppressed proliferation,migration and invasion of the gastric cancer cell lines AGS and MGC803. Bioinformatic analysis identified the 3'-untranslated region of eukaryotic translation initiation factor 5A2(EIF5A2) as a putative binding site of mi R-30 b. Luciferase reporter assays and Western blot analysis confirmed the EIF5A2 gene as a target of mi R-30 b. Moreover,expression levels of theEIF5A2 targets E-cadherin and Vimentin were altered following transfection of mi R-30 b ***: Our findings describe a link between mi R-30 b and EIF5A2,which plays an important role in mediating epithelial-mesenchymal transition.

关键词： mi R-30b Gastric cancer EIF5A2 Migration Invasion

BET Surface Area and Porous Structure of Fullerenes and Fullerene Soots

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Chemical Research in Chinese Universities 1999年第1期15卷 92-95页

作者： CHEN Jian-xin SHENG Guo-ying LIU Shu-ying LIU Zi-yang LIU Zhi-qiang FU Jia-mo ZHANG xiao-mei Changchun Institute of Applied Chemistry a Chinese Academy of SciencesChangchun130022 State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of ScienoesGuangzhou510640 Institute of Animal Saience Guangdong Acadeny of Agricultural Science510640 Environmental Monitoring Centeral Station off Jilin Province Changchun130011

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关键词： Fullerenes Fullerene soots Surface area Pore size distribution Adsorbent