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Traditional Chinese herbal medicine Astragalus Radix and its effects on intestinal absorption of aconite alkaloids in rats

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Chinese Herbal Medicines 2021年第2期13卷 235-242页

作者： Xin-li Liang Miao-miao Ji Lai Chen Ye Liao xiao-qiang kong Xi-qiang Xu Zheng-gen Liao Danny W.Wilson Key Laboratory of Modern Preparation of Chinese Meteria Medica Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Laboratory of Animal Research Center for Science and Technology Jiangxi University of Traditional Chinese MedicineNanchang 210023China Shengjing Hospital of China Medical University Shenyang 110122China Research Centre for Infectious Diseases(RCID) University of AdelaideAdelaide SA5005Australia

Objective:Astragalus Radix(AR,Huangqi in Chinese) has been widely used as a qi(energy) restoring herb that is thought to act through reinvigorating the spleen and *** is used to rebalance the body temperature during illness and played an irreplaceable role in disease control since ancient times,but it is limited by its strong neuro and *** the Song Dynasty(1227),the two herbs have been commonly used as herbal pairs including in the famous Qifu Decotion,from the "Wei's Family Prescription".However,many ancient texts also record that they are not compatible using together,suggesting they can have negative outcomes when *** study investigated whether Astragali Radix had either positive or negative effects on absorption of six different active alkaloids derived from ***:Single intestinal perfusion model was used to study the effects of Astragali Radix on aconite alkaloids *** of ABC transporters and distribution of three tight junction proteins on the surface of intestinal enothelium were assessed by Reverse Transcription-Polymerase Chain Reaction(RT-PCR),Western blot and immunofluorescence microscopy,***:The results showed that aconite alkaloids absorption could be inhibited,and different concentrations of Astragali Radix considerably increased the expression levels of the ABC transporters and tight junction proteins with Astragali Radix ***:These results suggest that Astragali Radix can block absorption of aconite alkaloids through the upregulation expression of ATP-binding cassette transporters(ABC transporters) and tight junction *** demonstrates that co-administration of Astragali Radix with other drugs might change the absorption profile of the second drug which is important to know in clinic therapy.

关键词： ABC transporter alkaloids of aconite Astragali Radix intestinal absorption tight junction

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Polymer-to-Monomers Chemically Recyclable Poly(imide-imine)Plastics with Extreme-Condition Resistance and Flame Retardancy

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Chinese Journal of Polymer Science 2024年第10期42卷 1525-1535,I0012页

作者： Zhen-Yu Wang xiao-kong Liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Polyimides are a family of high-tech plastics that have irreplaceable applications in the fields of aerospace,defense,and opto-electronics,but polyimides are difficult to be reprocessed and recycled at the end of their service life,resulting in a significant waste of ***,it is of great significance to develop recyclable polyimides with comparable properties to the commercial ***,we report a novel polymer-to-monomers chemically recyclable poly(imide-imine)(PtM-CR-PII)plastic,synthesized by cross-linking the amine-terminated aromatic bisimide monomer and the hexa-vanillin terminated cyclophosphazene monomer via dynamic imine *** PtM-CR-PII plastic exhibits comparable mechanical and thermal properties as well as chemical stability to the commercial *** PtM-CR-PII plastic possesses a high Young’s modulus of≈3.2 GPa and a tensile strength as high as≈108 MPa,which also exhibits high thermal stability with a glass transition temperature of≈220℃.Moreover,the PtM-CR-PII plastic exhibits outstanding waterproofness,acid/alkali-resistance,and solvent-resistance,its appearance and mechanical properties can be well maintained after long-term soaking in water,highly concentrated acid and base,and various organic ***,the cyclophosphazene moieties endow the PtM-CR-PII plastic with excellent flame *** PtM-CR-PII plastic exhibits the highest UL-94 flame-retarding rating of V-0 and a limiting oxygen index(LOI)value of 45.5%.Importantly,the PtM-CR-PII plastic can be depolymerized in an organic solvents-acid mixture medium at room temperature,allowing easy separation and recovery of both monomers in high *** recovered pure monomers can be used to regenerate new PtM-CR-PII plastics,enabling sustainable polymer-monomers-polymer circulation.

关键词： Chemical recyclability Polyimides Polyimines Dynamic imine bonds Mechanical properties Chemical stability

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Current understanding of ELF4 deficiency:a novel inborn error of immunity

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World Journal of Pediatrics 2024年第5期20卷 444-450页

作者： Hong-qiang Du xiao-Dong Zhao Department of Rheumatology&Immunology National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Child Rare Diseases in Infection and ImmunityChildren’s Hospital of Chongqing Medical UniversityZhongshan Er Road 136Yuzhong DistrictChongqingChina

Background ELF4 deficiency has been recently recognized as a novel disorder within the spectrum of inborn errors of immunity(IEIs),specifically categorized as a“disease of immune dysregulation.”Cases of this condition,reported by our team and others,are very limited *** such,our current knowledge of this new disease remains *** review aims to provide a brief overview of the clinical manifestations,pathogenesis,and treatment strategies for this novel *** sources A comprehensive review was conducted after an extensive literature search in the PubMed/Medline database and websites concerning transcriptional factor ELF4 and reports concerning patients with ELF4 *** search strategy was“ELF4 OR ETS-related transcription factor Elf-4 OR EL4-like factor 4 OR myeloid Elf-1-like factor”as of the time of manuscript *** The current signature manifestations of ELF4 deficiency disorder are recurrent and prolonged oral ulcer,abdominal pain,and diarrhea in pediatric *** some cases,immunodeficiency and autoimmunity can also be *** Sanger sequencing or whole exome sequencing can be used to detect variation in ELF4 *** blotting for ELF4 expression of the patient’s cells can confirm the pathogenic effect of the *** fully confirm the pathogenicity of the variant,further functional test is strongly *** and biologics are the mainstream management of ELF4 deficiency *** Pediatric males presenting with recurring ulcerations in digestive tract epithelium with or without recurrent fever should be suspected of *** atypical presentations are prominent,variations in ELF4 gene should be carefully evaluated functionally due to the complex nature of ELF4 *** of treating DEX includes use of glucocorticoid and biologics and more precise treatment needs more patients to identify and further mechanistic study.

关键词： ELF4 transcription factor Immune dysregulation Inborn errors of immunity Mechanism Recurrent infections

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Unconventional Fluorescent and Multi-responsive Polysiloxane:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第5期42卷 579-590,I0006页

作者： xiao-Di Li Shu-Sheng Li Xu-Bao Jiang xiao-Li Zhu Xiang Zheng kong College of Chemistry and Chemical Engineering University of JinanJinan250022China College of Chemical Engineering Tianjin UniversityTianjin300072China Foshan(Southern China)Institute for New Materials Foshan528200China

Owing to their high significance in fundamental study and diverse applications,stimuli-responsive and fluorescent polymers,particularly those with cluster-triggered emission(CTE)featured by non-conjugated chromophores,have drawn tremendous attention in recent *** this work,fluorescent and multi-responsive polysiloxane(FRPS)was synthesized by hydrolytic condensation polymerization of 3-aminopropyl methyl diethoxysilane(APMS)with 3-(N-isopropyl propionamide)iminopropyl methyl diethoxysilane(APMS-NIP),which was formed in situ through aza-Michael addition between APMS and N-isopropyl *** was not only highly sensitive to temperature,pH and CO_(2) in water,but also showed an enhanced and stimuli-adjustable fluorescence *** effects of monomer feeding,pH and CO_(2) on its lower critical solution temperature and fluorescent property were *** fluorescence emission was ascribed to CTE *** addition,FRPS was shown to be highly potential as physiological indicator for cell imaging,and for controlled release and trace detection of *** study provides therefore a type of stimuli-responsive and fluorescent material for potential applications in biomedical fields,and it is also of great significance for understanding of the fluorescence mechanism of polysiloxane-based stimuli-responsive polymers.

关键词： Polysiloxane Multi-responsiveness Cluster-triggered emission Cell imaging Controlled drug release

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Non-contact and full-field online monitoring of curing temperature during the in-situ heating process based on deep learning

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Advances in Manufacturing 2024年第1期12卷 167-176页

作者： qiang-qiang Liu Shu-Ting Liu Ying-Guang Li Xu Liu xiao-Zhong Hao College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816People’s Republic of China

Online monitoring of the curing temperature field is essential to improving the quality and efficiency of the manufacturing process of composite *** embedded sensor-based technologies have difficulty monitoring the full temperature field or have to introduce heterogeneous items that could have an undesired impact on the *** this paper,a non-contact,full-field monitoring method based on deep learning that predicts the internal temperature field of composite parts in real time using surface temperature measurements of auxiliary materials is *** the proposed method,an average temperature monitoring accuracy of 97%is achieved in various heating *** addition,this method also demonstrates satisfying feasibility when a stronger thermal barrier covers the *** method was experimentally validated during the self-resistance electric heating process,in which the monitoring accuracy reached 93.1%.This method can potentially be applied to automated manufacturing and process control in the composites industry.

关键词： Online monitoring Curing temperature field Deep learning(DL) In-situ heating

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Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-xiao Feng Hua Zou Yuan-qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury

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Boosting oxygen vacancies by modulating the morphology of Au decorated In_(2)O_(3)with enhanced CO_(2)hydrogenation activity to CH_(3)OH

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Journal of Environmental Sciences 2024年第6期140卷 91-102页

作者： Ruxian Hou Jiewen xiao Qian Wu Tianyu Zhang qiang Wang Beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Engineering Research Center for Water Pollution Source Control&Eco-remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China

CO_(2)hydrogenation to methanol has become one of the most promising ways for CO_(2)utilization,however,the CO_(2)conversion rate and methanol selectivity of this reaction still need to be improved for industrial *** we investigated the structure-activity relationship for CO_(2)conversion to methanol of In_(2)O_(3)-based catalysts by modulating morphology and decorating *** different Au/In_(2)O_(3)catalysts were prepared,their activity follow the sequence of Au/In_(2)O_(3)-nanosphere(Au/In_(2)O_(3)-NS)>Au/In_(2)O_(3)-nanoplate(Au/In_(2)O_(3)-NP)>Au/In_(2)O_(3)-hollow microsphere(Au/In_(2)O_(3)-HM).Au/In_(2)O_(3)-NS exhibited the best performance with good CO_(2)conversion of 12.7%,high methanol selectivity of 59.8%,and large space time yield of 0.32 g CH_(3)OH/(hr·gcat)at 300℃.The high performance of Au/In_(2)O_(3)-NS was considered as the presence of *** contributes to the creation of more surface oxygen vacancies,which further promoted the CO_(2)adsorption and facilitated CO_(2)activation to form the formate intermediates towards *** work clearly suggests that the activity of In_(2)O_(3)catalyst can be effective enhanced by structure engineering and Au decorating.

关键词： CO_(2)hydrogenation Methanol Au/In_(2)O_(3) Morphology Oxygen vacancies

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Recent Developments of Photodeformable Polymers:From Materials to Applications

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Research 2024年第2期2023卷 729-752页

作者： Shuting kong Hailan Wang Eethamukkala Ubba Yuxin xiao Tao Yu Wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)Northwestern Polytechnical University127 West Youyi RoadXian 710072China OMC Research Laboratory.Department of Chemistry School of Advanced SciencesVITVelloreTamilnaduIndia Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China

Photodeformable polymer materials have a far influence in the fields of flexibility and *** stimulation energy is converted into mechanical energy through molecular *** kinds of photodeformable polymer materials,liquid crystalline polymer(LCP)photodeformable materials have been a hot topic in recent *** such as azobenzene,a-cyanostilbene,and 9,10-dithiopheneanthracene have been widely used in LCP,which are helpful for designing functional molecules to increase the penetration depth of light to change physical *** to the various applications of photodeformable polymer materials,there are many excellent reports in intelligent *** this review,we have systematized LCP containing azobenzene into 3 categories depending on the degree of crosslinking liquid crystalline elastomers,liquid crystalline networks,and linear *** structural,typical polymer materials and their applications are *** issues faced and future directions to be developed for photodeformable polymer materials are also summarized.

关键词： properties. field. crystalline

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Energy consumption optimization for edge computing-supported cellular networks based on optimal transport theory

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Science China(Information Sciences) 2024年第2期67卷 201-218页

作者： Xiangyu LV xiaohu GE Yi ZHONG qiang LI Yong xiao School of Electronic Information and Communications Huazhong University of Science and Technology

With advancements in mobile communication technologies, there have been multiple user device(UD) connections to cellular networks. Because of changes in the spatial distribution of UDs and application requirements, the traditional offloading mechanism based on the nearest distance will result in heavy loads for some base stations(BSs). Because there is a high-order relationship between the energy consumption of the BS processing tasks and the number of computing tasks, the traditional offloading mechanism will result in high energy consumption, and UD’s offloading decision must be dynamically adjusted. The offloading decision of UDs is optimized based on detailed information about various parameters associated with a network from the standpoint of distribution. This information includes details regarding the spatial distribution of UDs,application requirements, and the offloading period of computing tasks. Based on optimal transport theory,an energy consumption optimization algorithm is suggested to lower the total amount of energy consumed by the offloading process of UDs’ computing tasks by reasonably planning the offloading BSs of the UDs in the networks. The simulation results show that the proposed offloading mechanism based on energy consumption optimization reduces the total energy consumption of the offloading process by 28.09% when compared to the traditional offloading mechanism, and the traffic managed by each BS is balanced.

关键词： optimal transport theory edge computing energy consumption reduction dynamic voltage frequency scaling

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Knowledge Graph Enhanced Transformers for Diagnosis Generation of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第3期30卷 267-276页

作者： WANG Xin-yu YANG Tao GAO xiao-yuan HU kong-fa School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing210023China School of Information Management Nanjing UniversityNanjing210023China Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing210023China Jiangsu Province Engineering Research Center of TCM Intelligence Health Service Nanjing210023China

Chinese medicine(CM)diagnosis intellectualization is one of the hotspots in the research of CM *** traditional CM intelligent diagnosis models transform the CM diagnosis issues into classification issues,however,it is difficult to solve the problems such as excessive or similar *** the development of natural language processing techniques,text generation technique has become increasingly *** this study,we aimed to establish the CM diagnosis generation model by transforming the CM diagnosis issues into text generation *** semantic context characteristic learning capacity was enhanced referring to Bidirectional Long Short-Term Memory(BILSTM)with Transformer as the backbone ***,the CM diagnosis generation model Knowledge Graph Enhanced Transformer(KGET)was established by introducing the knowledge in medical field to enhance the inferential *** KGET model was established based on 566 CM case texts,and was compared with the classic text generation models including Long Short-Term Memory sequence-to-sequence(LSTM-seq2seq),Bidirectional and Auto-Regression Transformer(BART),and Chinese Pre-trained Unbalanced Transformer(CPT),so as to analyze the model ***,the ablation experiments were performed to explore the influence of the optimized part on the KGET *** results of Bilingual Evaluation Understudy(BLEU),Recall-Oriented Understudy for Gisting Evaluation 1(ROUGE1),ROUGE2 and Edit distance of KGET model were 45.85,73.93,54.59 and 7.12,respectively in this *** with LSTM-seq2seq,BART and CPT models,the KGET model was higher in BLEU,ROUGE1 and ROUGE2 by 6.00–17.09,1.65–9.39 and 0.51–17.62,respectively,and lower in Edit distance by 0.47–*** ablation experiment results revealed that introduction of BILSTM model and prior knowledge could significantly increase the model ***,the manual assessment indicated that the CM diagnosis results of the KGET model used

关键词： Chinese medicine diagnosis knowledge graph enhanced transformer text generation

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