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面向铁路数据应用的可视化交互设计系统

制造业自动化 2024年第1期46卷 105-110页

作者：戚小玉中国铁道科学研究院集团有限公司电子计算技术研究所北京100081

介绍了面向铁路数据应用的数据可视化交互设计系统。该系统基于数据可视化图形库与交互式代码,封装可视化组件图形,构建可视化操作界面,实现可视化与可视分析展示。系统以敏捷开发、零代码编辑、多场景复用等特点为铁路行业的用户提供... 详细信息

介绍了面向铁路数据应用的数据可视化交互设计系统。该系统基于数据可视化图形库与交互式代码,封装可视化组件图形,构建可视化操作界面,实现可视化与可视分析展示。系统以敏捷开发、零代码编辑、多场景复用等特点为铁路行业的用户提供面向铁路场景应用的多维度、多层级、多种形式的数据可视化展示功能。同时,结合需求分析,提出了系统技术架构与功能流程,阐述说明了铁路数据应用可视化服务架构与典型应用场景,为铁路数据可视化与可视分析提供更加便捷高效的解决方案。

关键词：数据可视化铁路数据应用可视分析交互设计系统信息可视化

Qualitative and quantitative detection of aldehydes in DNA with 2-amino benzamidoxime derivative

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Chinese Chemical Letters 2023年第1期34卷 317-321页

作者： Na Li qian Zhou Kun Li Ting Jiang xiao-qi yu Laboratory of Green Chemistry and Technology(Ministry of Education) College of ChemistrySichuan UniversityChengdu 610064China Department of Chemistry Xihua UniversityChengdu 610039China

An aldehyde-reactive probe based on 2-amino benzamidoxime(ABAO)framework was introduced,which can selectively label aldehydes in DNA through intramolecular ring closure under mild aqueous *** screened ABAO derivatives that can undergo a cyclization with the formylated nucleobases to generate a fluorescence nucleoside,and of these derivatives 5–methoxy-ABAO(PMA)emerged as the optimal *** can sensitively and selectively react with 5f U,5f C and AP to form fluorogenic dihydroquinazoline derivatives,which also can quantify DNA damages induced byγ-***-initiated labeling strategy provides great convenience for qualitative and quantitative detection of aldehydes in DNA.

关键词： Aldehydes in DNA 2-Amino benzamidoxime derivative Intramolecular ring closure Fluorescent adducts Quantitative analysis

Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes

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Chinese Chemical Letters 2009年第5期20卷 523-526页

作者： qing Xiang Xiang Li Qun Zhang xiao qi yu Ru Gang Xie Department of Chemistry and Life Science Leshan Teachers College Leshan 614004 China Department of Chemistry Sichuan University Chengdu 610064 China

The activities of the catalytic hydrolysis of phosphate diester （BNPP） [bis（p-nitrophenyl）phosphate diester] and plasmid DNA （pUC 18） by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with le--Zn（II） complex （composed of lipophilic group） as catalyst. The hydrolysis rate enhancement is up to 3.64 × 10^4 fold. These metal complexes could effectively promote the cleavage of plasmid DNA （pUC18） at physiological conditions.

关键词： Catalytic hydrolysis Macrocyclic polyamine Zn(II) complex BNPP Plasmid DNA

A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO2 in living cells

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Science China Chemistry 2017年第6期60卷 793-798页

作者： Jin Yang Kun Li Ji-Ting Hou Chun-Yan Lu Ling-Ling Li Kang-Kang yu xiao-qi yu College of Chemistry Key Laboratory of Green Chemistry and Technology (Ministry of Education) Siehuan University Chengdu 610064 China Department of Radiology West China Hospital Siehuan University Chengdu 610064 China

A novel coumarin-based "turn-on" fluorescent probe SS-1 was developed for selective detection of SO_2 derivatives in 100% water solution among reactive sulfur species(RSS). The detection limit of the method was 91.7 nM. Moreover, the probe exhibited low cytotoxicity and was successfully applied in the imaging of endogenously generated SO_2 in HeLa cells.

关键词： endogenously generated SO2 fluorescent probe bioimaging

Quassinoids from the Root Barks of Ailanthus altissima:Isolation,Configurational Assignment,and Cytotoxic Activities

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Chinese Journal of Chemistry 2021年第4期39卷 879-886页

作者： Ye-qing Du Ming Bai xiao-qi yu Tian-Ming Lv Bin Lin xiao-xiao Huang Shao-Jiang Song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyangLiaoning 110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China

Main observation and conclusion Quassinoids,a class of highly oxygenated triterpenes,have been isolated as bitter principles from the plants of Simaroubaceae *** new quassinoids,chouchunlactone A-E(1-5),and two known ones were identified from the root barks of Ailanthus altissima Swingle(Simaroubaceae).The chemical structures of the new compounds were deduced by spectroscopic data analyses,NMR calculations and DP4+probability *** absolute configurations were defined by comparison of their experimental and calculated electronic circular dichroism(ECD)spectra data,and compounds 1-2 were further confirmed by single-crystal X-ray ***,compound 5 showed potencies equivalent to sorafenib(IC50 value,9.70μmol·L–1)against HepG2 *** Hoechst 33342 staining,JC-1 fluorescent dye and Annexin V/PI analysis studies demonstrated that 5 can induce apoptosis and attenuate mitochondrial membrane potential(MMP)in HepG2 cells.

关键词： Ailanthus altissima Simaroubaceae Quassinoids Cytotoxicity Apoptosis

连续性血液净化与间歇性血液透析对脓毒症合并急性肾损伤患者RAAS系统指标和血清sTREM-1、HMGB1、TLR4的影响

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现代生物医学进展 2024年第17期24卷 3265-3268页

作者：苏梅王海霞苏晓峰张超祁小宇解放军总医院第五医学中心危重症医学科北京100071 解放军总医院第五医学中心呼吸与危重症医学科北京100071 北京卫戍区海淀第十一离休养所门诊部北京100080 承德医学院基础医学院基础医学研究所河北承德067000 解放军总医院第五医学中心检验科北京100071

目的:对比脓毒症合并急性肾损伤(AKI)患者分别经间歇性血液透析(IHD)、连续性血液净化(CBP)治疗后血清肾素-血管紧张素-醛固酮(RAAS)系统指标和血清高迁移率族蛋白1(HMGB1)、可溶性髓系细胞触发受体-1(sTREM-1)、Toll样受体4(TLR4)的变... 详细信息

目的:对比脓毒症合并急性肾损伤(AKI)患者分别经间歇性血液透析(IHD)、连续性血液净化(CBP)治疗后血清肾素-血管紧张素-醛固酮(RAAS)系统指标和血清高迁移率族蛋白1(HMGB1)、可溶性髓系细胞触发受体-1(sTREM-1)、Toll样受体4(TLR4)的变化情况。方法:选取2019年1月~2023年6月期间我院收治的107例脓毒症合并AKI患者。根据随机数字表法将患者分为间歇组(n=53,接受IHD治疗)和连续组(n=54,接受CBP治疗)。对比两组RAAS系统指标、血清sTREM-1、HMGB1、TLR4、肾功能、免疫功能指标。结果:治疗后,两组肾素活性(PRA)、醛固酮(ALD)、血管紧张素Ⅰ(AngI)、sTREM-1、HMGB1、TLR4、尿素氮(BUN)、血肌酐(Scr)下降,且连续组低于间歇组(P<0.05)。治疗后,两组CD8^(+)下降,且连续组低于间歇组;CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)升高,且连续组高于间歇组(P<0.05)。结论:与IHD治疗相比,CBP治疗脓毒症合并AKI,可进一步改善肾功能,提高免疫功能,调节RAAS系统指标和血清sTREM-1、HMGB1、TLR4水平。

关键词：血液净化血液透析脓毒症急性肾损伤 RAAS系统 sTREM-1 HMGB1 TLR4

Enantioselective Hydrolysis of α-Amino Acid Ester by Chiral Metallomicelles

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Chinese Chemical Letters 1998年第4期9卷 335-337页

作者： Jing Song YOU xiao qi yu xiao Ling ZHANG and Ru Gang XIE(Department of Chemistry, Sichuan University, Chengdu 610064) Department of Chemistry Sichuan University Chengdu 610064 China

A series of chiral lipophilic Cu(Ⅱ) complexes were investigated as catalysts for the enantioselective hydrolysis of R(S)-p-nitrophenyl N-dodecanoyl-phenylalaninate in micelles. The highest enantioselectivity (kR/ks=7... 详细信息

关键词： micelle chiral metallomicelle enantioselective hydrolysis

Octopus Manganese Porphyrin with Polyglycol Chains as a Catalyst for the β -Selective Epoxidation of Cholesterol Derivatives

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Chinese Chemical Letters 2004年第8期15卷 915-918页

作者： Run Hua LI yuan Cong ZHAO Jiang WU Jing Song YOU xiao qi yu Department of Chemistry Sichuan UniversityChengdu 610064

Synthesis of a novel octopus porphyrin with polyglycol chains 1a was achieved. The catalytic activity of la's manganese complex for the epoxidation of cholesterol derivatives with PhIO give a satisfactory conversion a... 详细信息

关键词： Octopus porphyrin synthesis epoxidation cholesterol derivatives.

Explosive synchronization of multi-layer complex networks based on inter-layer star network connection

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Chinese Physics B 2021年第12期30卷 264-270页

作者： Yan-Liang Jin Run-Zhu Guo xiao-qi yu Li-Quan Shen Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai Institute for Advanced Communication and Data ScienceShanghai UniversityShanghai 200072China School of Communication and Information Engineering(SCIE) Shanghai UniversityShanghai 200000China

Explosive synchronization(ES)is a first-order transition phenomenon that is ubiquitous in various physical and biological *** recent years,researchers have focused on explosive synchronization in a single-layer network,but few in multi-layer *** paper proposes a frequency-weighted Kuramoto model in multi-layer complex networks with star connection between layers and analyzes the factors affecting the backward critical coupling strength by both theoretical analysis and numerical *** results show that the backward critical coupling strength of each layer network is influenced by the inter-layer interaction strength and the average *** number of network layers,the number of nodes,and the network topology can not directly affect the synchronization of the *** the inter-layer interaction strength can prevent the emergence of explosive synchronization and increasing the average degree can promote the generation of explosive synchronization.

关键词： explosive synchronization Kuramoto model multi-layer networks