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Analysis of TLR4 and TLR2 polymorphisms in inflammatory bowel disease in a Guangxi Zhuang population

World Journal of Gastroenterology 2012年第46期18卷 6856-6860页

作者： Lan Chen Mei-Jiao Lin Ling-Ling Zhan xiao-ping lv Department of Gastroenterology the First Affiliated Hospital of Guangxi Medical University (West) Department of Clinical Experimental Medicine the First Affiliated Hospital of Guangxi Medical University

AIM: To study the polymorphisms of toll-like receptor 4 (TLR4) gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp and susceptibility to inflammatory bowel disease (IBD) in the Zhuang population from Guangxi, China. METHODS: A case-control study was performed from February 2007 to October 2011 which included 146 Zhuang patients with IBD in the experimental group and 164 healthy Zhuang subjects who acted as the control group. All patients and healthy subjects were from the Guangxi Zhuang Autonomous Region of China. Genomic DNA was extracted from intestinal tissue by the phenol chloroform method. TLR4 gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp were amplified by polymerase chain reaction (PCR), and then detected by PCR-restriction fragment length polymorphism (RFLP). RESULTS: The TLR4 gene Asp299Gly was digested using Nco Ⅰ restriction enzyme, and a single band of 249 bp was observed which showed that it was a wild type (AA). The TLR4 gene Thr399Ile was digested using Hinf Ⅰrestriction enzyme and only the wild type (CC) was detected. In addition, the TLR2 gene Arg-677Trp was digested using Aci Ⅰ restriction enzyme and only the wild type (CC) was detected. The TLR2 gene Arg753Gln was digested using Pst Ⅰ restriction enzyme. Only the wild type (GG) as a single band of 254 bp was observed during RFLP. Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China. CONCLUSION: The TLR4 gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp polymorphisms may not be associated with IBD in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.

关键词： Toll-like receptor 2 Toll-like receptor 4 Inflammatory bowel disease Gene polymorphism

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Placement of prophylactic pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: A meta-analysis

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World Journal of Gastroenterology 2014年第22期20卷 7040-7048页

作者： Qing-Qing Shi xiao-Yi Ning Ling-Ling Zhan Guo-Du Tang xiao-ping lv Department of Gastro-entero-lo-gy the First Affiliated Ho-spital o-f Guangxi Medical University Department o-f Hemato-lo-gy the First Affiliated Ho-spital o-f Guangxi Medical University Department o-f Clinical Experimental Medicine the First Affiliated Ho-spital o-f Guangxi Medical University

AIM: To assess the effectiveness of pancreatic stents for preventing pancreatitis in high-risk patients after endoscopic retrograde cholangiopancreatography (ERCP).

关键词： Pancreatic stent Endoscopic retrograde cholangiopancreatography Pancreatitis Hyperamylasemia Meta-analysis

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Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway

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World Journal of Gastroenterology 2023年第22期29卷 3422-3439页

作者： Jun-Hua Fan Na Luo Geng-Feng Liu xiao-Fang Xu Shi-Quan Li xiao-ping lv Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hepatic fibrosis is a common pathological process of chronic liver diseases with various causes,which can progress to *** To evaluate the effect and mechanism of action annexin(Anx)A1 in liver fibrosis and how this could be targeted *** CCl4(20%)and active N-terminal peptide of AnxA1(Ac2-26)and N-formylpeptide receptor antagonist N-Boc-Phe-Leu-Phe-Leu-Phe(Boc2)were injected intraperitoneally to induce liver fibrosis in eight wild-type mice/Anxa1 knockout mice,and to detect expression of inflammatory factors,collagen deposition,and the role of the Wnt/β-catenin pathway in hepatic *** Compared with the control group,AnxA1,transforming growth factor(TGF)-β1,interleukin(IL)-1βand IL-6 expression in the liver of mice with hepatic fibrosis induced by CCl4 was significantly increased,which promoted collagen deposition and expression ofα-smooth muscle actin(α-SMA),collagen type I and connective tissue growth factor(CTGF),and increased progressively with ***4 induced an increase in TGF-β1,IL-1βand IL-6 in liver tissue of AnxA1 knockout mice,and the degree of liver inflammation and fibrosis and expression ofα-SMA,collagen I and CTGF were significantly increased compared with in wild-type *** treatment with Ac2-26,expression of liver inflammatory factors,degree of collagen deposition and expression of a-SMA,collagen I and CTGF were decreased compared with before ***2 inhibited the anti-inflammatory and antifibrotic effects of ***1 downregulated expression of the Wnt/β-catenin pathway in CCl4-induced hepatic *** vitro,lipopolysaccharide(LPS)induced hepatocyte and hepatic stellate cell(HSC)expression of ***2-26 inhibited LPS-induced RAW264.7 cell activation and HSC proliferation,decreased expression ofα-SMA,collagen I and CTGF in HSCs,and inhibited expression of the Wnt/β-catenin pathway after HSC *** therapeutic effects were inhibited by *** AnxA1 inhibited

关键词： Annexin A1 Active N-terminal peptide of annexin A1 Macrophage Hepatic stellate cell Wnt/β-catenin Liver fibro

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Pathogenesis of autoimmune hepatitis

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World Journal of Hepatology 2021年第8期13卷 879-886页

作者： Jun-Hua Fan Geng-Feng Liu xiao-Dan lv Rui-Zhi Zeng Ling-Ling Zhan xiao-ping lv Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Experimental Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

Autoimmune hepatitis(AIH)is a chronic progressive liver disease whose etiology and pathogenesis are not yet *** is currently believed that the occurrence of AIH is closely related to genetic susceptibility and immune abnormalities,and other factors such as environment,viral infection and drugs that may cause immune *** article reviews the pathogenesis of AIH and describes the latest research results in the past 5 years.

关键词： Autoimmune hepatitis Genetic susceptibility environmental factors Immunomodulation Drug-induced liver injury Intestinal microbes

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Infliximab is effective in the treatment of ulcerative colitis with dermatomyositis:A case report

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World Journal of Gastroenterology 2020年第46期26卷 7425-7435页

作者： Bin-Bin Huang Li-Chun Han Geng-Feng Liu xiao-Dan lv Guang-Li Gu Shi-Quan Li Lan Chen Hui-Qin Wang Ling-Ling Zhan xiao-ping lv Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Joint,skin,oral cavity,and eye lesions are the most common extraintestinal manifestations of ulcerative colitis that can occur before or after its *** cases of ulcerative colitis with dermatomyositis(DM)are *** this study,we report a rare case of ulcerative colitis with DM that was effectively treated with *** SUMMARY The patient was a 57-year-old female with a 2-year history of *** patient was admitted to hospital with abdominal pain,diarrhea,and blood in stool lasting for more than 2 *** revealed multiple erosions and ulcers in the entire colon and *** sections showed chronic inflammatory cell infiltration,especially neutrophil infiltration,in the colonic mucosa;therefore,the patient was diagnosed with ulcerative *** of 5-aminosalicylic acid was added to her treatment based on the original treatment for DM,but its effect was *** patient’s discomfort was relieved after infliximab *** Infliximab can improve DM in the treatment of ulcerative *** need to raise awareness about patients with inflammatory bowel disease who have rare extraintestinal manifestations.

关键词： Ulcerative colitis Dermatomyositis Extraintestinal manifestation Infliximab Mesalazine Case report

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Association between NOD2/CARD15 gene polymorphisms and Crohn's disease in Chinese Zhuang patients

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World Journal of Gastroenterology 2014年第16期20卷 4737-4744页

作者： Wei-Yan Long Lan Chen Cui-Liang Zhang Rong-Mao Nong Mei-Jiao Lin Ling-Ling Zhan xiao-ping lv Department of Gastroenterology the First Affiliated Hospital of Guangxi Medical University Department of Clinical Experimental Medicine the First Affiliated Hospital of Guangxi Medical University

AIM: To assess the relationship between the P268S, JW1 and N852S polymorphisms and Crohn’s disease (CD) susceptibility in Zhuang patients in Guangxi, China.

关键词： Crohn’ s disease, NOD2/CARD15, Single nucleotide polymorphisms

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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： Jie Pang Lin-Yan Qian ping lv xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

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A Generalized MSST Algorithm for Counting Points of Elliptic Curves over F_(p)^(n)

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Journal of Systems Science & Complexity 2024年第4期37卷 1738-1754页

作者： LI xiao lv Chang PAN Zhizhong Key Laboratory of Cyberspace Security Defense Institute of Information EngineeringChinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100085China Huawei Technologies Co. Ltd.Shenzhen 518129China

Elliptic curve cryptography is an important part of nowaday's public key *** points of elliptic curves over finite fields is of great significance to the selection of safety *** present,there are many p-adic algorithms,such as SST algorithm,generalized AGM algorithm,Kedlaya algorithm,etc.,which can deal with the situation of finite fields of small *** this paper,the authors generalize the MSST algorithm of characteristic 2 to general fields of odd characteristic,and propose the generalized MSST *** generalized MSST algorithm is achieved by combining the advantages of the SST algorithm and the generalized AGM *** the time complexity of the multiplication of two n-bit numbers is denoted as O((n)^(μ)),then the time complexity of the generalized MSST algorithm is O(n^(2μ+1/1+μ)),which is the same as the improved SST *** practical experiments,the running time of the generalized MSST algorithm is less than that of the improved SST algorithm.

关键词： Elliptic curve generalized AGM algorithm generalized MSST algorithm SST algorithm

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Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer

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World Journal of Gastroenterology 2024年第16期30卷 2195-2208页

作者： xiao-Jun Zhang Yan Yu He-ping Zhao Lei Guo Kun Dai Jing lv Department of Clinical Laboratory Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Department of Clinical Laboratory Yanliang Railway Hospital of Xi’anXi’an 710089Shaanxi ProvinceChina

As a highly invasive malignancy,esophageal cancer(EC)is a global health issue,and was the eighth most prevalent cancer and the sixth leading cause of cancerrelated death worldwide in *** to its highly immunogenic nature,emerging immunotherapy approaches,such as immune checkpoint blockade,have demonstrated promising efficacy in treating EC;however,certain limitations and challenges still *** addition,tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment(TIME);thus,understanding the TIME is urgent and crucial,especially given the importance of an immunosuppressive microenvironment in tumor *** aim of this review was to better elucidate the mechanisms of the suppressive TIME,including cell infiltration,immune cell subsets,cytokines and signaling pathways in the tumor microenvironment of EC patients,as well as the downregulated expression of major histocompatibility complex molecules in tumor cells,to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of ***,personalized treatments could be developed to maximize the advantages of immunotherapy.

关键词： Esophageal cancer Esophageal squamous cell carcinoma Esophageal adenocarcinoma Tumor immune microenvironment Immunosuppression Immunotherapy

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Trends in medication use and treatment patterns in Chinese patients with inflammatory bowel disease

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World Journal of Gastroenterology 2022年第30期28卷 4102-4119页

作者： Ling-Ya Yao Bu-Le Shao Feng Tian Mei Ye Yu-Qin Li xiao-Lei Wang Lin Wang Shao-Qi Yang xiao-ping lv Yan Jia Xue-Hong Wang xiao-Qi Zhang Yan-Ling Wei Qian Cao Department of Gastroenterology Sir Run Run Shaw HospitalCollege of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430000Hubei ProvinceChina Department of Gastroenterology Bethune First Affiliated Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Gastroenterology Shanghai 10th People's HospitalTongji UniversityShanghai 200072China Department of Gastroenterology Zhongshan Hospital Affiliated to Xiamen UniversityXiamen 361000Fujian ProvinceChina Department of Gastroenterology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The 7th Medical Center of Chinese PLA General HospitalBeijing 100000China Department of Gastroenterology Second Xiangya HospitalChangsha 410011Hunan ProvinceChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjing 210000Jiangsu ProvinceChina Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqing 400000China

BACKGROUND Medications for inflammatory bowel disease(IBD)have changed dramatically over ***,no study on long-term medication profiles has been conducted in the Chinese *** To evaluate temporal changes in medication use and treatment patterns for Chinese patients with *** A multicenter retrospective cohort study was conducted among Chinese patients newly diagnosed with Crohn’s disease(CD)and ulcerative colitis(UC)between January 1999 and December *** characteristics and drug prescriptions were *** in medication use and therapeutic patterns were *** In total,3610 patients were *** follow-up,5-aminosalicylates(5-ASA)and corticosteroids(CS)prescriptions gradually decreased,accompanied by a notable increase in immunosuppressants(IMS)and infliximab(IFX)prescriptions in patients with *** rates of 5-ASA and CS were stable,whereas IMS and IFX slightly increased since 2007 in patients with ***(n=957)analyses showed a switch from conventional medications to IFX in patients with CD,while 5-ASA and CS were still steadily prescribed in patients with *** regression analyses revealed that surgical history,disease behavior,and disease location were associated with initial therapeutic strategies in patients with ***,medications before diagnosis,disease location,and diagnostic year might affect initial strategies in patients with *** Long-term treatment strategies analyses has provided unique insight into the switch from conventional drugs to IFX in Chinese patients with CD.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Medication trends Treatment pattern Infliximab

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