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TREM-1和COX-2在直肠癌组织中的表达及其与预后的关系

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西安交通大学学报（医学版） 2017年第5期38卷 720-724页

作者：张蕊崔慧霞杨旭王晓鹏张文陆锦州医科大学研究生学院辽宁锦州121000 锦州医科大学护理学院辽宁锦州121000 锦州医科大学附属第一医院放疗科辽宁锦州121000

目的检测TREM-1、COX-2在直肠癌组织及癌旁组织中的表达差异,探讨二者与临床病理特征的关系,及其对患者生存的影响。方法应用免疫组织化学法,对68例直肠癌组织和50例癌旁组织的TREM-1和COX-2的表达进行检测。并对患者定期随访,分析两因... 详细信息

目的检测TREM-1、COX-2在直肠癌组织及癌旁组织中的表达差异,探讨二者与临床病理特征的关系,及其对患者生存的影响。方法应用免疫组织化学法,对68例直肠癌组织和50例癌旁组织的TREM-1和COX-2的表达进行检测。并对患者定期随访,分析两因子与预后的关系。结果直肠癌组织中TREM-1、COX-2的阳性表达率高于癌旁组织(P<0.05)。TREM-1的表达与淋巴结转移相关,COX-2与病理分期、淋巴结转移相关(P<0.05),两因子与年龄、性别、组织分化程度及肿瘤大小无关。两者之间的表达呈正相关(r=0.550,P<0.001)。TREM-1、COX-2阳性表达组总生存期(OS)均较阴性组缩短(P<0.05)。COX多元回归分析显示TREM-1的表达、病理分期、淋巴结有无转移、肿物大小对预后有影响。结论 TREM-1、COX-2在直肠癌组织中表达增高,提示两者可能促进直肠癌的发展和淋巴结转移,且二者的表达与患者不良预后相关。

关键词：直肠癌髓样细胞触发受体-1(TREM-1) 环氧化酶-2(COX-2)

Synthesis and Crystal Structure of A Novel Macrolide

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Synthesis and Crystal Structure of A Novel Macrolide

圆柱模型下电子回旋共振微波等离子体离子输运过程的数值研究

大环化学和超分子化学的新发展——当前学科交叉的一个重要桥梁——中国化学会全国第十五届大环化学暨第七届超分子化学学术讨论会

作者： LENG Xin LIU xiao-Ju zhang peng-Fei YANG Bing-Qin~* (College of Chemistry and Materials Science,Northwest University,Xi’an,Shanxi 710069)

A novel macrolide(CHNO) has been prepared,and the structure has been elucidated by X-ray *** Compound crystallizes in Orthorhombic system,space group P2(1)2(1)2(1),with a = 7.4667(11)(?),b = 8.8481(13)(?),c = 22.383(3... 详细信息

关键词： macrolide synthesis X-ray crystal structure

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物理学报 1997年第12期46卷 2376-2383页

作者：宫野温晓军张鹏云邓新绿大连理工大学物理系

在圆柱模型下，采用ＭｏｎｔｅＣａｒｌｏ方法模拟了电子回旋共振（ＥＣＲ）微波等离子体源中离子离开放电室后历经中性区、鞘层区以及工件表面二次电子发射形成的虚拟阴极“屏蔽区”，最后被加负偏压的工件表面吸收的全过程．研究了鞘... 详细信息

在圆柱模型下，采用ＭｏｎｔｅＣａｒｌｏ方法模拟了电子回旋共振（ＥＣＲ）微波等离子体源中离子离开放电室后历经中性区、鞘层区以及工件表面二次电子发射形成的虚拟阴极“屏蔽区”，最后被加负偏压的工件表面吸收的全过程．研究了鞘层边界处的衔接问题，得到了光滑自洽的电势分布曲线及工件表面离子的能量分布和角分布，同时讨论了磁场、气压以及二次电子发射对鞘势的影响．

关键词：等离子体源数值 ECR 微波等离子体离子输运

Motivational interviewing in postoperative rehabilitation and chronic disease management: Current findings and future research directions

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World Journal of Psychiatry 2025年第1期15卷 26-31页

作者： Bing-Ren zhang xiao Yang Affiliated Hospital(School of Clinical Medicine) Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina Mental Health Education and Counseling Center Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina

This editorial highlights a recently published study examining the effectiveness of music therapy combined with motivational interviewing(MI)in addressing an-xiety and depression among young and middle-aged patients following percuta-neous coronary *** further explores existing evidence and potential future research directions for MI in postoperative rehabilitation and chronic disease *** aims to facilitate behavioral change and promote healthier lifestyles by fostering a trusting relationship with patients and enhan-cing intrinsic *** has demonstrated its effectiveness in posto-perative recovery for oncological surgery,stroke,organ transplants,and gastroin-testinal procedures,as well as in managing chronic conditions such as diabetes,obesity,and periodontal *** approach is patient-centered,adaptable,cost-effective,and easily replicable,though its limitations include reliance on the therapist’s expertise,variability in individual responses,and insufficient long-term follow-up *** research could focus on developing individualized and precise intervention models,exploring applications in digital health management,and confirming long-term outcomes to provide more compre-hensive support for patient rehabilitation.

关键词： Chronic disease management Motivational interviewing Patient-centered Postoperative rehabilitation Treatment adherence

Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang Dai Guoyao Yue Yiman zhang Lulu Li Zhong-Zhen Yu peng Min Hao-Bin zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen zhang Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia peng Wen Qin Xuebing Yan Kun zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu zhang Min Yi Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： xiaodong Yang Haochen Shen xiaoming xiao Zhichao Li Qi Zhou Wei Yang Bin Jiang Yongli Sun Luhong zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting