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Sporamin suppresses growth of xenografted colorectal carcinoma in athymic BALB/c mice by inhibiting liver β-catenin and vascular endothelial growth factor expression

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World Journal of Gastroenterology 2019年第25期25卷 3196-3206页

作者： Chun Yang Jing-Jie zhang xiao-peng zhang Rong xiao peng-Gao Li School of Public Health Capital Medical UniversityBeijing Key Laboratory of Clinical Epidemiology

BACKGROUND Colorectal cancer(CRC)is the third most common malignancy of the digestive tract and the fifth leading cause of cancer-related mortality in ***,a Kunitz-type trypsin inhibitor isolated from sweet potato,is a potential anti-cancer agent with activities against a number of malignant tumor cells in *** liver secretes a myriad of endocrine factors that may facilitate the growth and transformation of tumors in the development of *** To investigate the effects of sporamin on liver morphology and biomarkers of xenografted CRC in the liver of athymic BALB/c *** Twenty-seven male BALB/c nude mice were randomly divided into control,vehicle,and sporamin *** in the latter two groups were intraperitoneally xenografted with LoVo colorectal carcinoma cells and intragastrically infused with saline or sporamin(0.5 g/kg body weight/d),respectively,for 3 *** and eosin(HE)staining of the sections was performed to observe morphological changes in hepatic tissue and real-time fluorescent quantitative PCR(qPCR)and enzyme-linked immunosorbent assay(ELISA)were used to measure the expression ofβ-catenin and vascular endothelial growth factor(VEGF)in the *** Sporamin significantly reduced the number and weight of tumor nodules formed in the abdominal *** with the vehicle group,the mean tumor weight(±SD)in the sporamin group was significantly reduced(0.44±0.10 g vs 0.26±0.15 g)and the total number of tumors decreased from 93 to *** staining showed that enlargement of the nucleus and synthesis of proteins within hepatocytes,as well as infiltration of inflammatory cells into the liver,were attenuated by *** staining and ELISA showed that the concentrations ofβ-catenin and VEGF in the liver were significantly reduced by *** with the vehicle group,the expression ofβ-catenin measured in integrated optical density units per area was reduced in the sporamin group(47.29±9.10 vs 26

关键词： Sporamin Colorectal cancer Liver Vascular endothelial growth factor β-catenin

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Comparison of the level of thrombus precursor protein in blood plasma between patients with acute cerebral infarction and healthy persons at different time

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Neural Regeneration Research 2006年第3期1卷 258-260页

作者： Chenghua xiao peng zhang Department of Neurology Affiliated Hospital of Xuzhou Medical College Xuzhou 221002 Jiangsu Province China

BACKGROUND： Thrombus precursor protein （TpP） is the index of thrombus activity level, and it is also early referencing index in detecting thrombus diseases. OBJECTIVE： To dynamically observe the changes of TpP level in blood plasma of patients with acute cerebral infarction at different time after onset, and to compare the differences of plasma TpP level between patients with acute cerebral infarction and healthy persons who received health examination. DESIGN： Controlled observation SETTING： Department of Neurology, Affiliated Hospital of Xuzhou Medical College PARTICIPANTS： Totally 58 patients with acute cerebral infarction who received the treatment in the Department of Neurology, Affiliated Hospital of Xuzhou Medical College between September 2004 and March 2005 were recruited in this study. They all met the diagnostic criteria revised by the 4^th National Conference of Cerebrovascular Disorders in 1995 and were diagnosed by clinical and skull CT and （or） MRI examinations. The patients included 33 male and 25 female aged from 36 to 87 years. Time to onset 〈 6 hours, 6 to 11 hours, 12 to 23 hours, 24 to 48 hours and 〉 48 hours were found in 10,11,14,10 and 13 patients respectively. Another 51 persons who homeochronously received the health body examination in our hospital were recruited, including 34 male and 17 female, aged 38 to 85 years, serving as control group. Patients with cardio-cerebrovascualr diseases or liver and kidney diseases were excluded. All the involved subjects were informed of the detected items. METHODS： About 4 mL venous blood was respectively taken from patients admitted to the hospital within 6 hours, 6 toll hours, 12 to 23 hours, 24 to 48 hours and more then 48 hours after onset, and healthy persons when receiving health examination. The level of TpP in blood plasma was measured with enzymelinked immunosorbent assay. MAIN OUTCOME MEASURES： ① Comparison of the level of plasma TpP between patients and controls;② Comparison of the level of p

关键词： Comparison of the level of thrombus precursor protein in blood plasma between patients with acute cerebral infarction and healthy persons at different time time

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Fast and Error-Bounded Space-Variant Bilateral Filtering

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Journal of Computer Science & Technology 2019年第3期34卷 550-568页

作者： Meng-Ke Yuan Long-Quan Dai Dong-Ming Yan Li-Qiang zhang Jun xiao xiao-peng zhang National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Computer Science and Technology Nanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Remote Sensing Science School of GeographyBeijing Normal UniversityBeijing 100875China

The traditional space-invariant isotropic kernel utilized by a bilateral filter(BF)frequently leads to blurry edges and gradient reversal artifacts due to tlie existence of a large amount of outliers in the local averaging ***,the efficient and accurate cstiinatioii of space-variant k(4rnels which adapt to image structures,and the fast realization of the corresponding space-variant bilateral filtering are challenging *** address these problems,we present a space-variant BF(SVBF).and its linear time and error-bounded acceleration ***,we accurately estimate spacevariant,anisotropic kernels that vary with image structures in linear time through structure tensor and mininnini spanning ***,we perform SVBF in linear time using two error-bounded approximation methods,namely,low-rank tensor approximation via higher-order singular value decomposition and exponential sum *** proposed SVBF can efficiently achieve good edge-preserving *** validate the advantages of the proposed filter in applications including:image denoising,image enhancement,and image focus *** results(leinonstrate that our fast and error-bounded SVBF is superior to state-of-the-art methods.

关键词： error-bounded acceleration edge-aware smoothing space-variant bilateral filtering

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Spectral CT imaging as a new quantitative tool? Assessment of perfusion defects of pulmonary parenchyma in patients with lung cancer

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Chinese Journal of Cancer Research 2013年第6期25卷 722-728页

作者： Ying-Shi Sun xiao-Yan zhang Yong Cui Lei Tang xiao-Ting Li Ying Chen xiao-peng zhang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of RadiologyPeking University Cancer Hospital & Institute

Objective： This study investigated the capability of dual-energy spectral computed tomography （CT） to quantitatively evaluate lung perfusion defects that are induced by central lung cancer. Methods： Thirty-two patients with central lung cancer underwent CT angiography using spectral imaging. A univariate general linear model was conducted to analyze the variance of iodine concentration/CT value with three factors of lung fields. A paired t-test was used to compare iodine concentrations and CT values between the distal end of lung cancer and the corresponding area in the contralateral normal lung. Results： Iodine concentrations increased progressively in the far, intermediate and near ground sides in the normal lung fields at 0.60±0.28, 0.93±0.27 and 1.25±0.38 mg/mL, respectively （P〈0.001）. The same trend was observed for the CT values [-（840.64±49.08）, -（812.66±50.85） and -（760.83±89.17） HU, P〈0.001]. The iodine concentration （0.70±0.42 mg/mL） of the lung field in the distal end of lung cancer was significantly lower than the corresponding area in the contralateral normal lung （1.19±0.62 mg/mL）（t=-7.23, P〈0.001）. However, the CT value of lung field in the distal end of lung cancer was significantly higher than the corresponding area in the contralateral normal lung [-（765.29±93.34） HU vs. -（800.07±76.18） HU, t=3.564, P=0.001]. Conclusions： Spectral CT imaging based on the spectral differentiation of iodine is feasible and can quantitatively evaluate pulmonary perfusion and identify perfusion defects that are induced by central lung cancer. Spectral CT seems to be a promising technique for the simultaneous evaluation of both morphological and functional lung information.

关键词： Spectral computed tomography (CT) quantitative analysis perfusion lung cancer

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Total ionizing dose effect modeling method for CMOS digital-integrated circuit

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Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： Bo Liang Jin-Hui Liu xiao-peng zhang Gang Liu Wen-Dan Tan Xin-Dan zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was *** digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional *** of these three parts was separately *** the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using *** the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area ***,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital *** experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose *** confirms the practicality and accuracy of the proposed modeling *** TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

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Fused monochromatic imaging acquired by single source dual energy CT in hepatocellular carcinoma during arterial phase: an initial experience

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Chinese Journal of Cancer Research 2014年第4期26卷 437-443页

作者： Shun-Yu Gao xiao-peng zhang Yong Cui Ying-Shi Sun Lei Tang xiao-Ting Li xiao-Yan zhang Jun Shan Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of RadiologyPeking University Cancer Hospital& Institute

Objective： To explore whether single and fused monochromatic images can improve liver tumor detection and delineation by single source dual energy CT （ssDECT） in patients with hepatocellular carcinoma （HCC） during arterial phase. Methods： Fifty-seven patients with HCC who underwent ssDECT scanning at Beijing Cancer Hospital were enrolled retrospectively. Twenty-one sets of monochromatic images from 40 to 140 keV were reconstructed at 5 keV intervals in arterial phase. The optimal contrast-noise ratio （CNR） monochromatic images of the liver tumor and the lowest-noise monochromatic images were selected for image fusion. We evaluated the image quality of the optimal-CNR monochromatic images, the lowest-noise monochromatic images and the fused monochromatic images, respectively. The evaluation indicators included the spatial resolution of the anatomical structure, the noise level, the contrast and CNR of the tumor. Results： In arterial phase, the anatomical structure of the liver can be displayed most clearly in the 65-keV monochromatic images, with the lowest image noise. The optimal-CNR monochromatic images of HCC tumor were 50-keV monochromatic images in which the internal structural features of the liver tumors were displayed most clearly and meticulously. For tumor detection, the fused monochromatic images and the 50-keV monochromatic images had similar performances, and were more sensitive than 65-keV monochromatic images. Conclusions： We achieved good arterial phase images by fusing the optimal-CNR monochromatic images of the HCC tumor and the lowest-noise monochromatic images. The fused images displayed liver tumors and anatomical structures more clearly, which is potentially helpful for identifying more and smaller HCC tumors.

关键词： Computed tomography (CT) dual energy hepatocellular carcinoma (HCC) image postprocessing comparative study

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Activation cross sections for reactions induced by 14 MeV neutrons on natural copper

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Nuclear Science and Techniques 2018年第10期29卷 254-260页

作者： Jing-Jie Ma Feng-Qun Zhou xiao-Jun Sun xiao-peng zhang Shu-Qing Yuan School of Electrical and Mechanical Engineering Pingdingshan UniversityPingdingshan 467000China Henan Quality Polytechnic Pingdingshan 467000China

The cross sections for the^(63)Cu(n,a)^(60(m+g))Co,^(65)Cu(n,2 n)^(64)Cu, and ^(65)Cu(n,p)^(65)Ni reactions have been studied in the neutron energy range of 13.5–14.8 MeV using the activation technique. The neutron beams were produced via the^3 H(d,n)~4 He reaction. The neutron energies of different directions in the measurements were determined beforehand by the method of cross section ratios for the^(90)Zr(n,2 n)^(89 m+g)Zr and ^(93)Nb(n,2 n)^(92 m)Nb reactions. The results in the present work were discussed and compared with measurement results found in the literatures.

关键词： Copper Activation Neutron Cross section Nuclear reaction

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Differentiation of human umbilical cord blood stem cells into hepatocytes in vivo and in vitro

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World Journal of Gastroenterology 2006年第25期12卷 4014-4019页

作者： xiao-peng Tang Min zhang Xu Yang Li-Min Chen Yang Zeng Research Center of Liver Diseases the Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

AIM： To study the condition and potentiality of human umbilical cord blood stem cells （HUCBSC） to differentiate into hepatocytes in vivo or in vitro. METHODS： In a cell culture study of human umbilical cord blood stem cell （HUCBSC） differentiation, human umbilical cord blood mononuclear cells （HUCBMNC） were separated by density gradient centrifugation. Fibroblast growth factor （FGF） and hepatocyte growth factor （HGF） and the supernatant of fetal liver were added in the inducing groups. Only FGF was added in the control group. The expansion and differentiation of HUCBMNC in each group were observed. Human alpha fetoprotein （AFP） and albumin （ALB） were detected by immunohistochemistry. In the animal experiments, the survival SD rats with acute hepatic injury after carbon tetrachloride （CCL4） injection 48 h were randomly divided into three groups. The rats in group A were treated with human umbilical cord blood serum. The rats in group B were treated with HUCBMNC transplantation. The rats in group C were treated with HUCBMNC transplantation followed by intraperitoneal cyclophosphamide for 7 d. The rats were killed at different time points after the treatment and the liver tissue was histopathologically studied and human AFP and ALB detected by immunohistochemistry. The human X inactive-specific transcript gene fragment in the liver tissue was amplified by PCR to find human DNA. RESULTS： The results of cell culture showed that adherent cells were stained negative for AFP or ALB in control group. However, the adherent cells in the inducing groups stained positive for AFP or ALB. The result of animal experiment showed that no human AFP or ALB positive cells present in the liver tissue of group A （control group）. However, many human AFP or ALB positive cells were scattered around sinus hepaUcus and the central veins of hepatic Iobules and in the portal area in group B and group C after one month. The fragment of human X chromagene could be detected in the liver tissue

关键词： Umbilical cord blood Stem cell Liver failure Cell transplantation Cell differentiation

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Systematic review of digital twin technology and applications

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Visual Computing for Industry,Biomedicine,and Art 2023年第1期6卷 119-138页

作者： Jun-Feng Yao Yong Yang Xue-Cheng Wang xiao-peng zhang Center for Digital Media Computing School of FilmXiamen UniversityXiamen 361005China School of Informatics Xiamen UniversityXiamen 361005China Key Laboratory of Digital Protection and Intelligent Processing of Intangible Cultural Heritage of Fujian and Taiwan Ministry of Culture and TourismXiamen 361005China State Key Laboratory of Multimodal Artificial Intelligence Systems the Institute of AutomationChinese Academy of SciencesBeijing 101408China

As one of the most important applications of digitalization,intelligence,and service,the digital twin(DT)breaks through the constraints of time,space,cost,and security on physical entities,expands and optimizes the relevant functions of physical entities,and enhances their application *** phenomenon has been widely studied in academia and *** this study,the concept and definition of DT,as utilized by scholars and researchers in various fields of industry,are *** internal association between DT and related technologies is *** four stages of DT development history are *** fundamentals of the technology,evaluation indexes,and model frameworks are ***,a conceptual ternary model of DT based on time,space,and logic is *** technology and application status of typical DT systems are ***,the current technical challenges of DT technology are analyzed,and directions for future development are discussed.

关键词： Digital twin Digitalization Virtual modeling Information technology Simulation

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Detoxification of insecticides, allechemicals and heavy metals by glutathione S-transferase SIGSTE1 in the gut of Spodoptera litura

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Insect Science 2015年第4期22卷 503-511页

作者： Zhi-Bin Xu xiao-peng Zou Ni zhang Qi-Li Feng Si-Chun Zheng Laboratory of Molecular and Developmental Entomology Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life Sciences South China Normal University Guangzhou 510631 China

Insect glutathione S-transferases （GSTs） play important roles in detoxifying toxic compounds and eliminating oxidative stress caused by these compounds. In this study, detoxification activity of the epsilon GST S1GSTE1 in Spodoptera litura was analyzed for several insecticides and heavy metals. S1GSTE1 was significantly up-regulated by chlor- pyrifos and xanthotoxin in the midgut of S. litura. The recombinant S1GSTE1 had Vmax （reaction rate of the enzyme saturated with the substrate） and Km （michaelis constant and equals to the substrate concentration at half of the maximum reaction rate of the enzyme） values of 27.95 ± 0.88μmol/min/mg and 0.87 ± 0.028 mmol/L for glutathione, respec- tively, and Vmax and Km values of 22.96 ± 0,78μmol/min/mg and 0.83 ± 0.106 mmol/L for 1-chloro-2,4-dinitrobenzene, respectively. In vitro enzyme indirect activity assay showed that the recombinant S1GSTE 1 possessed high binding activities to the insecticides chlor- pyrifos, deltamethrin, malathion, phoxim and dichloro-diphenyl-trichloroethane （DDT）. S1GSTE1 showed higher binding activity to toxic heavy metals cadmium, chromium and lead than copper and zinc that are required for insect normal growth. Western blot analysis showed that S1GSTE1 was induced in the gut of larvae fed with chlorpyrifos or cadmium. S1GSTE1 also showed high peroxidase activity. All the results together indicate that S1G- STE1 may play an important role in the gut orS. litura to protect the insect from the toxic effects of these compounds and heavy metals.

关键词： glutathioneS-transferase heavy metal insecticide midgut Spodoptera litura

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