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MCSTransWnet:A new deep learning process for postoperative corneal topography prediction based on raw multimodal data from the Pentacam HR system

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Medicine in Novel Technology and Devices 2024年第1期21卷 53-63页

作者： nan cheng Zhe Zhang Jing Pan xiao-Na Li Wei-Yi chen Guang-Hua Zhang Wei-Hua Yang College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030600ShanxiChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040GuangdongChina Department of Intelligence and Automation Taiyuan UniversityTaiyuan 030032ShanxiChina Graphics and Imaging Laboratory University of GironaGirona 17004Spain

This work provides a new multimodal fusion generative adversarial net(GAN)model,Multiple Conditions Transform W-net(MCSTransWnet),which primarily uses femtosecond laser arcuate keratotomy surgical parameters and preoperative corneal topography to predict postoperative corneal topography in astigmatism-corrected *** MCSTransWnet model comprises a generator and a discriminator,and the generator is composed of two *** first sub-generator extracts features using the U-net model,vision transform(ViT)and a multi-parameter conditional module branch.The second sub-generator uses a U-net network for further image *** discriminator uses the pixel discriminator in ***,most GAN models are convolutional neural networks;however,due to their feature extraction locality,it is difficult to comprehend the relationships among global ***,we added a vision Transform network as the model branch to extract the global *** is normally difficult to train the transformer,and image noise and geometric information loss are ***,we adopted the standard U-net fusion scheme and transform network as the generator,so that global features,local features,and rich image details could be obtained *** experimental results clearly demonstrate that MCSTransWnet successfully predicts postoperative corneal topographies(structural similarity=0.765,peak signal-to-noise ratio=16.012,and Fréchet inception distance=9.264).Using this technique to obtain the rough shape of the postoperative corneal topography in advance gives clinicians more references and guides changes to surgical planning and improves the success rate of surgery.

关键词： Deep learning Generative adversarial networks Corneal topography Transformer W-net U-net Medical imaging Multimodal fusion

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Curcumin for gastric cancer:Mechanism prediction via network pharmacology,docking,and in vitro experiments

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3635-3650页

作者： Peng-Hui Yang Ya-nan Wei Bi-Juan xiao Si-Yi Li Xin-Long Li Liang-Jun Yang Hua-Feng Pan Geng-Xin chen The Second School of Clinical Medicine Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Traditional Chinese Medicine The People's Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Centre for Translational Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long ***,the mechanism by which curcumin affects gastric cancer(GC)has not been *** To elucidate the potential mechanisms of curcumin in the treatment of *** Network pharmacological approaches were used to perform network analysis of *** first analyzed Lipinski’s Rule of Five for the use of *** latent targets were predicted using the PharmMapper,SwissTargetPrediction and DrugBank network *** disease targets were mined through the GeneCard,OMIM,DrugBank and TTD network ***,GO enrichment,KEGG enrichment,protein-protein interaction(PPI),and overall survival analyses were *** results were further verified through molecular docking,differential expression analysis and cell *** We identified a total of 48 curcumin-related genes with 31 overlapping GC-related *** intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant *** PPI analysis,6 hub targets were identified,namely,estrogen receptor 1(ESR1),epidermal growth factor receptor(EGFR),cytochrome P450 family 3 subfamily A member 4(CYP3A4),mitogen-activated protein kinase 14(MAPK-14),cytochrome P450 family 1 subfamily A member 2(CYP1A2),and cytochrome p450 family 2 subfamily B member 6(CYP2B6).These factors are correlated with decreased survival rates among patients diagnosed with *** docking analysis further substantiated the strong binding interactions between Curcumin and the hub target *** experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their *** levels of hub targets CYP3A4,MAPK14,CYP1A2,and CYP2B6 in BGC-823 cells were significantly increased in each dose *** Curcumin can play an anti-GC role through a variety of

关键词： Curcumin Gastric cancer Network pharmacology Molecular docking Survival analysis

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Recent Advances in the Synthesis of Zeolites from Solid Wastes

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Chemical Research in Chinese Universities 2024年第4期40卷 646-656页

作者： LIU Pei WU Qinming chen Zhenghai xiao Feng-Shou Key Laboratory of Biomass Chemical Engineering of Ministry of Education and College of Chemical and Biological Engineering Zhejiang UniversityHangzhou310028P.R.China Zhejiang Provincial Innovation Center of Green Petrochemical Technology Ningbo315048P.R.China Kente Catalysts Inc. Xianju317300P.R.China

With the rapid development of industrialization,it is inevitable to produce solid wastes in the fields of energy petrochemical ***,the storage and utilization of these solid wastes have become a considerable *** to the main element composition of these solid wastes including silicon and aluminum,it has attracted extensive attention for synthesizing *** review summarized the properties of major solid wastes including coal fly ash,coal gangue,spent fluid catalytic cracking(FCC)catalyst,lithium slag,bauxite residue,and waste ***,the preparation of LTA,FAU,ZSM-5,SSZ-13,Beta,and MOR zeolites from these solid wastes were ***,the current challenges and perspectives were discussed.

关键词： Solid waste Zeolite Utilization Sustainable route Application

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Impact of nutritional support on immunity,nutrition,inflammation,and outcomes in elderly gastric cancer patients after surgery

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2175-2182页

作者： xiao-Wan chen xiao-Chun Guo Fen cheng Department of Gastrointestinal Surgery Hubei Cancer HospitalWuhan 430079Hubei ProvinceChina Department of Gastroenterology The First People’s Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina

BACKGROUND Postoperative rehabilitation of elderly patients with gastric cancer has always been the focus of clinical *** the intervention by a full-course nutritional support team can have a positive impact on the postoperative immune function,nutritional status,inflammatory response,and clinical outcomes of this special population has not yet been fully *** To evaluate the impact of full-course nutritional support on postoperative comprehensive symptoms in elderly patients with gastric *** This is a retrospective study,including 60 elderly gastric cancer patients aged 70 years and above,divided into a nutritional support group and a control *** nutritional support group received full postoperative nutritional support,including individualized meal formulation,and intravenous and parenteral nutrition supplementation,and was regularly evaluated and adjusted by a professional nutrition *** control group received routine postoperative *** After intervention,the proportion of CD4+lymphocytes(25.3%±3.1%vs 21.8%±2.9%,P<0.05)and the level of immunoglobulin G(12.5 G/L±2.3 G/L vs 10.2 G/L±1.8 G/L,P<0.01)were significantly higher in the nutritional support group than in the control group;the changes in body weight(-0.5 kg±0.8 kg vs-1.8 kg±0.9 kg,P<0.05)and body mass index(-0.2±0.3 vs-0.7±0.4,P<0.05)were less significant in the nutritional support group than in the control group;and the level of C-reactive protein(1.2 mg/L±0.4 mg/L vs 2.5 mg/L±0.6 mg/L,P<0.01)and WBC count(7.2×10^(9)/L±1.5×10^(9)/L vs 9.8×10^(9)/L±2.0×10^(9)/L,P<0.01)were significantly lower in the nutritional support group than in the control *** addition,patients in the nutritional support group had a shorter hospital stay(10.3 d±2.1 d vs 14.8 d±3.6 d,P<0.05)and lower incidence of infection(15%vs 35%,P<0.05)in those of the control *** The intervention by the nutritional support team has a positive impact on postoperative immune function,

关键词： Elderly gastric cancer Postoperative Nutritional support Immune function Inflammatory response Clinical outcome

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C-terminal frameshift mutations generate viable knockout mutants with developmental defects for three essential protein kinases

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aBIOTECH 2024年第2期5卷 219-224页

作者： Yun Zhang Miao-Miao Cui Run-nan Ke Yue-Dan chen Kabin Xie National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Plant Pathology Huazhong Agricultural UniversityWuhan 430070China

Loss-of-function mutants are fundamental resources for gene function ***,it is difficult to generate viable and heritable knockout mutants for essential ***,we show that targeted editing of the C-terminal sequence of the embryo lethal gene MITOGEN-ACTIVATED PROTEIN KINASES 1(OsMPK1)results in weak *** C-terminal-edited osmpk1 mutants displayed severe developmental defects and altered disease resistance but generated tens of viable seeds that inherited the *** the same C-terminal editing approach,we also obtained viable mutants for a wallassociated protein kinase(Os07g0493200)and a leucine-rich repeat receptor-like protein kinase(Os01g0239700),while the null mutations of these genes were *** data suggest that protein kinase activity could be reduced by introducing frameshift mutations adjacent to the C-terminus,which could generate valuable resources for gene function studies and tune protein kinase activity for signaling pathway engineering.

关键词： CRISPR/Cas9 Lethal mutant Protein kinases Genome editing C-terminus

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Inhibiting plastic tensile instability of non-symmetric thin-walled shell component via increasing regional metal inflow based on heterogeneous pressure-carrying medium

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Chinese Journal of Aeronautics 2024年第1期37卷 391-413页

作者： nan XIANG Yiquan SHU Pengyi WANG Menghan YANG Haoran WANG Tao HUANG Junqing GUO Fuxiao chen School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China National Key Laboratory for Precision Heat Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China College of Mechanical&Electrical Engineering Shaanxi University of Science&TechnologyXi’an 710021China Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal new Materials and Advanced Processing Technology Luoyang 471023China

Heterogeneous pressure-carrying medium was employed to establish a differentiated pressure field on sheet metal in flexible die forming process in this work,which aimed at matching the non-symmetric shape of target component and improving metal inflow to avoid local tensile ***,metal inflow corresponding to the differentiated pressure field was analytically *** of a typical non-symmetric shell component was experimentally and numerically studied based on the proposed *** with forming processes based on the uniform pressure,difference of metal inflow in two sides of the non-symmetric component increased from 2.16 mm to 3.36 mm and metal inflow in critical region increased by 11.9%when differentiated pressure field(taking heterogeneous elastomer#4–3 for example)was *** resultant maximum thinning ratio decreased by 4.2% and the uniformity of shell thickness increased by 16.9%.With the decrease of Shore hardness of elastomer in the formed region,stress path in the ready-to-form region transferred towards the bi-axial tension stress state,i.e.,stress ratio(a)***,stress triaxiality(η)in characteristic regions were regulated appropriately,which decreased the risk of tensile *** was attributed to the decreased normal pressure and frictional resistance at sheet/elastomer interface in the formed region.

关键词： Aluminum alloys Finite element method Metal forming Plastic deformation Sheet metal

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Transmit Power Minimization for IRS-Assisted NOMA-UAV Networks

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China Communications 2024年第5期21卷 137-152页

作者： Zhao chen Pang xiaowei Tang Jie Liu Mingqian Zhao nan Zhang Xiuyin Wang Xianbin School of Information and Communication Engineering Dalian University of TechnologyDalian 116024China School of Electronic and Information Engineering South China University of TechnologyGuangzhou 510641China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Department of Electrical and Computer Engineering Western UniversityLondonON N6A 5B9Canada

The flexibility of unmanned aerial vehicles(UAVs)allows them to be quickly deployed to support ground *** reflecting surface(IRS)can reflect the incident signal and form passive beamforming to enhance the signal in the specific *** by the promising benefits of both technologies,we consider a new scenario in this paper where a UAV uses non-orthogonal multiple access to serve multiple users with *** to their distance to the UAV,the users are divided into the close users and remote *** UAV hovers above the close users due to their higher rate requirement,while the IRS is deployed near the remote users to enhance their received *** aim at minimizing the transmit power of UAV by jointly optimizing the beamforming of UAV and the phase shift of IRS while ensuring the decoding ***,the problem is ***,we decompose it into two sub-problems,including the transmit beamforming optimization and phase shift optimization,which are transformed into second-order cone programming and semidefinite programming,*** propose an iterative algorithm to solve the two sub-problems *** results prove the effectiveness of the proposed scheme in minimizing the transmit power of UAV.

关键词： intelligent reflecting surface nonorthogonal multiple access phase shift optimization transmit beamforming optimization unmanned aerial vehicle

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Clinical manifestations,diagnosis and long-term prognosis of adult autoimmune enteropathy:Experience from Peking Union Medical College Hospital

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World Journal of Gastroenterology 2024年第19期30卷 2523-2537页

作者： Mu-Han Li Ge-Chong Ruan Wei-Xun Zhou xiao-Qing Li Sheng-Yu Zhang Yang chen xiao-Yin Bai Hong Yang Yu-Jie Zhang Peng-Yu Zhao Ji Li Jing-nan Li Department of Gastroenterology Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Scinences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Tianjin First Central HospitalNankai UniversityTianjin 300192China Affairs Office Chinese Academy of Medical Sciences&Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE *** To improve overall understanding of this disease’s diagnosis and *** We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic *** Diarrhea in AIE patients was characterized by secretory *** common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and *** blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal ***,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte *** patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)*** were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s *** cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,*** Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult *** long-term prognosis is still unsatisfac

关键词： Autoimmune enteropathy Clinical manifestations Diagnostic criteria Pathological features Long-term prognosis

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Mazabraud’s syndrome in female patients:Two case reports

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World Journal of Orthopedics 2024年第6期15卷 593-601页

作者： Xiu-Mao Li Ze-Hao chen Ke-Yi Wang Jun-nan chen Zhao-Nong Yao Yu-Hong Yao xiao-Wei Zhou Nong Lin Department of Orthopedics The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Orthopedics Research Institute Zhejiang UniversityHangzhou 310009Zhejiang ProvinceChina State Key Laboratory of Transvascular Implantation Devices Hangzhou 310009Zhejiang ProvinceChina Songyang Branch of the Second Affiliated Hospital School of MedicineZhejiang UniversityLishui 331124Zhejiang ProvinceChina

BACKGROUND Mazabraud’s syndrome(MS)is a rare and slowly progressive benign disease characterized by the concurrent presence of fibrous dysplasia of bone and intramuscular myxoma,and is thought to be associated with mutations of the GNAS *** date,only about 100 cases of MS have been reported in the literature,but its standard treatment strategy remains *** SUMMARY We report two cases of MS in young women who underwent different treatments based on their symptoms and disease *** first patient,aged 37,received internal fixation and intravenous bisphosphonate for a pathological fracture of the right femoral neck,excision of a right vastus medialis myxoma was subsequently performed for pain control,and asymptomatic psoas myxomas were monitored without *** testing confirmed a GNAS gene mutation in this *** second patient,aged 24,underwent right vastus intermedius muscle myxoma resection,and conservative treatment for fibrous dysplasia of the *** patients were followed-up for 17 months and 3 years,respectively,and are now in a stable *** Various treatments have been selected for MS patients who suffer different *** main treatment for myxomas is surgical resection,while fibrous dysplasia is selectively treated if the patient experiences pathological fracture or severe ***,given the documented instances of malignant transformation of fibrous dysplasia in individuals with MS,close follow-up is necessary.

关键词： Mazabraud's syndrome Fibrous dysplasia Intramuscular myxoma Bisphosphonate Case report

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Astronomical influence of the development of Paleogene thin coal seam groups in offshore Lacustrine basins:A case study of the ZhuⅠDepression's Enping Formation located in the northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 136-150页

作者： Yan Liu Shengbing Huang Dongdong Wang nan Li Yuting Yin Ying chen Zengxue Li College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China CNOOC Research Institute Co. Ltd.Beijing 100028China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK

The development of the Paleogene coal seams in China's offshore basin areas generally had the characteristics of coal measures with large thicknesses,large numbers of coal seams,thin single coal seams,poor stability,scattered vertical distribution,and a wide distribution *** study selected the Enping Formation of the ZhuⅠDepression in the northern section of the South China Sea as an example to determine the macro-control factors of the development of the Paleogene coal seam *** analysis was carried out on the influencing effects and patterns of the astronomical cycles related to the development of the thin coal seam groups in the region.A floating astronomical time scale of the Enping Formation was established,and the sedimentary time limit of the Enping Formation was determined to be approximately 6.15 Ma±.In addition,the cyclostratigraphy analysis results of the natural gamma-ray data of Well XJ in the Enping Formation of the Xijiang Sag revealed that the development of the thin coal seams had probably been affected by short eccentricity and precession *** formation process of coal seams was determined to have been affected by high seasonal contrast,precipitation,and *** the periods with high values of short eccentricity,the seasonal contrasts tended to be *** those periods,fluctuations in the precession controls resulted in periodic volume changes in precipitation and insolation of the region,resulting in the development of thin coal *** was also found that the periods with low precession were the most conducive to coal seam *** that basis,combined with such factors as sedimentary environmental conditions conducive to the development of thin coal seam groups,this study established a theoretical model of the comprehensive influences of short eccentricity and precession on the development and distribution of Paleogene thin coal seam groups in offshore lacustrine *** patterns of the Paleogene astrono

关键词： Paleogene Pearl(Zhujiang)River Mouth Basin coal seam development astronomical cycles

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