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Minimalistic approach to left atrial appendage occlusion guided by cardiac computed tomography angiography

Journal of Geriatric Cardiology 2024年第4期21卷 431-442页

作者： Xian-Sai MENG Qing-Song WANG Xin-Yan WANG Xu LU Yang MU Jing WANG Ting-Ting SONG Yun-Dai chen Tao chen Jun GUO Graduate School of Chinese PLA Medical College BeijingChina Senior Department of Cardiology the Sixth Med-ical CenterChinese PLA General HospitalBeijingChina

OBJECTIVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who underwent LAAO, with or without CCTA-guided, were matched(1:2). Each step of the LAAO procedure in the computed tomography(CT) guidance group(CT group) was directed by preprocedural CT planning. In the control group, LAAO was performed using the standard method. All patients were followed up for 12 months, and device surveillance was conducted using *** A total of 90 patients were included in the analysis, with 30 patients in the CT group and 60 matched patients in the control group. All patients were successfully implanted with Watchman devices. The mean ages for the CT group and the control group were 70.0 ± 9.4 years and 68.4 ± 11.9 years(P = 0.52), respectively. The procedure duration(45.6 ± 10.7 min vs. 58.8 ± 13.0 min,P < 0.001) and hospital stay(7.5 ± 2.4 day vs. 9.6 ± 2.8 day, P = 0.001) in the CT group was significantly shorter compared to the control group. However, the total radiation dose was higher in the CT group compared to the control group(904.9 ± 348.0 m Gy vs.711.9 ± 211.2 m Gy, P = 0.002). There were no significant differences in periprocedural pericardial effusion(3.3% vs. 6.3%, P = 0.8) between the two groups. The rate of postprocedural adverse events(13.3% vs. 18.3%, P = 0.55) were comparable between both groups at 12 months *** CCTA is capable of detailed LAAO procedure planning. Minimalistic LAAO with preprocedural CCTA planning was feasible and safe, with shortened procedure time and acceptable increased radiation and contras consumption. For patients with contraindications to general anesthesia and/or transesophageal echocardiography, this promising method may be an alternative to conventional LAAO.

关键词： anesthesia matched approach

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Performance test of a half-feed peanut-cleaning picker suitable for clay hill areas in southern China

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 156-164页

作者： Shenying Wang Zhaoyan You Dawei Sun Qiang xiao Qiaojun Luo Lin He Key Laboratory of Modern Agricultural Intelligent Equipment in South China Ministry of Agriculture and Rural AffairsGuangzhou 510630China nanjing Institute of Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014China Key Laboratory of Agricultural Equipment for Hilly and Mountainous Areas in Southeastern China(Co-construction by Ministry and Province) Ministry of Agriculture and Rural AffairsHangzhou 310021China Inner Mongolia Autonomous Region Agricultural and Animal Husbandry Technology Promotion Center Hohhot 010000China

To solve the problems of excessive soil lumps,broken branches and seedlings in pods and difficulty in removing impurities in the harvested pods of peanuts in the hilly areas of southern China,which is due to the high soil viscosity and easy hardening,and to improve the soil removal effect of the peanut half-feed pod picker in hilly areas of China,this article designed a half-feed peanut-cleaning picker suitable for southern clay hilly areas and provided a detailed introduction to the overall structure,working principle,and adjustment methods of various operating *** field measurement experiments,the influencing factors and laws of soil removal performance indicators,such as the comprehensive soil removal rate and POD drop rate,were *** results showed that the comprehensive soil removal rate gradually increased with increasing soil patting frequency,soil patting amplitude,and picking roller speed,first increased and then decreased with increasing picking roller gap and gradually decreased with increasing soil patting plate gap and clamping conveyor chain *** comprehensive soil removal rate of the soil patting plate using the opposite patting method was greater than that of the swinging patting *** soil removal pod drop rate increased gradually with increasing soil patting frequency and amplitude and decreased with increasing soil patting plate gap and clamping conveyor chain *** soil removal pod drop rate of the soil patting plate using swing patting was lower than that using the opposite patting *** speed and gap of the picking roller had no effect on the soil removal pod drop *** frequency,amplitude,form,and gap of the soil patting plate had extremely significant impacts on the rate of decrease in the number of soil removal pod drop *** clamping conveyor chain speed had a significant impact,while the speed and gap of the picking roller had no significant *** influence of all factors on the comprehens

关键词： peanut southern clay hilly areas picker comprehensive soil removal rate soil removal pod drop rate

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A novel cabazitaxel liposomes modified with ginsenoside Rk1 for cancer targeted therapy

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Acupuncture and Herbal Medicine 2024年第1期4卷 113-121页

作者： Dandan Huang Zhongjie Tang xiao Pu Tianqi Wang Feiyan Gao Chong Li Medical Research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqingChina Department of Pharmacy National University of SingaporeSingapore 117545Singapore

Objective:In this study,we aim to enhance the anti-prostate cancer efficacy of cabazitaxel(CTX)and reduce its immunosuppression and systemic toxicity by developing CTX-loaded liposomes modified with ginsenoside Rk1(Rk1/CTX-Lip).Methods:Physical and chemical properties of Rk1/CTX-Lip were *** evaluated the biological functions of Rk1/CTXLip,both in vitro and in vivo.A subcutaneous prostate cancer(RM-1)-bearing mouse model was established to study the efficacy of Rk1/CTX-Lip inhibition in ***,a Candida albicans infection model was established in tumor-bearing mice to study the infection-relieving efficacy of Rk1/***,biocompatibility and in vivo safety of Rk1/CTX-Lip were ***:We successfully prepared Rk1/CTX-Lip,achieving high CTX encapsulation efficiency(97.24±0.75)%and physical ***1/CTX-Lip demonstrated evasion of macrophage phagocytosis,effective tumor tissue targeting,and a significant reduction(>50%)in average tumor volume compared with Chol/***,it relieved the concurrent infection burden and effectively regulated immune organs and cells,demonstrating superior ***:Rk1/CTX-Lip presents a promising new therapy for prostate cancer and holds potential for relieving concurrent fungal infections in cancer patients with low immunity.

关键词： Cabazitaxel Fungal infection Ginsenoside Rk1 Liposome-drug delivery system Prostate cancer

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Urgent one-stage endoscopic treatment for choledocholithiasis related moderate to severe acute cholangitis: A propensity scorematched analysis

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World Journal of Gastroenterology 2024年第15期30卷 2118-2127页

作者： Yang Zhou Yin-Qiu Zhang Shuai-Jing Huang Yan Liang xiao Liang Masoom Wali Ya-Dong Feng Department of Gastroenterology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Department of Gastroenterology BenQ Medical CenterThe Affiliated BenQ Hospital of Nanjing Medical UniversityNanjing 210019Jiangsu ProvinceChina

BACKGROUND During emergency endoscopic retrograde cholangiopancreatography(ERCP),the safety and feasibility of performing one-stage endoscopic treatment for patients with acute cholangitis(AC)due to choledocholithiasis are *** To investigate the safety and feasibility of one-stage endoscopic treatment for moderate to severe *** We enrolled all patients diagnosed with moderate to severe cholangitis due to common bile duct stones from January 2019 to July *** outcomes were compared in this study between patients who underwent ERCP within 24 h and those who underwent ERCP 24 h later,employing a propensity score(PS)*** primary outcomes were intensive care unit(ICU)admission rates,ICU length of stay,and duration of antibiotic *** In total,we included 254 patients and categorized them into two groups based on the time elapsed between admission and intervention:The urgent group(≤24 h,n=102)and the elective group(>24 h,n=152).Ninety-three pairs of patients with similar characteristics were selected by PS *** urgent ERCP group had more ICU admissions(34.4%vs 21.5%,P=0.05),shorter ICU stays(3 d vs 9 d,P<0.001),fewer antibiotic use(6 d vs 9 d,P<0.001),and shorter hospital stays(9 d vs 18.5 d,P<0.001).There were no significant differences observed in adverse events,in-hospital mortality,recurrent cholangitis occurrence,30-d readmission rate or 30-d *** Urgent one-stage ERCP provides the advantages of a shorter ICU stay,a shorter duration of antibiotic use,and a shorter hospital stay.

关键词： Acute cholangitis Endoscopic retrograde cholangiopancreatography One-stage treatment Optimal time

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Effects of psychological nursing in Parkinson's related depression patients undergoing functional magnetic resonance imaging:A randomized controlled trial

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World Journal of Clinical Cases 2024年第17期12卷 3086-3093页

作者： xiao-Xia Zhang xiao-Hui Zhang Yan-Chao Dong Department of Internal Medicine The First hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina Department of Gastroscope The First hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina Medical Imaging Center The First hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina

BACKGROUND Patients with Parkinson’s disease(PD)often experience depression,and some may require magnetic resonance imaging(MRI)for diagnosis,which can lead to MRI failure due to *** To explore the value of psychological interventions in successfully completing functional MRI scans of the brain for PD-related *** Ninety-six patients with PD were randomly divided into two *** control group(47 patients)received general care,and the experimental group(49 patients)received general care combined with psychological *** Unified Parkinson's Disease Assessment Scale(UPDRS),Hamilton Depression Scale(HAMD),and Geriatric Depression Scale(GDS)-15 scores,heart rate,systolic blood pressure,and MRI-Anxiety Questionnaire(MRI-AQ)scores before and after the scan were *** completion rate of magnetic resonance(MR)scanning,scanning duration,and image quality scores were *** Before scanning,no statistically significant difference was observed between the two groups in terms of heart rate,systolic blood pressure,and UPDRS,HAMD,GDS-15,and MRI-AQ *** scanning,systolic blood pressure,MRI-AQ score,and scan time in the experimental group were significantly lower than those in the control group,whereas the scan completion rate and image quality score were significantly higher than those in the control *** Psychological nursing interventions are helpful in alleviating PD-related depression and assessing MR depression scores and may be helpful in the successful completion of functional MRI scans of the patient's brain.

关键词： Magnetic resonance imaging Psychological nursing Parkinson's disease Depression Claustrophobia

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基于文化再生产的大学校庆形象景观设计策略研究

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设计 2024年第7期37卷 41-45页

作者：吕游陈楠清华大学美术学院

探究如何构建利于文化更新的校庆形象景观设计策略。针对目前大学校庆设计的现状进行反思,以文化再生产理论为基础归纳大学文化资本构成及相应文化素材库的挖掘,从而提出符合时代语境的“分析层-提炼层-实践层”三层次大学文化创新再造... 详细信息

探究如何构建利于文化更新的校庆形象景观设计策略。针对目前大学校庆设计的现状进行反思,以文化再生产理论为基础归纳大学文化资本构成及相应文化素材库的挖掘,从而提出符合时代语境的“分析层-提炼层-实践层”三层次大学文化创新再造的设计框架。生成由“文化资本提炼-文化视觉转译-形象景观打造”为路径的校庆形象景观设计策略。针对清华大学110周年校庆,通过建立由视觉、空间及文创三方耦合的校庆形象景观设计系统以实现大学文化“再生产”的创新目的,为大学形象的当代塑造提供路径参考。

关键词：文化再生产文化资本清华大学大学形象校庆设计形象景观

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Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal carcinoma prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1796-1807页

作者： Ren-Qi Mu Jun-Wei Lv Cai-Yun Ma xiao-Hui Ma Dong Xing Hou-Sheng Ma Department of Radiology Yantai Mountain HospitalYantai 264001Shandong ProvinceChina Department of Radiology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina Department of Gynaecology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina The First Clinical Medical College Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Rectal carcinoma(RC),one of the most common malignancies globally,presents an increasing incidence and mortality year by year,especially among young people,which seriously affects the prognosis and quality of life of *** present,dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum carbohydrate antigen 19-9(CA19-9)and CA125 Levels have been used in clinical practice to evaluate the T stage and differentiation of ***,the accuracy of these evaluation modalities still needs further *** study explores the application and value of these methods in evaluating the T stage and differentiation degree of *** To analyze the diagnostic performance of DCE-MRI parameters combined with serum tumor markers(TMs)in assessing pathological processes and prognosis of RC *** A retrospective analysis was performed on 104 RC patients treated at Yantai Yuhuangding Hospital from May 2018 to January *** were categorized into stages T1,T2,T3,and T4,depending on their T stage and differentiation *** addition,they were assigned to low(L group)and moderate-high differentiation(M+H group)groups based on their differentiation *** levels of DCE-MRI parameters and serum CA19-9 and CA125 in different groups of patients were *** addition,the value of DCE-MRI parameters[volume transfer constant(Ktrans),rate constant(Kep),and extravascular extracellular volume fraction(Ve)in assessing the differentiation and T staging of RC patients was ***,the usefulness of DCE-MRI parameters combined with serum CA19-9 and CA125 Levels in the evaluation of RC differentiation and T staging was *** Ktrans,Ve,CA19-9 and CA125 were higher in the high-stage group and L group than in the low-stage group and M+H Group,respectively(P<0.05).The areas under the curve(AUCs)of the Ktran and Ve parameters were 0.638 and 0.694 in the diagnosis of high and low stages,respectively,and 0.672 and 0

关键词： Rectal carcinoma Volume transfer constant Rate constant Extravascular extracellular volume fraction Serum carbohydrate antigen 19-9 Serum carbohydrate antigen 125

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深部高应力厚煤层巷道高效快支快掘技术的研究

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煤矿现代化 2024年第4期33卷 13-17页

作者：陈孝山西阳泉南煤集团南庄公司山西阳泉045000

南庄煤矿在分析研究顶板连续梁理论的基础上,提出大间排距高效能锚杆支护技术。应用FLAC数值模拟开展模拟试验,得出锚杆长度3 m、网度1.1 m的最佳支护参数。在8824工作面应用效果表明,该参数能够该支护参数条件下,巷道顶板下沉量不超过2... 详细信息

南庄煤矿在分析研究顶板连续梁理论的基础上,提出大间排距高效能锚杆支护技术。应用FLAC数值模拟开展模拟试验,得出锚杆长度3 m、网度1.1 m的最佳支护参数。在8824工作面应用效果表明,该参数能够该支护参数条件下,巷道顶板下沉量不超过20 mm,巷道支护作用避免应力集中且能够连续有效地作用于顶板,有效避免巷道顶板的拉伸破坏。同时,试验应用了细牙螺纹钢锚杆、快速整体式聚酯纤维网、高强钢绞线锚索、液压扭矩扳手等先进施工技术,极大提高了支护效率,实现巷道的快速支护。

关键词： FLAC数值模拟高效快掘支护参数锚固参数

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基于建模数据和最优化算法的GaN HEMT精确电热行为建模方法

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电源学报 2024年第1期22卷 153-162页

作者：肖龙陈冬冬闽南理工学院电子与电气工程学院泉州362700

为了实现对氮化镓高电子迁移率晶体管GaN HEMT(gallium nitride high electron mobility transistor)高速开关带来的开通过压、误导通、开关振荡和EMI噪声等问题展开定量的仿真分析,提出了一种基于建模数据和最优化算法的门极增强型GaN ... 详细信息

为了实现对氮化镓高电子迁移率晶体管GaN HEMT(gallium nitride high electron mobility transistor)高速开关带来的开通过压、误导通、开关振荡和EMI噪声等问题展开定量的仿真分析,提出了一种基于建模数据和最优化算法的门极增强型GaN HEMT电热行为模型建模方法。相比较于常规GaN HEMT行为模型,所提出的建模方法采用2个简单的建模公式实现了对GaN HEMT在第一和第三象限宽工作温度范围内的电热特性进行准确的建模。同时采用一个紧凑的建模公式实现对GaN HEMT非线性寄生电容的精确建模。此外,提出了一种遗传算法和Levenberg-Marquardt算法组合的优化算法,基于该优化算法和建模数据实现了对建模参数的快速提取,在较大程度上减小了建模时间和工作量。仿真表明,所提出的建模方法能够实现对不同公司多个型号的GaN HEMT器件展开精确的建模。最后通过吻合的动态仿真和实验数据验证了所提建模方法的正确性和有效性。

关键词：氮化镓高电子迁移率晶体管电热行为模型最优化算法参数提取

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SVM Approximate-based Internal Model Control Strategy

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自动化学报 2008年第2期34卷 172-179页

作者： WANG Yao-nan YUAN xiao-Fang College of Electrical and Information Engineering Hunan University Changsha 410082 P.R. China

一台支持向量机器(SVM ) 近似底的内部模型控制(IMC ) 策略为同步发电机的蒸气 valving 控制被介绍。建议 SVM IMC 策略包括二主要部分：在内部模型结构的 SVM 近似反的控制器和无常赔偿。SVM 反的控制器经由泰勒扩大用一条输入产量近... 详细信息

一台支持向量机器(SVM ) 近似底的内部模型控制(IMC ) 策略为同步发电机的蒸气 valving 控制被介绍。建议 SVM IMC 策略包括二主要部分：在内部模型结构的 SVM 近似反的控制器和无常赔偿。SVM 反的控制器经由泰勒扩大用一条输入产量近似途径直接被导出，并且没有进一步的联机训练，它通过非线性的系统鉴定被实现。而且，一个坚韧性过滤器在内部模型结构被用于无常赔偿。模拟为蒸气 valving 控制显示出 SVM IMC 策略的有效性。

关键词：内模控制非线性控制支持向量机神经网络逼近模型

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