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ARTIFICIAL BOUNDARY METHOD FOR BURGERS＇ EQUATION USING NONLINEAR BOUNDARY CONDITIONS

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Journal of Computational Mathematics 2006年第3期24卷 295-304页

作者： Hou-de Han xiao-nan wu Zhen-li Xu Department of Mathematical Sciences Tsinghua University Beijing 100084. China Department of Mathematics Hong Kong Baptist University Kowloon Tong Hong Kong Department of Mathematics University of Science and Technology of China Hefei 230026 China

This paper discusses the numerical solution of Burgers＇ equation on unbounded domains. Two artificial boundaries are introduced and boundary conditions are obtained on the artificial boundaries, which are in nonlinear forms. Then the original problem is reduced to an equivalent problem on a bounded domain. Finite difference method is applied to the reduced problem, and some numerical examples are given to show the effectiveness of the new approach.

关键词： Burgers' equation Unbounded domain Artificial boundary condition.

On the distinct reactivity of two isomers of[IrC_(4)H_(2)]^(+)toward methane and water

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Science China Chemistry 2022年第9期65卷 1720-1724页

作者： Bowei Yuan Zizhuang Liu xiao-nan wu Shaodong Zhou College of Chemical and Biological Engineering Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture TechnologyZhejiang UniversityHangzhou 310027China Department of Chemistry Fudan UniversityShanghai 200438China

The gas-phase reactions of[IrC_(4)H_(2)]^(+)with methane and water have been explored by using mass spectrometry combined with quantum chemical ***,under the employed conditions,two isomers of[IrC_(4)H_(2)]^(+)co-exist with different *** of them only activates methane while the other is solely reactive with water to produce ***,upon varying the coordination patterns,the Ir center gains rather distinct capabilities of mediating the bond breaking and making *** reactivity toward methane mainly depends on the orbital orientation,while the π-aromaticity of the reaction complex matters for the conversion of *** experimental and theoretical findings in this work not only imply the promising role the Ir atom can play in the bulk-system methane conversion,but may also be instructive on how to construct a highperformance center for steam reforming of methane.

关键词： aromaticity Ir-complex orbital distribution steam-reforming of methane

Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway

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World Journal of Gastroenterology 2015年第36期21卷 10385-10399页

作者： Zhi-Ping Yang Yan Zhao Fang Huang Jie Chen Ya-Hong Yao Jun Li xiao-nan wu Public Health College Fujian Medical University The First Affiliated Hospital of Xiamen University

AIM: To investigate the anti-tumor effects of equol in gastric cancer cells and the underlying molecular ***: MGC-803 cells were employed for in vitro experiments in this study. Cells were treated with control(vehicle,0.1% DMSO) or equol under specified dose titration or time courses. Cell viability was examined by MTS assay,and the levels of Ki67 were determined by q PCR and immunofluorescent assay. Changes in cell cycle distribution and apoptosis rate were detected by flow cytometry. The m RNA expression of cyclin E1 and P21WAF1 was determined by q PCR. The protein levels of cell cycle regulators,PARP and Caspase-3 cleavage,and the phosphorylation of Akt were examined by Western blot. In addition,to characterize the role of elevated Akt activation in the anti-tumor effect exerted by equol,Ly294002,a PI3K/AKT pathway inhibitor,was used to pretreat MGC-803 cells. RESULTS: Equol(5,10,20,40,or 80 μmol/L) inhibited viability of MGC-803 cells in a dose- and timedependent manner after treatment for 24,36,or 48 h(P < 0.05 for all). Equol also decreased the m RNA(P <0.05 for 12 and 24 h treatment) and protein levels of Ki67. Equol treatment significantly induced G0/G1 cell cycle arrest(P < 0.05),with the percentages of G0/G1 cells of 32.23% ± 3.62%,36.31% ± 0.24%,45.58% ± 2.29%,and 65.10% ± 2.04% for equol(0,10,20,or 30 μmol/L) treatment,respectively,accompanied by a significant decrease of CDK2/4(P < 0.05 for 24 and 48 h treatment) and Cyclin D1/Cyclin E1(P < 0.05),and an increased level of P21WAF1(P < 0.05). A marked increase of apoptosis was observed,with the percentages of apoptotic cells of 5.01% ± 0.91%,14.57% ± 0.99%,37.40% ± 0.58%,and 38.46% ± 2.01% for equol(0,5,10,or 20 μmol/L) treatment,respectively,accompanied by increased levels of cleaved PARP and caspase-3. In addition,we found that equol treatment increased P-Akt(Ser473 and Thr308) at 12 and 24 h compared to vehicle-treated control; longer treatment for 48 h decreased P-Akt(Ser473 and Thr308)

关键词： Equol Apoptosis Chemoprevention Gastric cancer G0/

Experimental and Theoretical Study of Hydrogen Atom Abstraction from Ethylene by Stoichiometric Zirconium Oxide Clusters

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Chinese Journal of Chemical Physics 2009年第6期22卷 635-641,J0002页

作者： xiao-nan wu Yan-xia Zhao Sheng-gui He Xun-lei Ding Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Graduate University of the Chinese Academy of Sciences Beijing 200049 China

The reactions of cationic zirconium oxide clusters （ZrxOy^＋） with ethylene （C2H4） were investigated by using a time-of-flight mass spectrometer coupled with a laser ablation/supersonic expansion cluster source. Some hydrogen containing products （ZrO2）xH^＋（x=-1-4） were observed after the reaction. The density functional theory calculations indicate that apart from the common oxygen transfer reaction channel, the hydrogen abstraction channel can also occur in （ZrO2）x^＋＋C2H4, which supports that the observed （ZrO2）xH^＋ may be due to （ZrO2）x^＋＋C2H4→（ZrO2）xH^＋＋C2H3. The rate constants of different reaction channels were also calculated by Rice-Rarnsberger-Kassel-Marcus theory.

关键词： Time-of-flight mass spectrometer Zirconium oxide clusters Fast flow reactor Density functional theory Rice-Ramsberger-Kassel-Marcus theory

A meta-analysis of Duhuo Jisheng decoction combined with non-operative therapy on lumbar disc herniation

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TMR Clinical Research 2019年第3期2卷 115-124页

作者： Chen-Yang Zhang Ling Li Zhao-Yong Li xiao-nan wu Shao-Feng Yang Hunan University of Traditional Chinese Medicine Changsha410208China The First Hospital of Hunan University of Chinese Medicine Changsha410007China

Objective:To systematically evaluate the cllinical efficacy of Duhuo Jisheng decoction(DHJSD)combined with non-surgical therapy on lumbar disc herniation(LDH).Methods:China Science and Technology Journal Database(VIP),Chinese National Knowledge Infrastructure(CNKI),WanFang Data,PubMed were searched and eligible randomized controlled clinical trials(RCTs)were *** reviewers evaluated the quality of the included RCTs and extracted data ***,data analysis was performed with RevMetn 4.2 ***:A total of 18 RCTs were enrolled,including 1682 ***-analysis results showed that the overall response rate of DHJSD combined with non-operative therapy group(treatment group)in the treatment of LDH was better than that of the non-operative therapy group(control group)[OR=4.29,95%CI(3.19,5.76),P<0.001].JOA score of the treatment group was significantly higher than that of control group[OR=3.96,95%CI(3.4,4.52),P<0.001].VAS score was dramatically lower in the treatment group than the control group[OR=-1.58,95%CI(-1.97,-1.18),P<0.001].Conclusion:The clinical efficacy of DHJSD combined with non-surgical therapy is better than that of non-surgical therapy ***,due to the low quality of the included literatures,large-scale and high-quality RCTs are still needed for further confirmation.

关键词： Duhuo Jisheng decoction(DHJSD) Lumbar disc herniation(LDH) Meta-Analysis Randomizedcontrolled trials(RCTs)

Clinical characteristics of sudden hearing loss during pregnancy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 165-172页

作者： xiao-nan wu Hong-Yang Wang xiao-Long Zhang Guo-Hui Chen Jing Guan Yun Gao Da-Yong Wang Qiu-Ju Wang Senior Department of Otolaryngology-Head&Neck Surgery The Sixth Medical Center of PLA General HospitalChinese PLA Medical SchoolBeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina

Objective:The objective of this study was to explore the clinical characteristics and management of sudden hearing loss(HL)during pregnancy,thus better guiding the clinical ***:The clinical and follow-up data of 17 patients(17 ears)with sudden HL during pregnancy were analyzed retrospectively(the observe group).Twelve nonpregnant female patients(12 ears)with sudden HL of similar clinical characteristics were selected as the control *** prognosis of the two groups was *** the patients were followed up after delivery,and two of them were readmitted to the hospital 1–2 months after ***:The observe group had better improvement in hearing and a higher response rate compared to the control *** pure tone hearing and speech recognition rate of patients could still be improved after the readmitted treatment,and the hearing could partially recover spontaneously during *** laboratory indicators that affect the inflammatory response and coagulation pathway were significantly different between the two ***:The hearing condition of sudden HL during pregnancy is severe,and the prognosis of these patients is better than nonpregnant patients of similar clinical *** treatment is still effective,and some patients showed self-healing with time during *** inflammatory response and coagulation function may affect the hearing of patients through a metabolic pathway.

关键词： management pregnancy prognosis sudden hearing loss

Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-Rong wu xiao-Hong He Yong-Fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

发酵莲子乳对小鼠胃肠道运动、吸收功能的调节作用

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世界华人消化杂志 2005年第21期13卷 2535-2539页

作者：吴小南陈洁汪家梨林建银福建医科大学公共卫生学院福建省福州市350004 福建医科大学分子医学研究中心福建省福州市350004

目的:探讨发酵莲子乳(LMFP)对胃肠道运动、吸收的调节作用.方法:小鼠按体质量区组随机分组并以蒸馏水、不同药物及不同浓度的LMFP进行相应干预.左旋精氨酸腹腔注射建模,测定胃及小肠酚红残留率及胃组织一氧化氮(NO)含量;复方地芬诺酯灌... 详细信息

目的:探讨发酵莲子乳(LMFP)对胃肠道运动、吸收的调节作用.方法:小鼠按体质量区组随机分组并以蒸馏水、不同药物及不同浓度的LMFP进行相应干预.左旋精氨酸腹腔注射建模,测定胃及小肠酚红残留率及胃组织一氧化氮(NO)含量;复方地芬诺酯灌胃制造便秘模型,观测炭末排出时间、黑便排出量、质量及含水率;皮下注射小剂量利血平建模,计算小肠推进率、尿木糖排出量.结果:胃组织NO含量与胃排空延缓正相关(r=0.475,P=0.010);较之左旋精氨酸模型组,250,500mL/LLMFP组、吗叮啉组胃酚红滞留率降低(22.78±6.95%,27.12±5.73%,22.82±5.63%vs34.76±9.15%,P<0.05),250mL/LLMFP组、吗叮啉组胃NO含量降低(26.13±4.95μmol/gpro,26.33±4.06μmol/gprovs38.33±9.82μmol/gpro,P<0.05),500,750mL/LLMFP组和吗叮啉组远端1/2小肠、750mL/LLMFP组和吗叮啉组远端2/3小肠酚红含量均增高(P<0.05).与复方地芬诺酯模型组相较,各浓度LMFP组炭末排出时间缩短(133.63±18.28,113.25±26.25min,141.75±25.95minvs175.50±24.04min,P<0.05)、黑便含水率升高(39.72±3.06%,42.48±3.07%,40.58±4.29%vs19.67±2.53%,P<0.05);250,500mL/LLMFP组黑便质量增加(0.68±0.16g,0.82±0.23gvs0.37±0.13g,P<0.01);1000mL/LLMFP组小肠推进率低于利血平模型组(79.93±14.52%vs97.64±5.68%,P=0.002),500,1000mL/LLMFP组木糖排出量较利血平模型组增高(10.54±2.48,12.24±2.15mgvs7.86±1.71mg,P<0.05).结论:LMFP对胃肠运动具有双相调节作用,可缓解便秘症状,促进小肠吸收功能.

关键词： LMFP对胃肠运动具有双相调节作用可缓解便秘症状促进小肠吸收功能

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基于氢同位素研究商用钯银合金膜的渗氚性能

原子能科学技术 2017年第8期51卷 1494-1499页

作者：黄豫韩兴博姚剑王广华吴小玲钱楠吴胜伟刘卫中国科学院上海应用物理研究所上海201800 中国科学院大学北京100049

钯银合金膜可用于熔盐堆尾气中气态氚(HT和T_2)的分离与纯化。本文研究了厚度为80μm的钯银合金膜在纯H_2气氛中及Ar气存在下对H_2的分离效果。结果表明,渗氢过程中氢原子在膜内部的体相扩散是控制速率的关键。Ar气存在时,在钯银合金膜... 详细信息

钯银合金膜可用于熔盐堆尾气中气态氚(HT和T_2)的分离与纯化。本文研究了厚度为80μm的钯银合金膜在纯H_2气氛中及Ar气存在下对H_2的分离效果。结果表明,渗氢过程中氢原子在膜内部的体相扩散是控制速率的关键。Ar气存在时,在钯银合金膜工作温度为480℃、混合气体进气流速为100mL/min、氢分压差为20~100kPa的条件下,钯银合金膜对H_2气的渗透通量随氢分压差的增大而增加,随Ar气浓度的升高而减小。在氢分压差相同的条件下,纯氢的渗透通量明显高于Ar-H_2混合气的渗透通量,说明钯银合金膜受Ar气的影响分离效果变差。渗氢后的钯银合金膜表面变得光滑,有晶界形成。

关键词：钯银合金膜气态氚氢分压差压力指数渗透通量