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Adrenocorticotropic hormone combined with magnesium sulfate therapy for infantile epileptic spasms syndrome:a real-world study

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World Journal of Pediatrics 2024年第8期20卷 834-847页

作者： Wen He Qiu-Hong Wang Jiu-Wei Li Yang-Yang Wang xiao-mei luo Lin Wan Jing Wang Xiu-Yu Shi Wei-Hua Zhang Fang Fang Li-Ping Zou Senior Department of Pediatrics the Seventh Medical Center of Chinese PLA General HospitalDepartment of Pediatricsthe First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology Beijing Children’s HospitalCapital Medical UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Infantile epileptic spasms syndrome(IESS)is a serious disease in infants,and it usually evolves to other epilepsy types or syndromes,especially refractory or super-refractory focal *** adrenocorticotropic hormone(ACTH)is one of the first-line and effective treatment plans for IESS,it has serious side effects and is not sufficiently *** A retrospective study of the clinical outcomes of ACTH combined with magnesium sulfate(MgSO4)therapy for IESS in two hospital centers was *** major outcome of the single and combined treatment was evaluated by changes in seizure frequency and improvements in hypsarrhythmia electroencephalography(EEG).To reduce the confounding bias between the two groups,we used SPSS for the propensity score matching(PSM)*** We initially recruited 1205 IESS patients from two Chinese hospitals and treated them with ACTH combined with MgSO4 and ACTH *** 1005 patients were enrolled in the treatment(ACTH combined with MgSO4:744,ACTH:261),and both treatment plans had a more than 55%response ***,compared to patients treated with ACTH alone,those patients treated with ACTH combined with MgSO4 had better performance in terms of the seizure frequency and hypsarrhythmia *** PSM,the two groups also showed significant differences in responder rate[70.8%(95%confidence interval,CI)=66.7%–74.8%)vs.53.8%(95%CI=47.4%–60.2%),P3 months(P<0.05).In addition,the overall incidence of adverse reactions in the ACTH combined with MgSO4 group was much lower than that in the ACTH group(31.4%vs.63.1%,P<0.001).During the treatment,only

关键词： Adrenocorticotropic hormone Clinical trial Infantile epileptic spasms syndrome Magnesium sulfate Real-world study

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Advances in cryoablation for pancreatic cancer

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World Journal of Gastroenterology 2016年第2期22卷 790-800页

作者： xiao-mei luo Li-Zhi Niu Ji-Bing Chen Ke-Cheng Xu Medical College Jinan University Guangzhou Fuda Cancer Hospital School of Medicine Jinan University

Pancreatic carcinoma is a common cancer of the digestive system with a poor prognosis. It is characterized by insidious onset, rapid progression, a high degree of malignancy and early metastasis. Atpresent, radical surgery is considered the only curative option for treatment, however, the majority of patients with pancreatic cancer are diagnosed too late to undergo surgery. The sensitivity of pancreatic cancer to chemotherapy or radiotherapy is also poor. As a result, there is no standard treatment for patients with advanced pancreatic cancer. Cryoablation is generally considered to be an effective palliative treatment for pancreatic cancer. It has the advantages of minimal invasion and improved targeting, and is potentially safe with less pain to the patients. It is especially suitable in patients with unresectable pancreatic cancer. However, our initial findings suggest that cryotherapy combined with 125-iodine seed implantation, immunotherapy or various other treatments for advanced pancreatic cancer can improve survival in patients with unresectable or metastatic pancreatic cancer. Although these findings require further in-depth study, the initial results are encouraging. This paper reviews the safety and efficacy of cryoablation, including combined approaches, in the treatment of pancreatic cancer.

关键词： Pancreatic cancer Cryoablation Combinationtherapy Cryoimmunotherapy

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Microstructural evaluation and mechanical properties of 7075 aluminum alloy prepared by controlled diffusion solidification

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China Foundry 2019年第4期16卷 238-247页

作者： Xiong Yang Yuan-dong Li xiao-mei luo Hong-wei Zhou Qi-yong Cai Ming Li Ying Ma State Key Laboratory ofAdvanced Processing and Recycling of Non-ferrous Metals Lanzhou University of Technology Lanzhou 730050 China Key Lab of Non-ferrous Metal Alloys and Processing Ministry of Education Lanzhou University of Technology L anzhou 730050 China

In the present work, 7075 aluminum alloy(Al-Zn-Mg-Cu) was produced by both conventional casting(CC) and controlled diffusion solidification(CDS) methods. Each sample was subjected to different heat-treatment conditions: as-cast, T4, and T6;and their microstructural and mechanical properties were investigated by optical microscopy(OM), scanning electron microscopy(SEM) and X-ray diffractometry(XRD). It was found that CDS promoted the formation of non-dendritic primary α-Al phase and reduced shrinkage porosity, thus resulting in improved mechanical properties. In addition, the eutectic phase of the CDS samples mainly consisted of T(Al-ZnMg-Cu) phase, which manifested a well-developed lamellar eutectic structure. However, in the CC samples, the T(Al-Zn-Mg-Cu) phase was composed of rod-like eutectics. Moreover, the θ(Al2 Cu) eutectic contents in the CC samples were greater than those in the CDS samples. Each element in the CC samples had an obvious change in the grain boundary, whereas the change in element content in the CDS samples was gradual. Therefore, the non-dendritic morphology of the primary phase and the presence of rod-like eutectics in the matrix of the CDS samples led to enhanced tensile strength and elongation under different heat treatment conditions.

关键词： primary α-Al phase eutectic phase solute atoms tensile strength elongation

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Study on carbon emission calculation method and carbon reduction indexes of urban building stock

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Science China(Technological Sciences) 2024年第9期67卷 2706-2726页

作者： YANG Liu ZHANG Nan LU mei luo ZhiXing DOU mei State Key Laboratory of Green Building Xi’an University of Architecture and TechnologyXi’an 710055China School of Architecture Xi’an University of Architecture and TechnologyXi’an 710055China School of Language Literature and LawXi’an University of Architecture and TechnologyXi’an 710055China School of Management Xi’an University of Architecture and TechnologyXi’an 710055China China Southwest Architectural Design and Research Institute Corp.Ltd. Chengdu 610041China

Carbon emissions associated with buildings are a major source of urban emissions. To put forward the methods and strategies to curb carbon emissions from urban building stock, it is not only necessary to establish a carbon emission calculation method for fine statistical analysis, but also to evaluate carbon emissions of urban planning schemes with applicable indexes. Currently,researches mainly focus on carbon emissions of individual buildings. When expanded to urban building stock, the calculation faces the lack of basic data, inadequate spatial analysis and unspecific carbon reduction indexes. Therefore, this study proposes a bottom-up calculation method for urban building stock, conducts spatial analysis based on carbon balance of urban grids, reveals the coupling mechanism between urban carbon reduction indexes and grid carbon emissions, and systematically establishes a carbon-reduction-oriented urban planning method that comprises calculation, analysis and evaluation, which is applied to Xi'an,China. This study provides a theoretical reference for cities to formulate carbon reduction targets and implement planning strategies by evaluating and predicting carbon emissions from urban building stock.

关键词： carbon emissions urban building stock calculation method carbon reduction index

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Characterizations of semihoops based on derivations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 291-310页

作者： WANG mei ZHANG xiao-hong School of Electrical and Control Engineering Shaanxi University of Science and TechnologyXi'an 710021China School of Arts and Sciences Shaanxi University of Science and TechnologyXi'an 710021China School of Mathematics and Statistics Weinan Normal UniversityWeinan 714099China

In this paper,we discuss the related properties of some particular derivations in semihoops and give some characterizations of ***,we prove that every Heyting algebra is isomorphic to the algebra of all multiplicative derivations and show that every Boolean algebra is isomorphic to the algebra of all implicative ***,we show that the sets of multiplicative and implicative derivations on bounded regular idempotent semihoops are in oneto-one correspondence.

关键词： (prelinear)semihoop derivation Heyting algebra Galois connection

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Influence of irbesartan combined with low dose urokinase on treatment effect and serologic indexes in elderlyisolated systolic hypertension patients

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Journal of Hainan Medical University 2017年第1期23卷 33-36页

作者： Gui-Peng Wang xiao-mei luo Fifth Affiliated Hospital of Xinjiang Medical University Xinjiang830011China

To study the influence of irbesartan combined with low dose urokinase on treatment effect and serologic indexes in elderly isolated systolic hypertension patients. Methods: One hundred and ten cases of elderly isolated systolic hypertension patients in our hospital during January 2013–January 2016 were randomly divided into observation group with 55 cases and control group with 55 cases. Patients in observation group received irbesartan combined with low dose hydrochlorothiazide treatment and those in control group received amlodipine combined with low dose hydrochlorothiazide treatment, each lasted for 4 weeks. After 4 weeks treatment, non-invasive blood pressure and blood pressure variability indexes were measured, serum endothelial function, inflammatory factors and oxidative stress indexes were measured. Results: After 4 weeks treatment, patients systolic blood pressure (SBP), 24 h mean systolic blood pressure (24 h SBP), 24 h systolic blood pressure standard deviation (24 h SSD) were significantly lower in observation group than in control group (P<0.05);serum endothelial function index EF-1 was lower in observation group than in control group, while NO and endothelial nitric oxide synthase (eNOS) were higher in observation group than in control group (P<0.05);serum high sensitivity C-reactive protein (hs-CRP), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF-α) contents were lower in observation group than in control group (P<0.05);serum oxidation index such as malondialdehyde (MDA) was lower in observation group than in control group, while antioxidant indexes such as total anti-oxidative capacity (TAC), superoxide dismutase (SOD), GSH were higher in observation group than in control group (P<0.05). Conclusions: Irbesartan combined with low dose hydrochlorothiazide can effectively reduce systolic hypertension and blood pressure variability in elderly isolated systolic hypertension patients, while optimizing the systemic inflammation and oxidative

关键词： Isolated systolic hypertension Irbesartan Low dose urokinase Serologic index

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Effect of Zn, Cu and Ni addition on microstructure and mechanical properties of ascast Mg-Dy alloys

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China Foundry 2016年第1期13卷 54-58页

作者： Guang-li Bi xiao-mei luo Jing Jiang Yong-gang Zhang Jian-ji Xu Jie-ming Chen Yuan-dong Li Ying Ma State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology Key Laboratory of Nonferrous Metal alloys and Processing Ministry of Education Lanzhou University of Technology

This paper presents some research information on the effects of Zn, Cu and Ni on the microstructure and mechanical properties of as-cast Mg-2Dy(at.%) alloys. The Mg-2Dy alloy is composed of α-Mg and Mg24Dy5 phases. With the addition of 0.5at.%Zn, 0.5at.%Cu and 0.5at.%Ni, respectively, besides α-Mg, the long period stacking order(LPSO) phases containing Zn, Cu, and Ni precipitated in the α-Mg interdentritic boundary. The addition of Ni effectively refined the dendrite arm spacing. The as-cast Mg-2Dy-0.5Ni alloy exhibited the best tensile strengths and elongation. The better mechanical properties were mainly attributed to small secondry dendrite arm spacing(SDAS) and high volume fraction of LPSO phases.

关键词： Mg-Dy-Zn(Cu,Ni) alloys LPSO phase microstructure mechanical properties

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Infinitely Many Solutions for a Class of Quasi-linear Elliptic Problem

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 728-743页

作者： xiao-yao JIA Zhen-luo LOU School of Economics and Management Zhongyuan University of TechnologyZhengzhou 450007China Mathematics and Statistics School Henan University of Science and TechnologyLuoyang 471023China

In this paper,we study the following quasi-linear elliptic equation:■where Ω?R^(N) is a bounded domain,λ>0 is a *** function ψ(|t|)t is the subcritical term,and φ(|t|)t is the critical Orlicz-Sobolev growth term with respect to φ.Under appropriate conditions on φ,ψ and φ,we prove the existence of infinitely many weak solutions for quasi-linear elliptic equation,for λ∈(0,λ_(0)),where λ_(0)> 0 is a fixed constant.

关键词： quasi-linear elliptic equations variational methods Orlicz-Sobolev spaces

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A new monitoring index for ecological vulnerability and its application in the Yellow River Basin,China from 2000 to 2022

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Journal of Arid Land 2024年第9期16卷 1163-1182页

作者： GUO Bing XU mei ZHANG Rui luo Wei School of Civil Engineering and Geomatics Shandong University of TechnologyZibo 255000China Key Laboratory of Remote Sensing of Gansu Province Heihe Remote Sensing Experimental Research StationNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China North China Institute of Aerospace Engineering Langfang 065000China

The ecological environment of the Yellow River Basin has become more fragile under the combined action of natural and manmade ***,the change mechanisms of ecological vulnerability in different sub-regions and periods vary,and the reasons for this variability are yet to be ***,in this study,we proposed a new remote sensing ecological vulnerability index by considering moisture,heat,greenness,dryness,land degradation,and social economy indicators and then analyzed and disclosed the spatial and temporal change patterns of ecological vulnerability of the Yellow River Basin,China from 2000 to 2022 and its driving *** results showed that the newly proposed remote sensing ecological vulnerability index had a high accuracy,at 86.36%,which indicated a higher applicability in the Yellow River *** 2000 to 2022,the average remote sensing ecological vulnerability index of the Yellow River Basin was 1.03,denoting moderate vulnerability *** intensive vulnerability area was the most widely distributed,which was mostly located in the northern part of Shaanxi Province and the eastern part of Shanxi *** 2000 to 2022,the ecological vulnerability in the Yellow showed an overall stable trend,while that of the central and eastern regions showed an obvious trend of *** gravity center of ecological vulnerability migrated southwest,indicating that the aggravation of ecological vulnerability in the southwestern regions was more severe than in the northeastern regions of the *** dominant single factor of changes in ecological vulnerability shifted from normalized difference vegetation index(NDVI)to temperature from 2000 to 2022,and the interaction factors shifted from temperature∩NDVI to temperature∩precipitation,which indicated that the global climate change exerted a more significant impact on regional *** above results could provide decision support for the ecological protection and restoration of the Y

关键词： ecological vulnerability spatio-temporal pattern gravity center migration trajectory interaction factors geodetector green index q-value

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Microstructure Regulation and Combustion Performance Optimization of PVDF/Al Composite Powder by Non-covalent Functionalized Graphenes

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 904-911页

作者：易卓然 DENG Haoyuan QIN mei 孙一 luo Guoqiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Graphene prepared by non-covalent modification of sulfonated poly(ether-ether-ketone)(SPG)was combined with polyvinylidene fluoride(PVDF)/Al to improve the PVDF/Al thermal conductivity while reducing the effect of the thermal resistance at the graphene-polymer *** regulation rule of SPG with different contents on the energy release of fluorine-containing system was *** the content of SPG is 4%,the peak pressure and rise rate of SPG/PVDF/Al composite powder during ignition reach the maximum of 4845.28 kPa and 8683.58 kPa/*** the content of SPG is 5%,the PVDF/Al composite powder is completely coated by SPG,and the calorific value of the material reachs the maximum of 29.094 kJ/*** the design and micro-control of the composite powder,the calorific value of the material can be effectively improved,but the improvement of the mass release rate still depends on the graphene content and surface modification state.

关键词： energetic materials PVDF/Al composites graphene modification energy release combustion

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