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NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-mao Xue Zhi-Jie xiao Pui-Chi Tin Hiu-Ling Fung Hoi-Tang Ma Jing-Ping Yun Judy Wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei wang Qi Liu Yang Ren Xun-Li wang xiao-Ya Cui xiao-Yang wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui Huang Ling-Kun Zhang Yi-Ping Lu Xu-Bo Li Huai-Jun Lin Yan Ma Wei-Ming Yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang Huang De-Zhuang wang Qing-Feng Liu Fei-Yang wang Hui Liu Hong-Hui Wu Li-Qiang wang Yang Lu Nan wang Tian-Li wang Wei-Bing Liao Yi-Han wang Yuan Wu Yu-Zhen Yin Jie Pan Yi Zhang Qing wang Jian-Yang Zhang Tao Yang Yasir Sohail Jin-Yu Zhang Hua Ji Qiang Li Wei-Di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

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A comprehensive review of recent advances in chronic pancreatitis

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Journal of Pancreatology 2024年第1期7卷 45-52页

作者： Sheng-Han mao Wen-Bin Zou xiao-Tong mao Zhao-Shen Li Zhuan Liao Department of Gastroenterology Changhai HospitalThe Naval Medical UniversityShanghaiChina Shanghai Institute of Pancreatic Diseases ShanghaiChina

Chronic pancreatitis(CP)is a multifaceted disorder influenced by environmental and genetic factors,with smoking and alcohol consumption being major *** developments encompass the advent of innovative transgenic models and the identification of susceptibility genes,shedding light on the genetic aspect of *** pathogenesis of this disease involves a complex interplay of pancreatic acinar cell dysfunction,inflammatory reactions,and *** research delves into understanding these molecular ***,a pivotal symptom of CP,has been increasingly studied to develop effective therapeutic *** advancements,including endoscopic ultrasound,radiomics,and blood-based markers,have shown potential in enhancing early CP ***,recent clinical trials have optimized treatment approaches,such as pancreatic stone fragmentation,stent placement,and decision-making between endoscopic and surgical *** therapies,including chemical pancreatectomy and gene therapy,present promising opportunities for improved CP management.

关键词： Chronic pancreatitis Diagnosis Endoscopy Etiology Mechanism Surgery

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Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan Gao Haixia He Xueping Li Liling Zhang Wei Xu Ru Feng Wenyu Li Yin xiao Xinxiu Liu Yu Chen xiaoxiao wang Bing Bai Huijing Wu Qingqing Cai Zhiming Li Jibin Li Suxia Lin Yanxia He Liqin Ping Cheng Huang Jiaying mao Xiujin Chen Baitian Zhao Huiqiang Huang State Key Laboratory of Oncology in South China&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Medical Oncology Hubei Cancer CenterWuhanChina Department of Clinical Research Sun Yat-sen University Cancer CenterGuanzhouChina Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 *** dose-limiting events were observed,RP2D of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

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抗核抗体谱对AIH-PBC OS及单纯AIH患者激素应答的影响

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解放军医学杂志 2024年第1期49卷 64-69页

作者：李琼田爱平毛永武王富春毛小荣兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院感染科甘肃兰州730000

目的探讨抗核抗体谱(ANAs)对自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征(AIH-PBC OS)及单纯AIH患者半年内激素应答的影响。方法回顾性分析2018年1月-2021年12月兰州大学第一医院收治的77例自身免疫性肝病(AILD)患者的资料,其中AIH-PB... 详细信息

目的探讨抗核抗体谱(ANAs)对自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征(AIH-PBC OS)及单纯AIH患者半年内激素应答的影响。方法回顾性分析2018年1月-2021年12月兰州大学第一医院收治的77例自身免疫性肝病(AILD)患者的资料,其中AIH-PBC OS组46例,单纯AIH组31例。均经肝穿刺活检组织病理检查确诊,并行糖皮质激素治疗。比较两组患者的一般临床特征、肝穿刺相关指标、自身抗体及免疫球蛋白指标,以及患者使用糖皮质激素初始及6个月内复查的生化及免疫球蛋白指标,根据谷草转氨酶(AST)、谷丙转氨酶(ALT)及免疫球蛋白G(IgG)水平评估治疗6个月内的激素应答情况,采用多因素有序logistic分析ANAs对两组患者激素应答结果的影响。结果ANAs阳性及阴性AILD患者中,AIH-PBC OS及单纯AIH患者占比均无统计学差异(55.6%vs.44.4%,65.6%vs.34.4%,P>0.05)。46例AIH-PBC OS患者中,ANAs阳性组25例,ANAs阴性组21例。ANAs阳性组半年内激素完全应答率低于ANAs阴性组(44.0%vs.76.2%),而激素不应答率高于ANAs阴性组(20.0%vs.0),差异有统计学意义(P0.05)。多因素有序logistic分析结果显示,AIHPBC OS患者中,ANAs阳性者半年内激素不应答的可能性较大,差异有统计学意义(P0.05)。结论在AIH-PBC OS患者中,ANAs阳性者半年内激素应答结果欠佳;在单纯AIH患者中,ANAs对激素应答结果无明显影响。

关键词：自身免疫性肝炎原发性胆汁性胆管炎重叠综合征抗核抗体谱激素生化应答

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Impact of fast-track surgery on perioperative care in patients undergoing hepatobiliary surgery

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3155-3162页

作者： xiao-Hong wang Fang-Fang Chen Jia Pan Yun-Fei Jiang Min-Yue Yao Jia-Li mao Ya-Feng Xu Department of General Surgery Kecheng District People's HospitalQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Fast-track surgery(FTS)is a modern nursing approach that has gained popularity in the perioperative phase of *** To investigate the impact of FTS on perioperative care for hepatobiliary *** A retrospective analysis was performed on 98 patients who underwent hepato-biliary surgery and were admitted to our hospital from August 2021 to October *** were divided into an observation group and a control group with 49 patients in each group according to different nursing *** control group was treated with standard nursing and the observation group was treated with FTS concept *** length of hospital stay,visual analog scale(VAS)score,wound complications,nursing satisfaction,self-rating scale(SAS)score,and SF-36 quality of life(QoL)score were compared between the two groups before and after *** The duration of hospitalization,hospitalization cost,operation time,first im-plantation time,exhaust time,and first defecation time were shorter than the observation group(P<0.05).Additionally,the observation group showed a sig-nificant difference between the VAS and SAS scores on days 1,3,and 7(P<0.05).The complication rate in the observation group was 4.05%was significantly lower than the 18.36%in the control group,and the comparison groups were statistically significant(χ2=5.018,P=0.025).The observation group had a significantly higher level of nurse satisfaction(94.92%)than the control group(79.59%;χ2=6.078,P=0.014).Both groups showed higher QoL scores after nursing care,with higher scores in the observation group than in the control group(P=0.032).CONCLUSION FTS in patients undergoing hepatobiliary surgery can effectively improve negative mood,QoL,and nursing sa-tisfaction;reduce wound complications;and accelerate patient rehabilitation.

关键词： Rapid rehabilitation surgery concept Hepatobiliary surgery Quality of life Wound complications Fast track surgery

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Anti-allodynic effects of intrathecal TLR4 antagonist LPS-RS in rats with bone cancer pain

Anti-allodynic effects of intrathecal TLR4 antagonist LPS-RS...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xiu LI,xiao-Wei wang,mao-Ying Qi Liang,Chang-Jiang YANG,Gen-Cheng WU,Yan-Qing wang~* Department of Integrative Medicine and Neurobiology,Shanghai Medical College,Fudan University,Shanghai 20032, China

＜正＞Objective Bone cancer pain,caused usually by primary bone cancer or secondary bone metastasis of the cancers originating from visceral organs,is one of the most serious cancer pains and,therefore,severely impairs the life quality of cancer ***,the molecular mechanism underlying the bone cancer pain is *** study reported that the toll-like receptor 4（TLR4） is a key factor for initiating glial activation which plays an important role in the formation of central sensitization in neurapathic *** order to investigate the possible role of spinal TLR4 in bone cancer pain,the present study was designed to reveal the changes of the TLR4 in a rat model of bone cancer *** The bone cancer pain animal model was induced by inoculating the rat mammary gland carcinoma cells Walker 256 into the medullar cavity of the tibia of Wistar rats by using percutaneous direct puncture ***4 mRNA and TLR4 protein were determined by RT-PCR and westernblot *** allodynia tested by Von Frey hair was measured at baseline and after intrathecally delivered TLR4 receptor antagonist *** Mechanical allodynia developed 6 days after cancer cell ***4 mRNA and protein in spinal cord was ***4 receptor antagonist significantly（P＜ 0.05） attenuated the mechanical allodynia in rats with bone cancer,as shown by increased PWPT. Conclusion Our findings demonstrate that toll-like receptor 4 contributes to the bone cancer pain-induced mechanical allodynia.

关键词： bone cancer pain allodynia spinal cord rats Toll-like receptor 4

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基于压力分布的环摆式双面抛光去除均匀性研究

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光学学报 2024年第16期44卷 278-291页

作者：毛晨肖博王春阳白祎凡黄思玲王大森西安工业大学兵器科学与技术学院陕西西安710000 西安工业大学光电工程学院陕西西安710000 西安工业大学西安市主动光电成像探测技术重点实验室陕西西安710000 中国兵器科学研究院宁波分院浙江宁波315103

构建了一种基于速度和压力分布模型的材料去除量分布计算模型。建立了环摆式双面抛光的有限元模型,对5种半径的上抛光盘在不同加工压力下与元件接触面的压力分布进行分析,通过拟合得到压力分布特性模型。根据Preston方程,将压力分布模... 详细信息

构建了一种基于速度和压力分布模型的材料去除量分布计算模型。建立了环摆式双面抛光的有限元模型,对5种半径的上抛光盘在不同加工压力下与元件接触面的压力分布进行分析,通过拟合得到压力分布特性模型。根据Preston方程,将压力分布模型与速度分布模型耦合,得到材料去除量分布计算模型。通过模拟加工计算,研究加工压力和上抛光盘尺寸对去除量分布及均匀性的影响,发现去除量分布主要受上抛光盘尺寸和摆动距离的影响,去除均匀性主要受加工压力的影响。通过加工实验,对所得到的材料去除量分布计算模型的准确性进行验证,并研究了加工压力和上盘尺寸对材料去除量分布及均匀性的影响。实验结果表明,上抛光盘的直径越大,则加工压力越小,材料去除的均匀性越好。基于去除量分布预测模型,利用得到的规律指导实际加工,选取初始表面面型峰谷(PV)值为2.09λ(λ=632.8 nm)、均方根(RMS)值为0.464λ的熔石英样件,通过材料去除量预测模型得到工艺参数的最优解。加工后元件表面面型PV值降至0.85λ,RMS值降至0.137λ。所提模型将元件表面PV值降低到λ以下的时间缩短至原来的50%,实现了元件表面面型的快速收敛。

关键词：大口径平面光学元件环摆式双面抛光法压力分布特性去除均匀性材料去除量计算模型

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基于红外辐射测温法的焊头动态高速真温测量系统研制

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光谱学与光谱分析 2024年第3期44卷 836-842页

作者：萧鹏台泓冰向茂林王伟宸张帆哈尔滨工业大学黑龙江哈尔滨150001 中国航天科工集团第四研究院北京100038 中国空空导弹研究院控制所河南洛阳471009

温度是用来表征物体特性的一个重要的基本参数,被广泛应用于金属加工、生产生活、航空航天等各个领域,温度测量的准确与否对每个行业都有着至关重要的影响。随着电子设备的尺寸不断微型化以及各种可穿戴智能设备的普及和发展,小型化成... 详细信息

温度是用来表征物体特性的一个重要的基本参数,被广泛应用于金属加工、生产生活、航空航天等各个领域,温度测量的准确与否对每个行业都有着至关重要的影响。随着电子设备的尺寸不断微型化以及各种可穿戴智能设备的普及和发展,小型化成为了电子元件技术水平的一个重要技术指标,所以电子元器件也一直朝着小尺寸、高集成化方向发展,而其焊接温度的波动引起的产品良品率也在不断降低。因此,如何实现电子元器件焊接过程中焊头温度的实时获取,已成为众多相关企业急需研究的课题。基于晶体管式焊接电源的工作特点,从分析焊头的结构特性入手,利用焊头的红外光谱辐射特性,设计了一种激光瞄准式的光学系统,采用朗伯体法对焊头进行温度测量,从而得到焊头工作时的实时真温。整个温度测量系统由硬件系统部分和软件系统部分构成。其中,硬件系统包括光学系统的设计、 I/V转换及放大电路和上位机的高速数据采集系统。软件系统主要包括上位机系统界面的设计。上位机软件采用LabVIEW进行程序设计,主要包括AD采集卡的配置与驱动、数据滤波、零点测量、温度标定、温度计算、实时温度曲线和数据存储。在系统建立、软件调试完毕后,采用标准空腔黑体炉对测温系统进行了校准。首先,利用整体黑体法对焊头工作时的发射率进行了试验,结果表明,在氧化和非氧化状态下,其发射率与文献数据基本一致。然后利用该发射率值,计算出了焊头上小孔的空腔黑体发射率。最后,利用恒流晶体管式焊接电源进行了系统稳定性和重复性实验。分析该方法的不确定度,得出该方法的总体不确定度在3%以内。通过对测温系统的标定和配置,该系统还可以应用在其他需要高速精确测温的场景。

关键词：焊头温度黑体法测温快速测量红外光谱发射率

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实时目标跟踪中自适应尺度计算

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计算机工程与设计 2017年第5期38卷 1314-1318页

作者：侯小毛王淑娟徐仁伯湖南信息学院电子信息学院湖南长沙410105 中原工学院信息商务学院信息技术系河南郑州450007 中南大学物理与电子学院湖南长沙410105

为能够更好地解决复杂视频中目标的大尺度变化问题,提出一个在跟踪检测框架下的尺度计算算法。主要把目标分为4部分,分别计算它们的尺度因子,通过基于颜色属性的核相关滤波找出各部分最大响应位置。为解决定位不准确的问题,采用加权系... 详细信息

为能够更好地解决复杂视频中目标的大尺度变化问题,提出一个在跟踪检测框架下的尺度计算算法。主要把目标分为4部分,分别计算它们的尺度因子,通过基于颜色属性的核相关滤波找出各部分最大响应位置。为解决定位不准确的问题,采用加权系数移除异常匹配点,将常规分类器所期望的训练输出转换成其它可操作的形式。仿真结果表明,该算法性能胜过其它现有算法,能够达到实时处理的要求。

关键词：相关滤波实时目标跟踪尺度计算核变换加权系数颜色属性

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