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Prognostic significance of urokinase-type plasminogen activator and its receptor in patients with systemic inflammatory response syndrome

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World Journal of Emergency Medicine 2011年第3期2卷 185-189页

作者： Li Yu Ding Long xiao-ling wu Jun-hui Yang Yuan-chao Yang Geng Fcng Intensive Care Unit Wuhan Central Hospital Wuhan 430014 China

BACKGROUND： This study aimed to determine the plasma levels of urokinase-type plasminogen activator （uPA）, urokinase-type plasminogen activator receptor （uPAR）, D-dimer, IL-6 and TNF-α, and observe the relations among uPA, uPAR, D-dimer, IL-6 and TNF-α in patients with systemic inflammatory response syndrome （SIRS）.METHODS： A prospective, clinical case-control study was conducted in patients with SIRS at age of more than 55 years old treated during 2008-2010 at wuhan Central Hospital. Venous blood samples were collected by routine venipuncture. Eighty-five patients were divided into two groups according to diagnostic criteria of SIRS： SIRS patients from intensive care units （n=50）, and non- SIRS patients from medical wards （n=35）. Thirty healthy blood donors who visited the General Health Check-up Division at wuhan Central Hospital served as controls. Excluded from the study were （1） those patients with pregnancy; （2） those with cancer; （3） those died after admission into the ICU in 7 days; （4） those received cardiopulmonary resuscitation; （5） those who had previous blood system diseases; and （6） those with SIRS before admission into the ICU. The levels of uPA, uPAR, D-D, IL-6 and TNF-a in blood were detected by commercial enzyme-linked immunosorbent assay （ELISA） kit. The data were analyzed using SPSS version 17.0 and expressed as mean ＋ standard. Student＇s t test and the Mann-Whitney U test were used in the analysis. The relations of uPA, uPAR and D-dimer, IL-6 TNF-α levels were analyzed using Spearman＇s rank-order correlation coefficient test. RESULTS： The plasma levels of uPA, uPAR, D-dimer, lL-6 and TNF-α in the patients with SIRS were obviously higher than those in the non-SIRS patients and controls （P〈0.001）. Correlation analysis showed a positive correlation between uPAR and IL-6 levels （r=0.395, P=0.004） and between uPAR and TNF-a levels （r=0.606, P〈0.001）, but no correlation between uPAR and D-dimer levels （r=0.069, P=0.632）. No correlation was observed b

关键词： Systemic inflammatory response syndrome Multiple organ dysfunctionsyndrome D-dimer Interleukin-6 Tumor necrosis factor-alpha Coagulant function

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Transforming growth factor-β1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population

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Acta Pharmacologica Sinica 2005年第6期26卷 714-720页

作者： Zhi-guang SU~2, Fu-qiang WEN, Yu-lin FENG, Min xiao, xiao-ling wu Laboratory of Pulmonary Medicine, West China Hospital, Sichuan University Key Laboratory of Biotherapy of Human Disease, Ministry of Education, Chengdu 610041, China Laboratory of Pulmonary Medicine West China Hospital Sichuan University Key Laboratory of Biotherapy of Human Disease Ministry of Education Chengdu 610041 China

Aim: To determine the frequencies of polymorphism and haplotype in the transforming growth factor-beta 1 （TGF-1） gene promoter in the Chinese population and to investigate the susceptibility of this population to chronic obstructive pulmonary disease （COPD）. Methods: The target fragments of the TGF-1 gene promoter were amplified and analyzed by polymerase chain reaction-restriction fragment length polymorphism technique in 84 COPD patients and 97 age- and sex-matched healthy controls. The test for Hardy-Weinberg equilibrium was performed using HWE program of the LINKUTIL package and statistical analysis was carried out with the SPSS statistical package. An expectation maximization algorithm was used for the pairwise linkage disequilibrium test and haplotype analysis. Results: More carriers of the -800A allele, or fewer carriers of the -509T allele, were detected in the COPD patients compared with the non-symptomatic control subjects [for the -800A allele, 29.8% vs 14.4%, respectively, x2=6.257, degrees of freedom （df）=l, P=0.012; for the -509T allele, 27.3% vs 44.3%, respectively,x2=5.582, df=l, P=0.018]. The prevalence of the -800A allele was significantly higher in the COPD patients than in control subjects OP=0.009), whereas the frequency of the -509T allele was significantly higher in control subjects than in the COPD patients （P=0.008）. In addition, this distribution tendency for the -800A or -509T allele was similar in heavy smokers （smoking history 鈮?0 pack years）; （number of packs of cigarettes per day multiplied by the number of years of smoking） X2=7.235, P=0.007, and X2=5.636, P=0.018, respectively). The linkage disequilibrium was found between -800 G鈫扐 and -509 C鈫扵（D>0.60,P<0.0001）, and the frequency of the AC haplotype, consisting of the least common base at -800 and the most common base at -509, was significantly higher in patients with COPD than in controls （0.056 vs 0.021, P<0.05）. Conclusions: The single nucleotide polymorphism （SNP） in the TGF-1 g

关键词： chronic obstructive pulmonary disease transforming growth factor-β1 single nucleotide polymorphisms haplotypes

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Association between Age-Related Macular Degeneration and Lens Opacity in Senior Population in Hainan Province

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Chinese Medical Journal 2018年第19期131卷 2352-2353页

作者： Kai-Yan Zhang Qiong-Lei Zhong Yan Xu Chuan-Xian Guo Si-Ying Chen Yi-Jie Yan xiao-ling wu Yun-Suo Gao Department of Ophthalmology Hainan General Hospital Haikou Hainan 570102 China Department of Ophthalmology Haikou No. 3 People's Hospital Haikou Hainan 571100 China Department of Medical Equipment Hainan General Hospital Haikou Hainan 570311 China

To the Editor： Cataract and age-related macular degeneration （AMD）, often develop concurrently, which are two of the leading causes of visual damages associated with aging. Sunlight is reported to contribute to the pathogenesis of both cataract and AMD. In cases of cataract, less sunlight could possibly access to the ocular fundus. On this basis, lens opacity maybe a protective factor for AMD. Nevertheless, there are still disputes up to now.

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia wu ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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葡萄膜恶性黑色素瘤中血管内皮生长因子水平与肿瘤转移的关系

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国际眼科杂志 2015年第9期15卷 1596-1599页

作者：白惠玲刘勤文瑾吴小玲甘肃省人民医院眼科中国甘肃省兰州市730000

目的:分析葡萄膜恶性黑色素瘤患者血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)的表达水平是否与葡萄膜恶性黑色素瘤的转移和预后有关。方法:采用ELISA法检测葡萄膜恶性黑色素瘤患者和正常对照组中外周血VEGF水平,... 详细信息

目的:分析葡萄膜恶性黑色素瘤患者血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)的表达水平是否与葡萄膜恶性黑色素瘤的转移和预后有关。方法:采用ELISA法检测葡萄膜恶性黑色素瘤患者和正常对照组中外周血VEGF水平,并采用RT-PCR和Westernblot检测葡萄膜恶性黑色素瘤患者肿瘤组织中VEGF mRNA和VEGF蛋白表达水平。对葡萄膜恶性黑色素瘤患者进行随访,用Kaplan-Meier法分析基线VEGF水平与患者术后转移的关系。结果:葡萄膜恶性黑色素瘤患者外周血VEGF水平较健康者升高。就诊时肿瘤发生转移的患者VEGF mRNA和VEGF蛋白表达水平均较未发生转移的患者升高。在随访过程中,血清VEGF≥700pg/m L的患者,肿瘤发生转移的风险较高。结论:葡萄膜恶性黑色素瘤患者中VEGF的表达水平与葡萄膜恶性黑色素瘤的转移密切相关。

关键词：葡萄膜恶性黑色素瘤血管内皮细胞生长因子肿瘤转移

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HSCs表型转化的信号转导通路及其阻断剂的研究进展

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世界华人消化杂志 2009年第22期17卷 2283-2291页

作者：杨斌曾维政吴晓玲中国人民解放军成都军区总医院消化内科四川省成都市610083

肝纤维化(liver fibrosis)与细胞外基质不断沉积和肝脏结构改变并最终演变为肝硬化的长期病理过程有密切关系.肝星状细胞(hepatic stellate cells,HSCs)的活化和表型转化是肝纤维化过程中的核心事件.各种细胞因子通过细胞信号传导通路影... 详细信息

肝纤维化(liver fibrosis)与细胞外基质不断沉积和肝脏结构改变并最终演变为肝硬化的长期病理过程有密切关系.肝星状细胞(hepatic stellate cells,HSCs)的活化和表型转化是肝纤维化过程中的核心事件.各种细胞因子通过细胞信号传导通路影响HSCs的表型转化及增殖.近年来对各种使HSCs活化的信号通路(signaling pathway)及相关阻断剂(inhibitors)的研究取得了一些进展,为肝纤维化的临床治疗提供了新的思路.但是由于各种细胞信号通路相互"交流"的复杂性和阻断剂作用的特异性,各种阻断剂的运用还仅限于实验室研究阶段.其运用于临床还需要更多资料证实.本文就HSCs表型转化的信号转导通路及其阻断剂的研究进展作一综述.

关键词：肝星状细胞肝纤维化信号通路阻断剂

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高原缺氧与肝脏损伤

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世界华人消化杂志 2009年第21期17卷 2171-2178页

作者：荣黎曾维政吴晓玲重庆医科大学附属第二医院消化内科重庆市400016 中国人民解放军成都军区总医院消化内科四川省成都市610083

高原自然条件恶劣,低气压、低氧分压、辐射强等因素严重影响人们的身体健康,使得高原病成为高原地区特有的常见病和多发病.随着军事、经济、文化的发展,越来越多的人进入高原,对高原病发病机制、临床症状、预防及治疗等研究成为热点.本... 详细信息

高原自然条件恶劣,低气压、低氧分压、辐射强等因素严重影响人们的身体健康,使得高原病成为高原地区特有的常见病和多发病.随着军事、经济、文化的发展,越来越多的人进入高原,对高原病发病机制、临床症状、预防及治疗等研究成为热点.本文就高原环境、肝细胞缺氧及由此可能导致的肝脏在细胞、分子及基因水平的变化作一综述.

关键词：高原缺氧肝细胞损伤

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： xiao Xiang Feng Gao Yu-Gui Peng Peng wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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Synchrotron radiation based-FTIR microspectroscopy study of the striatum in 6-hydroxydopamine rat model of Parkinson’s disease

Synchrotron radiation based-FTIR microspectroscopy study of ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hong-Yan ZHU~*,xiao PEI,ling-Yan wu Lab.of Neuropharmacology and Neurotoxicology,School of Life Sciences,Shanghai University,Shanghai 200444, China

＜正＞In the present study,synchrotron radiation-based Fourier transform infrared（FTIR） was used to analyze the biochemical composition of the striatal neurons in normal and Parkinson’s disease（PD） rat brain *** rat model of PD was established by 6-hydroxydopamine destroying the nigrostriatal *** detailed spectral analyses showed significant changes of cellular compositions such as lipids,proteins and nucleic acids in PD neurons with respect to *** a result,the intensities of spectral absorption assigned to lipid in the striatal neurons of PD were higher than that of ***,the unsaturation level of phospholipids decreased for PD neurons with respect to normal,indicating the high level of lipid *** analysis of protein secondary structure showed a significantly higher ratio of P-sheet in PD neurons compared to that of ***,the content of nucleic acids in PD neurons decreased in comparison to *** finding suggest that the biochemical changes in the striatal neurons might be involved in the pathogenesis of PD.

关键词： fourier transform infrared Parkinson’s disease

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离心油泵的性能与相似准则的关系

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上海交通大学学报 2003年第5期37卷 686-689页

作者：陈晓玲张武高黄震上海交通大学机械与动力工程学院上海200030

实验研究了输送介质的粘度、泵轴转速等参数对离心油泵性能的影响 .使用相似分析方法 ,以雷诺数为准则数 ,考察了离心油泵在不同流量系数下的性能变化规律 .结果表明 ,输送粘性流体时。

关键词：离心油泵性能实验相似准别

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