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Influence of plasma peening on oxidation of H13 hot work steel in water vapor

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 305-309页

作者： MIN Yong-an xu xiao WU xiao-chun LI lin xu Luo-ping School of Materials Science and Engineering Shanghai University Shanghai 200072 China School of Materials Science and Engineering Shanghai University Shanghai 200072 China School of Materials Science and Engineering Shanghai University Shanghai 200072 China School of Materials Science and Engineering Shanghai University Shanghai 200072 China School of Materials Science and Engineering Shanghai University Shanghai 200072 China

The surface oxidation films on H13 steel samples, obtained by different oxidation processes were observed by optical microscope. It is shown that the oxidation speed of H13 steel is increased remarkably due to the surface modification of plasma peening. Further researches were made by XRD, SEM and EDS. The activation of H13 surface caused by plasma peening and the subsequent higher oxygen diffusion rate into the steel seem to be the main reasons of higher oxidation speed. The nitride layer, generally formed on the steel surface under plasma nitriding process, can be substituted by oxide in subsequent oxidation process, which can reduce the risk of heat cracking in some hot work applications. Therefore, the plasma nitriding plus oxidation process is a proper choice for some hot work dies, which demands high hardness to avoid indentation as well as high toughness to avoid cracks.

关键词： oxidation hot work tool steel plasma nitriding surface treatment

Relationship of Somatic Cell Count with Milk Yield and Composition in Chinese Holstein Population

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Agricultural Sciences in China 2010年第10期9卷 1492-1496页

作者： GUO Jia-zhong LIU xiao-lin xu A-juan XIA Zhi College of Animal Science and Technology Shaanxi Key Laboratory of Molecular Biology for Agriculture Northwest A＆F University Yangling 712100 P.R.China

The objective of this study was to analyze the relationship of somatic cell count （SCC） with milk yield, fat and protein percentage, fat and protein yield using analysis of variance and correlation analysis in Chinese Holstein population. The 10 524 test-day records of 568 Chinese Holstein Cattle were obtained from 2 commercial herds in Xi＇an region of China during February 2002 to March 2009. Milk yield, fat percentage, fat and protein yield initially increased and then dropped down with parity, whereas protein percentage decreased and SCC increased. Analysis of variance showed highly significant effects of different subclasses SCC on milk yield and composition （P〈 0.01）. Compared with milk yield with SCC ≤ 200 000 cells mL-1, milk yield losses with SCC of 200 000-500 000 cells mL-1, 501000-1 000 000 cells mL-1, ≥ 1 000 000 cells mL-1 were 0.387, 0.961 and 2.351 kg, respectively. The highly significant negative correlation coefficient between somatic cell score （SCS） and milk and protein yield, milk yield and fat and protein percentage, protein percentage and fat yield were -0.084, -0.037, -0.061, -0.168, and -0.088, respectively （P〈 0.01）. The highly significant positive correlation coefficients between SCS and fat yield and fat and protein percentage, milk yield and fat and protein yield, fat percentage and protein percentage and fat yield, protein yield and protein percentage and fat yield were 0.041, 0.177, 0.105, 0.771, 0.865, 0.122, 0.568, 0.318, and 0.695, respectively （P〈 0.01）. There was no significant relationship between fat percentage and protein yield （P 〉 0.05）. The results of the present study first time provide the relevant base-line data for assessing milk production at Xi＇an region of China.

关键词： Holstein cattle milk yield milk composition somatic cell count somatic cell score

Role of microRNA-21 in uveal melanoma cell invasion and metastasis by regulating p53 and its downstream protein

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1258-1268页

作者： Ying-Chih Wang xuan Yang Wen-Bin Wei xiao-lin xu Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Tongren HospitalCapital Medical University

AIM： To reveal the insight mechanism of liver metastasis in uveal melanoma, we investigated cell functions of microRNA-21 in three different uveal melanoma cell lines and analyze the relationship of target gene p53 and its downstream targets which been found significant expression in our previous ***： Quantitative real-time polymerase chain reaction （qRT-PCR） was used to detect microRNA-21 expression in normal uveal tissue and uveal melanoma cell lines. Lenti-virus expression system was used to construct OCM-1, MuM-2B and M619 cell line with stable overexpression and inhibition of microRNA-21. In vitro cell function tests such as cell proliferation, cell apoptosis, cell circle and abilities of migration and invasion were examined by MTT, BrdU assay, flow cytometry, transwell assay and Matrigel invasion assay respectively. The target gene was predicted by bioinformatics and confirmed by using a dual luciferase reporter assay. The expression of p53 and its suspected downstream targets LIM and SH3 protein 1 （LASP1） and Glutathione S Transferase pi （GST-Pi） were determined by qRT-PCR in mRNA level and western blotting analysis in protein level. Finally, the effect of microRNA-21 in a xenograft tumor model was assessed in four-week-old BALB/c nude mice. RESULTS： Compared to normal uveal melanoma, expressions of microRNA-21 were significantly higher in uveal melanoma cell lines. Overexpression of microRNA-21 promoted proliferation, migration, and invasion of OCM-1, M619 and MuM-2B cells, while inhibition of microRNA-21 reveal opposite effects. Wild type p53 was identified as a target gene of microRNA-21-3p, and proved by dual luciferase reporter assay. Up-regulated microRNA-21 inhibited the expression of wild type p53 gene, and the increased expression of LASP1 in mRNA level and protein level, while down-regulated microRNA-21 presented opposite way. However, GST-pi showed the potential pattern as expected, but relative mRNA level showed no statistically signific

关键词： uveal melanoma microRNA-21 p53 LIMand SH3 protein 1 Glutathione S Transferase pi

Detection of a high-confidence quasi-periodic oscillation in radio light curve of the high redshift FSRQ PKS J0805–0111

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Research in Astronomy and Astrophysics 2021年第3期21卷 243-250页

作者： Guo-Wei Ren Hao-Jing Zhang Xiong Zhang Nan Ding Xing Yang Fu-Ting Li Pei-lin Yan xiao-lin xu College of Physics and Electronics Yunnan Normal UniversityKunming 650500China Department of Astronomy Xiamen UniversityXiamen 361005China School of Physical Science and Technology Kunming UniversityKunming 650214China

In this work,we have searched for quasi-periodic oscillations(QPOs)in the 15 GHz light curve of the FSRQ PKS J0805-0111 monitored by the Owens Valley Radio Observatory(OVRO)40 m telescope during the period from 2008 January 9 to 2019 May 9,using the weighted wavelet Z-transform(WWZ)and the Lomb-Scargle Periodogram(LSP)*** is the first time to search for a periodic radio signal in the FSRQ PKS J0805-0111 by these two *** methods consistently reveal a repeating signal with a periodicity of 3.38±0.8 yr(>99.7%confidence level).In order to determine the significance of the periods,the false alarm probability method was applied,and a large number of Monte Carlo simulations were *** possible explanations,we discuss a number of scenarios including the thermal instability of thin disks scenario,the spiral jet scenario and the binary supermassive black hole *** expect that the binary black hole scenario,where the QPO is caused by the precession of binary black holes,is the most likely *** PKS J0805-0111 thus could be a good binary black hole *** the binary black hole scenario,the distance between the primary black hole and the secondary black hole is about 1.71×10^(16) cm.

关键词： active galactic nuclei:flat spectrum radio quasar:individual:PKS J0805–0111 galaxies:jets method:time series analysis

The expression of c-src gene in the carcinogenesis process of human cardia adenocarcinoma

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World Journal of Gastroenterology 1999年第6期5卷 488-491页

作者： WANG Xiu Jie, YUAN Shu Lan, xiao lin, WANG xu Hua and WANG Chao Jun Institute of Cancer Research First University Hospital West China University of Medical Sciences Chengdu 610041 Sichuan Province China Department of Oncology China

AIM To investigate the activation, expression of c src gene and its role in the carcinogenetic process of human cardia adenocarcinoma (CA). METHODS Fifty six cases of CA, 34 cases of normal, 36 cases of protiferative epithelia adjacent to carcinoma, and 20 cases of lymph node metastases of CA were studied for PP60 c src , the expression product of c src gene immunohistochemically by using the specific monoclonal antibody, Mab327. RESULTS The positive rates of PP60 c src in the normal epithelia, protiferative epithelia, CA and lymph node metastases were 29 4% (10/*!34), 94 4% (34/*!36), 71 4% (40/*!56) and 60 0% (12/*!20) , respectively, among them, the differences of the positive rates were statistically significant ( P <0 01) . The expression levels of PP60 c src in CA and proliferative epithelia were significantly higher than that in the normal epithelia ( P <0 01) . The PP60 c src positive rates in the papillary, tubular, poorly differentiated and mucous adenocarcinoma were 75 0% (6/*!8) , 81 8% (18/*!22) , 50 0% (10/*!20) and 100 0% (6/*!6) , respectively, whereas those of tubular and mucous adenocarcinomas were significantly higher than those of papillary and poorly differentiated adenocarcinomas ( P <0 05) , and the PP60 c src expression levels of tubular and mucous adenocarcinomas were also significantly higher than those of papillary and poorly differentiated adenocarcinomas ( P <0 01) . CONCLUSION The activation and expression of c src gene are associated with the initiation and development of human CA; the protein amount of PP60 c src increased during the process of carcinogenesis; and PP60 c src expression is also related to lymph node metastases.

关键词： c src gene expression product PP60 c src cardia adenocarcinoma carcinogenesis neoplasm metastasis immunohistochemistry

Rare giant corneal keloid presenting 26 years after trauma:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9776-9782页

作者： Shang Li Jiang Lei Ying-Hui Wang xiao-lin xu Ke Yang Ying Jie Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LabBeijing 100005China Department of Ophthalmology The First People's Hospital of Lanzhou CityLanzhou 730050Henan ProvinceChina

BACKGROUND Corneal keloid is a rare clinical disease with an unknown etiology,which is easily *** is the most effective treatment but is rarely reported in the ***,we report the clinical features,histopathology,and surgical outcome of a giant corneal keloid with trophoblastic vessels and discuss the genesis of the *** SUMMARY A 36-year-old young man was admitted to the hospital because of a large mass on the surface of the left *** patient had suffered an injury to his left eye at the age of 6-years-old;however,as the injury did not cause cornea perforation,he did not undergo *** lamp exam showed a large,elevated,opaque lesion that covered the entire cornea and protruded from the surface of the *** segment optical coherence tomography(AS-OCT) revealed a lesion of irregular density involving the anterior *** suspected a secondary corneal fibroproliferative mass based on the clinical history,and slit lamp and AS-OCT *** patient subsequently underwent a superficial keratectomy and keratoplasty,and the final diagnosis of corneal keloid was confirmed by intraoperative histopathological *** Non-penetrating corneal trauma damages corneal epithelium basement membrane,initiating stromal fibrosis and causing corneal ***-OCT and biopsy confirm diagnosis.

关键词： Corneal keloid Histopathology Immunohistochemical staining Anterior segment ocular coherence tomography Deep anterior lamellar keratoplasty Case report

Hepatitis B Virus Surface Antigen Promotes Stemness of Hepatocellular Carcinoma through Regulating MicroRNA-203a

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 118-129页

作者： Yu-Fei Qin Zi-Yu Zhou Hou-Wei Fu Hao-Ming lin Lei-Bo xu Wen-Rui Wu Chao Liu xiao-lin xu Rui Zhang Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation and Department of BiliaryPancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Department of Ultrasound Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongChina

Background and Aims:Patients with persistent positive hepatitis B surface antigen(HBsAg),even with a low HBVDNA load,have a higher risk of hepatocellular carcinoma(HCC)than those without HBV *** that tumor stemness has a critical role in the occurrence and maintenance of neoplasms,this study aimed to explore whether HBsAg affects biological function and stemness of HCC by regulating microRNA,and to explore underlying ***:We screened out miR-203a,the most significant down-regulated microRNA in the microarray analysis of HBsAg-positive samples and focused on that miRNA in the ensuing *** vitro and in vivo functional experiments were performed to assess its regulatory *** effect of miR-203a on stemness and the possible correlation with BMI1 were analyzed in this ***:MiR-203a was significantly down-regulated in HBsAg-positive HCC with the sharpest decrease shown in microarray *** negative correlation between miR-203a and HBsAg expression was confirmed by quantitative real-time PCR after stimulation or overexpression/knockdown of HBsAg in *** demonstrated the function of miR-203a in inhibiting HCC cell proliferation,migration,clonogenic capacity,and tumor development in ***,the overexpression of miR-203a remarkably increases the sensitivity of tumor cells to 5-FU treatment and decreases the proportion of HCC cells with stem *** concordance with our study,the survival analysis of both The Cancer Genome Atlas database and samples in our center indicated a worse prognosis in patients with low level of *** also found that BMI1,a gene maintains the self-renewal capacity of stem cells,showed a significant negative correlation with miR-203a in HCC specimen(p<0.001).Similarly,opposite BMI1 changes after overexpression/knockdown of miR203a were also confirmed in *** luciferase reporting assay suggested that miR-203a may regulate BMI1 expression by direct ***:HBsAg m

关键词： Hepatitis B surface antigen Hepatocellular carcinoma microRNA Stemness

Rovai＇s Classroom Community Scale and Its Application in Chinese College English Class

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Sino-US English Teaching 2011年第9期8卷 592-598页

作者： ZHANG Yan-yang lin xiao xu Ming Zhejiang University Hangzhou China

The purpose of this study is to introduce the CCS （Classroom Community Scale） established by Rovai （2002） and its application among freshmen in China with regard to how well their college English class builds a sense of classroom community. In addition, the reliability of CCS as applied in face-to-face classroom setting and the influence of gender and graduating high school of students on their perceptions of classroom community are also examined.

关键词： CCS (Classroom Community Scale) connectedness learning gender graduating high school

Adenocarcinoma of the nonpigmented ciliary epithelium manifested as an anterior chamber mass

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 485-487页

作者： Hai-Xia Bai Wen-Bin Wei Bin Li xiao-lin xu Wen-Li Yang Fei Gao Zhi-Bao Zhang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology & Visual Sciences Key Laboratory Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University

Dear Editor,Adenocarcinoma of the nonpigmented ciliary epithelium（NPCE）is a rare malignant tumor which is not easy to be found in the early stage（[1]）.Herein,we report a case of adenocarcinoma of the NPCE in a Chi... 详细信息

关键词： epithelium chamber adenocarcinoma moderately Figure neoplasm papillary fundus malignancy bilateral