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Mass spectrometry imaging and single-cell transcriptional profiling reveal the tissue-specific regulation of bioactive ingredient biosynthesis in Taxus leaves

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Plant Communications 2023年第5期4卷 29-45页

作者： xiaori Zhan Tian Qiu Hongshan Zhang Kailin Hou Xueshuang liang Cheng Chen Zhijing Wang Qicong Wu xiaojia Wang xiao-lin li Mingshuang Wang Shangguo Feng Houqing Zeng Chunna Yu Huizhong Wang Chenjia Shen College of life and Environmental Sciences Hangzhou Normal UniversityHangzhou 311121China Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants Hangzhou Normal UniversityHangzhou 311121China Kharkiv Institute Hangzhou Normal UniversityHangzhou 311121China College of Pharmacy Hangzhou Normal UniversityHangzhou 311121China State Key Laboratory Breeding Base of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China

Taxus leaves provide the raw industrial materials for taxol,a natural antineoplastic drug widely used in the treatment of various ***,the precise distribution,biosynthesis,and transcriptional regulation of taxoids and other active components in Taxus leaves remain ***-assisted laser desorption/ionization–mass spectrometry imaging analysis was used to visualize various secondary metabolites in leaf sections of Taxus mairei,confirming the tissue-specific accumulation of different active ***-cell sequencing was used to produce expression profiles of 8846 cells,with a median of 2352 genes per *** on a series of cluster-specific markers,cells were grouped into 15 clusters,suggesting a high degree of cell heterogeneity in *** *** data were used to create the first Taxus leaf metabolic single-cell atlas and to reveal spatial and temporal expression patterns of several secondary metabolic *** to the cell-type annotation,most taxol biosynthesis genes are expressed mainly in leaf mesophyll cells;phenolic acid and flavonoid biosynthesis genes are highly expressed in leaf epidermal cells(including the stomatal complex and guard cells);and terpenoid and steroid biosynthesis genes are expressed specifically in leaf mesophyll cells.A number of novel and cell-specific transcription factors involved in secondary metabolite biosynthesis were identified,including MYB17,WRKY12,WRKY31,ERF13,GT_2,and *** research establishes the transcriptional landscape of major cell types in *** leaves at a single-cell resolution and provides valuable resources for studying the basic principles of cell-type-specific regulation of secondary metabolism.

关键词： scRNA-seq taxol biosynthesis Taxus mairei secondary metabolism transcription regulation

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新常态下林业供给侧改革对木材进口的影响与对策

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林产工业 2019年第12期56卷 73-75页

作者：林小莉烟台大学文经学院

随着我国林业供给侧改革持续推进,林业资源的开发和利用日趋科学化、集约化。简要介绍了林业供给侧现状,探讨了林业供给侧改革对木材进口的影响,在此基础上提出规避林业供给侧改革对木材进口影响的措施,以期为我国林业供给侧改革提供参考。

关键词：木材锯材木材加工林业供给侧改革新常态木材进口

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Study of Elastic and Inelastic Scattering and One-Nucleon Transfer in ^(16)O-^(116)Sn Reaction

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Chinese journal of nuclear physics 1995年第3期17卷 239-246页

作者： Lu Xiu-qin Ma Yong Guo Ji-yu Zhao Kui Cheng Ye-hao Huang xiao-lin li Zhi-chang li Shu-yuan Ruan Ming Jiang Cheng-lie China Institute of Atomic Energy,P.O.Box 275(10),Beijing 102413 中国原子能科学院北京

Angular distributions have been measured for the elastic and inelastic scattering and one-nucle-on transfer of 88.0 MeV 16O on 116***-channels calculations have been performed for the elasticand inelastic scattering,and DWBA treatment for one-proton stripping(16O,15N),and one-neutron pick-up(16O,17O)*** results compared with the previous 64 MeV ones show energy dependence inthe optical potentials and also in the normalization factors with the spectroscopic factors preserving consis-tent in DWBA analysis,which might relate to the threshold anomaly phenomena.

关键词： Heavy ion reaction Optical potential DWBA and CCBA analysis

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Erosion Resistance Behaviours of H13 Steel to Molten ADC12 Alloy

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材料热处理学报 2004年第5期25卷 239-243页

作者： MINYong-an XULuo-ping WUxiao-chun lilin WANGRong SchoolofmaterialsscienceandEngineering ShanghaiUniversityShanghaiChina

H13 hot work steel samples and surface water vapor oxidized H13 samples were immersed into molten ADC 12 alloy under static resting or dynamic rotating conditions. Weigh-losing method was used to discover the influences of temperature, time and surface conditions on the erosion resistance of H13 steel. The interfaces between the steel and the molten alloy were studied with optical microscopy to compare the different erosion resistance behaviours. The results show that the composite layer outside of the compounds layers changes obviously with increasing temperature, lasting time or sample movement. The better erosion resistance of H13 steel can be endowed with the oxide films, which would gradually decrease along with the dissolve of the films.

关键词：抗腐蚀性氧化薄膜热锻模具钢铝合金

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Free triiodothyronine in relation to coronary severity at different ages： Gensini score assessment in 4206 euthyroid patients

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Journal of Geriatric Cardiology 2016年第12期13卷 978-983页

作者： Bing-Yang ZHOU Yuan-lin GUO Na-Qiong WU Cheng-Gang ZHU Ying GAO Ping QING xiao-lin li Yao WANG Geng liU Qian DONG Jian-Jun li Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academyof Medical Sciences and Peking Union Medical College Beifing China

Objective To study whether free triiodothyronine （FT3） within normal range has effects on the presence and severity of coronary ar- tery disease （CAD） in different gender and age groups. Methods A total of 4206 euthyroid patients were consecutively enrolled and di- vided into CAD group （n = 3306） and non-CAD group （n = 900）. All patients underwent coronary angiography （CAG）. Gensini score （GS） was used to determine the severity of coronary artery stenosis. Severe CAD was defined as GS 〉 32 and mild CAD was defined as GS 〈 32. Logistic regression analysis and linear regression analysis were conducted to determine the association of FT3 with CAD in patients with different gender and ages. Results Concentration of FT3 was lower in patients with CAD than that in angiography-normal control group （P 〈 0.05）. In addition, concentration of FT3 was lower in severe CAD than that in mild CAD. After adjusting for traditional cardiovascular risk factors and potential confounders, FT3 was negatively correlated with the presence of CAD, but not in the old patients （〉 65 years old）. Mul- tivariable linear regression analysis showed that FT3 was negatively associated with GS in male and young patients with stable CAD, but not in the old patients. Conclusions Low FT3 within normal range was negatively associated with the presence and severity of CAD in young patients, but not in the old ones. Further studies are needed to confirm our findings.

关键词： Coronary angiography Coronary artery disease Euthyroidism Free triiodothyronine Gensini score

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外阴阴道假丝酵母菌病患者肠道假丝酵母菌携带与阴道假丝酵母菌感染之间的关系

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中华妇产科杂志 2011年第7期46卷 496-500页

作者：林晓丽李真左绪磊上海市长宁区中心医院妇产科 200336 复旦大学附属金山医院妇产科

目的采用微生物学和分子生物学方法，研究外阴阴道假丝酵母菌病患者肠道假丝酵母菌携带与阴道假丝酵母菌感染之间的关系。方法收集2006年4月至2008年2月间上海市长宁区中心医院就诊的148例外阴阴道假丝酵母菌病患者的阴道分泌物和肛拭... 详细信息

目的采用微生物学和分子生物学方法，研究外阴阴道假丝酵母菌病患者肠道假丝酵母菌携带与阴道假丝酵母菌感染之间的关系。方法收集2006年4月至2008年2月间上海市长宁区中心医院就诊的148例外阴阴道假丝酵母菌病患者的阴道分泌物和肛拭子标本进行假丝酵母菌的培养和鉴定。采用内转录间隔区（ITS）PCR和随机扩增多态性DNA（RAPD）PCR方法对两处假丝酵母菌基因组DNA进行比对和分型，从而确定其关系。比较合并肠道携带假丝酵母菌的外阴阴道假丝酵母菌病患者与单纯阴道感染假丝酵母菌但肠道内无假丝酵母菌携带者阴道局部使用抗真菌药物治疗后复发率的差异。结果148例外阴阴道假丝酵母菌患者中，白假丝酵母菌感染占绝大多数（91．9％，136／148）；33．1％（49／148）的患者合并肠道携带假丝酵母菌。ITSPCR结果显示，92％（22／24）的患者肠道与阴道假丝酵母菌菌株间有高度同源性。患者在接受阴道局部抗真菌治疗后，合并肠道携带假丝酵母菌的外阴阴道假丝酵母菌病患者，其复发率（7／14）高于单纯的阴道感染者[复发率为21％（6／29）]，两者比较，差异有统计学意义（P〈0．05）。结论肠道携带假丝酵母菌与外阴阴道假丝酵母菌病之间存在着一定的关系。外阴阴道假丝酵母菌病患者在合并肠道携带假丝酵母菌时，阴道局部治疗后的外阴阴道假丝酵母菌病复发率较高。

关键词：念珠菌病外阴阴道肠疾病念珠菌病带病原状态复发

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An oversampling approach for mining program specifications

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Frontiers of Information Technology & Electronic Engineering 2018年第6期19卷 737-754页

作者： Deng CHEN Yan-duo ZHANG Wei WEI Rong-cun WANG xiao-lin li Wei liU Shi-xun WANG Rui ZHU Hubei Provincial Key Laboratory of Intelligent Robot Wuhan Institute of Technology School of Computer Science and Technology China University of Mining and Technology School of Computer and Information Engineering Henan Normal University

Automatic protocol mining is a promising approach for inferring accurate and complete API protocols. However, just as with any data-mining technique, this approach requires sufficient training data（object usage scenarios）. Existing approaches resolve the problem by analyzing more programs, which may cause significant runtime overhead. In this paper, we propose an inheritance-based oversampling approach for object usage scenarios（OUSs）. Our technique is based on the inheritance relationship in object-oriented programs. Given an object-oriented program p, generally, the OUSs that can be collected from a run of p are not more than the objects used during the run. With our technique, a maximum of n times more OUSs can be achieved, where n is the average number of super-classes of all general OUSs. To investigate the effect of our technique, we implement it in our previous prototype tool, ISpec Miner, and use the tool to mine protocols from several real-world programs. Experimental results show that our technique can collect 1.95 times more OUSs than general approaches. Additionally, accurate and complete API protocols are more likely to be achieved. Furthermore, our technique can mine API protocols for classes never even used in programs, which are valuable for validating software architectures, program documentation, and understanding. Although our technique will introduce some runtime overhead, it is trivial and acceptable.

关键词： Object usage scenario API protocol mining Program temporal specification mining Oversampling

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Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

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Measurement of the Mass Excess of ^(158)Sm

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Chinese journal of nuclear physics 1995年第3期17卷 234-238页

作者： Zhao Kui Guo Ji-yu Lu Xiu-qin Cheng Ye-hao Huang xiao-lin Ma Yong li Shu-yuan Ruan Ming li Zhi-chang Jiang Cheng-lie China Institute of Atomic Energy,P.O.Box 275(10),Beijing 102413 中国原子能科学院北京

A Q-value of —4.076±0.151 MeV has been determined for the two-proton transfer reaction160Gd(18O,20Ne)158Sm,which yields a first experimental measured value of —65.764±0.151 MeV forthe mass excess of 158Sm,the nucl... 详细信息

关键词： Heavy ion reaction Q-value Mass excess

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Is prophylactic somatostatin effective to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis or hyperamylasemia？ A randomized, placebo-controlled pilot trial

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Chinese Medical Journal 2013年第13期126卷 2403-2408页

作者： WANG Zi-kai YANG Yun-sheng CAI Feng-chun WANG Yong-hua SHI xiao-lin DING Chen li Wen Department of Gastroenterology and Hepatology Chinese People'sLiberation Army (Jeneral Hospital Bmjing 100853 China

Background Effects of prophylactic somatostatin on post-endoscopic retrograde cholangiopancreatography （ERCP） pancreatitis （PEP） and hyperamylasemia remain inconclusive. This study aimed to examine whether high-dose, long-term continuous infusion of somatostatin can reduce the incidence of PEP and post-ERCP hyperamylasemia. Methods This was a randomized, placebo-controlled pilot trial. One hundred and twenty-four patients scheduled for ERCP from December 2008 to May 2010 randomly received one of the following three interventions： pre-ERCP somatostatin （0.5 mg/h for 24 hours, starting 1 hour prior to ERCP; n=36）, post-ERCP somatostatin （0.5 mg/h for 24 hours, starting 1 hour after ERCP; n=47）, or placebo （saline for 24 hours, starting 1 hour prior to ERCP; n=41）. Serum amylase and lipase concentrations were measured 1 to 3 hours prior to ERCP and 6, 24, and 48 hours after ERCP. Results The three groups did not differ in age, gender, medical history, or ERCP procedure （catheterization using contrast or guidewire, pancreatic duct visualization, procedure time, or procedure type）. The rate of PEP was 13.7% （17/124） in the overall study sample and 16.7% （6/36）, 10.6% （5/47）, and 14.6% （6/41） in the pre-ERCP somatostatin, post- ERCP somatostatin, and placebo groups, respectively （P=0.715）. The rate of post-ERCP hyperamylasemia was 19.4% （7/36）, 21.3% （10/47）, and 46.3% （19/41） in the pre-ERCP somatostatin, post-ERCP somatostatin, and placebo groups, respectively （P=0.011）. Conclusions High-dose, long-term continuous infusion （0.5 mg/h for 24 hours） of somatostatin, performed as either a pre- or post-ERCP, can reduce the incidence of hyperamylasemia, but not PEP.

关键词： somatostatin endoscopic retrograde cholangiopancreatography post-endoscopic retrogradecholangiopancreatography pancreatitis hyperamylasemia

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