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Zishenpingchan granules for the treatment of Parkinson＇s disease：a randomized,double-blind,placebo-controlled clinical trial

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Neural Regeneration Research 2018年第7期13卷 1269-1275页

作者： Qing Ye xiao-lei yuan Can-Xing yuan Hong-Zhi Zhang Xu-Ming Yang Department of Neurology LONGHUA Hospital Shanghai University of Traditional Chinese Medicine Shanghai China Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China Acupuncture and Tuina College of Shanghai University of Traditional Chinese Medicine Shanghai China

Levodopa preparations remain the preferred drug for Parkinson＇s ***,long-term use of levodopa may lead to a series of motor *** studies have shown that the combination of levodopa and Zishenpingchan granules（consisting of Radix Rehmanniae preparata,Lycium barbarum,Herba Taxilli,Rhizoma Gastrodiae,Stiff Silkorm,Curcuma phaeocaulis,Radix Paeoniae Alba,Rhizoma Arisaematis,Scorpio and Centipede） can markedly improve dyskinesia and delay the progression of Parkinson＇s disease,with especially dramatic improvements of non-motor ***,the efficacy of this combination has not been confirmed by randomized controlled *** current study was approved by the Hospital Ethics Committee and was registered in the Chinese Clinical Trial Register（registration number：Chi CTR-INR-1701194）.From December 2014 to December 2016,128 patients（72 males and 56 females,mean age of 65.78 ± 6.34 years） with Parkinson＇s disease were recruited from the Department of Neurology of Longhua Hospital and Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine in *** were equally allocated into treatment and control *** addition to treatment with dopamine,patients in treatment and control groups were given Zishenpingchan granules or placebo,respectively,for 24 *** efficacy was assessed using the Unified Parkinson＇s Disease Rating Scale,on-off phenomenon,Hoehn-Yahr grade,Scales for Outcomes in Parkinson＇s disease–Autonomic,Parkinson＇s disease sleep scale,Hamilton Anxiety Scale,Hamilton Depression Scale,Mini-Mental State Examination,and the Parkinson＇s Disease Quality of Life *** neural networks were used to determine weights at which to scale these *** results demonstrated that Zishenpingchan granules significantly reduced the occurrence of motor complications,and were useful for mitigating dyskinesia and non-motor symptoms of Parkinson＇s *** combination of Chin

关键词： nerve regeneration levodopa motion complications non-motor symptoms traditional Chinese medicine treatment artificial neural networks Zishenpingchan granules randomized controlled trials neurodegenerative diseases neural regeneration

Hierarchical micro-mobility management in high-speed multihop access networks

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The Journal of China Universities of Posts and Telecommunications 2006年第4期13卷 7-12页

作者： TANG Bi-hua MA xiao-lei LIU yuan-an GAO Jin-chun School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

This article integrates the hierarchical micro-mobility management and the high-speed multihop access networks （HMAN）, to accomplish the smooth handover between different access reuters. The proposed soft handover scheme in the high-speed HMAN can solve the micro-mobility management problem in the access network. This article also proposes the hybrid access muter （AR） advertisement scheme and AR selection algorithm, which uses the time delay and stable route to the AR as the gateway selection parameters. By simulation, the proposed micro-mobility,management scheme can achieve high packet delivery fraction and improve the lifetime of network.

关键词： Ad-hoc networks hierarchical micro-mobility management wireless multihop access network

Biological Fingerprinting Analysis of Interaction Between Taxoids in Taxus and Microtubule Protein by Microdialysis Coupled with High-performance Liquid Chromatography/Mass Spectrometry for Screening Antimicrotubule Agents

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Chemical Research in Chinese Universities 2008年第4期24卷 411-419页

作者： lei xiao-yuan KONG Liang SU Xing-ye GUO Ming ZOU Han-fa National Chromatographic R＆A Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China College of Marine Environmental Engineering Dalian Fisheries University Dalian 116023 P R. China Department of Chemistry and Chemical Technology Dalian University Dalian 116622 P. R. China

Some natural products, such as traditional Chinese medicines（TCMs）, contain compounds with anticancer activity and have attracted a great interest in recent years as alternative anticancer therapies. A quick and convenient assay for screening antimicrotubule compounds in which in vitro microdialysis/high-performance liquid chromatography （HPLC） is used to monitor the binding of the compounds extracted from TCM Taxus cuspidata Siebold ＆ Zucc（Taxus） to microtubules is reported. It was observed that the extract of Taxus contains at least five compounds which have affinity interaction with microtubules by biological fingerprinting analysis, and they were identified as the taxoids of taxol, baccatin III, 10-deacetylbaccatin Ⅲ（10-DAB）, cephalomannine and 7-epi-10-deacetyltaxol （7-epi-10-DAT） based on the comparison of their high-performance liquid chromatographic/mass spectrometric and UV spectra with those of the standard samples, both assembly-promoting and disassembly-inhibiting characteristics of those compounds were evaluated. It was observed that baccatin Ⅲ and 10-DAB bound to microtubules and the binding degrees were influenced by GTP. Competitive binding behavior of taxol with other four taxoids to microtubules was also investigated.

关键词： Microdialysis/high-performance liquid chromatography(HPLC) Biological fingerprinting analysis Taxoids Microtubule Taxus

Prediction of chemical short-range order in high-/medium-entropy alloys

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Journal of Materials Science & Technology 2024年第2期169卷 115-123页

作者： Pei-Yu Cao Jing Wang Ping Jiang Yun-Jiang Wang Fu-Ping yuan xiao-lei Wu State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of ScienceBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Chemical short-range orders(CSROs),as the built-in sub-nanoscale entities in a high-/medium-entropy alloy(H/MEA),have aroused an ever-increasing *** multi-principal elements in an H/MEA to form a complex concentrated solution,a variety of sub-systems of species exist to induce the metastable ordered compounds as candidates for ultimate *** issues remain pending on the origin of CSROs as to how to judge if CSRO will form in an H/MEA and particularly,what kind of CSROs would be stably produced if there were multiple ***,the first-principles method,along with the proposed local formation energy calculation in allusion to the atomic-scale chemical heterogeneities,is used to predict the CSRO formation based on the mechanical stability,thermodynamic formation energy,and electronic *** simulations are detailed in an equiatomic ternary VCoNi MEA with three kinds of potential compounds,i.e.,L1_(1),L1_(2),and B2,in the face-centered cubic *** turns out that L1_(1)is stable but hard to grow up so as to become the final CSRO.L1_(1)is further predicted as CSROs in CrCoNi,but unable to form in FeCoNi and CrMnFeCoNi *** predictions are consistent with the experimental *** findings shed light on understanding the formation of *** method is applicable to other H/MEAs to design and tailor CSROs by tuning chemical species/contents and thermal processing for high performance.

关键词： Short-range order High-entropy alloy Microstructure First-principles calculation Gibbs free energy Local electronic density of states

Metarelation2vec:A Metapath-Free Scalable Representation Learning Model for Heterogeneous Networks

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Tsinghua Science and Technology 2024年第2期29卷 553-575页

作者： lei Chen yuan Li Yong lei Xingye Deng School of Information and Electrical Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan 411201China

Metapaths with specific complex semantics are critical to learning diverse semantic and structural information of heterogeneous networks(HNs)for most of the existing representation learning ***,any metapaths consisting of multiple,simple metarelations must be driven by domain *** sensitive,expensive,and limited metapaths severely reduce the flexibility and scalability of the existing models.A metapath-free,scalable representation learning model,called Metarelation2vec,is proposed for HNs with biased joint learning of all metarelations in a bid to address this ***,a metarelation-aware,biased walk strategy is first designed to obtain better training samples by using autogenerating cooperation probabilities for all metarelations rather than using expert-given ***,grouped nodes by the type,a common and shallow skip-gram model is used to separately learn structural proximity for each node ***,grouped links by the type,a novel and shallow model is used to separately learn the semantic proximity for each link ***,supervised by the cooperation probabilities of all meta-words,the biased training samples are thrown into the shallow models to jointly learn the structural and semantic information in the HNs,ensuring the accuracy and scalability of the *** experimental results on three tasks and four open datasets demonstrate the advantages of our proposed model.

关键词： metarelation random walk heterogeneous network metapath representation learning

Realizing quantum imaginary time evolution in experiment

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 167-168页

作者： xiao yuan Center on Frontiers of Computing Studies Peking UniversityBeijing 100871China School of Computer Science Peking UniversityBeijing 100871China

NISQ,or Noisy Intermediate-Scale Quantum computing,represents a pivotal and the state-of-the-art quantum technology[1].Characterized by intermediate-scale quantum devices that are beyond classical computational capabilities yet fall short of the error-correction thresholds required for fault-tolerant quantum computing,NISQ devices exhibit both promise and *** devices hold immense potential in solving certain computational problems that surpass classical capabilities,with wide applications in optimization,machine learning,and quantum chemistry.

关键词： quantum imaginary correction

A Trust Evaluation Mechanism Based on Autoencoder Clustering Algorithm for Edge Device Access of IoT

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Computers, Materials & Continua 2024年第2期78卷 1881-1895页

作者： xiao Feng Zheng yuan Cyber Security Academy Beijing University of Posts and TelecommunicationsBeijing100876China Department of Cyberspace Security Beijing Electronic Science and Technology InstituteBeijing100070China State Grid Info-Telecom Great Power Science and Technology Co. Ltd.Beijing102211China

First,we propose a cross-domain authentication architecture based on trust evaluation mechanism,including registration,certificate issuance,and cross-domain authentication processes.A direct trust evaluation mechanism based on the time decay factor is proposed,taking into account the influence of historical interaction *** weight the time attenuation factor to each historical interaction record for updating and got the new historical record *** refer to the beta distribution to enhance the flexibility and adaptability of the direct trust assessment model to better capture time trends in the historical *** we propose an autoencoder-based trust clustering *** perform feature extraction based on *** leibler(KL)divergence is used to calculate the reconstruction *** constructing a convolutional autoencoder,we introduce convolutional neural networks to improve training efficiency and introduce sparse constraints into the hidden layer of the *** sparse penalty term in the loss function measures the difference through the KL *** clustering is performed based on the density based spatial clustering of applications with noise(DBSCAN)clustering *** the clustering process,edge nodes have a variety of trustworthy attribute *** assign different attribute weights according to the relative importance of each attribute in the clustering process,and a larger weight means that the attribute occupies a greater weight in the calculation of ***,we introduced adaptive weights to calculate comprehensive trust *** experiments prove that our trust evaluation mechanism has excellent reliability and accuracy.

关键词： Cross-domain authentication trust evaluation autoencoder

A state-of-the-art review on delayed expansion of cemented paste backfill materials

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Rare Metals 2024年第8期43卷 3475-3500页

作者： Meng-yuan Li Li-Jie Guo Yue Zhao lei Zhang Kai Yang xiao-Peng Peng Andrew Pan BGRIMM Technology Group Beijing 100160China National Centre for International Research On Green Metal Mining Beijing102628China Department of Civil and Mineral Engineering University of TorontoTorontoON M5S 1A4Canada

Utilizing delayed expansion cemented paste backfill materials(DECPB) in mine backfill operations offers an effective solution to the challenge of achieving proper contact between the in-situ cemented backfill mass and the roof in mined-out areas(backfill-roof contact).This article presents recent progress in both theoretical and experimental research concerning *** types and mechanisms of expansive additives,including expansive agents,foaming agents,and expansive mineral materials relevant to DECPB,are explained,along with their impact on the expansive properties and mechanical characteristics of *** composition,material characteristics,preparation methods,and controlled release mechanisms of microcapsules are *** methods for measuring the volume change rate of paste backfill slurries are *** indicates that an appropriate content of expansive additives not only enhances the expansive properties of cemented paste backfill materials but also contributes to improving their mechanical *** foaming agents and bentonite are found to be more suitable for preparing DECPB compared to expansive *** delayed expansion of cemented paste backfill material is influenced by microcapsules,with their wall materials,preparation parameters,and the alkaline slurry environment affecting their controlled release *** and optimizing precise measurement devices and methods forfor the volume change rate of cemented paste backfill materials is essential requirement for studying the performance of *** delayed expansion technology with retarding techniques in cemented paste backfill materials can provide a reliable solution for achieving proper backfill-roof contact in the future.

关键词： Paste backfill Delayed expansion Mining with backfill Expansive additives Tailings

Comparison of inebilizumab or rituximab in addition to glucocorticoid therapy for neuromyelitis optica spectrum disorders

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1073-1078页

作者： Chu-yuan Lou Yong Wang Jia-yuan Xing Teng Ma lei Tao xiao-Tang Wang Run-Sheng Wang Neuroophthalmic Center Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004Shaanxi ProvinceChina

AIM:To investigate the short-term efficacy and safety of inebilizumab for neuromyelitis optica spectrum disorders(NMOSD).METHODS:A total of 33 patients with NMOSD treated with inebilizumab(Group INB,n=15)or rituximab(Group RTX,n=18)in addition to high-dose glucocorticoids were *** groups underwent hormone shock therapy during the acute ***,Group INB received inebilizumab injections during the remission phase,while Group RTX received rituximab injections.A comparison of aquaporins 4(AQP4)titer values,peripheral blood B lymphocyte counts,and visual function recovery was conducted before and 8wk after ***,adverse reactions and patient tolerability were analyzed after using inebilizumab treatment ***:Following inebilizumab treatment,there was a significantly improvement in the visual acuity of NMOSD patients(P0.05).Furthermore,inebilizumab exhibited higher safety levels than that of rituximab ***:The combination of inebilizumab and high-dose glucocorticoids proves to be *** comparison to rituximab injections,inebilizumab displays better tolerance and ***,it demonstrates a partial effect in preventing optic nerve ***,it stands as an effective method to reduce the disability rates and improve the daily living ability of patients with NMOSD.

关键词： neuromyelitis optica spectrum disorders inebilizumab rituximab glucocorticoids