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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting zhang Yanlin Fu Peiyan Long xiao Gao Zhengwei Wang Zhizhong Guan xiaolan Qi Wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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拆方益肝康不同药物血清对肝星状细胞胶原代谢及TGF-β1的影响

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世界华人消化杂志 2009年第27期17卷 2773-2777页

作者：房澍名姚冬梅张晓岚姚希贤河北医科大学第二医院消化科河北省消化病重点实验室河北省消化病研究所河北省石家庄市050000

目的:探讨益肝康抗肝纤维化作用机制、配伍意义,并采用对比血清药理学方法探讨更为科学的中药研究方法.方法:分别制备益肝康及其拆方-丹参小复方正常大鼠(A组,A1组:正常大鼠血清对照组;A2组:正常大鼠丹参小复方血清组;A3组:正常大鼠益... 详细信息

目的:探讨益肝康抗肝纤维化作用机制、配伍意义,并采用对比血清药理学方法探讨更为科学的中药研究方法.方法:分别制备益肝康及其拆方-丹参小复方正常大鼠(A组,A1组:正常大鼠血清对照组;A2组:正常大鼠丹参小复方血清组;A3组:正常大鼠益肝康血清组)与肝纤维化大鼠(B组,B1组:肝纤维化大鼠血清对照组;B2组:肝纤维化大鼠丹参小复方血清组;B3组:肝纤维化大鼠益肝康血清组)药物血清,温育体外培养的HSC,3H-脯氨酸掺入法检测胶原合成,Western blot技术检测TGF-β1蛋白表达,RT-PCR技术检测TGF-β1mRNA表达.结果:益肝康及丹参小复方正常大鼠与肝纤维化大鼠药物血清均可以抑制HSC胶原合成(100mL/L时A组:2275.00±114.30cpm,2401.87±108.50cpm vs2963.62±128.01cpm;B组:2205.31±108.97cpm,2462.70±177.02cpm vs3179.12±223.34cpm;200mL时A组:2372.96±123.3cpm vs2515.37±98.25cpm vs3209.38±110.75cpm;B组:2394.29±150.50cpm vs2611.25±126.05cpm vs3490.46±183.16cpm,P<0.05或0.01),100mL时降低TGF-β1基因及蛋白表达(均P<0.01).2组在胶原合成、TGF-β1基因及蛋白表达益肝康组作用优于丹参小复方(均P<0.01),而益肝康组与丹参小复方组比较则B组血清作用优于A组(益肝康组:TGF-β1基因:0.356±0.032vs0.568±0.028;TGF-β1蛋白:0.458±0.009vs0.639±0.102;丹参小复方组:0.601±0.047vs0.810±0.051;0.612±0.126vs0.860±0.138,P<0.05或P<0.01).结论:益肝康及丹参小复方均可抑制HSC胶原合成,其主要机制之一是抑制TGF-β1基因和蛋白表达,益肝康更具配伍意义,肝纤维化大鼠药物血清药效优于正常大鼠血清药效.

关键词：益肝康肝纤维化肝星状细胞转化生长因子beta-1 血清药理学

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-Zhao xiao Hao-Ling zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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FAK-ERK信号转导通路在FRNK抑制肝星状细胞胶原合成中的作用

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世界华人消化杂志 2009年第14期17卷 1402-1405页

作者：申建刚张晓岚魏娟霍晓霞桑荣霞安君艳深圳市人民医院广东省深圳市518003 河北医科大学第二医院消化科河北省石家庄市050000 石家庄市人民医院消化科河北省石家庄市050000

目的:探讨FAK-ERK信号转导通路在黏着斑激酶相关非激酶(FAK-related non-kinase,FRNK)质粒转染抑制肝星状细胞(hepatic stellate cells,HSCs)胶原合成中的作用.方法:在体外,以FN诱导HSCs增殖,采用脂质体介导的方法用FRNK表达质粒瞬时转... 详细信息

目的:探讨FAK-ERK信号转导通路在黏着斑激酶相关非激酶(FAK-related non-kinase,FRNK)质粒转染抑制肝星状细胞(hepatic stellate cells,HSCs)胶原合成中的作用.方法:在体外,以FN诱导HSCs增殖,采用脂质体介导的方法用FRNK表达质粒瞬时转染HSCs,利用3H-Pro掺入技术测定HSCsⅠ型胶原的合成,Western blot及RT-PCR方法检测FRNK、FAK、p-FAK(Tyr397)、ERK蛋白和mRNA的表达.结果:FRNK表达质粒成功转染HSCs,在翻译后水平抑制FAK磷酸化.在FRNK转染HSC48h后胶原合成能力较空质粒组显著下降(498.17±73.20vs748.33±61.30,P<0.01).FRNK抑制FAK磷酸化和在翻译和转录水平抑制ERK1、p-ERK的表达,而FN则促进FAK和ERK1、p-ERK在翻译和转录水平的表达.结论:FRNK可以使HSCs胶原合成能力降低,FAK-ERK信号转导通路可能发挥了负调控作用.

关键词：肝星状细胞黏着斑激酶相关非激酶细胞外信号调节激酶胶原免疫蛋白印迹

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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin zhang Guangyu Yang Lei xiao Zhiyong Kan Jing Guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： xiaohong Zou Qian Lu Mingcong Tang Jie Wu Kouer zhang Wenzhi Li Yunxia Hu xiaomin Xu xiao zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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以渗出性腹水为首发表现的克罗恩病1例

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世界华人消化杂志 2008年第35期16卷 4027-4029页

作者：刘玉然邸菁华张晓岚房澍名任锡玲河北医科大学第二医院消化科河北省石家庄市050000 深泽县医院河北省深泽县052560

患者,女性,因腹胀腹痛乏力1mo入院.B超示腹部大量游离液体.肠镜见末端回肠大小不等的5个阿弗他溃疡,溃疡之间黏膜正常.病理见黏膜及黏膜下大量炎症细胞浸润及非干酪样坏死性肉芽肿.诊断为"克罗恩病".予以奥沙拉嗪口服,后患者腹痛、腹胀... 详细信息

患者,女性,因腹胀腹痛乏力1mo入院.B超示腹部大量游离液体.肠镜见末端回肠大小不等的5个阿弗他溃疡,溃疡之间黏膜正常.病理见黏膜及黏膜下大量炎症细胞浸润及非干酪样坏死性肉芽肿.诊断为"克罗恩病".予以奥沙拉嗪口服,后患者腹痛、腹胀减轻,腹水消退.1mo后复查B超示腹水消失,肠镜仅见末端回肠一小溃疡,余未见异常.

关键词：克罗恩病腹腔积液肠结核

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肝淀粉样变1例

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世界华人消化杂志 2010年第12期18卷 1287-1289页

作者：郝礼森郭剑郑力博朱芳丽刘小娟张晓岚秦玉彩河北医科大学第二医院消化内科河北省石家庄市050000 华北煤炭医学院附属医院消化内科河北省唐山市063000

患者,男,58岁,因发现上腹部包块、尿色深黄、体质量下降半年入院.入院后检查发现患者肝脏肿大、肝功能轻度异常,伴有蛋白尿及碱性磷酸酶增高,经肝穿刺活检确诊为肝淀粉样变.肝淀粉样变临床少见,诊断困难,预后较差.

关键词：肝淀粉样变肝肿大肝穿刺活检

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Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu xiao Shangru Zhai Chuang Xue Guangping Zheng Deqing zhang Renchao Che Junye Cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： xiao-xiao zhang Li Jia Xiu-Jun Zhan Charity Ngina Qing-Rui zhang xiao-Ge Li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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