检索结果-南通市图书馆

Current therapies for osteoarthritis and prospects of CRISPR-based genome,epigenome,and RNA editing in osteoarthritis treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 159-183页

作者： Yuxi Chen xiao Luo Rui kang Kaixin cui Jianping Ou Xiya Zhang Puping Liang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center for Reproductive Medicine The Third Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhouGuangdong 510630China

Osteoarthritis(OA)is one of the most common degenerative joint diseases worldwide,causing pain,disability,and decreased quality of *** balance between regeneration and inflammation-induced degradation results in multiple etiologies and complex pathogenesis of ***,there is a lack of effective therapeutic strategies for OA *** the development of CRISPR-based genome,epigenome,and RNA editing tools,OA treatment has been improved by targeting genetic risk factors,activating chondrogenic elements,and modulating inflammatory *** by cell therapy and in vivo delivery vectors,genome,epigenome,and RNA editing tools may provide a promising approach for personalized OA *** review summarizes CRISPR-based genome,epigenome,and RNA editing tools that can be applied to the treatment of OA and provides insights into the development of CRISPR-based therapeutics for OA ***,in-depth evaluations of the efficacy and safety of these tools in human OA treatment are needed.

关键词： Osteoarthritis Genome editing Epigenone editing RNA editing

Analytical model for predicting time-dependent lateral deformation of geosynthetics-reinforced soil walls with modular block facing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 711-725页

作者： Luqiang Ding Chengzhi xiao Feilong cui School of Civil and Transportation Engineering Hebei University of TechnologyTianjin300401China

To date,few models are available in the literature to consider the creep behavior of geosynthetics when predicting the lateral deformation(d)of geosynthetics-reinforced soil(GRS)retaining *** this study,a general hyperbolic creep model was first introduced to describe the long-term deformation of geosynthetics,which is a function of elapsed time and two empirical parameters a and *** conventional creep tests with three different tensile loads(Pr)were conducted on two uniaxial geogrids to determine their creep behavior,as well as the a-Pr and b-Pr *** test results show that increasing Pr accelerates the development of creep deformation for both ***,a and b respectively show exponential and negatively linear relationships with Pr,which were confirmed by abundant experimental data available in other *** on the above creep model and relationships,an accurate and reliable analytical model was then proposed for predicting the time-dependent d of GRS walls with modular block facing,which was further validated using a relevant numerical investigation from the previous *** evaluation and comparison of the proposed model with six available prediction models were *** a parametric study was carried out to evaluate the effects of wall height,vertical spacing of geogrids,unit weight and internal friction angle of backfills,and factor of safety against pullout on d at the end of construction and 5 years *** findings show that the creep effect not only promotes d but also raises the elevation of the maximum d along the wall ***,the limitations and application prospects of the proposed model were discussed and analyzed.

关键词： Geosynthetics Creep behavior Geosynthetics-reinforced soil(GRS)walls Lateral deformation Analytical model

Effect of CeO_2 on heat transfer and crystallization behavior of rare earth alloy steel mold fluxes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2019年第5期26卷 565-572页

作者： Ze-yun Cai Bo Song Long-fei Li Zhen Liu xiao-kang cui School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

To improve the heat transfer capability and the crystallization property of the traditional mold flux, CaF_2 was replaced with B_2O_3. Then, the influences of CeO_2 on the heat transfer and the crystallization of the CaF_2-bearing mold flux and the new mold flux with 10 wt% B_2O_3 were studied using a slag film heat flux simulator and X-ray diffraction(XRD). The results revealed that the addition of CeO2 reduced the heat transfer by increasing the solid slag thickness and the crystallization of two mold fluxes. However, CeO_2 had less effect on the B_2O_3-containing mold flux compared with the CaF_2-bearing mold flux. According to the analyses, the CeO_2 contents in the CaF_2-bearing mold flux and the B_2O_3-containing mold flux should not exceed 8 wt% and 12 wt%, respectively. Therefore, these experimental results are beneficial to improve and develop the mold flux for casting rare earth alloy steels.

关键词： cerium oxide boron trioxide mold fluxes heat transfer crystallization rare earth alloy steels

Aging Mechanism and Life Estimation of Photovoltaic Inverter DC-link Capacitors in Alternating Humid and Thermal Environment

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electrical Engineering 2024年第1期10卷 48-62页

作者： Quanyi Gao Shuaibing Li Yi cui Yongqiang kang Haiying Dong School of New Energy and Power Engineering Lanzhou Jiaotong UniversityLanzhou 730070China State Key Laboratory of Large Electric Drive System and Equipment Technology Tianshui 741000China School of Engineering University of Southern QueenslandSpringfield 4300Australia

DC-link capacitors play a vital role in managing ripple voltage and current in converters and various *** study focuses on exploring the aging characteristics of DC-link capacitors in alternating humid and thermal environments aligned with the operational conditions in photovoltaic and wind power *** to relevant power equipment standards,we designed a 24-h alternating humid and thermal aging environment tailored to the requirements of DC-link *** aging test platform is established,and 20 widely used metallized polypropylene film capacitors are selected for *** such as the capacitance,equivalent series resistance(ESR),and phase angle are assessed during aging,as well as the onset time and extent of aging at various *** study focuses on the aging mechanisms,analyzing electrode corrosion,the self-healing process,and dielectric *** the aging characteristics enabled us to calculate the lifespan of the capacitor and predict it under different degrees of capacitance *** results show that under alternating humid and thermal conditions,capacitance attenuation and ESR increase exhibit exponential nonlinearity,influenced by factors such as the oxidation and self-healing of capacitive metal electrodes,dielectric main-chain fracture,and crystal *** study underscores the pivotal role of encapsulation in determining the aging decay time.

关键词： DC-link capacitors aging mechanism life prediction metallized film capacitors

Challenges in Li-ion battery high-voltage technology and recent advances in high-voltage electrolytes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 73-98页

作者： Jianguo Liu Baohui Li Jinghang Cao xiao Xing Gan cui Shandong Key Laboratory of Oil&Gas Storage and Transportation Safety College of Pipeline and Civil EngineeringChina University of Petroleum(East China)Qingdao 266580ShandongChina

The electrolyte directly contacts the essential parts of a lithium-ion battery,and as a result,the electrochemical properties of the electrolyte have a significant impact on the voltage platform,charge discharge capacity,energy density,service life,and rate discharge *** raising the voltage at the charge/discharge plateau,the energy density of the battery is ***,this causes transition metal dissolution,irreversible phase changes of the cathode active material,and parasitic electrolyte oxidation *** article presents an overview of these concerns to provide a clear explanation of the issues involved in the development of electrolytes for high-voltage lithium-ion ***,solidstate electrolytes enable various applications and will likely have an impact on the development of batteries with high energy *** is necessary to improve the high-voltage performance of electrolytes by creating solvents with high thermal stabilities and high voltage resistance and additives with superior film forming performance,multifunctional capabilities,and stable lithium *** offer suggestions for the future development of high-energy lithium-ion batteries,we conclude by offering our own opinions and insights on the current development of lithium-ion batteries.

关键词： Lithium-ion battery High voltage Electrolyte additive Solid electrolyte

Highly-chlorinated inert and robust interphase without mineralization of oxide enhancing high-rate Li metal batteries

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 239-243页

作者： Long Li kang Yang Chenpeng Xi Mengchao Li Borong Li Gui Xu Yuanbin xiao Xiancai cui Zhiliang Liu Lingyun Li Yan Yu Chengkai Yang Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesSchool of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China College of Material Sciences and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Side reactions and dendrite growth triggered by the unstable interface and inhomogeneous deposition have become the biggest obstacle to the commercialization for lithium metal *** this study,a highly-chlorinated organic-inorganic hybrid interfacial protective layer is developed by rationally tuning the interfacial passivation and robustness to achieve the convenient and efficient Li metal *** polyvinyl chloride(PVC)can effectively resist water and oxygen,which is confirmed by density functional *** organic-dominant solid electrolyte interphases(SEI)with lithium chloride are investigated by the X-ray photoelectron spectroscopy(XPS)with little mineralization of oxide,such as Li_(2)O and Li_(2)CO_(3).With such artificial SEI,a uniform and dense lithium deposition morphology are formed and an ultra-long stable cycle of over 500 h are achieved even at an ultra-high current density of 10 m A/cm^(2).Moreover,the simple and convenient protected anode also exhibits excellent battery stability when paired with the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)and LiFePO_(4)(LFP)cathode,showing great potential for the commercial application of lithium metal batteries.

关键词： Highly-chlorinated Water/oxygen resistance Stable interphase Dendrite-free lithium metal batteries High-rate

Effects of Mg and La on the evolution of inclusions and microstructure in Ca-Ti treated steel

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2021年第12期28卷 1940-1948页

作者： Lei Wang Bo Song Zhan-bing Yang xiao-kang cui Zhen Liu Wen-sen Cheng Jing-hong Mao School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China

The evolution of inclusions and the formation of acicular ferrite(AF)in Ca-Ti treated steel was systematically investigated after Mg and La *** inclusions in the molten steel were Ca-Al-O,Ca-Al-Mg-O,and La-Mg-Ca-Al-O after Ca,Mg,and La addition,*** type of oxide inclusion in the final quenched samples was the same as that in the molten ***,unlike those in molten steel,the inclusions were Ca-Al-Ti-O+MnS,Ca-Mg-Al-Ti-O+MnS,and La-Ca-Mg-Al-Ti-O+MnS in Mg-free,Mg-containing,and La-containing samples,*** inclusions distributed dispersedly in the La-containing *** addition,the average size of the inclusions in the La-containing sample was the smallest,while the number density of inclusions was the *** size of effective inclusions(nucleus of AF formation)was mainly in the range of 1-3μ*** addition,the content of ferrite side plates(FSP)decreased,while the percentage of AF increased by 16.2%due to the increase in the number of effective inclusions in the La-containing sample in this study.

关键词： steel ferrite microstructure

Existence of long-range magnetic order in Heisenberg spin nanoribbons with edge modification

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第7期76卷 136-146页

作者： Da-cheng Ma Ling-yi cui Chu-xiao Sun xiao-dan Chi Zheng-Nan XianYu An Du College of Science Northeastern University Department of Basic Science Dalian Naval Academy Department of Physics College of Sciences Shenyang University of Chemical Technology National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern University Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of Education

Long-range magnetic order appears on a side decorated Heisenberg spin nanoribbon at nonzero temperature, although no spontaneous magnetization exists in a one-or two-dimensional isotropic Heisenberg model at any nonzero temperature according to the Mermin–Wagner theorem. By use of the spin Green's function method, we calculated the magnetizations of Heisenberg nanoribbons decorated by side spins with single-ion anisotropy and found that the system exhibits a nonzero transition temperature, whether the decorated edge spins of the system link together or separate from each other. When the width of the nanoribbon achieves infinite limit, the transition temperatures of the system tend to the same finite constant eventually whether one edge or both edges are decorated by side spins in the nanoribbon. The results reveal that the magnetism of a low-dimensional spin system is different from that of a three-dimensional spin system. When the single-ion anisotropy of edge spins in a Heisenberg spin nanoribbon can be modulated by an electric field experimentally, various useful long-range magnetic orders of the system can be obtained. This work can provide a detailed theoretical basis for designing and fabricating next-generation low-dimensional magnetic random-access memory.

关键词： Heisenberg model long-range magnetic order magnetic anisotropy Nanoribbon transition temperature

Synthesis,Style Editing,and Animation of 3D Cartoon Face

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第2期29卷 506-516页

作者： Ming Guo Feng Xu Shunfei Wang Zhibo Wang Ming Lu Xiufen cui xiao Ling School of Software and BNRist Tsinghua UniversityBeijing 100084China Department of Multimedia and Smart Guangdong OPPO Mobile Telecommunications Corp.Ltd.Dongguan 523860China Intel Labs IntelBeijing 100089China

As a popular kind of stylized face,cartoon faces have rich application *** is challenging to create personalized 3D cartoon faces directly from 2D real ***,in order to adapt to more application scenarios,automatic style editing,and animation of cartoon faces is also a crucial problem that is urgently needed to be solved in the industry,but has not yet had a perfect *** solve this problem,we first propose“3D face cartoonizer”,which can generate high-quality 3D cartoon faces with texture when fed into 2D facial *** contribute the first 3D cartoon face hybrid dataset and a new training strategy which first pretrains our network with low-quality triplets in a reconstruction-then-generation manner,and then finetunes it with high-quality triplets in an adversarial manner to fully leverage the hybrid ***,we implement style editing for 3D cartoon faces based on k-means,which can be easily achieved without retrain the neural *** addition,we propose a new cartoon faces'blendshape generation method,and based on this,realize the expression animation of 3D cartoon faces,enabling more practical *** dataset and code will be released for future research.

关键词： cartoon 3D face animation computer graphics