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Present situation of minimally invasive surgical treatment for early gastric cancer

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1154-1165页

作者： Chun-Yan Li Yi-Feng Wang Li-Kang Luo xiao-jun yang The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medicine College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Centre Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina The Second Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Lanzhou University People's Clinical Hospital Lanzhou 730000Gansu ProvinceChina Gansu Research Center of Prevention and Control Project for Digestive Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Minimally invasive surgery is a kind of surgical operation,which is performed by using professional surgical instruments and equipment to inactivate,resect,repair or reconstruct the pathological changes,deformities and wounds in human body through micro-trauma or micro-approach,in order to achieve the goal of treatment,its surgical effect is equivalent to the traditional open surgery,while avoiding the morbidity of conventional surgical *** addition,it also has the advantages of less trauma,less blood loss during operation,less psychological burden and quick recovery on patients,and these minimally invasive techniques provide unique value for the examination and treatment of gastric cancer *** minimally invasive surgical techniques have developed rapidly and offer numerous options for the treatment of early gastric cancer(EGC):endoscopic mucosal resection(EMR),underwater EMR(UEMR),endoscopic submucosal dissection(ESD),endoscopic full-thickness resection(EFTR),endoscopic submu-cosal excavation(ESE),submucosal tunnel endoscopic resection,laparoscopic and endoscopic cooperative surgery(LECS);Among them,EMR,EFTR and LECS technologies have a wide range of applications and different modific-ations have been derived from their respective surgical operations,such as band-assisted EMR(BA-EMR),conven-tional EMR(CEMR),over-the-scope clip-assisted EFTR,no-touch EFTR,the inverted LECS,closed LECS,and so *** new and improved minimally invasive surgeries are more precise,specific and effective in treating different types of EGC.

关键词： Minimally invasive surgery Early gastric cancer Endoscopic mucosal resection Endoscopic full-thickness resection Laparoscopic and endoscopic cooperative surgery

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Refractory autoimmune hemolytic anemia in a patient with systemic lupus erythematosus and ulcerative colitis:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2286-2292页

作者： Dai-Xing Chen Yue Wu Sui-Feng Zhang xiao-jun yang Department of Digestive System Chongqing Traditional Chinese Medicine HospitalChongqing 400021China

BACKGROUND Ulcerative colitis(UC)and systemic lupus erythematosus(SLE)are both systemic immunoreactive diseases,and their pathogenesis depends on the interaction between genes and environmental *** are no reports of UC with SLE in China,but six cases of SLE with UC have been reported in *** combination of these two diseases has distinct effects on the pathogenesis of both *** SUMMARY A female patient(30 years old)came to our hospital due to dull umbilical pain,diarrhea and mucous bloody stool in August 2018 and was diagnosed with *** symptoms were relieved after oral administration of mesalazine(1 g po tid)or folic acid(5 mg po qd),and the patient were fed a control *** june 24,2019,the patient was admitted for treatment due to anemia and *** hospitalization,the patient had repeated low-grade fever and a progressively decreased Hb *** tests revealed positive antinuclear antibody test,positive anti-dsDNA antibody,0.24 g/L C3(0.9-1.8 g/L),0.04 g/L C4(0.1-0.4 g/L),32.37 g/L immunoglobulin(8-17 g/L),and 31568.1 mg/24 h total 24-h urine protein(0-150 mg/24 h).The patient was diagnosed with SLE involving the joints,kidneys and blood *** reported cases of SLE were retrieved from PubMed to characterize clinicopathological features and identify prognostic factors for *** The patient was discharged in remission after a series of treatments,such as intravenous methylprednisolone sodium succinate,intravenous human immunoglobulin,cyclophosphamide injection,and plasma *** discharge,the patient took oral prednisone acetate tablets,cyclosporine capsules,hydroxychloroquine sulfate tablets and other treatments for symptoms and was followed up regularly for 1 month,after which the patient's condition continued to improve and stabilize.

关键词： Plasma exchange Autoimmune hemolytic anemia Systemic lupus erythematosus Ulcerative colitis Case report

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Preventive and inhibitive effects of Yiwei xiaoyu granules on the development and progression of spasmolytic polypeptideexpressing metaplasia lesions

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1741-1754页

作者： Wan-Qun Chen Feng-Liang Tian Jin-Wei Zhang xiao-jun yang Yan-Ping Li Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China Department of Dermatology and Cosmetology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND Spasmolytic polypeptide-expressing metaplasia(SPEM)is a potential preneoplastic *** To elucidate the microRNA(miR)-7-mediated preventive and inhibitive effects of Yiwei xiaoyu granules(YWXY)in SPEM *** Gastric mucosa biopsies were collected from chronic atrophic gastritis patients and healthy people with signed informed *** was administered to the mice with induced SPEM by tamoxifen,and the gastric mucosa was harvested on the tenth day of the *** immunohistochemistry and immunofluorescence were performed to validate the SPEM,lesions and the potential mechanism was *** transcripts were detected with reverse transcriptionquantitative polymerase chain *** The expression of miR-7 was downregulated in the SPEM lesions,and expression of trefoil factor 2(TFF2)and clusterin was high in the human gastric *** vivo experiments showed that YWXY could inhibit the cell proliferation in the tamoxifen-induced SPEM lesions by regulating ***,YWXY could restore the expression of miR-7 by regulating TFF2 by detection with immunofluorescence but not with reverse transcription-quantitative polymerase chain reaction,indicating its potential mechanism of targeting miR-7 by mediating *** expression of vascular endothelial growth factor-βand gastric intrinsic factor was restored within 3 d of YWXY administration for the SPEM lesions,speculating that the possible mechanism of YWXY is to inhibit the development and progression of SPEM by regulating vascular endothelial growth factor-βand gastric intrinsic *** miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric *** is able to inhibit the cell proliferation and restore the expression of miR-7 by mediating TFF2 in the SPEM mouse model.

关键词： Spasmolytic polypeptide-expressing metaplasia Yiwei xiaoyu Granules MicroRNA-7 Chronic atrophic gastritis Trefoil factor 2 Gastric precancerous lesions

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Pancreas-preserving duodenectomy for treatment of a duodenal papillary tumor:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4748-4753页

作者： Biao Wu Shi-Yong Chen Yuan Li Yu He Xin-Xin Wang xiao-jun yang Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina

BACKGROUND Duodenal papillary tumor is a rare tumor of the digestive tract,accounting for about 0.2%of gastrointestinal tumors and 7%of periampullary *** clinical manifestations of biliary obstruction are most *** benign tumors or small malignant tumors are often not easily found because they have no obvious symptoms in the early *** resection is the only treatment for duodenal papillary *** present,the methods of operation for duodenal papillary tumors include pancreatoduodenectomy,duodenectomy,ampullectomy,and endoscopic *** SUMMARY A 47-year-old man was admitted to because of a duodenal mass that had been discovered 2 mo *** gastroscopy at another hospital revealed a duodenal papillary mass that had been considered to be a high-grade intraepithelial ***,we conducted a multidisciplinary group discussion and decided to perform a pancreas-preserving duodenectomy and a R0 resection was successfully *** surgery,the patient underwent a follow-up period of 5 *** recurrence or metastasis *** According to our experience with a duodenal papillary tumor,compared with pancreaticoduodenectomy,the use of pancreas-preserving duodenectomy can preserve pancreatic function,maintain gastrointestinal structure and function,reduce tissue damage and complications,and render the postoperative recovery ***-preserving duodenectomy for treatment of a duodenal papillary tumor is feasible under strict control of surgical indications.

关键词： Duodenal papillary tumor Benign tumor Malignant tumor Pancreaspreserving duodenectomy Case report

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Ongoing green peafowl protection in China

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Zoological Research 2019年第6期40卷 580-582页

作者： Fei Wu De-jun Kong Peng-Fei Shan Jie Wang Gladys Nyakeru Kungu Guang-Yi Lu xiao-jun yang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China College of Agronomy and Life Sciences Kunming UniversityKunming Yunnan 650214China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China Henan University of Urban Construction Pingdingshan Henan 467036China

DEAR EDITOR,The green peafowl (Pavo muticus) is one of the most threatened pheasants in the world. In China, it is widely appreciated for its beauty as well as historical and cultural value, but current populations number less than 500 individuals. Recently, Tang and colleagues reported in Science that the green peafowl is likely to become extinct due to the construction of the Jiasajiang Level 1 Hydropower Station within the Red River Upstream District (RRUD) and thus called for a stop to this project (Tang et al., 2019). According to our recent surveys, however, this species is still extant in 22 counties of Yunnan Province, China, among which, only two within the RRUD have been predicted to be affected by floods from the hydropower station. Therefore, the conclusion that the species will likely go extinct in China upon completion of the dam is unwarranted. In fact, construction of the Jiasajiang Level 1 Hydropower Station was stopped in August 2017. The main challenge for green peafowl conservation is that over 65% of the population occurs outside of protected reserves in China. Fortunately, the Chinese government has adopted an Ecological Redline (ERL) strategy to achieve ecological civilization plans, thus bringing new hope to the conservation of green peafowls both inside and outside of protected reserves. As a top conservation priority for China, the government is fully committed to conserving this peafowl.

关键词： green peafowl protection

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Application of multiple Roux-en-Y hepaticojejunostomy reconstruction by formation of bile hilar duct lake in the operation of hilar cholangiocarcinoma

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World Journal of Clinical Cases 2020年第1期8卷 68-75页

作者： xiao-jun yang xiao-Hua Dong Shi-Yong Chen Biao Wu Yu He Bao-Long Dong Bing-Qiang Ma Peng Gao Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina School of Clinical Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND Hilar cholangiocarcinoma is the most common malignant tumor of the extrahepatic bile *** now,radical resection has been the most effective method for the long-term survival of patients with the ***,many problems have emerged in the field of hepatobiliary surgery for a long time,including complex surgical procedures,low resection rate,and postoperative *** have adopted the“multiple Roux-en-Y hepaticojejunostomy reconstruction by formation of a bile duct lake”technique in the treatment of hilar cholangiocarcinoma since 2008,and obtained satisfactory short-and longterm *** To examine the feasibility of the application of multiple Roux-en-Y hepaticojejunostomy reconstruction by formation of a bile duct lake in the operation of hilar cholangiocarcinoma METHODS A retrospective analysis was performed for the clinical data,surgical methods,and results of 76 patients with hilar cholangiocarcinoma who were treated with hilar bile duct lake-forming multiple Roux-en-Y hepaticojejunostomy reconstruction at Gansu Provincial *** In all 76 cases,the operation was successful and no operative death *** mean(range)operation time was 215.4±53.5 min(124–678 min),and the amount of bleeding during the operation was 428.2±63.8 mL(240–2200 mL).The overall 1-year survival rate was 78.9%,and the 3-year survival rate was 32.8%.CONCLUSION The multiple Roux-en-Y hepaticojejunostomy reconstruction technique with formation of a bile duct lake is safe and effective for the surgical treatment of hilar cholangiocarcinoma.

关键词： Hilar cholangiocarcinoma Bile duct lake Hepaticojejunostomy

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Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 276-288页

作者： Hui-Qi Zhao Bao-Long Dong Min Zhang xiao-Hua Dong Yu He Shi-Yong Chen Biao Wu xiao-jun yang Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Pathology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina School of Clinical Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Gansu ProvinceChina

BACKGROUND The kinesin superfamily protein member KIF21B plays an important role in regulating mitotic progression;however,the function and mechanisms of KIF21B in cancer,particularly in hepatocellular carcinoma(HCC),are *** To explore the role of KIF21B in hepatocellular carcinoma and its effect on prognosis after *** First,data on the differential expression of KIF21B in patients with HCC from The Cancer Genome Atlas database was ***,the expression levels of KIF21B in HCC cell lines and hepatocytes were detected by reverse transcription-polymerase chain reaction,and its biological effect on BEL-7404 cells was evaluated by KIF21B *** analysis was used to validate the differential expression of KIF21B in HCC tissues and adjacent normal tissues from 186 patients with HCC after *** Kaplan-Meier method was used to assess prognosis *** KIF21B expression levels were significantly higher in HCC tissues than in corresponding adjacent normal *** expression levels of KIF21B in four HCC cell lines were higher than that in normal liver *** experiments showed that KIF21B knockdown remarkably suppressed cell proliferation and induced ***,immunohistochemistry results are consistent with The Cancer Genome Atlas analysis,with KIF21B expression levels being increased in HCC tissues compared to adjacent normal *** and multivariate analyses revealed KIF21B as an independent risk factor for overall survival and disease-free survival in patients with HCC after *** Taken together,our results provide evidence that KIF21B plays an important role in HCC progression and may be a potential diagnostic and prognostic marker for HCC.

关键词： Hepatocellular carcinoma KIF21B Proliferation Apoptosis Prognosis

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Giant hemangioma of the caudate lobe of the liver with surgical treatment:A case report

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World Journal of Clinical Cases 2021年第21期9卷 5980-5987页

作者： Xin-Xin Wang Bao-Long Dong Biao Wu Shi-Yong Chen Yu He xiao-jun yang Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Gansu University of Chinese Medicine The 1st Clinical Medicine CollegeLanzhou 730000Gansu ProvinceChina Peoples Clinical Medicine College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Gansu Research Center of Prevention and Control Project for Digestive Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Caudate lobe hemangioma of the liver is relatively *** to the unique anatomical location of the caudate lobe,the caudate lobectomy accounts for only 0.5%to 4%of hepatic resection,which is difficult to operate and takes a long time,and even has many postoperative *** SUMMARY A 34-year-old female presented with a 1 year history of intermittent pain in the right side of the waist without obvious *** laboratory blood tests were within normal *** green 15 min retention was rated 2.9%,and Child-Pugh was rated *** tomography and magnetic resonance imaging diagnosed giant hemangioma of the caudate lobe with hemangioma of left lobe of *** discussion,surgical treatment was performed,which lasted 410 min,with intraoperative bleeding of about 600 mL and postoperative pathological findings of cavernous *** were no obvious postoperative complications,and the patient was discharged 10 d after *** Caudate lobectomy is difficult due to its special anatomical *** the condition of fully exposing the anatomy of the first porta hepatis,the second porta hepatis,the third porta hepatis,the fourth porta hepatis and middle hepatic vein and combining with the Pringle maneuver,caudate lobectomy can be performed in a precise and safe process.

关键词： Caudate lobe hemangioma Caudate lobectomy Case report

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Yiwei xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach

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World Journal of Clinical Cases 2024年第13期12卷 2201-2209页

作者： Wan-Qun Chen Qing-Feng Fan Yuan-jun He Fei Li Xin Wu Yan-Ping Li xiao-jun yang Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND The Correa sequence,initiated by Helicobacter pylori(***),commonly progresses to gastric cancer through the stage of chronic atrophic gastritis(CAG).Although eradication of *** only reduces the risk of gastric cancer,it does not eliminate the risk for neoplastic *** xiaoyu granules(YWXY)are a commonly used composite preparation in Chinese ***,the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of *** To demonstrate the effectiveness of YWXY in patients with CAG and spleenstomach deficiency syndrome(DSSS),by alleviating histological scores,improving response rates for pathological lesions,and achieving clinical efficacy in relieving DSSS *** We designed a double-blind,randomized,controlled *** study enrolled seventy-two ***-negative patients(mean age,52.3 years;38 men)who were randomly allocated to either the treatment group or control group in a 1:1 ratio,and treated with 15 g YWXY or 0.36 g Weifuchun(WFC)tablet combined with the respective dummy for 24 *** pre-randomization phase resulted in the exclusion of 72 patients:50 participants did not meet the inclusion criteria,12 participants declined to participate,and 10 participants were excluded for various other *** visits were conducted during the study,and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh *** also evaluated endoscopic performance scores,total symptom scores,serum pepsinogen and *** Six patients did not complete the trial *** with YWXY improved the Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)stage,compared with WFC(P<0.05).YWXY provided better relief from symptoms of DSSS and better improvement in serum gastric fun

关键词： Chronic atrophic gastritis Yiwei xiaoyu granules Randomized clinical trial Weifuchun tablet Traditional Chinese medicine Helicobacter pylori

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Software-Defined Cluster

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Journal of Computer Science & Technology 2015年第2期30卷 252-258页

作者：聂华杨晓君刘淘英 School of Computer and Communication Engineering University of Science and Technology Beijing Beijing 100083 China Dawning Information Industry Co. Ltd Beijing 100193 China Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China

The cluster architecture has played an important role in high-end computing for the past 20 years. With the advent of Internet services, big data, and cloud computing, traditional clusters face three challenges： 1） providing flexible system balance among computing, memory, and I/O capabilities; 2） reducing resource pooling overheads; and 3） addressing low performance-power efficiency. This position paper proposes a software-defined cluster （SDC） architecture to deal with these challenges. The SDC architecture inherits two features of traditional cluster： its architecture is multicomputer and it has loosely-coupled interconnect. SDC provides two new mechanisms： global I/O space （GIO） and hardware-supported native access （HNA） to remote devices. Application software can define a virtual cluster best suited to its needs from resources pools provided by a physical cluster, and traditional cluster ecosystems need no modification. We also discuss a prototype design and implementation of a 32-processor cloud server utilizing the SDC architecture.

关键词： software-defined cluster global I/O space hardware-supported native access

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