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Cuproptosis mediates copper-induced testicular spermatogenic cell death

Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang Xu-jun Yu jun-jun Li Yao xiao Guang-Sen Li Fang Yang Liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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Diagenetic evolution and reservoir quality of the Oligocene sandstones in the Baiyun Sag, Pearl River Mouth Basin, South China Sea

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Acta Oceanologica Sinica 2024年第2期43卷 67-82页

作者： Bing Tian Shanshan Zuo Youwei Zheng Jie Zhang Jiayu Du jun tang Institute of Mining and Coal Inner Mongolia University of Science and TechnologyBaotou 014010China Institute of Science Inner Mongolia University of Science and TechnologyBaotou 014010China

The Oligocene Zhuhai sandstones are significant reservoirs for hydrocarbons in the Baiyun Sag, South China *** effective appraisal, exploration and exploitation of such a deep-water hydrocarbon sandstone, samples of five wells from depths of 850 m to 3 000 m were studied. A series of comprehensive petrographic and geochemical analyses were performed to unravel the diagenetic features and their impact on the reservoir ***, the sandstones are dominated by feldspathic litharenites and lithic arenites with fine to medium grain sizes and moderate to good sorting. The reservoir quality varies greatly with a range of porosity from 0.2% to 36.1% and permeability from 0.016 ×10~(–3) μm~2 to 4 301 ×10~(–3) μm~2, which is attributed to complex diagenetic evolution related to sedimentary facies;these include compaction, cementation of calcite, dolomite, siderite and framboidal pyrite in eogenetic stage;further compaction, feldspar dissolution, precipitation of ferrocalcite and ankerite, quartz cements, formation of kaolinite and its illitization, precipitation of albite and nodular pyrite, as well as hydrocarbon charge in mesogenetic stage. The dissolution of feldspar and illitization of kaolinite provide internal sources for the precipitation of quartz cement, while carbonate cements are derived from external sources related to interbedded mudstones and deep fluid. Compaction is the predominant factor in reducing the total porosity, followed by carbonate cementation that leads to strong heterogeneity. Feldspar dissolution and concomitant quartz and clay cementation barely changes the porosity but significantly reduces the *** high-quality reservoirs can be concluded as medium-grained sandstones lying in the central parts of thick underwater distributary channel sandbodies(>2 m) with a high content of detrital quartz but low cement.

关键词： Baiyun Sag Oligocene Zhuhai Formation diagenesis reservoir quality

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Geochemical identification of a source rock affected by migrated hydrocarbons and its geological significance:Fengcheng Formation,southern Mahu Sag,junggar Basin,NW China

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Petroleum Science 2024年第1期21卷 100-114页

作者： Wen-Long Dang Gang Gao Xin-Cai You Ke-Ting Fan jun Wu De-Wen Lei Wen-jun He Yong tang State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum(Beijing)Beijing102249China School of GeoSciences China University of Petroleum(Beijing)Beijing102249China Exploration&Development Institute Xinjiang Oil Field CompanyKaramay834000XinjiangChina

The Fengcheng Formation is a crucial source rock and the primary reservoir for oil accumulation in the Mahu *** oils are distributed throughout the Fengcheng Formation,ranging from the edge to the interior of the sag in the southern Mahu *** crude oils originate from in-situ source rocks in shallowly buried areas and the inner deep *** migration,the crude oil from the inner deep sag affects the source rocks close to carrier beds,leading to changes in the organic geochemical characteristics of the source *** changes might alter source rock evaluations and oil-source *** on data such as total organic carbon(TOC),Rock-Eval pyrolysis of source rocks,and gas chromatography-mass spectrometry(GC-MS)of the saturated fraction,and considering the geological characteristics of the study area,we define the identification characteristics of source rock affected by migrated hydrocarbons and establish the various patterns of influence that migrated hydrocarbons have on the source rock of the Fengcheng Formation in the southern Mahu *** source rocks of the Fengcheng Formation are mostly fair to good,containing mainly Type II organic matter and being thermally mature enough to generate *** rocks affected by migrated hydrocarbons exhibit relatively high hydrocarbon contents(S1/TOC>110 mg HC/g TOC,Extract/TOC>30%,HC:hydrocarbon),relatively low Rock-Eval Tmax values,and relatively high tricyclic terpane contents with a descending and mountain-shaped ***,biomarker composition parameters indicate a higher thermal maturity than in-situ source *** a comparison of the extract biomarker fingerprints of adjacent reservoirs and mudstones in different boreholes,three types of influence patterns of migrated hydrocarbons are identified:the edge-influence of thin sandstone-thick mudstone,the mixed-influence of sandstone-mudstone interbedded,and the full-influence of thick sandstone-thin *** finding reminds

关键词： Organic geochemistry Source rock Influence of migrated hydrocarbons Fengcheng Formation Southern Mahu Sag

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Emerging memristors and applications in reservoir computing

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Frontiers of physics 2024年第1期19卷 219-239页

作者： Hao Chen Xin-Gui tang Zhihao Shen Wen-Tao Guo Qi-jun Sun Zhenhua tang Yan-Ping Jiang School of Physics and Optoelectronic Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China

Recently, with the emergence of ChatGPT, the field of artificial intelligence has garnered widespread attention from various sectors of society. Reservoir Computing (RC) is a neuromorphic computing algorithm used to analyze time-series data. Unlike traditional artificial neural networks that require the weight values of all nodes in the trained network, RC only needs to train the readout layer. This makes the training process faster and more efficient, and it has been used in various applications, including speech recognition, image classification, and control systems. Its flexibility and efficiency make it a popular choice for processing large amounts of complex data. A recent research trend is to develop physical RC, which utilizes the nonlinear dynamic and short-term memory properties of physical systems (photonic modules, spintronic devices, memristors, etc.) to construct a fixed random neural network structure for processing input data to reduce computing time and energy. In this paper, we introduced the recent development of memristors and demonstrated the remarkable data processing capability of RC systems based on memristors. Not only do they possess excellent data processing ability comparable to digital RC systems, but they also have lower energy consumption and greater robustness. Finally, we discussed the development prospects and challenges faced by memristors-based RC systems.

关键词： reservoir computing memristor resistive switching artificial synapse neuromorphic computing

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Effect of titanium on the sticking of pellets based on hydrogen metallurgy shaft furnace:Behavior analysis and mechanism evolution

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 282-291页

作者： Jinge Feng Jue tang Zichuan Zhao Mansheng Chu Aijun Zheng xiaobing Li xiao’ai Wang School of Metallurgy Northeastern UniversityShenyang 110819China Institute for Frontier Technologies of Low-carbon Steelmaking Northeastern UniversityShenyang 110819China Liaoning Low-carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education Shenyang 110819China Zhang Xuan Technology of HBIS Group Co. Ltd.Shijiazhuang 050000China Xuanhua Iron and Steel Group Co. Ltd.Shijiazhuang 050000China Iron and Steel Research Institute of HBIS Group Co. Ltd.Shijiazhuang 050000China

Direct reduction based on hydrogen metallurgical gas-based shaft furnace is a promising technology for the efficient and low-carbon smelting of vanadium-titanium ***,in this process,the sticking of pellets occurs due to the aggregation of metal-lic iron between the contact surfaces of adjacent pellets and has a serious negative effect on the continuous *** paper presents a detailed experimental study of the effect of TiO2 on the sticking behavior of pellets during direct reduction under different *** showed that the sticking index(SI)decreased linearly with the increasing TiO2 *** phenomenon can be attributed to the increase in unreduced FeTiO3 during reduction,leading to a decrease in the number and strength of metallic iron interconnections at the sticking *** the TiO2 addition amount was raised from 0 to 15wt%at 1100°C,the SI also increased from 0.71%to 59.91%.The connection of the slag phase could be attributed to the sticking at a low reduction temperature,corresponding to the low sticking ***,the interconnection of metallic iron became the dominant factor,and the SI increased sharply with the increase in re-duction ***2 had a greater effect on SI at a high reduction temperature than at a low reduction temperature.

关键词： titanium sticking index hydrogen metallurgy direct reduction pellets

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Phosphorylated cellulose nanofibers establishing reliable ion-sieving barriers for durable lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第5期92卷 619-628页

作者： Zihao Li Pengsen Qian Hongyang Li He xiao jun Chen Gaoran Li School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina National Forestry and Grassland Administration Key Laboratory of Plant Fiber Functional Materials Fuzhou 350108FujianChina

The shuttle effect is among the most characteristic and formidable challenges in the pursuit of high-performance lithium-sulfur(Li-S)***,phosphorylated cellulose nanofibers(pCNF)are intentionally engineered to establish an ion-sieving barrier against polysulfide shuttling and thereby improve battery *** phosphorylation,involving the grafting of phosphate groups onto the cellulose backbone,imparts an exceptional electronegativity that repels the polysulfide anions from penetrating through the ***,the electrolyte wettability and Li^(+)transfer can be significantly promoted by the polar nature of pCNF and the facile Li^(+)*** such,rational ion management is realized,contributing to enhanced reversibility in both sulfur and lithium *** a result,Li-S cells equipped with the self-standing pCNF separator demonstrate outstanding long-term cyclability with a minimum fading rate of 0.013%per cycle over 1000 cycles at 1 C,and a decent areal capacity of 5.37 mA h cm^(-2) even under elevated sulfur loading of 5.0 mg cm^(-2) and limited electrolyte of 6.0 mL g^(-1).This work provides a facile and effective pathway toward the well-tamed shuttle effect and highly durable Li-S batteries.

关键词： Lithium-sulfur batteries Cellulose Phosphorylation Ion-sieving Shuttle effect

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Drug delivery with Mn-doped MoO_(2) for photothermalenhanced chemotherapy in fighting cancers

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Rare Metals 2024年第5期43卷 2230-2240页

作者： Ping Zhao Hai-Fa Zheng Ju Peng Xing-Long Li Fazal Raziq xiao-jun Liu Hao-Quan Yu Jin-Lu tang Yi-Fan Kang Wen-Huan Huang School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900 ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'an 710021China

Although chemotherapy has been intensively applied in cancer treatments,its inadequate therapeutic efficacy and severe side effects are still under constant *** used as anti-tumor drug delivery system(DDS)have attracted tremendous attentions owing to their various intriguing ***,Mn-doped MoO_(2)nanoparticles coated with ZrO_(2)and capped with Bi_(2)O_(3)have been designed as a DDS,namely *** possesses good magnetic properties,great photothermal conversion ability,sensitive tumor microenvironment(TME)responsiveness,and good biocompatibility in hemocompatibility in ***,MMZB has been utilized to load the chemotherapeutic agent daunomycin(DNM)(MMZB@DNM)for chemo-photothermal combined ***@DNM demonstrates a more impressive anti-cancer effect than the individual photothermal or chemotherapy both in vitro and in ***,the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in *** contribution provides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments,which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.

关键词： Mn-doped MoO_(2) Bi_(2)O_(3) Nanocarrier Photothermal Chemotherapy

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High-entropy oxide-supported platinum nanoparticles for efficient hydrogen evolution reaction

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Rare Metals 2024年第4期43卷 1537-1546页

作者： Ming-Yu Fan Jia-jun Wang jun Zhao Hong Zhang Tian-Yi Ma xiao-Peng Han Wen-Bin Hu School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Key Laboratory of Advanced Ceramics and Machining TechnologyTianjin UniversityTianjin300350China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China School of Science RMIT UniversityMelbourneVIC3000Australia

High-entropy oxides(HEOs)are a new class of single-phase structures with unique electronic and catalytic properties;therefore,it is worthwhile to explore their applications in *** this study,a Pt/(FeCoNiCrAl)_(3)O_(4)nanohybrid using HEO as a support was developed as an efficient catalyst for the hydrogen evolution reaction(HER).Pt/(FeCoNiCrAl)_(3)O_(4)exhibited high HER activity with a low overpotential of 22 mV at10 mA·cm^(-2),outperforming other binary,ternary,and quaternary *** HER activity of Pt/(FeCoNiCrAl)_(3)O_(4)was higher than that of a commercial Pt/C with a significantly lower Pt *** catalyst exhibited good activity and long-term stability(60 h)in an electrolytic water-splitting *** good activity can be attributed to the fact that the introduction of Pt effectively facilitates electronic interactions between Pt and the *** addition,the HEO substrate was more favorable for dispersing Pt particles,optimizing the electrochemical specific surface area,and significantly reducing the charge resistance of the *** study extends the application of HEOs in electrocatalysis and demonstrates the promising prospects of HEOs as supports for electrocatalysts.

关键词： High-entropy oxides Hydrogen evolution reaction Nanohybrid Water electrolysis

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Chiral phonon activated spin Seebeck effect in chiral materials

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 149-155页

作者： xiao Li Jinxin Zhong Jinluo Cheng Hao Chen Huiqian Wang jun Liu Dali Sun Lifa Zhang jun Zhou Phonon Engineering Research Center of Jiangsu Province Center for Quantum Transport and Thermal Energy ScienceSchool of Physics and TechnologyNanjing Normal UniversityNanjing 210023China Center for Phononics and Thermal Energy Science China-EU Joint Lab for NanophononicsSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of ScienceChangchun 130033China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleigh NC 27606USA Department of Physics North Carolina State UniversityRaleigh NC 27695USA Organic and Carbon Electronics Laboratories(ORaCEL) North Carolina State UniversityRaleigh NC 27606USA

Efficient generation of spin polarization is very important for spintronics and quantum computation. In chiral materials without magnetic order nor spin-orbit coupling, we find a new spin selectivity effect—chiral phonon activated spin Seebeck(CPASS)effect. Starting with the nonequilibrium distribution of chiral phonons under a temperature gradient, the CPASS coefficients are computed based on the Boltzmann transport theory. With both the phonon-drag and band transport contributions, the spin accumulations generated by the CPASS effect exhibit quadratic dependence on the temperature gradient. The strength of the CPASS effect and the relative magnitude of both contributions are tunable by the chemical potential modulation. The CPASS effect, which gives a promising explanation on the traditional chiral-induced spin selectivity effect, provides opportunities for the exploration of advanced spintronic devices based on chiral materials even in the absence of any magnetic order and spin-orbit coupling.

关键词： spin Seebeck effect chiral phonon phonon-drag contribution efficient spin generation

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Algorithm of symbol generation and configuration of land polygons in present land-use map

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中国有色金属学会会刊：英文版 2011年第S3期21卷 743-747页

作者： ZUO xiao-qing, NIE jun-tang Faculty of Land Resource Engineering, Kunming University of Science and Technology, Kunming 650093, China Faculty of Land Resource Engineering Kunming University of Science and Technology Kunming 650093 China

The symbolization of land polygon is an important part of cartography. In the mapping of traditional present land-use maps, the symbol of land polygons was usually filled by the method of filling or plotting, but these methods can't solve the spatial conflicts of the symbol. According to the principle of cartography, the rule of how to symbolize the land polygon was summarized, and a new method that can generate and deploy the land symbols was presented. By making use of C# programming language and Arc Engine developing components, the algorithm can generate land symbols presenting triangle and adjust the coordinate of the symbol. Through mapping the present land-use map of Honghe county, this algorithm can reduce 88.84% of the spatial conflicts error rate compared with the traditional methods. It improves the accuracy and efficiency of the map symbolic.

关键词： land symbol present land use map symbol configuration spatial conflict

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