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The solar wind plasma upstream of Mars observed by Tianwen-1:Comparison with Mars Express and MAVEN

Science China Earth Sciences 2022年第4期65卷 759-768页

作者： Kai FAN Limei YAN Yong WEI Aibing ZHANG Linggao KONG Markus FRÄNZ Fei HE Lihui CHAI Chongjing YUAN Yuqi WANG jun ZHONG Zhaojin RONG Zhonghua YAO Yongxin PAN jun CUI Jiansen HE Wenya LI Binbin tang Chi WANG Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China National Space Science Center Chinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of Space Environment Exploration Beijing 100190China Key Laboratory of Science and Technology on Space Environment Situational Awareness Chinese Academy of SciencesBeijing 100190China Max-Planck-Institute for Solar System Research Goettingen 37077Germany State Key Laboratory of Space Weather Chinese Academy of SciencesBeijing 100190China School of Atmospheric Sciences Sun Yat-Sen UniversityZhuhai 519082China Institute of Space Physics and Applied Technology Peking UniversityBeijing 100871China

On the great journey to Mars,China’s first planetary exploration mission,the Tianwen-1 came within 26 million kilometers of Mars from 31 October 2020 to 25 January 2021 and was getting closer to its destination,the red planet,in search of answers to the cataclysmic climate change that occurred in Martian *** the escape of the Martian atmosphere and the loss of surface water were firmly influenced by solar ***-1 provided a unique chance to depict the solar wind streams between Earth and Mars during the minimum of Solar Cycle *** the three-month cruise phase of Tianwen-1,the solar wind flows were successively observed at Earth,Tianwen-1,and *** the field of view correction and noise reduction,the solar wind velocity and density measured by Tianwen-1 show good agreement with those at Earth and *** results indicate that the performance of the ion analyzer onboard the Tianwen-1 orbiter is reliable and *** is worth looking forward to the joint observations of ion escape with other Mars probes in the following Martian years.

关键词： Tianwen-1 Mars Plasma moment Solar wind

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中山市翠亨国家湿地公园植物景观探析

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陕西林业科技 2024年第1期52卷 87-92页

作者：凌仲铭汤景林蔡以政黎永泰黄晓晶中山翠亨新区工程项目建设事务中心广东中山528400 广州林芳生态科技有限公司广东广州510520

使用样线和样方法,在2022年2月对广东中山翠亨湿地内的植物进行了调查,并统计分析了公园内主要植物的种类及观赏特点,结果显示:乔木以观叶和观形为主,灌木以观花为主,草本以观花、观叶为主。陆地植物景观带以羊蹄甲、香樟、秋枫、朴树... 详细信息

使用样线和样方法,在2022年2月对广东中山翠亨湿地内的植物进行了调查,并统计分析了公园内主要植物的种类及观赏特点,结果显示:乔木以观叶和观形为主,灌木以观花为主,草本以观花、观叶为主。陆地植物景观带以羊蹄甲、香樟、秋枫、朴树等为基调,乔木类型多样、季相变化丰富,水生植物景观带以芦苇、美人蕉、再力花、风车草、莲等为主,整体富有湿地景观的典型美感。

关键词：中山翠亨湿地公园植物调查景观分析

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Tumor-Penetrating and Mitochondria-Targeted Drug Delivery Overcomes Doxorubicin Resistance in Lung Cancer

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Chinese Journal of Polymer Science 2023年第4期41卷 525-537,I0006页

作者： Meng-Xue Zhou Jia-Yu Zhang xiao-Meng Cai Rui Dou Li-Fo Ruan Wen-Jiang Yang Wen-Chu Lin jun Chen Yi Hu CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics and University of Chinese Academy of Sciences(UCAS)Chinese Academy of Sciences(CAS)Beijing100049China Key Laboratory of Tea Biology and Resource Utilization of Ministry of Agriculture Tea Research InstituteChinese Academy of Agricultural SciencesHangzhou310008China Division of Nuclear Technology and Applications Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing100049China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China

As one of the major challenges in tumor chemotherapy,multidrug resistance typically correlates with the poor drug penetration within tumor tissues and drug efflux by the ATP-driven efflux pumps in tumor ***,we design a kind of near-infrared(NIR)light-and acidity-activated micellar i PUTDN nanoparticle for mitochondria-targeting doxorubicin(DOX)delivery to combat DOX resistance in small-cell lung *** the PEGylated i PUTDN nanoparticles can keep stealth in blood circulation,NIR irradiation at the tumor region can peel off the PEG shell from the nanoparticles,and the exposed i RGD can facilitate deep tumor penetration of the *** being internalized by DOX-resistant H69AR cells,the poly(β-aminoester)s(PAE)-based nanoparticles can release the triphenylphosphonium(TPP)-conjugated DOX(TDOX)into the cytosol,which can further accumulate in mitochondria with the aid of ***,the mitochondrial membrane potential and ATP content are both reduced in DOX-resistant H69AR *** in vivo therapeutic results show that TDOX-loaded nanoparticles with the aid of NIR light irradiation can effectively suppress the DOX-resistant small-cell lung cancer without noticeable adverse effects.

关键词： Doxorubicin NIR/p H-dual sensitive nanoparticles Tumor penetration Mitochondria Drug resistance

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LERANS健康教育对甲状腺癌患者术后康复、吞咽功能及心理调适能力的影响

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海南医学 2024年第15期35卷 2265-2270页

作者：汤洁闫文润田海龙陆晓梅杨亚萍郑州大学第一附属医院咽喉头颈外科河南郑州450000 郑州大学第一附属医院介入手术室河南郑州450000

目的探究聆听、建立、应用、提高、反馈、强化(LEARNS)健康教育在甲状腺癌患者中的应用效果。方法选取2021年1月至2023年6月就诊于郑州大学第一附属医院的90例甲状腺癌患者作为研究对象,按随机数表法分为观察组和对照组各45例。对照组... 详细信息

目的探究聆听、建立、应用、提高、反馈、强化(LEARNS)健康教育在甲状腺癌患者中的应用效果。方法选取2021年1月至2023年6月就诊于郑州大学第一附属医院的90例甲状腺癌患者作为研究对象,按随机数表法分为观察组和对照组各45例。对照组患者给予常规健康教育,观察组患者于此基础上给予LEARNS健康教育,干预至出院后1个月,比较两组患者的术后康复及术后1 d视觉模拟量表(VAS)评分,以及术后1 d和干预后的吞咽功能[洼田饮水试验、吞咽功能评估表(GUSS)]、颈部活动度及肩关节功能评价量表评分,并采用心理健康调查表(MHI-38)(由心理痛苦分量表、心理幸福感分量表构成)评价两组患者干预前后的心理调适能力。结果观察组患者术后1 d VAS评分为(2.96±0.45)分,明显低于对照组的(3.47±0.62)分,恢复进食时间、住院时间分别为(5.36±1.67)h、(4.12±1.56)d,明显短于对照组的(9.67±2.28)h、(6.77±2.00)d,差异均有统计学意义(P<0.05);干预后,观察组患者的洼田饮水试验评分为(1.45±0.20)分,明显低于对照组的(1.67±0.36)分,GUSS评分为(19.58±1.87)分,明显高于对照组的(18.67±2.20)分,差异均有统计学意义(P<0.05);干预后,观察组患者的颈部向健侧屈、向患侧屈、前屈及后伸活动度分别为(38.21±4.20)°、(35.64±4.36)°、(41.24±5.33)°、(35.16±3.54)°,明显高于对照组的(33.67±5.13)°、(31.25±4.65)°、(38.20±4.54)°、(32.00±3.12)°,差异均有统计学意义(P<0.05);干预后,观察组患者肩部功能量表中的肩关节活动范围、疼痛、日常生活能力、肌力评分分别为(25.47±4.15)分、(29.10±4.62)分、(35.26±5.10)分、(5.12±0.62)分,明显高于对照组的(21.56±3.98)分、(26.03±5.10)分、(31.06±4.78)分、(4.68±0.53)分,差异均有统计学意义(P<0.05);干预后,观察组患者心理痛苦分量表中焦虑、抑郁、行为/情绪失控评分分别为(15.39±3.44)分、(8.53±2.40)分、(14.33±3.50)分,明显低于对照组的(20.36±3.20)分、(11.35±2.55)分、(19.45±4.55)分,心理幸福感分量表中总正性情感、情感纽带、生活满意度评分分别为(50.53±4.70)分、(9.80±2.50)分、(5.50±1.62)分,明显高于对照组的(42.65±5.43)分、(7.13±2.01)分、(4.13±1.10)分,差异均有统计学意义(P<0.05)。结论LEARNS健康教育有助于加速甲状腺癌患者康复进程,增强心理调适能力,促进吞咽及肩颈功能早期康复,具有一定的临床应用价值。

关键词：健康教育甲状腺癌心理调适能力吞咽功能肩关节功能

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Bedside anterior segment optical coherence tomography-assisted reattachment of severe hemorrhagic Descemet’s membrane detachment after ab externo 360-degree suture trabeculotomy combined with trabeculectomy

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 316-319页

作者： Shan-Shan Liu Li-Mei Liu xiao-jun Fan xiao-Xiang Sun Fu-Mei Yin Fang-Xing Zhu Ji-Bing Wang Glaucoma Unit Department of OphthalmologyWeifang Eye HospitalNational Key Clinical SpecialtyWeifang 261000Shandong ProvinceChina

Dear Editor,We report a case of severe hemorrhagic Descemet’s membrane detachment(HDD)following ab external360-degree suture trabeculotomy with trabeculectomy that was successfully managed with the guidance of bedside anterior segment optical coherence tomography(ASOCT).Descemet’s membrane detachment(DMD)is a complication that impairs vision and is commonly observed after cataract ***’s reported a high incidence(25%-82%)of focal DMD that were mostly subclinical and detected only with gonioscopy[1].

关键词： hemorrhagic suture surgery

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一种定向非采集式气载放射性核素在线测量系统的研制

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四川环境 2024年第2期43卷 111-116页

作者：王亮唐传丰朱小铰吕映赋邓志鹏余鹏四川省辐射环境管理监测中心站成都610031 成都理工大学核技术与自动化工程学院成都610059 成都新核泰科科技有限公司成都610052

无论是发生核爆、核事故或核设施正常运行期间,都会向大气中排放放射性核素。为了更加及时、准确、有效地评价气载放射性,根据建立的各核素的照射量率与其活度浓度的数理模型,结合地面伽马射线屏蔽装置,研制了定向非采集式气载放射性核... 详细信息

无论是发生核爆、核事故或核设施正常运行期间,都会向大气中排放放射性核素。为了更加及时、准确、有效地评价气载放射性,根据建立的各核素的照射量率与其活度浓度的数理模型,结合地面伽马射线屏蔽装置,研制了定向非采集式气载放射性核素在线测量系统,并计算了气载放射性核素40 K的活度浓度。结果表明研制的定向非采集式气载放射性核素在线测量系统能够精确测量大气的放射性核素的活度浓度,并具有方便快捷、测量范围大、响应时间低、能实现在线测量等优点。

关键词：大气放射性核素在线测量伽马射线测量气载放射性

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氦气球阀主密封密封结构研究

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阀门 2024年第2期 174-180页

作者：陆佳杰杨强强袁红亚蒋勇汤晓刚覃捷中核苏阀科技实业股份有限公司江苏苏州215151 华能核能技术研究院有限公司上海201200 华能山东石岛湾核电有限公司山东威海264309

阐述了随着我国能源需求的持续增长及能源结构改革需要,核能快堆及高温气冷堆等四代核电技术上也有了突破,对阀门的结构和性能提出了更高的要求。球阀具有大流量、低流阻、操作方便等优点,在高温气冷堆等四代核电势必得到广泛应用。介... 详细信息

阐述了随着我国能源需求的持续增长及能源结构改革需要,核能快堆及高温气冷堆等四代核电技术上也有了突破,对阀门的结构和性能提出了更高的要求。球阀具有大流量、低流阻、操作方便等优点,在高温气冷堆等四代核电势必得到广泛应用。介绍了研究高温气冷堆核级氦气球阀结构选型的意义,通过研究分析确定了上装式低内漏率球阀结构的选型开发,同时为了确保其密封性能能够满足要求,对样机进行了一系列的氦检漏试验,证明了该结构选型的良好密封性能。通过本课题的研究,掌握了核级氦气球阀满足低内漏率要求的主密封结构关键技术,解决了氦气等高渗透性介质工况阀门主密封结构密封性能保证的难题,可以为高温气冷堆核级氦气球阀等具有低内漏率要求球阀的结构设计提供借鉴。

关键词：氦气工况低内漏率球阀无摩擦硬化处理上装式

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Hydrogen sulfide induces apoptosis of pulmonary artery smooth muscle cell in rats with pulmonary hypertension induced by high pulmonary blood flow

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Chinese Medical Journal 2009年第24期122卷 3032-3038页

作者： LI Wei JIN Hong-fang LIU Die SUN Jing-hui JIAN Pei-jun LI xiao-hui tang Chao-shu DU jun-bao Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Pediatrics Jilin University First Hospital Changchun Jilin 130021 China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100191 China Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China

Background Abnormal apoptosis of pulmonary artery smooth muscle cells （PASMCs） is an important pathophysiological process in the pulmonary artery structural remodeling and pulmonary hypertension. We investigated possible effect of endogenous hydrogen sulfide （H2S） on apoptosis of PASMCs during the development of pulmonary hypertension induced by high pulmonary blood flow. Methods Thirty-nine male Sprague-Dawley rats were randomly assigned to 4-week control, 4-week shunt, 4-week shunt＋propargylglycine （PPG）, 11-week control, 11-week shunt and 11-week shunt＋sodium hydrosulfide （NariS） groups. Rats in 4-week shunt, 4-week shunt＋PPG, 11-week shunt and 11-week shunt＋NariS groups underwent an abdominal aorta-inferior vena cava shunt. Rats in 4-week shunt＋PPG group were intraperitoneally injected with PPG, an inhibitor of endogenous H2S production, for 4 weeks. Rats in 11-week shunt＋NariS group were intraperitoneally injected with NariS, a H2S donor, for 11 weeks. Lung tissue H2S was evaluated by sulfide-sensitive electrode. Apoptosis of PASMCs were detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labelling （TUNEL）. Expressions of Fas, bcl-2 and caspase-3 in the PASMCs were analyzed with immunochemical staining. Results Four weeks after the shunting operation, the apoptosis of PASMCs and expression of Fas and caspase-3 were significantly decreased （P 〈0.01）, but expression of bcl-2 increased significantly （P 〈0.01）. PPG administration further inhibited the apoptosis of PASMCs, downregulated the expression of Fas and caspase-3 （P 〈0.01）, but increased the expression of bcl-2 （P 〈0.01）. After 11 weeks of shunting operation, the apoptosis of PASMCs and expression of Fas and caspase-3 were significantly decreased （P 〈0.01）, but expression of bcl-2 increased obviously （P 〈0.01）. NariS administration significantly increased the apoptosis of PASMCs, upregulated the expression of Fas and caspase-3, but inhibited the expression of bcl-2. Conclusions H2S indu

关键词： high pulmonary blood flow pulmonary hypertension hydrogen sulfide apoptosis

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Purification and characterization of biologically active recombinant human Eppin expressed in Escherichia coli

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Chinese Medical Journal 2008年第7期121卷 620-624页

作者： ZHU Qing-yi GU xiao-jian YANG Jin WANG jun-hong tang Bo WU Hong-fei Department ot Urology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Urology Jiangsu Province Hospital of TraditionalChinese Medicine Nanjing Jiangsu 210029 China Department of Biochemistry School of Life Science NanjingUniversity Nanjing Jiangsu 210093 China

Background Eppin （epididymis protease inhibitor） appears to play an important role in primate fertility. However, the function of Eppin and its antibody in men and its relationship with men＇s infertility are poorly studied. To reveal the significance and possibility of detection of anti-Eppin antibody in clinical infertilty cases, we developed an Escherichia coil expression system for the expression of biologically active human Eppin. Methods The human Eppin gene was cloned into PET-28a（＋） vector after induction with 0.5 mmol/L isopropy-β-Dthiogalactoside （IPTG） at 26℃ for 4 hours, and the expressed fusion protein His6-Eppin was purified by Ni2. affinity chromatography. Afterwards, six female 8-week-old Balb/c mice were immunized with purified His6-Eppin for three weeks. Their sera were collected and polyclonal antibodies against His6-Eppin were purified, all of which were further verified by Western-blot and immunofluorescence analysis. Results About 18.33 mg His6-Eppin was obtained from 1-L flask culture. The produced polyclonal antibodies against His6-Eppin recognized the Eppin protein both in human epididymis and in HEK293T cells by over-expression of the recombinant human Eppin. Conclusion The purified His6-Eppin protein has biological activity, which might be a candidate for clinical diagnosis of infertility and development of male immuno-contraceptive agents.

关键词： epididymis protease inhibitor expression purification biological function

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单孔胸腔镜联合肺段切除治疗磨玻璃结节的临床应用

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现代肿瘤医学 2024年第3期32卷 482-485页

作者：陆佳昊谢骏唐佳陈晓春韩松周开国苏州科技城医院胸外科江苏苏州215153

目的:研究单孔胸腔镜联合肺段切除外科治疗磨玻璃结节的疗效和安全性。方法:回顾性分析2019年01月至2022年12月我科收治的具有手术指征的79例磨玻璃结节患者行单孔胸腔镜解剖性肺段切除作为研究对象,根据手术方式的不同分成两组,48例患... 详细信息

目的:研究单孔胸腔镜联合肺段切除外科治疗磨玻璃结节的疗效和安全性。方法:回顾性分析2019年01月至2022年12月我科收治的具有手术指征的79例磨玻璃结节患者行单孔胸腔镜解剖性肺段切除作为研究对象,根据手术方式的不同分成两组,48例患者采用联合肺段切除作为观察组,31例患者采用单个肺段切除作为对照组,对比两组手术相关情况和术后并发症。结果:两组患者在清扫淋巴结、拔除上胸管时间、术后首次下床活动时间、住院时间、术后48 h VAS评分、术后并发症方面,差异无统计学意义(P>0.05)。在手术时间、术中出血量、留置下胸管时间、总引流量、总费用方面,观察组差于对照组(P<0.05)。两组术后随访6~42(23.85±10.12)个月,未有复发、远处转移以及死亡病例发生。结论:磨玻璃结节采用单孔胸腔镜联合肺段切除治疗,安全性和疗效性值得肯定。

关键词：磨玻璃结节肺段切除单孔胸腔镜手术

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