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Science China Earth Sciences 2024年

作者： xiaojuan FENG Guohua DAI Ting LIU juan JIA Erxiong ZHU Chengzhu LIU Yunpeng ZHAO Ya WANG Enze KANG Jun xiao Wei LI State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences China National Botanical Garden College of Resources and Environment University of Chinese Academy of Sciences Department of Earth Sciences National Natural Science Foundation of China

Soil carbon sequestration is listed by the United Nations Framework Convention on Climate Change as one of the key ways to achieve long-term “carbon neutrality” in the context of global warming. Soil carbon sequestration is a complex biogeochemical process that involves plants, microbes, and rock minerals at its core. Yet, its regulation mechanisms and promotion pathways remain unclear. This paper reviews recent progress in the related domestic and international research and provides an overview of the key processes and mechanisms of soil carbon sequestration. The main pathways for enhancing soil carbon sequestration (including plant inputs, mineral protection, microbial transformation, and rock weathering) are summarized. The paper also discusses and synthesizes how advanced biogeochemical methods and technologies may be employed to explore soil carbon sequestration mechanisms and potentials. The overall aim of this review is to improve our understanding of soil carbon sequestration as a nature-based solution to combatting climate change from the biogeochemistry perspective, and to highlight the role of fundamental research in Earth Sciences in helping to achieve China’s carbon neutrality goals.

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Virtual reality-based cognitive-behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction:a randomised clinical trial

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General Psychiatry 2024年第2期37卷 189-196页

作者： Yuanyuan Li juan Peng Pingyuan Yang Jiajun Weng Yan'e Lu Jiajia Liu Shikun Xu Lihua Guan Dong Huang Qibing Wang Juying Qian Zexin Zhao Yabin Wei Junbo Ge xiao Huang Department of Psychological Medicine Zhongshan Hospital Fudan UniversityShanghaiChina Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina Department of Psychological Medicine Shanghai Geriatric Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina Beijing Key Laboratory of Drug Dependence Research National Institute on Drug DependencePeking UniversityBeijingChina

Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their *** timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental *** We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their *** In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February *** who were Han Chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support ***-CBT consisted of four modules and was delivered at the bedside over a 1-week *** were done at baseline,immediately after treatment and at 3-month *** intention-to-treat analysis began in June *** primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control *** 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,p<0.001)and 3-month follow-up(Cohen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire *** was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CB

关键词： admitted behaviour treatment

Cost-effectiveness analysis of different anesthesia strategies for transperineal MRI/US fusion prostate biopsy

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Asian Journal of Andrology 2024年第4期26卷 409-414页

作者： Di Jin xiao-Qi Kong Ya-juan Zhu Zong-Xin Chen Xi-Ming Wang Cai-Hua Xu Jin-Xian Pu Jian-Quan Hou Yu-Hua Huang Fu-Hai Ji Chen Huang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China.

This study aims to conduct a cost-effectiveness analysis of three different anesthesia strategies,namely chatting while under local anesthesia(Chat-LA),total intravenous anesthesia(TIVA),and general anesthesia with laryngeal mask airway(GA-LMA),employed in transperineal magnetic resonance imaging(MRI)/ultrasound(US)fusion prostate biopsy(TP-MUF-PB).A retrospective study was conducted involving 1202 patients who underwent TP-MUF-PB from June 2016 to April 2023 at The First Affiliated Hospital of Soochow University(Suzhou,China).Clinical data and outcomes,including total costs,complications,and quality-adjusted life years(QALYs),were *** sensitivity and subgroup analyses were also ***-LA was found to be the most cost-effective option,outperforming both TIVA and ***,subgroup analyses revealed that in younger patients(under 65 years old)and those with smaller prostate volumes(<40 ml),TIVA emerged as a more cost-effective *** Chat-LA may generally be the most cost-effective and safer anesthesia method for TP-MUF-PB,personalization of anesthesia strategies is crucial,considering specific patient demographics such as age and prostate volume.

关键词： anesthesia strategy cost-effectiveness analysis economic evaluation prostate biopsy prostate cancer

前列地尔注射液联合缬沙坦分散片治疗糖尿病肾病的临床疗效分析

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药物评价研究 2016年第5期39卷 832-834页

作者：赵筱娟周淑娟李红莉延安市人民医院肾脏内科陕西延安716000

目的探讨缬沙坦分散片联合前列地尔注射液治疗糖尿病肾病的疗效。方法选取延安市人民医院肾脏内科2012年3月—2015年12月收治的糖尿病肾病230例,随机分为两组。缬沙坦组(109例)口服缬沙坦分散片治疗,联合用药组(121例)口服缬沙坦分散片... 详细信息

目的探讨缬沙坦分散片联合前列地尔注射液治疗糖尿病肾病的疗效。方法选取延安市人民医院肾脏内科2012年3月—2015年12月收治的糖尿病肾病230例,随机分为两组。缬沙坦组(109例)口服缬沙坦分散片治疗,联合用药组(121例)口服缬沙坦分散片加静脉滴注前列地尔注射液治疗,观察并记录治疗前后尿素氮(BUN)、血肌酐(Cr)、尿白蛋白排泄率(UAER)、血浆黏度、红细胞比容、血沉方程K值、血浆纤维蛋白原等指标的变化,评价前列地尔注射液联合缬沙坦分散片治疗糖尿病肾病的疗效。结果与治疗前相比,治疗后两组BUN、Cr、UAER等各项指标均明显下降(P<0.05),且联合用药组这些指标明显低于缬沙坦组(P<0.05)。与治疗前相比,治疗后两组血浆黏度、红细胞比容、血沉方程K值、血浆纤维蛋白原水平均明显下降(P<0.05),且联合用药组在上述指标的水平均明显低于缬沙坦组(P<0.05)。随访1个月期间,缬沙坦组不良反应6例,联合用药组3例,两组均无严重不良反应。结论前列地尔注射液联合缬沙坦分散片对糖尿病肾病具有较好的治疗效果,能减少尿蛋白排出,改善肾功能和肾脏血液流变学指标,不良反应轻微,值得临床推广使用。

关键词：缬沙坦分散片前列地尔注射液糖尿病肾病肾功能血液流变学指标

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利率市场化改革的信贷配置质量效应研究

南通大学学报（社会科学版） 2024年第1期40卷 132-148,160页

作者：马娟沈小燕南通大学商学院

不当行政干预造成区域壁垒,诱发寻租问题,是导致要素市场分割与资源错配的重要成因,信贷市场尤为如此。基于商业银行信贷行为选择视角,运用2003—2019年我国31个省份的面板数据,对地方政府干预情形下我国利率市场化改革的信贷配置质量... 详细信息

不当行政干预造成区域壁垒,诱发寻租问题,是导致要素市场分割与资源错配的重要成因,信贷市场尤为如此。基于商业银行信贷行为选择视角,运用2003—2019年我国31个省份的面板数据,对地方政府干预情形下我国利率市场化改革的信贷配置质量效应加以研究。结果表明,在干预市场条件下,商业银行具有较强的信贷寻租动机,信贷投放更倾向于迎合地方政府需求而非商业化导向;利率市场化改革带来的市场约束收紧尽管可促使商业银行增强信贷投放的商业性,显著增强区域贷款增长对盈利能力的敏感性,但无法对其信贷寻租动机形成有效抑制,以致其对信贷配置的质量效应难以发挥。而良好的地方政府治理可有效提升利率市场化改革的信贷配置质量效应。研究结论有助于厘清高质量发展要求下深化利率市场化改革的关键点,也为新形势下破除地方行政壁垒、增强地方金融监管效能以助推全国统一大市场建设提供经验参考。

关键词：利率市场化信贷配置质量效应信贷寻租地方金融监管

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-Na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing Zhang Kai-Wen Liu Na Li Jia-Chen Cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen xiao-Hu Fan Sai-juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

Development and validation of a circulating tumor DNA-based optimization-prediction model for short-term postoperative recurrence of endometrial cancer

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World Journal of Clinical Cases 2024年第18期12卷 3385-3394页

作者： Yuan Liu xiao-Ning Lu Hui-Ming Guo Chan Bao juan Zhang Yu-Ni Jin Department of Gynaecology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Endometrial cancer(EC)is a common gynecological malignancy that typically requires prompt surgical intervention;however,the advantage of surgical management is limited by the high postoperative recurrence rates and adverse *** studies have highlighted the prognostic potential of circulating tumor DNA(ctDNA)monitoring for minimal residual disease in patients with *** To develop and validate an optimized ctDNA-based model for predicting shortterm postoperative EC *** We retrospectively analyzed 294 EC patients treated surgically from 2015-2019 to devise a short-term recurrence prediction model,which was validated on 143 EC patients operated between 2020 and *** factors were identified using univariate Cox,Lasso,and multivariate Cox regressions.A nomogram was created to predict the 1,1.5,and 2-year recurrence-free survival(RFS).Model performance was assessed via receiver operating characteristic(ROC),calibration,and decision curve analyses(DCA),leading to a recurrence risk stratification *** Based on the regression analysis and the nomogram created,patients with postoperative ctDNA-negativity,postoperative carcinoembryonic antigen 125(CA125)levels of<19 U/mL,and grade G1 tumors had improved RFS after *** nomogram’s efficacy for recurrence prediction was confirmed through ROC analysis,calibration curves,and DCA methods,highlighting its high accuracy and clinical ***,using the nomogram,the patients were successfully classified into three risk *** The nomogram accurately predicted RFS after EC surgery at 1,1.5,and 2 *** model will help clinicians personalize treatments,stratify risks,and enhance clinical outcomes for patients with EC.

关键词： Circulating tumor DNA Endometrial cancer Short-term recurrence Predictive model Prospective validation

Thoracic giant cell tumor after two total en bloc spondylectomies including one emergency surgery:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2894-2903页

作者： Hai-Feng Liang Hao Xu Meng-Na Zhan Jian xiao juan Li Qin-Ming Fei Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Orthopaedic Surgery Shanghai Geriatric Medical CenterShanghai 201104China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Orthopaedic Surgery Zhongshan Hospital Wusong BranchFudan UniversityShanghai 200940China

BACKGROUND For patients with acute paraplegia caused by spinal giant cell tumor(GCT)who require emergency decompressive surgery,there is still a lack of relevant reports on surgical *** study is the first to present the case of an acute paraplegic patient with a thoracic spinal GCT who underwent an emergency total en bloc spondylectomy(TES).Despite tumor recurrence,three-level TES was repeated after denosumab *** SUMMARY A 27-year-old female patient who underwent single-level TES in an emergency presented with sudden severe back pain and acute paraplegia due to a thoracic spinal *** emergency TES,the patient's spinal cord function recovered,and permanent paralysis was *** postoperative histopathological examination revealed that the excised neoplasm was a rare ***,the tumor recurred 9 months after the first *** 12 months of denosumab therapy,the tumor size was reduced,and tumor *** prevent recurrent tumor progression and provide a possible cure,a three-level TES was performed *** patient returned to an active lifestyle 1 month after the second surgery,and no recurrence of GCT was found at the last *** This patient with acute paraplegia underwent TES twice,including once in an emergency,and achieved good therapeutic *** in emergency surgery is feasible and safe when conditions permit;however,it may increase the risk of tumor recurrence.

关键词： Giant cell tumor Thoracic spine Emergency treatment Total en bloc spondylectomy Denosumab therapy Case report

Advances in the biological function of interleukin 38 and its study in immune diseases

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Microenvironment & Microecology Research 2023年第1期5卷 16-21页

作者： Tian-xiao Cui Cui-Ting Gong Ye Yerdingqmk Mizaniye Kaharv xiao-juan zhou Ji-Yun Zhang Department of Rheumatology and Immunology Second HospitalUrumqi 830063China

IL-38 is a newly discovered anti-inflammatory cytokine that belongs to the IL-1 family's IL-36 subfa+***,recent studies have shown that it can interact with multiple receptors to impede downstream signaling pathway activation,thereby restraining the differentiation and maturation of Th17 *** IL-38 enhances the immunosuppressive activity of Treg by inhibiting the transformation of CD4+T cells to Th17 cells,it can also exert its immune regulatory role by binding to the corresponding IL-38 receptor on the cell surface,which in turn inhibits classical signaling pathways such as NF-κB,P38,or JNK ***-38 has been shown to alleviate disease progression in Rheumatoid Arthritis(RA),Systemic lupus erythematosus(SLE),cardiovascular disease(CVD),and other diseases by reducing the production of inflammatory cytokines and limiting the inflammatory response that is dependent on T cell ***,an increasing body of evidence suggests that IL-38 is a promising therapeutic target for these *** article primarily reviews the immunological function of IL-38 and its involvement in related diseases,providing insights and theoretical support for chronic inflammatory and autoimmune diseases.

关键词： systemic lupus erythematosus interleukin-38 Th17 cells receptors

我国狂犬病疫苗生产用毒株糖蛋白氨基酸序列及其抗原位点分析

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中国生物制品学杂志 2006年第1期19卷 31-33,51页

作者：尹娟肖健周志军朱华松端义坤武汉生物制品研究所武汉430060

目的分析我国狂犬病疫苗生产用毒株aG(PG)株和CTN株糖蛋白结构及抗原位点的差异。方法登录GenBank搜寻aG株和CTN株糖蛋白的氨基酸序列,用Vector NTI Suite8软件分析两毒株糖蛋白的同源性;用DNAStar5分析两毒株糖蛋白的二级结构和潜在的... 详细信息

目的分析我国狂犬病疫苗生产用毒株aG(PG)株和CTN株糖蛋白结构及抗原位点的差异。方法登录GenBank搜寻aG株和CTN株糖蛋白的氨基酸序列,用Vector NTI Suite8软件分析两毒株糖蛋白的同源性;用DNAStar5分析两毒株糖蛋白的二级结构和潜在的抗原位点。结果aG株和CTN株的糖蛋白氨基酸序列的同源性为88·2%,特征性二级结构的位置与数量相似,主要的抗原位点均为13个。结论两毒株的糖蛋白氨基酸序列虽然存在一定的差异,但生产的狂犬病疫苗均能产生较好的保护效果,提示某些表位是产生中和抗体的关键。

关键词：狂犬病疫苗糖蛋白氨基酸抗原位点