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Subacute liver and respiratory failure after segmental hepatectomy for complicated hepatolithiasis with secondary biliary cirrhosis: A case report

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World Journal of Gastrointestinal Surgery 2022年第4期14卷 341-351页

作者： Wen-Juan Fan xiao-jing zou Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Emergency Department/Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Despite being a benign disease, hepatolithiasis has a poor prognosis because of its intractable nature and frequent recurrence. Nonsurgical treatment is associated with high incidences of residual and recurrent stones. Consequently, surgery via hepatic lobectomy or segmental hepatectomy has become the main treatment modality. Clinical management and resolution of complicated hepatolithiasis with bilateral or diffuse intrahepatic stones remain very difficult and challenging. Repeated cholangitis and calculous obstruction may result in secondary biliary cirrhosis, a limiting factor in the treatment of *** SUMMARY A 53-year-old woman with a 5-year history of intermittent abdominal pain and fever was admitted to the hepatopancreatobiliary surgery department following worsening symptoms over a 3-d period. Blood tests revealed elevated transaminases, alkaline phosphatase, γ-glutamyl transpeptidase, and total bilirubin, as well as anemia. Magnetic resonance cholangiopancreatography showed dilatation of the intrahepatic, left and right hepatic, common hepatic, and common bile ducts, and multiple short T2 signals in the intrahepatic and common bile ducts. Abdominal computed tomography showed splenomegaly and splenic varices. The diagnosis was bilateral hepatolithiasis and choledocholithiasis with cholangitis. Surgical treatment included hepatectomy of segments Ⅱ and Ⅲ, cholangioplasty, left hepaticolithotomy, second biliary duct exploration, choledocholithotomy, T-tube drainage, and accretion lysis. Surgical and pathological findings confirmed secondary biliary cirrhosis. Liver-protective therapy and anti-infectives were administered. The patient developed liver and respiratory failure, severe abdominal infection, and septicemia. Eventually, her family elected to discontinue *** Liver transplantation, rather than hepatectomy, might be a treatment option for complicated bilateral hepatolithiasis with secondary liver cirrhosis.

关键词： Hepatolithiasis Hepatectomy Liver failure Biliary cirrhosis Septicemia Case report

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Hepatitis B virus upregulates host expression of α-1,2-mannosidases via the PPARα pathway

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World Journal of Gastroenterology 2016年第43期22卷 9534-9543页

作者： Song Hu Li-Bin Jiang xiao-jing zou Wei Yi De-Ying Tian Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

AIM To assess the effects of hepatitis B virus(HBV) on the expression of host α-1,2-mannosidases and determine the underlying *** We measured the expression levels of MAN1A1, MAN1A2, MAN1B1, and MAN1C1 in cell lines HepG 2.2.15, HepN 10, HepA D38 and Hep G2 by Western blot. Viral antigens(HBs Ag and HBe Ag) in the culture medium were measured using the chemiluminescence method. HBV DNA quantification assays were performed using a commercial real-time PCR kit. Protein levels of human liver tissue α-1,2-mannosidases were also evaluated by Western blot. Plasmids containing seven individual viral genes of HBV(PTT22-HBx, PTT22-HBs, PTT22-pre S2, PTT22-pre S1, PTT22-HBc, PTT22-HBe, and PTT22-HBp) or control plasmids(PTT22-vector) were transfected into Hep G2 cells. MK886(PPARα) and GW9662(PPARγ) inhibitors were used to explore the effects of HBV on α-1,2-mannosidase expression after the PPARα and PPARγ pathways were *** We showed that the expression of α-1,2-mannosidases was higher in stably transfected HBV cells than in controls. The expression levels of α-1,2-mannosidase were higher in AD38 cells than those in ND10 cells, which were in turn greater than those in G2.2.15 cells, and positively correlated with the expression of HBsA gin all the cell lines. Levels of α-1,2-mannosidase in nontumorous liver tissues of HBV-related HCC patients were also higher than in the tissues from non-HBVrelated HCC patients. Moreover, transfecting Hep G2 cells with a component of the HBV viral envelope also increased the expression of α-1,2-mannosidases. However, this envelope protein component could not induce MAN1C1 expression in the presence of a PPARα inhibitor, MK886. We also found that MK886 did not affect the expression of MAN1C1 in AD38 cells without tetracycline in the culture medium. This phenomenon was not observed in the case of *** Our results indicate that HBV increases the expression of α-mannosidases both in vitro and in vivo via ac

关键词： Hepatitis B Pattern recognition receptors α-Mannosidase Glycosylation Dendritic cells

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Overview of point-of-care ultrasound in diagnosing intestinal obstruction

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World Journal of Emergency Medicine 2022年第2期13卷 135-140页

作者： Rui-ting Li Yue Zhao xiao-jing zou Hua-qing Shu Ting Zhou Shang-wen Pan Xue-hui Gao Hai-yan Huang Hong Liu You Shang Department of Critical Care Medicine Institute of Anesthesia and Critical Care MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Critical Care Medicine Jin Yin-tan HospitalWuhan 430048China

Intestinal obstruction(IO),which refers to a partial or complete blockage of the intestine,is an emergency gastrointestinal disorder commonly seen in the intensive care unit(ICU)and emergency department and associated with high morbidity and mortality.[1,2]Common etiologies of IO include adhesions,hernias,intussusception,foreign bodies,ischemia,tumors,*** in the diagnosis and management of IO is associated with higher mortality due to complications such as bowel necrosis,perforation,sepsis,and septic shock.[3]IO can be divided into small bowel obstruction(SBO)and colonic obstruction(CO).In SBO,74%of cases are caused by adhesions,which may respond to conservative *** is critical to identify which of those cases may progress and require emergent surgical intervention with the help of the diagnostic and assessment *** contrast to SBO,most cases of CO demand *** this instance,appropriate assessment tools are required to define the location of the obstruction,which will assist in the proper surgical procedure.[4]

关键词： intestine diagnosis ischemia

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Evaluation of the therapeutic efficiency of mandibular anterior implant-supported fixed bridges with cantilevers

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Chinese Medical Journal 2013年第24期126卷 4665-4669页

作者： WU Min-jie WANG xiao-jing zou Li-dong XU Wei-hua ZHANG Xiang-hao Second Dental Center Peking University School and Hospital of Stomatology Beijing 100101 China

Background Dental implant technology has developed rapidly in recent years. However, the use of implant-supported fixed bridges with cantilevers has been controversial. The purpose of this study was to evaluate the clinical results of the mandibular anterior implant-supported fixed bridges with a cantilever. Method Thirty-three patients （15 males, 18 females; mean age, 42.6 years; range 20-54 years） with two missing anterior mandibular teeth had single implant-supported fixed bridges with a cantilever. Clinical examination was recorded and radiographs were taken. The mean duration of follow-up was 30 months （15-44 months）. Results All implants survived. Loosening or fracture of the prosthesis was not observed. All patients were satisfied with the treatment. The mean bone resorption values after 12, 24, and 36 months of implant loading were 0.94, 1.18 and 1.35 mm respectively. The changes of gingival papilla height ranged from 0 to 0.5 mm. There was significant difference between 1-year and 2 or 3 years restoration groups regarding the average gingival height changes （P 〈0.05）. Conclusion After careful and precise selection of patients, restoration with a single implant-supported fixed bridge with a cantilever can be recommended if two anterior mandibular teeth are missing.

关键词： dental implant fixed partial denture, mandibular prostheses bone resorption

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Autoantigen administration confers diabetes-preventive properties to NOD mice derived dendritic cells

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Journal of Microbiology and Immunology 2007年第1期5卷 69-77页

作者： MING XIANG xiao LEI zou jing XU YAO YAO JIN FANG ZHANG Department of Pharmacology School of Pharmacy Tongji Medical College Huazhong Science and Technology University Wuhan P. R. China

Administration of autoantigen can be of value for prevention of autoimmune diabetes and it has been speculated that the control point of dendritic cells(DC)for the induction of peripheral toler- ance may be highly *** examined the properties of DC associated with immune suppression in NOD mice by insulin injection subcutaneously and their ability to suppress diabetes transfer by diabeto- genic effector cells in secondary NOD-SCID *** data showed that the surface expressions of MHCⅡand CD86 on NOD-derived DC were increased after insulin treatment compared with those on PBS controlled *** dendritic cells with a mature phenotype and increased MLR stimulation adop- tively transferred immune tolerogenic effects on secondary NOD-SCID mice,which were associated with significantly greater IL-10,TGF-beta production and CD4^+ CD25^+ T differentiation from splenocytes compared with NOD-SCID control ***,treatment with DC remarkably decreased the incidence of diabetes in secondary *** results suggest that a subtype of DC generated by insulin subcutaneous treated NOD mice confers potential protection against diabetes through polarizing the immune response towards a Th2 regulatory pathway.

关键词： Diabetes Dendritic cells Immune tolerance NOD mice

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu jing Zhang jing Yang jinghui Chen Xingyue xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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Inhibition of ethanol-induced toxicity by tanshinone ⅡA in PC12 cells

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Acta Pharmacologica Sinica 2006年第6期27卷 659-664页

作者： Xian-fang MENG~2 xiao-jing zou~3 Bin PENG~2 jing SHI~2 Xin-min GUAN~2 Chun ZHANG~(4,5)2 Department of Neurobiology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China 3 Department of Anesthesiology,4 Department of Nephrology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022.China Department of Neurobiology Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To observe the effects of tanshinone IIA(Tan IIA)on the neurotoxicityinduced by ethanol in PC 12 cells and to explore its protective ***:PC 12cell survival was measured by MTT *** formation of reactive oxygenspecies(ROS)and lactate dehydrogenase(LDH)release were detected by 2′,7′-dichlorofluorescin(DCF)fluorescence and calorimetric method,*** of cell apoptosis was monitored by flow *** expression ofp53 was detected by immuno-fluorescence and flow ***:Ethanolsignificantly impaired the survival of PC12 cells as demonstrated by MTT *** also induced significant ROS formation and increased LDH ***-incubation with Tan IIA in the culture medium significantly reversed these *** caused cell apoptosis and the upregulation of p53 *** anti-apoptosis effects of Tan IIA on ethanol-induced toxicity were accompanied by thedownregulation of pro-apoptotic p53 protein ***:Tan IIAcan protect neurons from apoptosis and might serve as a potential therapeuticdrug for neurological disorders induced by ethanol.

关键词： apoptosis ethanol PC12 cells p53 tanshinone ⅡA

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眼底动脉硬化与血生化指标的相关性研究

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国际眼科杂志 2019年第3期19卷 488-490页

作者：郝燕燕邹晓静张爱中国浙江省温州市中医院检验科 325000 中国浙江省温州市中医院眼科 325000

目的:探讨血生化指标中总胆固醇、低密度脂蛋白以及血糖水平与眼底动脉硬化的相关性。方法:本次研究选取2017-02/2018-01我院就诊的97例眼底动脉硬化患者进行血生化指标检测作为观察组。另选取同期来我院行健康体检结果为正常的98例受... 详细信息

目的:探讨血生化指标中总胆固醇、低密度脂蛋白以及血糖水平与眼底动脉硬化的相关性。方法:本次研究选取2017-02/2018-01我院就诊的97例眼底动脉硬化患者进行血生化指标检测作为观察组。另选取同期来我院行健康体检结果为正常的98例受试者作为对照组。检测两组血生化指标,然后进行比较。结果:观察组总胆固醇、低密度脂蛋白、血糖水平、血压水平明显高于对照组(P<0.05)。当患者血生化常规中血糖、总胆固醇以及低密度脂蛋白越高,眼底动脉硬化程度越高。通过纳入多因素分析,血糖、血压、总胆固醇以及低密度脂蛋白水平与眼底动脉硬化呈正相关。结论:血糖、总胆固醇、血压以及低密度脂蛋白水平越高,患者眼底动脉硬化越严重,临床通过检测眼底动脉硬化水平有利于治疗监控、诊断病变。

关键词：血生化低密度脂蛋白水总胆固醇眼底动脉硬化

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Aging exaggerated proliferation of vascular smooth muscle cells is related to attenuation of Jagged1 expression in endothelial cells

Aging exaggerated proliferation of vascular smooth muscle ce...

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第十三次全国心血管病学术会议

作者： WU xiao-jing,HUANG Lan,zou Yun-zeng,GE Jun-bo *Cardiovascular Center of Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China

Objective Aging has been shown to enhance the neointimal formation due to abnormal growth of vascular smooth muscular cells(VSMC),which is regulated by endothelial *** mechanism of how endothelium affects the growth of VSMC in the process remains *** here examined the role of Jagged1,a regulator for cell *** and Results Male Sprague-Dawley rats at 3(young) and 22(old) month-old were subjected to a balloon catheter injury in the

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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