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Study of the effects of bisphenol A using human fetal lung fibroblasts

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Journal of Environmental Sciences 2016年第10期28卷 6-10页

作者： Jeffrey Tao Lily xiao jing sun X.Chris Le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and Pathology University of Alberta

Bisphenol A （BPA, 2,2-bis（4-hydroxyphenyl） propane; CAS# 80-05-7） is a highly produced industrial chemical, with an estimated four billion kilograms produced worldwide each year （reviewed in Vandenberg et al., 2010）. BPA serves as a monomer in the manufacture of polycarbonate, a hard, clear plastic. Polycarbonate plastics are used in many consumer products

关键词： Bisphenol A (BPA)Estrogen receptorsEndocrine disruptorsDevelopmental effectsImmune effectsCytokinesAsthma

Bio-inspired barnacle cement coating of biodegradable magnesium alloy for cerebrovascular application

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Rare Metals 2024年第10期43卷 5164-5185页

作者： Hang Li Fei Wang xiao-jing sun Liu-Jie Qi jing-An Li Mujahid Iqbal Shao-Kang Guan School of Material Science and Engineering Zhengzhou UniversityZhengzhou 450000China Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold(Ministry of Education) Zhengzhou UniversityZhengzhou 450000China Department of Physics University of Agriculture FaisalabadFaisalabad 38000Pakistan

Ischemic stroke is increasing worldwide,and stent intervention has gradually become one of the effective *** to its good mechanical properties and biocompatibility,biodegradable Mg-Zn-Y-Nd alloy(ZE21B)has good application prospects in vascular ***,too fast degradation and delayed endothelialization are the bottleneck problem to limit its further *** this study,the bio-inspired coating barnacle cement cp19k is constructed on ZE21B surface through electrostatic spraying to improve the corrosion resistance and pro-endothelialization *** coating was evaluated through electrochemistry,static immersion corrosion,in vitro blood experiments and cell ***19k effectively improved the corrosion resistance of the substrate ZE21B,reduced the degradation rate,improved endothelial cell proliferation and migration capabilities,inhibited smooth muscle cells proliferation and regulated contractile phenotype,inhibited macrophage adhesion,regulated macrophage M2 phenotype,and reduced the expression of inflammatory factor of TNF-a and inhibited fibroplasia in *** data indicated that the barnacle cement cp19k coating had potential application on the surface modification of Mg alloy cerebrovascular stent.

关键词： Cerebrovascular stent Biodegradable magnesium alloy Barnacle cement cp19k Proendothelialization M2 phenotype

Utility of cooling patches to prevent hand-foot syndrome caused by pegylated liposomal doxorubicin in breast cancer patients

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World Journal of Clinical Cases 2021年第33期9卷 10075-10087页

作者： Yan-Fu Zheng Xin Fu xiao-Xu Wang xiao-jing sun xiao-Dan He Department of Breast Oncology Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina Department of Gynecology Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina

BACKGROUND Pegylated liposomal doxorubicin(PLD)uses the hydrophilic layer of liposomes to reach the sweat on the skin surface or accumulate in the sweat glands,producing toxic free radicals and oxidative damage,resulting in hand-foot syndrome(HFS).Regional cooling can induce vasoconstriction to reduce the release of drugs in the limbs and reduce the accumulation of drugs in sweat glands;thus,decreasing the incidence and severity of *** To study the efficacy of cooling patches to prevent HFS caused by PLD in the *** This is a retrospective cohort *** breast cancer patients(n=101)who were treated with PLD in two breast wards at our department from February 2020 to February 2021 were enrolled in the study and were randomly divided into the cooling group(51 patients)and the control group(50 patients).Patients in the control group only received routine care,while the patients in the cooling group applied cooling patches,based on routine care,to the palm and back of the hands 15 min before chemotherapy infusion for 10 *** patients took a corresponding dose of dexamethasone orally one day before chemotherapy,on the day of chemotherapy,and one day after ***23.0 version was used to analyze the data in this *** occurrence and severity of HFS was analyzed by the Mann-Whitney U test,and scores were analyzed by the Student’s t test or Wilcoxon rank-sum test.A P value<0.05 was regarded as statistically *** In this study,neither group of patients developed Grade 3 *** the control group,the incidence of Grade 1 HFS and Grade 2 HFS was 38%and 2%,***,in the cooling group,only one person developed Grade 1 HFS(2%),and none of the patients developed Grade 2 *** findings showed that cooling patches can effectively reduce the frequency and severity of HFS(P<0.0001)in the *** the fourth chemotherapy cycle,although general self-efficacy scale scores in the cooling group were low,they we

关键词： The cooling patch Hand-foot syndrome Pegylated liposomal doxorubicin Breast cancer Self efficacy Quality of life

Low frequency vibration tests on a floating slab track in an underground laboratory

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第5期12卷 345-359页

作者： De-yun DING Wei-ning LIU Ke-fei LI xiao-jing sun Wei-feng LIU School of Civil Engineering Beijing Jiaotong University Beo'ing 100044 China Beij'ing Urban Engineering Design and Research Institute Co. Ltd. Beijing 100037 China

Low frequency vibrations induced by underground railways have attracted increasing attention in recent years. To obtain the characteristics of low frequency vibrations and the low frequency performance of a floating slab track (FST), low frequency vibration tests on an FST in an underground laboratory at Beijing Jiaotong University were carried out. The FST and an unbalanced shaker SBZ30 for dynamic simulation were designed for use in low frequency vibration experiments. Vibration measurements were performed on the bogie of the unbalanced shaker, the rail, the slab, the tunnel invert, the tunnel wall, the tunnel apex, and on the ground surface at distances varying from 0 to 80 m from the track. Measurements were also made on several floors of an adjacent building. Detailed results of low frequency vibration tests were reported. The attenuation of low frequency vibrations with the distance from the track was presented, as well as the responses of different floors of the building. The experimental results could be regarded as a reference for developing methods to control low frequency vibrations and for adopting countermeasures.

关键词： Low frequency vibrations Laboratory tests Floating slab track (FST) Vibration isolation efficiency

CP-25 reverses prostaglandin E4 receptor desensitization-induced fibroblast-like synoviocyte dysfunction via the G protein-coupled receptor kinase 2 in autoimmune arthritis

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Acta Pharmacologica Sinica 2019年第8期40卷 1029-1039页

作者： xiao-yi Jia Yan Chang Fang Wei Xing Dai Yu-jing Wu xiao-jing sun Shu Xu Hua-xun Wu Chun Wang Xue-zhi Yang Wei Wei Institute of Clinical Pharmacology Anhui Medical University Key Laboratory of Anti-inflammatory and Immune Medicine Ministry of Education Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine School of Pharmacy Anhui University of Chinese Medicine

Paeoniflorin-6’-O-benzene sulfonate(CP-25)is a novel compound derived from paeoniflorin that has been demonstrated to have therapeutic effects in a rat model of rheumatoid arthritis(RA).However,the underlying mechanism has not been elucidated to *** explored this mechanism in the present study by treating rats with adjuvant arthritis(AA)with *** found that the membrane EP4 protein level was downregulated;whereas,GRK2 was upregulated,in fibroblast-like synoviocyte(FLS)s of AA ***(PGE)2 stimulated FLS proliferation and enhanced the membrane EP4 receptor protein level;the latter was reversed by the administration of an EP4 receptor agonist,whereas the membrane GRK2 protein level gradually *** changes in the EP4 receptor and GRK2 expression were enhanced by TNF-α,and the former was accompanied by an alteration in the cyclic(c)AMP *** EP4 receptor agonist stimulation increased the association between GRK2 and the EP4 ***2 knockdown abrogated the abnormalities in FLS *** CP-25 treatment(100 mg/kg)suppressed joint inflammation with an efficacy that was similar to that of *** finding was associated with EP4 upregulation and GRK2 downregulation in ***,GRK2 plays an important role in the abnormal FLS proliferation observed in AA possibly by promoting EP4 receptor desensitization and decreasing the cAMP *** results demonstrate that CP-25 has therapeutic potential for the treatment of human RA via GRK2 regulation.

关键词： adjuvant-induced arthritis paeoniflorin-6’-O-benzene sulfonate fibroblast-like synoviocytes G protein-coupled receptor kinase 2 prostaglandin E2

Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose

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Neuroscience Bulletin 2012年第5期28卷 561-566页

作者： xiao-jing sun Lei Zhao Na Zhao xiao-Li Pan Guo-Qiang Fei Li-Rong Jin Chun-Jiu Zhong Department of Neurology Zhongshan Hospital & Shanghai Medical College Fudan University Shanghai 200032 China State Key Laboratory of Medical Neurobiology Institute of Brain Science Fudan University Shanghai 200032 China

Objective To determine whether high glucose enhances β-amyloid （Aβ） production in HEK293 Swedish mutant （APPsw） cells with Aβ precursor protein （APP） overexpression, and whether under this condition benfotiamine reduces the increased Aβ production. Methods HEK293 APPsw cells were cultured with different concentrations of glucose for different times. TheAβ content in the supernatant was determined by ELISA. To investigate the mechanism by which benfotiamine reduced Aβ production, glycogen synthase kinase-3 （GSK-3） activity and expression were measured after the cells were cultured with 5.5 g/L glucose for 12 h. Results With 1.0, 3.0, 4.5, 5.5, 6.5, 7.5, 8.5, or 10.5 g/L glucose, Aβ production by HEK293 APPsw cells was highest in the presence of 5.5 g/L glucose for 6 and 12 h. The difference in Aβ content between 5.5 and 1.0 g/L was most marked after incubation for 12 h. Benfotiamine at 20 and 40 μg/mL significantly reduced Aβ production in cells incubated with 5.5 g/L glucose for 12 h. Moreover, 40 μg/mL benfotiamine significantly enhanced the ratio of phosphorylated GSK-3 to total GSK-3, together with consistent down-regulation of GSK-3 activity. Conclusion High glucose increases Aβ production by HEK293 APPsw cells while benfotiamine prevents this increase. This is correlated with the modulation of GSK-3 activity.

关键词： Alzheimer’s disease β-amyloid high glucose benfotiamine glycogen synthase kinase

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan Yu xiao-Li Li xiao-Ting sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Underlying Mechanisms of Memory Deficits Induced by Etomidate Anesthesia in Aged Rat Model： Critical Role of Immediate Early Genes

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Chinese Medical Journal 2016年第1期129卷 48-53页

作者： Xu Li Fen Lu Wei Li Jun Xu xiao-jing sun LJng-Zhi Qin Qian-Lin Zhang Yong Yao Qing-Kai Yu Xin-Liang Liang Department of Pathology Affiliated Cancer Hospital of Zhengzhou University Henan Provincial Cancer Hospital Zhengzhoo Henan 450008 China Department of Neurology Affiliated People's Hospital of Zhengzhou University Henan Provincial People's Hospital Zhengzhou Henan 450003 China Department of Medical Development Affiliated People's Hospital of Zhengzhou University Henan Provincial People's Hospital Zhengzhou Henan 450003 China

Background： Etomidate （R- 1 -[ 1 -ethylphenyl] imidazole-5-ethyl ester） is a widely used anesthetic drug that had been reported to contribute to cognitive deficits after general surgery. However, its underlying mechanisms have not been fully elucidated. In this study, we aimed to explore the neurohiological mechanisms of cognitive impairments that caused by etomidate. Methods： A total of 30 Sprague-Dawley rats were used and divided into two groups randomly to receive a single injection ofeiomidate or vehicle. Then, the rats＇ spatial memory ability and neuronal survival were evaluated using the Morris water maze test and Nissl staining, respectively. Furthermore, we analyzed levels of oxidative stress, as well as cyclic adenosine 3＇,5＇-monophosphate response element-binding （CREB） protein phosphorylation and immediate early gene （IEG, including Arc, c-fos, and Egrl） expression levels using Western blot analysis. Results： Compared with vehicle-treated rats, the etomidate-treated rats displayed impaired spatial learning （day 4：27.26 ± 5.33 s vs. 35.52 ± 3.88s, t 2.988, P 0.0068; day 5： 15.84±4.02svs.30.67±4.23s,t=3.013,P=0.0057;day6：9.47±2.35svs.25.66±4.16s,t=3.567, P = 0.0036） and menaory ability （crossing times： 4.40 ± 1.18 vs. 2.06 ± 0.80, t = 2.896, P 0.0072; duration： 34.00± 4.24 s vs. 18.07 ±4.79 s, t = 3.023, P= 0.0053; total swimming distance： 40.73 ±3.45 cm vs. 27.40± 6.56 cm, t = 2.798, P = 0.0086） but no neuronal death. Furthermore, etomidate did not cause oxidative stress or deficits in CREB phosphorylation. The levels of multiple lEGs （Arc： vehicle treated rats 100%, etomidate treated rats 86%, t = 2.876, P 0.0086; c-los： Vehicle treated rats 100%, etomidate treated rats 72%, t =2.996, P = 0.0076; Egrl ： Vehicle treated rats 100%, etomidate treated rats 58%, t = 3.011, P=0.0057） were significantly reduced in hippocampi ofetomidate-treated rats. Conclusion： Our data suggested that etomidate might induce memory impairment in rats via inhibition of lEG expres

关键词： Anesthesia Cyclic Adenosine 3',5'-Monophosphate Response Element-binding Phosphorylation Etomidate ImmediateEarly Genes Neuronal Death Oxidative Stress

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日本线下仓库构成常设机构案法律评析

税务与经济 2017年第6期 95-100页

作者：崔晓静孙奇敏武汉大学法学院湖北武汉430072

在数字经济背景下,现有的常设机构定义可能无法正确反映跨国企业与非居民国之间的"经济关联",因此,也无法使税收与经济活动发生地或价值创造地相匹配。日本法院在最近的一项判决中认定,美国纳税人通过线上店在日本进行销售活动时使用的... 详细信息

在数字经济背景下,现有的常设机构定义可能无法正确反映跨国企业与非居民国之间的"经济关联",因此,也无法使税收与经济活动发生地或价值创造地相匹配。日本法院在最近的一项判决中认定,美国纳税人通过线上店在日本进行销售活动时使用的日本公寓和仓库,可以构成其在日本的常设机构。常设机构的界定问题对于协调各国对跨国企业的征税权具有重要意义,这一判决对如何适用OECD范本第五条第四款规定的常设机构的特定活动豁免规则具有重要的借鉴意义,也可以为理解BEPS行动计划一和行动计划七的相关内容提供参考。

关键词：常设机构特定活动豁免数字经济