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Unraveling brain aging through the lens of oral microbiota

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang jing qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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Kinetics of Hepatitis B Surface Antigen Level in Chronic Hepatitis B Patients who Achieved Hepatitis B Surface Antigen Loss during Pegylated Interferon Alpha-2a Treatment

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Chinese Medical Journal 2017年第5期130卷 559-565页

作者： Ming-Hui Li Lu Zhang xiao-jing qu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping HU Zhen-Zhen Li Wen-Hao Hua Shu-jing Song Yao Xie Liver Diseases Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Clinical Test Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background： Hepatitis B surfhce antigen （HBsAg） Ioss/seroconversion is considered to be the ideal endpoint of antiviral therapy and the ultimate treatment goal in chronic hepatitis B （CHB）. This study aimed to assess the patterns of ttBsAg kinetics in CHB patients who achieved HBsAg loss during the treatment of pegylated interferon （PEG-IFN） α-2a. Methods： A total of 150 patients were enrolled, composing of 83 hepatitis B envelope antigen （H BeAg）-positive and 67 HBeAg-negative patients. Patients were treated with PEG-IFN α-2a180 μg/week until HBsAg loss/seroconversion was achieved, which occurred within 96 weeks. Serum hepatitis B virus deoxyribonucleic acid and serological indicators （HBsAg, anti-HBs, HBeAg, and anti-HBe） were determined before and every 3 months during PEG-1FN α-2a treatment. Biochemical markers and peripheral blood neutrophil and platelet counts were tested every 1-3 months. Results： Baseline HBsAg levels were 2.5 ± 1.3 log IU/ml, and decreased rapidly at 12 and 24 weeks by 48.3%, and 88.3%, respectively. The mean time to HBsAg loss was 54.2 ± 30.4 weeks, though most patients needed extended treatment and 30.0% of HBsAg loss occurred during 72-96 weeks. Baseline HBsAg levels were significantly higher in HBeAg-positive patients （2.9 ± 1.1 log 1U/ml） compared with HBeAg-negative patients （2.0 ± 1.3 log I U/ml; t = 4.733, P 〈 0.001）, but the HBsAg kinetics were similar. Patients who achieved HBsAg loss within 48 weeks had significantly lower baseline HBsAg levels and had more rapid decline of HBsAg at 12 weeks compared to patients who needed extended treatment to achieve HBsAg loss. Conclusions： Patients with lower baseline HBsAg levels and more rapid decline during early treatment with PEG-IFN are more likely to achieve HBsAg loss during 96 weeks of treatment, and extended therapy longer than 48 weeks may be required to achieve HBsAg loss.

关键词： Chronic Hepatitis B Hepatitis B Surface Antigen Kinetics Pegylated Interferon Alfa-2a

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Ratios of T-helper 2 Cells to T-helper 1 Cells and Cytokine Levels in Patients with Hepatitis B

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Chinese Medical Journal 2017年第15期130卷 1810-1815页

作者： Ming-Hui Li Dan Zhang Lu Zhang xiao-jing qu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping Hu Hong-xiao Hao Wen-Hao Hua Shu-jing Song Gang Wan Shun-Ai Liu Yao Xie Liver Diseases Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Clinical Laboratory Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background：Hepatitis B is an immune response-mediated *** aim of this study was to explore the differences of ratios of T-helper （Th） 2 cells to Thl cells and cytokine levels in acute hepatitis B （AHB） patients and chronic hepatitis B virus （HBV）-infected patients in immune-tolerance and immune-active ***：Thirty chronic HBV-infected patients in the immune-tolerant phase （IT group） and 50 chronic hepatitis B patients in the immuneactive （clearance） phase （IC group）,32 AHB patients （AHB group）,and 13 healthy individuals （HI group） were enrolled in the *** cell proportions in peripheral blood,cytokine levels in plasma,and serum levels of HBV DNA,hepatitis B surface antigen,and hepatitis B e antigen were ***：The Th1 cell percentage and Th2/Th1 ratio in the HBV infection group （including IT,IC,and AHB groups） were significantly different from those in HI group （24.10% ± 8.66% and 1.72 ± 0.61 vs.15.16% ± 4.34% and 2.40 ± 0.74,respectively;all P 〈 0.001）.However,there were no differences in the Th1 cell percentages and Th2/Th1 ratios among the IT,IC,and AHB *** HBV infection group,the median levels of Flt3 ligand （Flt3L）,interferon （IFN）-γ,and interleukin （IL）-17A were significantly lower than those in HI group （29.26 pg/ml,33.72 pg/ml,and 12.27 pg/ml vs.108.54 pg/ml,66.48 pg/ml,and 35.96 pg/ml,respectively;all P 〈 0.05）.IFN-α2,IL-10,and transforming growth factor （TGF）-β2 median levels in hepatitis group （including patients in AHB and IC groups） were significantly higher than those in IT group （40.14 pg/ml,13.58 pg/ml,and 557.41 pg/ml vs.16.74 pg/ml,6.80 pg/ml,and 419.01 pg/ml,respectively;all P 〈 0.05）,while patients in hepatitis group had significant lower Flt3L level than IT patients （30.77 vs.59.96 pg/ml,P =0.021）.Compared with IC group,patients in AHB group had significant higher median level s of IL-1 0,TGF-β 1,and TGF-β2 （22.77 pg/ml,10,447.00 pg/ml,and 782.28 pg/ml vs.8.66 pg/ml,3755.50 pg/ml,and 482.87 pg/ml,respectively

关键词： Acute Hepatitis B Chronic Hepatitis B, Cytokine: Immune-tolerance T Lymphocytes

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An Efficient and Flexible Bifunctional Dual-Band Electrochromic Device Integrating with Energy Storage

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Nano-Micro Letters 2025年第4期17卷 419-434页

作者： Zekun Huang Yutao Peng jing Zhao Shengliang Zhang Penglu Qi Xianlin qu Fuqiang Yan Bing Ding Yimin Xuan xiaogang Zhang Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China Key Laboratory of Thermal Management and Energy Utilization of Aviation Vehicles College of Energy and Power EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China Center for Microscopy and Analysis Nanjing University of Aeronautics and AstronauticsNanjing 211106People’s Republic of China

Dual-band electrochromic devices capable of the spectral-selective modulation of visible(VIS)light and near-infrared(NIR)can notably reduce the energy consumption of buildings and improve the occupants’visual and thermal ***,the low optical modulation and poor durability of these devices severely limit its practical ***,we demonstrate an efficient and flexible bifunctional dual-band electrochromic device which not only shows excellent spectral-selective electrochromic performance with a high optical modulation and a long cycle life,but also displays a high capacitance and a high energy recycling efficiency of 51.4%,integrating energy-saving with *** nanowires structure and abundant oxygen-vacancies of oxygen-deficient tungsten oxide nanowires endows it high flexibility and a high optical modulation of 73.1%and 85.3%at 633 and 1200 nm *** prototype device assembled can modulate the VIS light and NIR independently and effectively through three distinct modes with a long cycle life(3.3%capacity loss after 10,000 cycles)and a high energy-saving performance(8.8℃lower than the common glass).Furthermore,simulations also demonstrate that our device outperforms the commercial low-emissivity glass in terms of energy-saving in most climatic zones around the *** windows represent an intriguing potential technology to improve the building energy efficiency.

关键词： Electrochromic Dual-band electrochromic devices Spectral-selective modulation Flexible Energy storage

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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我国不同地区花生蓟马的物种组成及种群动态

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中国油料作物学报 2025年第1期47卷 176-185页

作者：曲春娟刘燊姜晓静朱悦曲明静李晓山东省花生研究所山东青岛266100 新疆农业大学农学院新疆乌鲁木齐830052 塔里木大学农学院新疆阿拉尔843300

为指导花生田蓟马的精准防控,了解和明确全国不同产区花生田蓟马的种类组成及其种群动态,采用盘拍法和色板诱集法对6个代表性地区的花生蓟马进行调查、鉴定,在此基础上对其多样性、相似性进行比较并对物种组成结构进行层次聚类分析。结... 详细信息

为指导花生田蓟马的精准防控,了解和明确全国不同产区花生田蓟马的种类组成及其种群动态,采用盘拍法和色板诱集法对6个代表性地区的花生蓟马进行调查、鉴定,在此基础上对其多样性、相似性进行比较并对物种组成结构进行层次聚类分析。结果表明,新疆乌鲁木齐、吉林公主岭、山西汾阳、山东青岛、福建泉州、广东湛江6个地区一共采集到14234头蓟马,隶属于3科6属10种;在属级和种级组成上表现为蓟马科属、种占比最大。从整体看,花蓟马/西花蓟马、烟蓟马、普通大蓟马和玉米黄呆蓟马是花生田的主要蓟马种类。不同地区蓟马群落的Shannon-Wiener多样性指数大小依次为青岛>乌鲁木齐>泉州>公主岭>湛江>汾阳,Simpson优势集中性指数大小依次为湛江>汾阳>公主岭>泉州>乌鲁木齐>青岛。蓟马群落两两之间的Jaccard相似性系数在0.40~1.00之间,为中等不相似、中等相似和极相似,以中等相似情况居多;6个地区被明显地聚类为北方产区和南方产区两大类。北方四个地区多以花蓟马/西花蓟马和烟蓟马为优势种,分别占所采集蓟马总数的35.72%~40.35%、15.20%~56.55%;普通大蓟马是南方两个地区的优势种,占蓟马总数的31.09%~74.32%。花蓟马/西花蓟马和普通大蓟马在整个花生生育期都有发生,而烟蓟马多在早期或早中期发生。此前在花生上极少关注的玉米黄呆蓟马,在北方和华南产区都可以大量稳定发生,具有为害花生的潜在风险。此外还发现,蓟马调查方法不同对最终得到的物种数目及占比均有影响。

关键词：花生蓟马物种组成优势种种群动态

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Plasmacytoid Dendritic Cell Function and Cytokine Network Profiles in Patients with Acute or Chronic Hepatitis B Virus Infection

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Chinese Medical Journal 2018年第1期131卷 43-49页

作者： Ming-Hui Li Lu Zhang Dan Zhang Wei-Hua Cao Tian-Lin Qi Hong-xiao Hao Xing-Yue Wang Chong-Ping Ran xiao-jing qu Shun-Ai Liu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping Hu Wen-Hao Hua Gang Wan Jun Cheng Yao Xie Liver Diseases Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Institute of Infectious Diseases Beijing DitanHospitai Capital Medical University Beijing 100015 China Clinical Test Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background： Plasmacytoid dendritic cells （pDCs） and cytokines play an important role in occurrence and recovery of hepatitis B virus （HBV） infection. The aim of this study was to explore the frequency and function ofpDC and serum cytokine network profiles in patients with acute or chronic HBV infection. Methods： The healthy individuals （HI group）, hepatitis B envelope antigen （HBeAg）-positive chronic HBV patients in immune tolerance （IT） phase （IT group）, HBeAg-positive chronic HBV patients （CHB group）, and acute HBV patients （AHB group） were enrolled in this study. The frequency of cluster of differentiation antigen 86 （CD86）＋ pDC and the counts of CD86 molecular expressed on surface ofpDC were tested by flow cytometer. The quantitative determinations ofcytokines, including Fins-like tyrosine kinase 3 ligand （FIt-3L）, interferon （1FN）-α2, IFN-γ, interleukin （IL）-17A, IL-6, IL-10, transforming growth factor （TGF）-β1 and TGF-β2, were performed using Luminex multiplex technology. Results： In this study, there were 13 patients in HI group, 30 in IT group, 50 in CHB group, and 32 in AHB group. Compared with HI group, HBV infected group （including all patients in IT, CHB and AHB groups） had significantly higher counts of CD86 molecular expressed on the surface ofpDC （4596.5 ± 896.5 vs. 7097.7 ± 3124.6; P 〈 0.001）. The counts of CD86 molecular expressed on the surface of pDC in CriB group （7739.2 ±4125.4） was significantly higher than that of IT group （6393.4 ± 1653.6, P=0.043）. Compared with IT group, the profile of cytokines of FIt-3L, IFN-γ, and IL-17A was decreased, IFN-α2 was significantly increased （P =0.012） in CH B group. The contents of IL-10, TGF-{31, and TGF-132 in AHB group were significantly increased compared with IT and CHB groups （all P 〈 0.05）. Conclusions： This study demonstrated that the function of pDC was unaffected in HBV infection. The enhanced function of pDC and IFN-α2 might involve triggering the immune response from IT to hepatitis active phase

关键词： Acute Hepatitis B Virus Infection Chronic Hepatitis B Virus Infection Interferon-α2 Interleukin-10 PlasmacytoidDendritic Cells

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Association of Cytokines with Alanine Aminotransferase, Hepatitis B Virus Surface Antigen and Hepatitis B Envelope Antigen Levels in Chronic Hepatitis B

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Chinese Medical Journal 2018年第15期131卷 1813-1818页

作者： Ming-Hui Li Yao Lu Lu Zhang Xing-Yue Wang Chong-Ping Ran Hong-xiao Hao Dan Zhang xiao-jing qu Ge Shen Shu-Ling Wu Wei-Hua Cao Tian-Lin Qi Ru-Yu Liu Lei-Ping Hu Min Chang Wen-Hao Hua Shun-Ai Liu Gang Wan Yao Xie Liver Diseases Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Beijing Key laboratory of Emerging Infectious Diseases Institute of Infectious Diseases Beijing Ditan Hospital Capital Medical University Beijing 100015 China Clinical Test Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Ming-Hui Li and Yao Lu contributed equally to this work

Background： Cytokines play an important role in occorrence and recovery of hepatitis B virus （HBV） infection. The aim of this study was to investigate the changes ofcytokines concentration and its correlation to alanine aminotransferase （ALT）, HBV deoxyribonucleic acid （HBV-DNA）, hepatitis B envelope antigen （HBeAg）, and HBV surface antigen （HBsAg） in the development of chronic hepatitis B （CHB）. Methods： Thirteen healthy individuals （HI）, 30 chronic HBV-infected patients in immune tolerant （IT） phase, and 55 CHB patients were enrolled between August 2015 and May 2017. The peripheral blood samples were collected from all individuals. Tile levels of interferon （IFN）-α2, interleukin （IL）-10, transforming growth factor （TGF）-β1, HBV-DNA, HBsAg, and HBeAg and liver function were measured. The quantitative determinations of cytokines levels, including I FN-ct2, IL-10, and TGF-[31 were performed using Luminex multiplex technology. The correlation of cytokines to ALT, HBV-DNA, HBsAg, and HBeAg was analyzed by linear regression analysis. Results： IFN-ct2 levels were similar between HI and IT groups （15.35 [5.70, 67.65] pg/ml vs. 15.24 [4.07, 30.73] pg/ml, Z = -0.610, P - 0.542）, while it elevated significantly in CH B group （35.29 [ 15.94, 70.15] pg/ml vs. 15.24 [4.07, 30.73] pg/ml; Z = -2.522, P = 0.012）. Compared with HI group （3.73 [2.98, 11.92] pg/ml）, IL-10 concentrations in IT group （5.02 [2,98, 10.11] pg/ml）, and CHB group （7.48 [3. I 0, 18.00] pg/ml） slightly increased （X^2 = 2.015, P - 0.365）, and there was no significant difference between IT and CHB group （Z =- 1.419, P = 0.156）. The TGF-β1 levels among HI （3.59 ±0.20 pg/ml）, IT （3.62 ±0.55 pg/ml）, and CHB groups （3.64±0.30 pg/ml） were similar （X^2=2.739, P = 0.254）. In all chronic HBV-infected patients （including patients in IT and CHB groups）, the elevation of IFN-α2 level was significantly associated with ALT level （β = 0.389, t = 2.423, P = 0.018）, and was also negatively correlated to HBV-DNA load （β = -0.35

关键词： Chronic Hepatitis B Hepatitis B Virus Deoxyribonucleic Acid Hepatitis B Virus Surface Antigen Intertferon-α2: lnterleukin- 10

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花生/玉米间作对暗黑鳃金龟和铜绿丽金龟发生的影响

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中国油料作物学报 2025年第1期47卷 167-175页

作者：曲春娟姜晓静万书波张正杜龙鞠倩李晓曲明静山东省花生研究所山东青岛266100 山东省农业科学院农作物种质资源研究所山东济南250100

为探明花生/玉米间作模式对农业重要害虫暗黑鳃金龟和铜绿丽金龟发生危害的影响,通过在笼罩栽培池、网室及大田3个条件下的试验,研究两种金龟子对花生/玉米的寄主选择性,探讨花生/玉米间作对两种金龟子幼虫发生的影响。结果表明:暗黑鳃... 详细信息

为探明花生/玉米间作模式对农业重要害虫暗黑鳃金龟和铜绿丽金龟发生危害的影响,通过在笼罩栽培池、网室及大田3个条件下的试验,研究两种金龟子对花生/玉米的寄主选择性,探讨花生/玉米间作对两种金龟子幼虫发生的影响。结果表明:暗黑鳃金龟对花生有明显的产卵选择偏好性,铜绿丽金龟对玉米有一定的产卵偏好性。花生单作区暗黑鳃金龟幼虫虫口密度是玉米单作区的3.55~6.59倍,而铜绿丽金龟幼虫虫口密度在两个单作区之间差异不显著;花生/玉米间作模式下,间作整体区域暗黑鳃金龟幼虫的平均虫口密度与花生单作区相比下降43.38%~70.84%,间作区花生带暗黑鳃金龟幼虫虫口密度与花生单作区相比下降33.55%~54.33%;铜绿丽金龟幼虫平均虫口密度与花生单作区和玉米单作区相比均略有变化但差异不显著。综上,花生/玉米间作种植模式可显著降低暗黑鳃金龟幼虫种群数量,但对铜绿丽金龟幼虫未产生显著影响。

关键词：花生/玉米间作暗黑鳃金龟铜绿丽金龟寄主选择虫口密度

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比较政治的知识特质与研究方法

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学习与探索 2025年第1期 39-49,F0002页

作者：李路曲崔婧上海师范大学哲学与法政学院

从知识特质来看,比较政治是一门将规范性思维、政治学理论与经验政治现象联系起来的“理论联系实际”的知识、理论和学问,尤其是探索政治制度以及与政治制度相关的政治现象变化规律的知识和理论,由于这种知识特质,比较政治主要是一种中... 详细信息

从知识特质来看,比较政治是一门将规范性思维、政治学理论与经验政治现象联系起来的“理论联系实际”的知识、理论和学问,尤其是探索政治制度以及与政治制度相关的政治现象变化规律的知识和理论,由于这种知识特质,比较政治主要是一种中观研究。任何中观研究都离不开微观的基础和宏观的指导,这就要求比较政治学研究者既要掌握一定的理论和方法,也要对政治现象尤其是政治发展有丰富的知识和认知,还要有深刻的实证研究经验。从研究方法来看,比较政治既不是宏观性的哲学分析,也不主要是数学方法,而是以个案或变量阐释为起点,进而进行个案内的因果分析、跨国的案例比较以及历史追踪、定性比较分析等方法的应用,并由这些方法经过多重演绎和检验而建构起理论模型。在越来越需要大数据分析方法支撑的今天,这种跨国的案例比较仍然是比较政治研究的主流方法。

关键词：比较政治知识特质中观研究比较方法

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