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Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment

World Journal of Diabetes 2024年第4期15卷 735-757页

作者： jing Gao Ying Zou {1.-Yu Lv Li Chen Xin-Guo Hou Department of Endocrinology Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Institute of Endocrine and Metabolic Diseases Shandong UniversityJinan 250012Shandong ProvinceChina Key Laboratory of Endocrine and Metabolic Diseases Shandong Province Medicine&HealthJinan 250012Shandong ProvinceChina Department of Endocrinology Jinan Clinical Research Center for Endocrine and Metabolic DiseaseJinan 250012Shandong ProvinceChina

BACKGROUND The cognitive impairment in type 2 diabetes mellitus(T2DM)is a multifaceted and advancing state that requires further exploration to fully ***-roinflammation is considered to be one of the main mechanisms and the immune system has played a vital role in the progression of the *** To identify and validate the immune-related genes in the hippocampus associated with T2DM-related cognitive *** To identify differentially expressed genes(DEGs)between T2DM and controls,we used data from the Gene Expression Omnibus database *** identify T2DM module genes,we used Weighted Gene Co-Expression Network *** the genes were subject to Gene Set Enrichment ***-protein interaction network construction and machine learning were utilized to identify three hub *** cell infiltration analysis was *** three hub genes were validated in GSE1.2539 via receiver operating characteristic curve *** experiments including reverse transcription quantitative real-time PCR,Western blotting and immunohistochemistry were conducted both in vivo and in *** identify potential drugs associated with hub genes,we used the Comparative Toxicogenomics Database(CTD).RESULTS A total of 576 DEGs were identified using *** taking the intersection of DEGs,T2DM module genes,and immune-related genes,a total of 59 genes associated with the immune system were ***,machine learning was utilized to identify three hub genes(H2-T24,Rac3,and Tfrc).The hub genes were associated with a variety of immune *** three hub genes were validated in *** experiments were conducted at the mRNA and protein levels both in vivo and in vitro,consistent with the bioinformatics ***,1. potential drugs associated with RAC3 and TFRC were identified based on the *** Immune-related genes that differ in expression in the hippocampus are closely linked to microgli

关键词： Bioinformatics analysis Type 2 diabetes mellitus Cognitive impairment Hippocampus Immune Microglia

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High-resolution neutronics model for ^(238)Pu production in high-flux reactors

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Nuclear Science and Techniques 2024年第5期35卷 226-236页

作者： Qing-Quan Pan Qing-Fei Zhao Lian-Jie Wang Bang-Yang Xia Yun Cai Jin-Biao Xiong xiao-{1. Liu School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610200China

We proposed and compared three methods(filter burnup,single energy burnup,and burnup extremum analysis)to build a high-resolution neutronics model for 238Pu production in high-flux *** filter burnup and single energy burnup methods have no theoretical approximation and can achieve a spectrum resolution of up to~1.eV,thereby constructing the importance curve and yield curve of the full energy *** burnup extreme analysis method combines the importance and yield curves to consider the influence of irradiation time on production efficiency,thereby constructing extreme *** three curves,which quantify the transmutation rate of the nuclei in each energy region,are of physical significance because they have similar distributions.A high-resolution neutronics model for ^(238)Pu production was established based on these three curves,and its universality and feasibility were *** neutronics model can guide the neutron spectrum optimization and improve the yield of ^(238)Pu by up to 1..81..The neutronics model revealed the law of nuclei transmutation in all energy regions with high spectrum resolution,thus providing theoretical support for high-flux reactor design and irradiation production of ^(238)Pu.

关键词： ^(238)Pu Neutronics model High-flux reactor Spectrum resolution Spectrum optimization

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Jejunal sarcomatoid carcinoma:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3723-3731页

作者： Qian Feng Wei Yu jing-Hui Feng Qiao Huang Gui-Xiang {1. The First College of Clinical Medical Science China Three Gorges UniversityYichang 443000Hubei ProvinceChina Department of Oncology Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Sarcomatoid carcinoma(SCA)of the jejunum is a rare and aggressive neoplasm affecting the smooth muscle cells of the *** study presents a recent case of jejunal SCA,detailing its diagnosis and treatment,thereby providing a reference for clinical *** SUMMARY A 65-year-old male presented to Yichang Central People's Hospital with a chief complaint of hemorrhoids.A computed tomography(CT)scan incidentally revealed multiple abnormal signals in the *** positron emission tomography/CT at Wuhan Union Hospital indicated malignant tumor progression,with a primary duodenal tumor and multiple metastases in the upper left ***,a large tumor was identified on the *** and immunohistochemical analyses of the resected specimen confirmed the diagnosis of jejunal *** patient received a combination therapy of sintilimab,nanoparticle albumin-bound paclitaxel,and ***-up imaging demonstrated significant reduction of hepatic and peritoneal *** patient has remained stable for over one year *** This case suggests that chemotherapy,immunotherapy,plus targeted therapy may represent an optimal treatment for intestinal SCA,meriting further investigation.

关键词： Jejunal sarcomatoid carcinoma Targeted therapy Immunotherapy Chemotherapy Case report

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First-principles study on the diffusion behavior of Cs and I in Cr coating

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Nuclear Science and Techniques 2024年第6期35卷 177-188页

作者： Shu-Ying Lin xiao-{1. Li Lin-Bing Jiang Xi-Jun Wu Hui-Qin Yin Yu Ma Wen-Guan Liu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of South ChinaHengyang 421001China

Cs and I can migrate through fuel-cladding interfaces and accelerate the cladding corrosion process induced by the fuel-cladding chemical *** coating has emerged as an important candidate for mitigating this chemical *** this study,first-principles calculations were employed to investigate the diffusion behavior of Cs and I in the Cr bulk and grain boundaries to reveal the microscopic interaction mitigation mechanisms at the fuel-cladding *** interaction between these two fission products and the Cr coating were studied systematically,and the Cs and I temperature-dependent diffusion coefficients in Cr were obtained using Bocquet’s oversized solute-atom model and Le Claire’s nine-frequency model,*** results showed that the Cs and I migration barriers were significantly lower than that of Cr,and the Cs and I diffusion coefficients were more than three orders of magnitude larger than the Cr self-diffusion coefficient within the temperature range of Generation-IV fast reactors(below 1.00 K),demonstrating the strong penetration ability of Cs and ***,Cs and I are more likely to diffuse along the grain boundary because of the generally low migration barriers,indicating that the grain boundary serves as a fast diffusion channel for Cs and I.

关键词： First-principles calculation Fuel cladding chemical interaction Cr coating Fission product Diffusion Grain boundary

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Miniature tunable Airy beam optical meta-device

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Opto-Electronic Advances 2024年第2期7卷 5-12页

作者： jing Cheng Zhang Mu Ku Chen Yubin Fan Qinmiao Chen Shufan Chen Jin Yao {1.yuan Liu Shumin {1. Din Ping Tsai Department of Electrical Engineering City University of Hong KongKowloonHong Kong SAR 999077China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong SAR 999077China Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong Kong SAR 999077China Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China

Tunable Airy beams with controllable propagation trajectories have sparked interest in various fields,such as optical manipulation and laser *** research approaches encounter challenges related to insufficient compactness and integration feasibility,or they require enhanced tunability to enable real-time dynamic manipulation of the propagation *** this work,we present a novel method that utilizes a dual metasurface system to surpass these limitations,significantly enhancing the practical potential of the Airy *** approach involves encoding a cubic phase profile and two off-axis Fresnel lens phase profiles across the two *** validity of the proposed strategy has been confirmed through simulation and experimental *** proposed meta-device addresses the existing limitations and lays the foundation for broadening the applicability of Airy beams across diverse domains,encompassing light-sheet microscopy,laser fabrication,optical tweezers,etc.

关键词： metasurface miniature device tunable Airy beam tunable meta-device

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Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease

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World Journal of Hepatology 2024年第5期16卷 703-715页

作者： Li Xu Yu-Hong Fan xiao-{1. Zhang Lan Bai State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Gannan Innovation and Translational Medicine Research InstituteGannan Medical UniversityGanzhou 341000China School of Basic Medical Sciences Wuhan UniversityWuhan 430060China

Non-alcoholic fatty liver disease(NAFLD)poses a significant health challenge in modern societies due to shifts in lifestyle and dietary *** complexity stems from genetic predisposition,environmental influences,and metabolic *** processes govern various cellular functions such as transcription,chromatin structure,and cell *** NAFLD,these epigenetic tendencies,especially the process of histone methylation,are intricately intertwined with fat accumulation in the *** methylation is regulated by different enzymes like methyltransferases and demethylases and influences the expression of genes related to *** early-stage NAFLD is reversible,its progression to severe stages becomes almost ***,early detection and intervention in NAFLD are crucial,and understanding the precise role of histone methylation in the early stages of NAFLD could be vital in halting or potentially reversing the progression of this disease.

关键词： Non-alcoholic fatty liver disease Mechanism Histone methylation Methyltransferases Demethytrasferases Epigenetic modification Adipogenesis

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Calmodulin-like 5 promotes PEDV replication by regulating late-endosome synthesis and innate immune response

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Virologica Sinica 2024年第3期39卷 501-512页

作者： Wen-Jun Tian Xiu-Zhong Zhang jing Wang Jian-Feng Liu Fu-Huang Li {1.-Jia Wang National Key Laboratory of Veterinary Public Health and Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology China Agricultural UniversityBeijing 100193China Beijing General Station of Animal Husbandry Service(South Section) Beijing102218China

The infection caused by porcine epidemic diarrhea virus(PEDV)is associated with high mortality in piglets *** factors involved in the efficient replication of PEDV,however,remain largely *** recent proteomic study in the virus-host interaction network revealed a significant increase in the accumulation of CALML5(EF-hand protein calmodulin-like 5)following PEDV infection.A further study unveiled a biphasic increase of CALML5 in 2 and 1. h after viral *** trends were observed in the intestines of piglets in the early and late stages of the PEDV ***,CALML5 depletion reduced PEDV mRNA and protein levels,leading to a one-order-of-magnitude decrease in virus *** the early stage of PEDV infection,CALML5 affected the endosomal trafficking pathway by regulating the expression of endosomal sorting complex related cellular ***5 depletion also suppressed IFN-βand IL-6 production in the PEDV-infected cells,thereby indicating its involvement in negatively regulating the innate immune *** study reveals the biological function of CALML5 in the virology field and offers new insights into the PEDV-host cell interaction.

关键词： Porcine epidemic diarrhea virus(PEDV) EF-hand protein calmodulin-like 5(CALML5) Late endosomes Innate immune response

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Factor Structure and Longitudinal Invariance of the CES-D across Diverse Residential Backgrounds in Chinese Adolescents

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International Journal of Mental Health Promotion 2024年第4期26卷 261-269页

作者： Yanjing Cao Chenchen Xu Qi Li Shan Lu jing xiao Beijing Key Laboratory of Learning and Cognition and Department of Psychology Capital Normal UniversityBeijing100048China Center for Child Development Capital Normal UniversityBeijing100048China

Background:Valid and reliable measures of depressive symptoms are crucial for understanding risk factors,outcomes,and interventions across rural and urban *** this need,the longitudinal invariance of these measures over time remains *** research explores the structural components of the Center for Epidemiological Studies Depression Scale(CES-D)and examines its consistency across various living environments and temporal stability in a cohort of Chinese ***:In the initial phase,1.042 adolescents furnished demographic details and undertook the CES-D *** a three-month interval,967 of these participants repeated the CES-D *** study employed Confirmatory factor analysis(CFA)to scrutinize the scale’s structural *** investigated factorial invariance by conducting a twopronged CFA:one comparing urban *** backgrounds,and another contrasting the results from the initial assessment with those from the ***:The CES-D demonstrated adequate reliability in both rural and urban high school student *** preliminary four-factor model applied to the CES-D demonstrated a good fit with the collected *** tests,including multigroup analyses comparing rural and urban samples and longitudinal assessments,confirmed the scale’s ***:The results suggest that the CES-D serves as a reliable instrument for evaluating depressive symptoms among Chinese *** applicability is consistent across different living environments and remains stable over time.

关键词： Depression factor structure measurement invariance Chinese adolescent longitudinal invariance

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Constructing inter-diffusive PtCuNi/WO_(3)interface to enhance the catalytic activity and stability in oxygen reduction

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Tungsten 2024年第2期6卷 293-303页

作者： Hao-Zhe Xu Dong Li Ying Chen Pin Fang xiao-Xing Ke Olga Demidenko Yu-{1. Li Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China Scientifi c-Practical Materials Research Centre National Academy of Sciences of Belarus220072 MinskBelarus

Platinum-group-metal-based alloy nanocrystals have been considered as the most effi cient catalysts for oxygen reduction reaction(ORR).However,the poor stability issues limit their further deployment in *** oxide(WO_(3))has received attention due to its intrinsic electrochemical stability and proton absorption/desorption *** this work,we prepared PtCuNi/WO_(3)/C hybrid catalyst with inter-diff usive alloy/WO_(3)interface on *** catalyst exhibits enhanced activity and stability associated with the WO_(3)*** characterization results suggest that the increased activity originates from the complementary proton supply of non-stoichiometric H_(x)WO_(3).Moreover,WO_(3)prevents the particle from dissolution and detachment under vigorous electrochemical *** enhanced stability originates from the electronic interaction established between Pt and *** work provides new strategies to design high-performance ORR catalysts by taking the merits of WO_(3)。

关键词： Tungsten oxide PtCuNi Interface Electronic interaction

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Literature Review of Driving Fatigue Research based on Bibliometric Analysis

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Fengxiang Guo Yiwen Zhou xiao'an Wang {1. Cai Faculty of Transportation Engineering， Kunming University of Science and Technology Yunnan Transportation Science Research Institute Co.， Ltd.

Driving for a long time can lead to fatigue， which can affect information processing and decision-making， potentially threatening driving safety. By exploring the generation and variation patterns of driving fatigue and clarifying the application status of its detection and warning technology， traffic safety can be improved. In order to understand the research progress of driving fatigue， based on the Web of Science core database， this paper obtained 21.7 English literature published from 1.98 to 2023 (as of May 1.， 2023)， covering a total of 5963 authors and 601. keywords， and the bibliometric tool VOSviewer and R-Bibliometrix are used to analyze the literatures. Firstly， the literature statistical analysis is carried out from annual distribution， country distribution， source journals， and core authors. Secondly， the research hotspots and trends are analyzed from keywords co-occurrence， high-impact literature， theme evolution， and development trends. Finally， the development trend of driving fatigue research is discussed. The result shows that the hotspots in the field of driving fatigue include driving fatigue detection， fatigue driving risk and fatigue research of professional drivers， driver alertness and coping strategies for driver fatigue， and driver fatigue under automatic driving. And the improvement of the accuracy and reliability of driving fatigue detection will be the difficult point to break through in the future. It is necessary to build a multi-disciplinary and meticulously quantified driving fatigue and its risk assessment system， and strengthen the control of fatigue risks. Research on intervention measures and education training for professional drivers needs to be deepened， while exploring the acceptance and compliance of intervention measures. Moreover， the evolution law and prevention strategies of driver fatigue under automatic conditions should be the focus of future research.

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