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Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： Hang Shu xiao-Yu Chen jie Zhao Pin Li Zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

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Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-Ling Liao xiao-Li Pu Zhi-Yi Zheng jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

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一种常温非清洗除锈剂的应用研究

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中国涂料 2016年第11期31卷 62-65页

作者：刘丽芸赵晓栋潘杰海洋化工研究院有限公司海洋涂料国家重点实验室山东青岛266071 浙江海洋学院浙江舟山316000

对一种常温施工、不需清洗的化学表面除锈产品进行了实验室研究。通过盐雾试验、附着力等研究了几种常用底漆与该除锈剂的相容性,同时研究了该除锈剂的涂刷方式对涂层附着力的影响。利用SEM、X-ray衍射等对铁锈转化后的表面状态和物相... 详细信息

对一种常温施工、不需清洗的化学表面除锈产品进行了实验室研究。通过盐雾试验、附着力等研究了几种常用底漆与该除锈剂的相容性,同时研究了该除锈剂的涂刷方式对涂层附着力的影响。利用SEM、X-ray衍射等对铁锈转化后的表面状态和物相成分进行了表征。

关键词：铁锈表面处理盐雾试验附着力

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai xiao-Yan Bao Lin-jie Wu Ya-Xin Qin Xin Tan xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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Isolation of a cellulase-producing bacterium,cloning and expression of its novel β-glucosidase gene

Isolation of a cellulase-producing bacterium,cloning and exp...

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重庆微生物学会第九届会员代表大会暨学术年会

作者： Ma Zhengang~1 Tang Jing~1 Lan Xiqian~1 xiao jie~1 pan Guoqing~1 Zhou Zeyang~(1,2*) (The key Sericultural Laboratory of Agricultural Ministry.Southwest University.Chongqing 400716,China) (College of Bioscience of Chongqing Normal University.Chongqing 40047,China)

[Objective]In order to get a cellulase-high-yielding bacterium,and try to obtain some novel cellulase genes.[Methods]CMCNa plate screening method was used to screen cellulose-producing bacteria strains,and one obtained strain was identified according to its 16S rDNA sequence,physiological and biochemical ***,a gene encoding a novel cellulolytic enzyme was cloned from this strain, and its sequence characters were ***,the heterologous expression of this gene was tested in a prokaryotic expression system.[Results]A facultative anaerobic strain which produced cellulase was obtained by the CMCNa plate *** strain was identified as Klebsiella sp..By a shotgun cloning method and with Escherichia coli as the host cell,we isolated a novelβ-glucosidase gene,nglu02,from the *** nglu02 was then successfully expressed in transformant *** strain BL21,and the recombinant enzyme was partially characterized.β-glucosidase activity could be detected in the supernatant of the transformant ***’s worth noting that the recombinant enzyme had certain alkali resistance and could keep its activity with the exist of Cu,Fe,EDTA and urea.[Conclusion]We successfully cloned a novelβ-glucosidase gene,nglu02 from the cellulase-producing *** also expressed the gene in prokaryotic expression system and testified that the produced protein was *** study offered some useful information for the endeavor to understand the molecular structure and mechanism of cellulolytic enzymes.

关键词： Cellulase Novelβ-Glucosidase Screen Identification Activity

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu xiao-Xuan Niu Wen-Chang Jia Jing Wen Xue-Lin Cheng Yan Han Ming-Hui Peng Jing Zhou Yao Liu Sun-Fang Jiang xiao-pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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Research on cubic polynomial acceleration and deceleration control model for high speed NC machining

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第3期9卷 358-365页

作者： Hong-bin LENG Yi-jie WU xiao-hong pan Institute of Modern Manufacture Engineering Zhejiang University Hangzhou 310027 China

To satisfy the need of high speed NC (numerical control) machining, an acceleration and deceleration (acc/dec) control model is proposed, and the speed curve is also constructed by the cubic polynomial. The proposed control model provides continuity of acceleration, which avoids the intense vibration in high speed NC machining. Based on the discrete characteristic of the data sampling interpolation, the acc/dec control discrete mathematical model is also set up and the discrete expression of the theoretical deceleration length is obtained furthermore. Aiming at the question of hardly predetermining the deceleration point in acc/dec control before interpolation, the adaptive acc/dec control algorithm is deduced from the expressions of the theoretical deceleration length. The experimental result proves that the acc/dec control model has the characteristic of easy implementation, stable movement and low impact. The model has been applied in multi-axes high speed micro fabrication machining successfully.

关键词： High speed NC machining Acceleration and deceleration (acc/dec) control model Cubic speed curve Discrete mathematical model Adaptive acceleration and deceleration control algorithm

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Understanding the discrepancy between the quality and yield in the synthesis of carbon nanotubes

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Nano Research 2015年第1期8卷 296-302页

作者： xiao Zhang pan Li Hongbo Zhang jie Liu Department of Chemistry Duke University Durham North Carolina 27708 United States

High-quality carbon nanotubes （CNTs） are promising materials in many applications. However, current chemical vapor deposition （CVD） methods for CNT synthesis suffer from the discrepancy between the quality and yield of CNTs： Low-quality CNTs can be synthesized with high yield, while high-quality CNTs can only be synthesized with low yield. Here a CVD method has been designed to synthesize both high-quality and low-quality CNTs using the same combination of catalyst and precursor. As a result, we were able to understand the reasons for the low yield in high-quality CNT synthesis and a method was derived to improve their yield. This understanding is an important step towards high- yield synthesis of high-quality CNTs.

关键词： carbon nanotubes chemical vapor deposition high quality high yield catalyst lifetime

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Controlling multiple optomechanically induced transparency in the distant cavity-optomechanical system

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Chinese Physics B 2021年第3期30卷 314-319页

作者： Rui-jie xiao Gui-Xia pan xiao-Ming Xiu College of Physical Science and Technology Bohai UniversityJinzhou 121013China School of Science Anhui University of Science and TechnologyHuainan 232001China

We theoretically investigate a two-cavity optomechanical system in which each optical cavity couples to a mechanical resonator via radiation pressure force,and the two optical cavities couple to each other via a distant *** study shows that the multiple optomechanically induced transparency can be observed from the output field at the probe *** number and width of the transparent windows can be tuned by the classical driving power *** also analyze the distance of the two outermost transparency windows,which shows a linear relation with the parameters Pl andλ.Our approach is feasible for controlling multipartite induced transparency,which represents a valuable step towards quantum networks with photonic and phononic circuits.

关键词： optomechanical system optomechanically induced transparency optical mode

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Spin polarization and production rate studies of surface muons in a novel solenoid capture system based on CSNS

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Nuclear Science and Techniques 2017年第8期28卷 61-68页

作者： Ran xiao Yan-Fen Liu xiao-jie Ni Zi-Wen pan Bang-Jiao Ye State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China Institute of High Energy Physics Chinese Academy ofSciences Beijing 100049 China

A novel surface muon capture system with a large acceptance was proposed based on the China spallation neutron source(CSNS).This system was designed using a superconducting solenoid where a long graphite target was put inside ***,the spin polarization evolution was studied in a constant uniform magnetic *** the magnetic field can interact with the spin of the surface muon,both the spin polarization and production rate of the surface muons collected by the new capture system were calculated by the *** results showed that the surface muons could still keep a high spin polarization([90%)with different magnetic fields(0–10 T),and the larger magnetic field is,the more surface muons can be ***,the proton phase space,Courant–Snyder parameters,and intensities of surface muons of different beam fractions were given with magnetic fields of 0 and *** solenoid capture system can focus proton and surface muon beams and collect p?and l?*** can also provide an intense energetic positron source.

关键词：自旋极化率采集系统 μ介子表面电磁生产均匀磁场自旋相互作用

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