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World Journal of Diabetes 2024年第5期15卷 945-957页

作者： Tao Kang xiao Qin yan Chen Qian yang Department of Neurology Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Diabetic peripheral neuropathy(DPN)is a debilitating complication of diabetes mellitus with limited available treatment *** Salviae,a traditional Chinese herb,has shown promise in treating DPN,but its therapeutic mech-anisms have not been systematically *** Radix Salviae(Danshen in pinin),a traditional Chinese medicine(TCM),is widely used to treat DPN in ***,the mechanism through which Radix Salviae treats DPN remains ***,we aimed to explore the mechanism of action of Radix Salviae against DPN using network *** The active ingredients and target genes of Radix Salviae were screened using the TCM pharmacology database and analysis *** genes associated with DPN were obtained from the Gene Cards and OMIM databases,a drug-com-position-target-disease network was constructed,and a protein–protein inter-action network was subsequently constructed to screen the main *** Ontology(GO)functional annotation and pathway enrichment analysis were performed via the Kyoto Encyclopedia of Genes and Genomes(KEGG)using *** A total of 56 effective components,108 targets and 4581 DPN-related target genes of Radix Salviae were *** with Radix Salviae for DPN mainly involved 81 target *** top 30 major targets were selected for enrichment analysis of GO and KEGG *** These results suggested that Radix Salviae could treat DPN by regulating the AGE-RAGE signaling pathway and the PI3K-Akt signaling ***,Danshen may affect DPN by regulating inflammation and apoptosis.

关键词： Diabetic peripheral neuropathy Radix Salviae Network pharmacology Systematic investigation

Quantum squeezing induced nonreciprocal phonon laser

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 20-30页

作者： Tian-Xiang Lu yan Wang Keyu Xia Xing xiao Le-Man Kuang Hui Jing College of Physics and Electronic Information Gannan Normal UniversityGanzhou 341000China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China College of Engineering and Applied Sciences National Laboratory of Solid State Microstructuresand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China

Phonon lasers or coherent amplifications of mechanical oscillations are powerful tools for fundamental studies on coherent acoustics and hold potential for diverse applications,ranging from ultrasensitive force sensing to phononic information ***,we propose the use of an optomechanical resonator coupled to a nonlinear optical resonator for directional phonon *** find that by pumping the nonlinear optical resonator,directional optical squeezing can occur along the pump *** a result,we can achieve the directional mechanical gain using directional optical squeezing,thereby leading to nonreciprocal phonon lasing with a well-tunable directional power *** work proposes a feasible way to build nonreciprocal phonon lasers with various nonlinear optical media,which are important for a wide range of applications,such as directional acoustic amplifiers,invisible sound sensing or imaging,and one-way phononic networks.

关键词： nonreciprocal phonon laser directional quantum squeezing optomechanics

Rotating Massive Strangeon Stars and X-Ray Plateau of Short GRBs

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Research in Astronomy and Astrophysics 2024年第3期24卷 47-57页

作者： Xi-yan yang xiao-Yu Lai Wei-Wei Tan Ren-Xin Xu School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhou 434023China Research Center for Astronomy Hubei University of EducationWuhan 4300205China Key Laboratory of Quark and Lepton Physics Central China Normal UniversityMinistry of EducationWuhan 430079China School of Physics Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

Strangeon stars,which are proposed to describe the nature of pulsar-like compact stars,have passed various observational *** maximum mass of a non-rotating strangeon star could be high,which implies that the remnants of binary strangeon star mergers could even be long-lived massive strangeon *** study rigidly rotating strangeon stars in the slowly rotating approximation,using the Lennard-Jones model for the equation of *** can significantly increase the maximum mass of strangeon stars with unchanged baryon numbers,enlarging the mass-range of long-lived strangeon *** spin-down after merger,the decrease of radius of the remnant will lead to the release of gravitational *** into account the efficiency of converting the gravitational energy luminosity to the observed X-ray luminosity,we find that the gravitational energy could provide an alternative energy source for the plateau emission of X-ray *** fitting results of X-ray plateau emission of some short gamma-ray bursts suggest that the magnetic dipole field strength of the remnants can be much smaller than that of expected when the plateau emission is powered only by spin-down luminosity of magnetars.

关键词： dense matter-(stars) pulsars general-(stars) gamma-ray burst general

Clinical efficacy and safety of erlotinib combined with chemotherapy in the treatment of advanced pancreatic cancer:A meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 921-931页

作者： xiao-yan Liu Hong-Nian Pan Yue Yu Cheeloo College of Medicine Shandong UniversityJinan 250012Shandong ProvinceChina Department of Gastroenterology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The Lu’an Hospital Affiliated to Anhui Medical UniversityThe Lu’an People's HospitalLu’an 237000Anhui ProvinceChina

BACKGROUND Advanced pancreatic cancer is resistant to chemotherapeutic drugs,resulting in limited treatment efficacy and poor *** administration of the chemotherapeutic gemcitabine and erlotinib is considered a potential first-line treatment for advanced pancreatic ***,their comparative benefits and potential risks remain *** To assess the clinical efficacy and safety of erlotinib combined with other chemotherapy regimens for the treatment of advanced pancreatic *** Literature on the clinical efficacy and safety of erlotinib combined with chemotherapy for advanced pancreatic cancer was retrieved through an online *** retrieved literature was subjected to a methodological qualitative assessment and was analyzed using the RevMan 5.3 *** randomized controlled trials involving 2444 patients with advanced pancreatic cancer were included in the *** Compared with chemotherapeutic treatment,erlotinib combined with chemotherapy significantly prolonged the progression-free survival time of pancreatic cancer patients[hazard ratio(HR)=0.78,95%CI:0.66-0.92,P=0.003].Meanwhile,the overall survival(HR=0.99,95%CI:0.72-1.37,and P=0.95)and disease control rate(OR=0.93,95%CI:0.45-0.91,P=0.84)were not significantly *** terms of safety,the erlotinib and chemotherapy combination was associated with a significantly higher risk of diarrhea(OR=3.59,95%CI:1.63-7.90,P<0.05)and rash(OR=3.63,95%CI:1.64-8.01,P<0.05)compared with single-agent ***,the risk of vomiting(OR=1.27,95%CI:0.62-2.59,P=0.51),regurgitation/anorexia(OR=1.61,95%CI:0.25-10.31,P=0.62),and infection(OR=0.72,95%CI:0.28-1.87,P=0.50)were not significant in either *** Compared with a single chemotherapeutic modality,erlotinib combined with gemcitabine can prolong progression-free survival in pancreatic cancer,but does not improve survival benefit or disease control rate,and can increase the risk of diarrhea and rash.

关键词： Erlotinib Chemotherapy Advanced pancreatic cancer Efficacy Safety Meta-analysis

Cadherin-18 loss in prospermatogonia and spermatogonial stem cells enhances cell adhesion through a compensatory mechanism

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Zoological Research 2024年第5期45卷 1048-1060页

作者： xiao-xiao Li Dan-Chen Zhang yan Wang jian Wen Xing-Ju Wang Yu-Lu Cao Ru jiang Jia-Rui Li Yi-Nuo Li He-He Liu Wen-Hai Xie Zheng-Feng Xu Ping Hu Kang Zou Germline Stem Cells and Microenvironment Lab College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China Stem Cell Research and Translation Center Nanjing Agricultural UniversityNanjingJiangsu 210095China School of Life Sciences and Medicine Shandong University of TechnologyZiboShandong 255000China Department of Prenatal Diagnosis Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Extracellular membrane proteins are crucial for mediating cell attachment,recognition,and signal transduction in the testicular microenvironment,particularly germline stem *** 18(CDH18),a type Ⅱ classical cadherin,is primarily expressed in the nervous and reproductive ***,we investigated the expression of CDH18in neonatal porcine prospermatogonia(ProSGs)and murine spermatogonial stem cells(SSCs).Disruption of CDH18 expression did not adversely affect cell morphology,proliferation,self-renewal,or differentiation in cultured porcine ProSGs,but enhanced cell adhesion and prolonged cell *** analysis indicated that the down-regulation of CDH18 in ProSGs significantly up-regulated genes and signaling pathways associated with cell *** further elucidate the function of CDH18 in germ cells,Cdh18 knockout mice were generated,which exhibited normal testicular morphology,histology,*** analysis showed increased expression of genes associated with adhesion,consistent with the observations in porcine *** interaction of CDH18withβ-catenin and JAK2 in both porcine ProSGs and murine SSCs suggested an inhibitory effect on the canonical Wnt and JAK-STAT signaling pathways during CDH18 ***,these findings highlight the crucial role of CDH18 in regulating cell adhesion in porcine ProSGs and mouse *** this regulatory mechanism provides significant insights into the testicular niche.

关键词： Extracellular signal Fertility Quiescency Wnt signaling pathway

Design of artificial biomimetic channels with Na^(+)permeation rate and selectivity potentially outperforming the natural sodium channel

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Nano Research 2024年第9期17卷 8638-8646页

作者： Zhi Zhu yan Zhao Chao Chang Shaojian yan Tingyu Sun Shiyu Gu yangmei Li Dengsong Zhang Chunlei Wang xiao Cheng Zeng School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Physics Peking UniversityBeijing 100871China International Joint Laboratory of Catalytic Chemistry College of SciencesShanghai UniversityShanghai 200444China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Artificial ion channels that enable high-efficiency ion transport have important implications in nanofluidics and biomedical applications such as drug ***,we show a simulation-based chemical design of a biomimetic sodium channel that possesses permeation rate and selectivity potentially higher than those of the state-of-the-art natural vertebrate voltage-gated sodium ***,our theoretical findings have undergone empirical testing,aligning well with the Arrhenius law as derived from a diverse range of experimental *** high-efficiency ion transport is achieved by anchoring the carboxylate functional groups within the channel filter.A key chemical guiding principle underlying the ion channel design is that the free-energy barrier for the Na^(+)passage across the channel should be comparable to typical thermal energy at room *** the implementation of the chemical design,we found that the relatively low free-energy barrier can be attributed to the compensation effect of the carboxylate groups to the partially lost oxygen shell of the ion within the ion channel,as well as to the consonant vibration of the ions inside and outside the *** mechanistic understanding brings new insight,at the molecular level,into the high-efficiency ion transport across the designed membrane *** proof of principle achieved from the simulations will stimulate future experimental confirmation and potential applications of the high-performance artificial channels in nanofluidics and in bioinspired iontronics.

关键词： sodium channels anchoring carboxylate functional groups molecular dynamics simulations low free-energy barrier for ion passage thermal kinetic energy

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han yan-Ting Liu Wei Huang Qi Wang Xin Xiong Ying Zhang jian-Guo Zhao Shi-Hua Li xiao-jiang Li Wei-Li yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

Mechanical properties of multi-scale germanium specimens from space solar cells under electron irradiation

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Chinese Journal of Aeronautics 2024年第1期37卷 173-185页

作者： jian QIU Maliya HEINI Jusha MA Wenjia HAN Xunchun WANG Jun YIN yan SHI Cunfa GAO State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Chemistry and Civil Engineering Shaoguan UniversityShaoguan 512005China Key Laboratory of Functional Materials and Devices for Special Environments of Chinese Academy of Sciences Chinese Academy of SciencesUrumqi 830011China Shanghai Institute of Space Power-Sources Shanghai 200245China

During long-term service in space,Gallium Arsenide(GaAs)solar cells are directly exposed to electron irradiation which usually causes a dramatic decrease in their *** the multilayer structure of solar cells,the germanium(Ge)layer occupies the majority of the thickness as the *** to the intrinsic brittleness of semiconductor material,there exist various defects during the preparation and assembly of solar cells,the influences of which tend to be intensified by the irradiation *** this work,first,Ge specimens for mechanical tests were prepared at scales from microscopic to ***,after different doses of electron irradiation,the mechanical properties of the Ge specimens were *** experimental results demonstrate that electron irradiation has an obvious effect on the mechanical property variation of Ge in diverse *** four-point bending test indicates that the elastic modulus,fracture strength,and maximum displacement of the Ge specimens all increase,and reach the maximum value at the irradiation dose of 1×10^(15)e/cm^(2).The micrometer scale cantilever and nanoindentation tests present similar trends for Ge specimens after *** Force Microscope(AFM)also observed the change in surface ***,a fitting model was established to characterize the relation between modulus change and electron irradiation dose.

关键词： Electron irradiation Germanium Mechanical properties Multi-scale Space solar cells

Solidification crack characteristics and sensitivity of peritectic steel

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Journal of Iron and Steel Research International 2024年第7期31卷 1668-1679页

作者： Ya-qiang Li jian-hua Liu Zi-ming Wang Ying-ying Li yang He xiao-wei Li Department of Automotive Engineering Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Hebei Special Vehicle Modification Technology Innovation Center Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou 213164JiangsuChina

The characteristics and sensitivity of solidification cracks in peritectic steels were investigated using directional solidifi-cation *** cracks were observed in both hypoperitectic steels(12CrlMoV,15CrMo)and hyper-peritectic steel(20CrMo)during solidification at growth velocities of 15,50,and 80 pm/*** the dendritic boundaries,sulphide precipitates were found,promoting crack *** on the statistical analysis of interdendritic cracks in peritectic steels,the area ratio(RA)of interdendritic cracks in a directional solidification structure was proposed to evaluate the crack sensitivity of peritectic ***,the crack sensitivities of peritectic steels(12CrlMoV,15CrMo,and 20CrMo)were tested,evaluated,and compared with the surface crack rates of three types of steels produced from a steel *** results demonstrated that RA was in good agreement with that of the steel plant,and the crack sensitivity of 12CrlMoV steel was the strongest,followed by that of 15CrMo and 20CrMo ***,RA can be used to evaluate the crack sensitivity of peritectic steel.

关键词： Peritectic steel-Directional solidification Growth velocity Dendritic structure Solidification crack Crack sensitivity

The Caching and Pricing Strategy for Information-Centric Networking with Advertisers’Participation

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China Communications 2024年第3期21卷 283-295页

作者： Zheng Quan yan Wenliang Wu Rong Tan xiaobin yang jian Yuan Liu Xu Zhenghuan Laboratory for Future Networks Department of AutomationUniversity of Science and Technology of ChinaHefei 230026China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China Institute of Advanced Technology University of Science and Technology of ChinaHefei 230088China Suzhou Nuclear Power Research Institute Suzhou 215004China National Engineering Laboratory for Public Safety Risk Perception and Control by Big Data(NEL-PSRPC) China Academy of Electronics and Information Technology of CETCBeijing 100041China

As users’access to the network has evolved into the acquisition of mass contents instead of IP addresses,the IP network architecture based on end-to-end communication cannot meet users’***,the Information-Centric Networking(ICN)came into *** a technical point of view,ICN is a promising future network *** and customizing a reasonable pricing mechanism plays a positive role in promoting the deployment of *** current research on ICN pricing mechanism is focused on paid ***,we study an ICN pricing model for free content,which uses game theory based on Nash equilibrium to *** this work,advertisers are considered,and an advertiser model is established to describe the economic interaction between advertisers and ICN *** solution can formulate the best pricing strategy for all ICN entities and maximize the benefits of each *** extensive analysis and numerical results show that the proposed pricing framework is significantly better than existing solutions when it comes to free content.

关键词： advertisers cache free content Information-Centric Networking pricing strategy