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Journal of Iron and Steel Research(International) 2023年第2期30卷 277-292页

作者： Jie Sun Fan Hou Yun-jian Hu Long-jun Wang Hao-yue Jin Wen Peng xiao-jian li Dian-hua Zhang State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

To solve the coupling relationship between the strip automatic gauge control and the looper control in traditional control strategy of tandem hot rolling,a distributed model predictive control(DMPC)strategy for the tandem hot rolling was explored,and a series of simulation experiments were carried out.Firstly,based on the state space analysis method,the multivariable dynamic transition process of hot strip rolling was studied,and the state space model of a gauge-looper integrated system in tandem hot rolling was established.Secondly,DMPC strategy based on neighborhood optimization was proposed,which fully considered the coupling relationship in this integrated system.Finally,a series of experiments simulating disturbances and emergency situations were completed with actual rolling data.The experimental results showed that the proposed DMPC control strategy had better performance compared with the traditional proportional-integral control and centralized model predictive control,which is applicable for the gauge-looper integrated system.

关键词： Tandem hot rolling Gauge Looper integrated system State space model Distributed model predictive control Neighborhood optimization

Lack of evolutionary convergence in multiple primary lung cancer suggests insufficient specificity of personalized therapy

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Journal of Genetics and Genomics 2023年第5期50卷 330-340页

作者： Hua Cheng Ziyan Guo xiaoyu Zhang xiao-Jin Wang Zizhang li Wen-Wen Huo Hong-Cheng Zhong xiao-jian li Xiang-Wen Wu Wen-Hao li Zhuo-Wen Chen Tian-Chi Wu Xiang-Feng Gan Bei-Long Zhong Vassily ALyubetsky Leonid Yu Rusin Junnan Yang Qiyi Zhao Qing-Dong Cao jian-Rong Yang Department of Thoracic Surgery The Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhaiGuangdong 519000China Department of Genetics and Biomedical Informatics Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Program in Cancer Research Zhongshan School of MedicineThe Fifth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Kharkevich Institute for Information Transmission Problems Russian Academy Sciences Moscow 127051Russia Department of Mathematical Logic and Theory of Algorithms Faculty of Mechanics and MathematicsLomonosov Moscow State UniversityMoscow 119991Russia Department of Infectious Diseases Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510630China Guangdong Provincial Key Laboratory of liver Disease Research the Third Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong 510630China Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhouGuangdong 510080China

Multiple primary lung cancer(MPLC)is an increasingly prevalent subtype of lung cancer.According to recent genomic studies,the different lesions of a single MPLC patient exhibit functional similarities that may reflect evolutionary convergence.We perform whole-exome sequencing for a unique cohort of MPLC patients with multiple samples from each lesion found.Using our own and other relevant public data,evolutionary tree reconstruction reveals that cancer driver gene mutations occurred at the early trunk,indicating evolutionary contingency rather than adaptive convergence.Additionally,tumors from the same MPLC patient are as genetically diverse as those from different patients,while within-tumor genetic heterogeneity is significantly lower.Furthermore,the aberrant molecular functions enriched in mutated genes for a sample show a strong overlap with other samples from the same tumor,but not with samples from other tumors or other patients.Overall,there is no evidence of adaptive convergence during the evolution of MPLC.Most importantly,the similar between-tumor diversity and between-patient diversity suggest that personalized therapies may not adequately account for the genetic diversity among different tumors in an MPLC patient.To fully exploit the strategic value of precision medicine,targeted therapies should be designed and delivered on a per-lesion basis.

关键词： Multiple primary lung cancer Cancer evolution Convergent evolution

The Survival Analysis of a Non-autonomous N-dimensional Volterra Mutualistic System in a Polluted Environment

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 133-140页

作者： xiao-jian li Ke Wang Department of Mathematics Northeast Normal University Changchun 130024 China Department of Mathematics Harbin Institute of Technology Weihai 264209 China

In this paper,we extend the autonomous n-Dimensional Volterra Mutualistic System to a non-autonomous system.The condition of persistence and extinction is obtained for each population,and thethreshold is established f... 详细信息

关键词：污染持久性消灭比拟理论阈值存在分析数学分析

Fault detection for sector-bounded non-linear systems with servo inputs and sensor stuck faults

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Journal of Control and Decision 2019年第3期6卷 147-165页

作者： Ying Gu xiao-jian li School of Science Dalian Jiaotong UniversityDalianChina College of Information Science and Engineering Northeastern UniversityShenyangChina State Key Laboratory of Synthetical Automation of Process Industries Northeastern UniversityShenyangChina

This paper addresses the fault detection(FD)problem for discretetime sector-bounded non-linear systems with finite-frequency servo inputs.The non-linear systems are firstly modelled as multi-models.The main contributions are that a novel FD filter which combines the finite-frequency H∞and H−indices is designed.Different from the existing methods,the proposed FD scheme guarantees that the generated residuals are robust against the servo inputs in fault-free case and sensitive to them in faulty cases.Thus,the small sensor stuck faults including outagefaults can be detected.For this class of systems,the existing finite-frequency FD filter design methods are invalid.A new lemma is developed to characterise the system performances in finite-frequency domain.In addition,sufficient conditions for the existence of such a FD filter are derived by introducing slack variable and linear matrix inequalities techniques.Finally,an example is presented to demonstrate the method and its effectiveness.

关键词： Fault detection servo inputs sensor stuck faults sector-bounded nonlinearity finite-frequency domain

Quantitatively Evaluating the Erosion and Preservation of Supergene Oxide Zones:Evidence from the Yulong Porphyry Cu Deposit,Eastern Tibetan Plateau

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Journal of Earth Science 2024年第1期35卷 280-282页

作者： xiao-Dong Deng jian-Wei li State Key Laboratory of Geological Processes and Mineral Resources and School of Earth ResourcesChina University of GeosciencesWuhan 430074China

INTRODUCTION.Weathering and erosion of sulfide ore deposits are important for understanding the post-mineralization processes that have significant effects on the preservation of primary orebodies(Velasco et al.,2013;Braxton et al.,2009;Brimhall et al.,1985).Supergene oxide zones are often developed in sulfide ore deposits,and are mainly composed of iron oxides and hydroxides zones in weathering profile(Andrew,1984;Thornber et al.,1981).

关键词： Eastern Tibetan weathering

In silico approach to explore the mechanism of bioactive ingredients from Belamcandae rhizoma against COVID-19

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Asian Toxicology Tesearch 2020年第4期2卷 130-142页

作者： Zi-Wei Hu Xun Song Jin-Hong lin xiao-jian li Zhen-Dan He School of Basic Medicine Health Science CenterShenzhen UniversityShenzhen 518000China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518000China.

Background:To date,the epidemic of COVID-19,which result from newly discovered virus named SARS-CoV-2,has spawned a heavy economic loss and continued to claim tens of thousands of lives.It’s urgent now that develop an ideal agent for suppressing the lifecycle of coronavirus while alleviate collateral severe inflammatory response.Belamcandae rhizoma,an herb which documented in various Chinese traditional medicine prescription,was reported to have effects of antiviral,anti-inflammatory and antipyretic.However,the relationship and related molecular mechanism between Belamcandae rhizoma and coronavirus are still unknown.Methods:Here,we achieved 14 kernel compounds from Belamcandae rhizoma and 261 validated“novel coronavirus pneumonia”correlative gene targets using a series of databases.Results:Subsequently,the pharmacology network and protein-protein interaction cluster,which constructed by the 20 overlapped genes targets between Belamcandae rhizoma and COVID-19,demonstrated that IL10,PTGS2,IL6,MAPK1,MAPK14 and CASP3 were as key targets in the treatment.The potential molecular mechanism involved IL-17,JAK-STAT and MAPK signaling pathways gained from gene enrichment analysis attract our attention.Molecular docking with 3CLpro of SARS-CoV-2 further suggested that luteolin and dinatin were the most bioactive compounds of Belamcandae rhizoma,among which luteolin connected with the maximum number of gene targets in above pharmacology network.Conclusion:Taken together,these findings provide deep insight into the putative therapeutic targets and underlying mechanism for COVID-19 treatment.

关键词： Belamcandae rhizoma COVID-19 Network pharmacology Mechanism Molecular docking

Development and validation of a prediction model for early screening of people at high risk for colorectal cancer

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World Journal of Gastroenterology 2024年第5期30卷 450-461页

作者： ling-li Xu Yi lin li-Yuan Han Yue Wang jian-Jiong li xiao-Yu Dai Department of General Surgery Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina Center for Health Economics Faculty of Humanities and Social SciencesUniversity of NottinghamNingbo 315100Zhejiang ProvinceChina Department of Global Health Ningbo Institute of Life and Health IndustryUniversity of Chinese Academy of SciencesNingbo 315000Zhejiang ProvinceChina School of Public Health Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a serious threat worldwide.Although early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not optimistic.In China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been conducted.Therefore,it is necessary to develop a simple and efficient early screening model for CRC.AIM To develop and validate an early-screening nomogram model to identify individuals at high risk of CRC.METHODS Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively analyzed.The cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect data.Of 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were not.The participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve analysis.Finally,the model was validated internally using a bootstrap resampling technique.RESULTS Seven variables,including demographic,lifestyle,and family history information,were examined.Multifactorial logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,Plifestyle(OR:0.45,95%CI:0.42-0.48,Plifestyle was a protective factor,whereas family history was the most significant risk factor.The area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training set ROC curve.The calibration curve demonstrated

关键词： Colorectal cancer Early screening model High-risk population Nomogram model Questionnaire survey Dietary habit living habit

Analysis of risk factors leading to anxiety and depression in patients with prostate cancer after castration and the construction of a risk prediction model

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World Journal of Psychiatry 2024年第2期14卷 255-265页

作者： Rui-xiao li Xue-lian li Guo-Jun Wu Yong-Hua Lei xiao-Shun li Bo li jian-Xin Ni Urology Hospital Xi'an People's Hospital(Xi'an Fourth Hospital)Xi'an 710199Shaanxi ProvinceChina Department of Surgery Xi'an Hospital of Traditional Chinese MedicineXi'an 710199Shaanxi ProvinceChina

BACKGROUND Cancer patients often suffer from severe stress reactions psychologically,such as anxiety and depression.Prostate cancer(PC)is one of the common cancer types,with most patients diagnosed at advanced stages that cannot be treated by radical surgery and which are accompanied by complications such as bodily pain and bone metastasis.Therefore,attention should be given to the mental health status of PC patients as well as physical adverse events in the course of clinical treatment.AIM To analyze the risk factors leading to anxiety and depression in PC patients after castration and build a risk prediction model.METHODS A retrospective analysis was performed on the data of 120 PC cases treated in Xi'an People's Hospital between January 2019 and January 2022.The patient cohort was divided into a training group(n=84)and a validation group(n=36)at a ratio of 7:3.The patients’anxiety symptoms and depression levels were assessed 2 wk after surgery with the Self-Rating Anxiety Scale(SAS)and the Selfrating Depression Scale(SDS),respectively.Logistic regression was used to analyze the risk factors affecting negative mood,and a risk prediction model was constructed.RESULTS In the training group,35 patients and 37 patients had an SAS score and an SDS score greater than or equal to 50,respectively.Based on the scores,we further subclassified patients into two groups:a bad mood group(n=35)and an emotional stability group(n=49).Multivariate logistic regression analysis showed that marital status,castration scheme,and postoperative Visual Analogue Scale(VAS)score were independent risk factors affecting a patient's bad mood(Plidation groups,patients with adverse emotions exhibited significantly higher risk scores than emotionally stable patients(Plidation group,the AUC,specificity,and sensitivity were 0

关键词： Prostate cancer Castration Anxiety and depression Risk factors Risk prediction model

Neuronomodulation of Excitable Neurons

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Neuroscience Bulletin 2024年第1期40卷 103-112页

作者： Yizhang Chen lin xiao jian Qiu Institute of Neuroscience Second Military Medical UniversityShanghai 200433China Institute for Brain Research and Rehabilitation Key Laboratory of BrainCognition and Education Sciences of Ministry of EducationSouth China Normal UniversityGuangzhou 510631China Department of Chemical Physiology and Biochemistry Oregon Health and Science UniversityPortlandOR 97239USA

Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in response to chemical substances,from spillover neuro-transmitters to paracrine or endocrine hormones circulating in the blood.Neuronomodulation can be direct or indirect,depending on the transduction pathways from the ligand binding site to the ion pore,either on the same molecule,i.***.the ion channel,or through an intermediate step on different molecules.The major players in direct neurono-modulation are ligand-gated or voltage-gated ion channels.The key process of direct neuronomodulation is the binding and chemoactivation of ligand-gated or voltage-gated ion channels,either orthosterically or allosterically,by various ligands.Indirect neuronomodulation involves metabotropic receptor-mediated slow potentials,where steroid hormones,cytokines,and chemokines can implement these actions.Elucidating neuronomodulation is of great significance for understanding the physiological mechanisms of brain function,and the occurrence and treatment of diseases.

关键词： Neuron Membrane potential Excitability Chemoactivation Neuronomodulation

Ni-Catalyzed Enantioselective Difunctionalization of Alkynes to Azepine Derivatives Bearing a Quaternary Center and an Unprotected Imine

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Chinese Journal of Chemistry 2024年第8期42卷 873-878页

作者： jian Long Zhiwu Lu xiao-lin li Peng Xue Wen-Bo liu Engineering Research Center of Organosilicon Compounds&Materials(Ministry of Education)and College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,The azepine ring is a prominent structural scaffold in biologically significant molecules. In this study, we present a Ni(II)-catalyzed asymmetric difunctionalization of alkynes, involving intermolecular regioselective arylation and intramolecular nitrile addition, enabling the synthesis of enantioenriched azepine derivatives. This reaction simultaneously installs an all-carbon quaternary stereocenter and introduces an unprotected imine functionality, showing great promise for subsequent transformations. The reaction exhibits good tolerance toward various functional groups, resulting in high yields and enantioselectivities. The synthetic utility of this methodology is further demonstrated through gram-scale synthesis and product derivatization. This research offers an efficient approach to the synthesis of seven-membered nitrogen heterocycles.

关键词： Nickel Asymmetric catalysis N-Heterocycles Alkyne functionalization Quaternary centers