检索结果-南通市图书馆

Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway

引用

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1018-1027页

作者： Yu-Sheng Zhu Si-Rui zhou hui-hui Zhang Tong Wang xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effect of epidermal growth factor receptor(EGFR)inhibition by erlotinib and EGFR siRNA on epidermal growth factor(EGF)-induced activation of retinal pigment epithelium(RPE)cells.METHODS:Human RPE cell line(ARPE-19 cells)was activated by 100 ng/mL EGF.Erlotinib and EGFR siRNA were used to intervene EGF treatment.Cellular viability,proliferation,and migration were detected by methyl thiazolyl tetrazolium(MTT)assay,bromodeoxyuridine(BrdU)staining assay and wound healing assay,respectively.EGFR/protein kinase B(AKT)pathway proteins and N-cadherin,α-smooth muscle actin(α-SMA),and vimentin were tested by Western blot assay.EGFR was also determined by immunofluorescence staining.RESULTS:EGF treatment for 24h induced a significant increase of ARPE-19 cells’viability,proliferation and migration,phosphorylation of EGFR/AKT proteins,and decreased total EGFR expression.Erlotinib suppressed ARPE-19 cells’viability,proliferation and migration through down regulating total EGFR and AKT protein expressions.Erlotinib also inhibited EGF-induced an increase of proliferative and migrative ability in ARPE-19 cells and clearly suppressed EGF-induced EGFR/AKT proteins phosphorylation and decreased expression of N-cadherin,α-SMA,and vimentin proteins.Similarly,EGFR inhibition by EGFR siRNA significantly affected EGF-induced an increase of cell proliferation,viability,and migration,phosphorylation of EGFR/AKT proteins,and up-regulation of N-cadherin,α-SMA,and vimentin proteins.CONCLUSION:Erlotinib and EGFR-knockdown suppress EGF-induced cell viability,proliferation,and migration via EGFR/AKT pathway in RPE cells.EGFR inhibition may be a possible therapeutic approach for proliferative vitreoretinopathy(PVR).

关键词： erlotinib epidermal growth factor receptor protein kinase B epithelial-mesenchymal transition retinal pigment epithelium cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Risk factors for cognitive impairment in patients with chronic kidney disease

引用

World Journal of Psychiatry 2024年第2期14卷 308-314页

作者： xiao-hui Wang Yong He Huan zhou Ting xiao Ran Du Xin Zhang Department of Nephrology The Fifth Hospital of WuhanWuhan 430050Hubei ProvinceChina Department of Nephrology The Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina

BACKGROUND Chronic kidney disease(CKD)patients have been found to be at risk of concurrent cognitive dysfunction in previous studies,which has now become an important public health issue of widespread concern.AIM To investigate the risk factors for concurrent cognitive dysfunction in patients with CKD.METHODS This is a prospective cohort study conducted among patients with CKD between October 2021 and March 2023.A questionnaire was formulated by literature review and expert consultation and included questions about age,sex,education level,per capita monthly household income,marital status,living condition,payment method,and hypertension.RESULTS Logistic regression analysis showed that patients aged 60-79 years[odds ratio(OR)=1.561,P=0.015]and≥80 years(OR=1.760,P=0.013),participants with middle to high school education(OR=0.820,P=0.027),divorced or widowed individuals(OR=1.37,P=0.032),self-funded patients(OR=2.368,P=0.008),and patients with hypertension(OR=2.011,P=0.041)had a higher risk of cognitive impairment.The risk of cognitive impairment was lower for those with a college degree(OR=0.435,P=0.034)and married individuals.CONCLUSION The risk factors affecting cognitive dysfunction are age,60-79 years and≥80 years;education,primary school education or less;marital status,divorced or widowed;payment method,selffunded;hypertension;and CKD.

关键词： Cognitive impairment Cognitive dysfunction Chronic kidney disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Embracing the age of artificial intelligence:paradigm shifts,opportunities,and challenges in the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

引用

Science China(Life Sciences) 2024年第6期67卷 1302-1304页

作者： Zhuo-Yu An xiao-hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China

Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an important medical development in treating hematological disorders.However,the risk of acute graft-versus-host disease(a GVHD)severely limits its use.a GVHD is a severe and potentially fatal complication of alloHSCT that causes inflammation and tissue damage.It often targets the skin.

关键词： hematopoietic graft artificial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

引用

Rare Metals 2024年第1期43卷 175-185页

作者： Jin-xiao Zheng Zi-An zhou Tiao Feng hui Li Cheng-Hua Sun NüWang Yang Tian Yong Zhao Shu-Yun zhou Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Bioinspired Smart Interfacial Science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering Physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaissance/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorption and decomposition, and strict requirements for seamless packaging and waterproofing.Here, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic Scintillators Underwater X-ray imaging Underwater nondestructive testing technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Natural variables separate the endemic areas of Clonorchis sinensis and Opisthorchis viverrini along a continuous, straight zone in Southeast Asia

引用

贫困所致传染病(英文) 2024年第2期13卷 1-13页

作者： Zheng Jin-Xin Zhu hui-hui Xia Shang Qian Men-Bao Nguyen Hung Manh Sripa Banchob Sayasone Somphou Khieu Virak Bergquist Robert zhou xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University The University of Edinburgh Shanghai China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasites and Vectors Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases Shanghai China Institute of Ecology and Biological Resources Graduate University of Science and Technology Vietnam Academy of Science and Technology Hoang Quoc Viet Street Hanoi Vietnam WHO Collaborating Centre for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Disease) Tropical Disease Research Laboratory Department of Tropical Medicine Faculty of Medicine Khon Kaen University Mittraparb Road Khon Kaen Thailand Lao Tropical and Public Health Institute Ministry of Health Vientiane Lao PDR National Centre for Parasitology Entomology and Malaria Control Ministry of Health Phnom Penh Cambodia Ingerod Brastad Sweden (formerly at the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases) World Health Organization Geneva Switzerland

Background Clonorchiasis and opisthorchiasis, caused by the liver flukesClonorchis sinensis andOpisthorchis viverrini respectively, represent significant neglected tropical diseases (NTDs) in Asia. The co-existence of these pathogens in overlapping regions complicates effective disease control strategies. This study aimed to clarify the distribution and interaction of these diseases within Southeast Asia.Methods We systematically collated occurrence records of human clonorchiasis (n = 1809) and opisthorchiasis (n = 731) across the Southeast Asia countries. Utilizing species distribution models incorporating environmental and climatic data, coupled machine learning algorithms with boosted regression trees, we predicted and distinguished endemic areas for each fluke species. Machine learning techniques, including geospatial analysis, were employed to delineate the boundaries between these flukes.Results Our analysis revealed that the endemic range ofC. sinensis andO. viverrini in Southeast Asia primarily spans across part of China, Vietnam, Thailand, Laos, and Cambodia. During the period from 2000 to 2018, we identifiedC. sinensis infections in 84 distinct locations, predominantly in southern China (Guangxi Zhuang Autonomous Region) and northern Vietnam. In a stark contrast,O. viverrini was more widely distributed, with infections documented in 721 locations across Thailand, Laos, Cambodia, and Vietnam. Critical environmental determinants were quantitatively analyzed, revealing annual mean temperatures ranging between 14 and 20 °C in clonorchiasis-endemic areas and 24–30 °C in opisthorchiasis regions (P < 0.05). The machine learning model effectively mapped a distinct demarcation zone, demonstrating a clear separation between the endemic areas of these two liver flukes with AUC from 0.9 to1. The study in Vietnam delineates the coexistence and geographical boundaries ofC. sinensis andO. viverrini, revealing distinct endemic zones and a transitional area where both liver fluke species overlap.Conclusions Our findings

关键词： Liver fluke Clonorchiasis Opisthorchiasis Clonorchis sinensis Opisthorchis viverrine Southeast Asia Machine learning Ecological study

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors

引用

Biomedical and Environmental Sciences 2024年第2期37卷 133-145页

作者： LIU xiao CAO Ying LIN xiao Wan GAO Dan Yang MIAO hui hui LI Tian Zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ages.However,the underlying mechanism is yet unknown.Our study aimed to explore the changes in metabolites in three specific brain regions and saliva of older mice with postoperative delirium behavior and to identify potential non-invasive biomarkers.Methods Eighteen-month-old male C57/BL6 mice were randomly assigned to the anesthesia/surgery or control group.Behavioral tests were conducted 24 h before surgery and 6,9,and 24 h after surgery.Complement C3(C3)and S100 calcium-binding protein B protein(S100beta)levels were measured in the hippocampus,and a metabolomics analysis was performed on saliva,hippocampus,cortex,and amygdala samples.Results In total,43,33,38,and 14 differential metabolites were detected in the saliva,hippocampus,cortex,and amygdala,respectively.“Pyruvate”“alpha-linolenic acid”and“2-oleoyl-1-palmitoy-snglycero-3-phosphocholine”are enriched in one common pathway and may be potential non-invasive biomarkers for POD.Common changes were observed in the three brain regions,with the upregulation of 1-methylhistidine and downregulation of D-glutamine.Conclusion Dysfunctions in energy metabolism,oxidative stress,and neurotransmitter dysregulation are implicated in the development of POD.The identification of changes in the level of salivary metabolite biomarkers could aid in the development of noninvasive diagnostic methods for POD.

关键词： Metabolomic Postoperative delirium(POD) Mechanism Biological marker

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Micro defects formation and dynamic response analysis of steel plate of quasi-cracking area subjected to explosive load

引用

Defence Technology（防务技术） 2024年第1期31卷 580-593页

作者： Zheng-qing zhou Ze-chen Du xiao Wang hui-ling Jiang Qiang zhou Yu-long Zhang Yu-zhe Liu Pei-ze Zhang Research Institute of Macro-Safety Science University of Science and TechnologyBeijing100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China School of Mechanical Engineering Nantong UniversityNantong226019China China North Industry Advanced Technology Generalization Institute Beijing100089China China Academy of Ordnance Science China

As the protective component,steel plate had attracted extensive attention because of frequently threats of explosive loads.In this paper,the evolution of microstructure and the mechanism of damage in the quasi-cracking area of steel plate subjected to explosive load were discussed and the relationships between micro defects and dynamic mechanical response were revealed.After the explosion experiment,five observation points were selected equidistant from the quasi-cracking area of the section of the steel plate along the thickness direction,and the characteristics of micro defects at the observation points were analyzed by optical microscope(OM),scanning electron microscope(SEM) and electron backscattered diffraction(EBSD).The observation result shows that many slip bands(SBs) appeared,and the grain orientation changed obviously in the steel plate,the two were the main damage types of micro defects.In addition,cracks,peeling pits,grooves and other lager micro defects were appeared in the lower area of the plate.The stress parameters of the observation points were obtained through an effective numerical model.The mechanism of damage generation and crack propagation in the quasicracking area were clarified by comparing the specific impulse of each observation point with the corresponding micro defects.The result shows that the generation and expansion of micro defects are related to the stress area(i.***.the upper compression area,the neutral plane area,and the lower tension area).The micro defects gather and expand at the grain boundary,and will become macroscopic damage under the continuous action of tensile stress.Besides,the micro defects at the midpoint of the section of the steel plate in the direction away from the explosion center(i.***.the horizontal direction) were also studied.It was found that the specific impulse at these positions were much smaller than that in the thickness direction,the micro defects were only SBs and a few micro cracks,and the those decreased with the increase of the distance from the e

关键词： Explosive load Quasi-cracking area Micro defects Steel plate Dynamic response Numerical simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rogue waves for the(2+1)-dimensional Myrzakulov–Lakshmanan-IV equation on a periodic background

引用

Communications in Theoretical Physics 2024年第4期76卷 32-42页

作者： xiao-hui Wang Zhaqilao College of Mathematics Science Inner Mongolia Normal UniversityHohhot 010022China Laboratory of Infinite-dimensional Hamiltonian System and Its algorithm Application Hohhot 010022China Center for Applied Mathematical Science Inner MongoliaHohhot 010022China

In this paper,the rogue wave solutions of the(2+1)-dimensional Myrzakulov–Lakshmanan(ML)-IV equation,which is described by five component nonlinear evolution equations,are studied on a periodic background.By using the Jacobian elliptic function expansion method,the Darboux transformation(DT)method and the nonlinearization of the Lax pair,two kinds of rogue wave solutions which are expressed by Jacobian elliptic functions dn and cn,are obtained.The relationship between these five kinds of potential is summarized systematically.Firstly,the periodic rogue wave solution of one potential is obtained,and then the periodic rogue wave solutions of the other four potentials are obtained directly.The solutions we find present the dynamic phenomena of higher-order nonlinear wave equations.

关键词： rogue waves on a periodic background (2+1)-dimensional Myrzakulov-Lakshmanan-IV equation Darboux transformation Jacobian elliptic function

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lightweight,Strong and High Heat-Resistant Poly(lactide acid)Foams via Microcellular Injection Molding with Self-Assembly Nucleating Agent

引用

Chinese Journal of Polymer Science 2024年第6期42卷 739-750页

作者： xiao-Hu Bing Wen-Yu Ma Ming-hui Wu Peng Gao xiao zhou Hai-Bin Luo Long Wang Wen-Ge Zheng School of materials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(lactide acid)(PLA)foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams,such as polystyrene(PS)foams.Nevertheless,PLA foam typically suffers from low heat-resistance and poor cellular structure stemming from its inherent slow crystallization rate and low melt strength.In this study,a high-performance PLA foam with well-defined cell morphology,exceptional strength and enhanced heat-resistance was successfully fabricated via a core-back microcellular injection molding(MIM)process.Differential scanning calorimetry(DSC)results revealed that the added hydrazine-based nucleating agent(HNA)significantly increased the crystallization temperature and accelerated the crystallization process of PLA.Remarkably,the addition of a 1.5 wt%of HNA led to a significant reduction in PLA’s cell size,from 43.5µm to 2.87µm,and a remarkable increase in cell density,from 1.08×10^(7)cells/cm^(3)to 2.15×10^(10)cells/cm^(3).This enhancement resulted in a final crystallinity of approximately 55.7%for the PLA blend foam,a marked improvement compared to the pure PLA foam.Furthermore,at 1.5 wt%HNA concentration,the tensile strength and tensile toughness of PLA blend foams demonstrated remarkable improvements of 136%and 463%,respectively.Additionally,the Vicat softening temperature of PLA blend foam increased significantly to 134.8°C,whereas the pure PLA foam exhibited only about 59.7℃.These findings underscore the potential for the preparation of lightweight injection-molded PLA foam with enhanced toughness and heat-resistance,which offers a viable approach for the production of high-performance PLA foams suitable for large-scale applications.

关键词： Poly(lactide acid) Nucleating agent Microcellular injection molding Heat-resistance Toughness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Spatiotemporal Distribution Characteristics of Cloud Types and Phases in the Arctic Based on CloudSat and CALIPSO Cloud Classification Products

引用

Advances in Atmospheric Sciences 2024年第2期41卷 310-324页

作者： Yue SUN huiling YANG hui xiao Liang FENG Wei CHENG Libo zhou Weixi SHU Jingzhe SUN Key Laboratory of Cloud-Precipitation Physics and Severe Storms(LACS) and Department of Lower Atmospheric Observation Research(LAOR)Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth Sciences University of Chinese Academy of Sciences(UCAS)Beijing 100049China Beijing Institute of Applied Meteorology Beijing 100029China

The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud types(high cloud, altostratus, altocumulus, stratus, stratocumulus, cumulus, nimbostratus, and deep convection) and three phases(ice,mixed, and water) in the Arctic. Possible reasons for the observed interannual variability are also discussed. The main conclusions are as follows:(1) More water clouds occur on the Atlantic side, and more ice clouds occur over continents.(2)The average spatial and seasonal distributions of cloud types show three patterns: high clouds and most cumuliform clouds are concentrated in low-latitude locations and peak in summer;altostratus and nimbostratus are concentrated over and around continents and are less abundant in summer;stratocumulus and stratus are concentrated near the inner Arctic and peak during spring and autumn.(3) Regional averaged interannual frequencies of ice clouds and altostratus clouds significantly decrease, while those of water clouds, altocumulus, and cumulus clouds increase significantly.(4) Significant features of the linear trends of cloud frequencies are mainly located over ocean areas.(5) The monthly water cloud frequency anomalies are positively correlated with air temperature in most of the troposphere, while those for ice clouds are negatively correlated.(6) The decrease in altostratus clouds is associated with the weakening of the Arctic front due to Arctic warming, while increased water vapor transport into the Arctic and higher atmospheric instability lead to more cumulus and altocumulus clouds.

关键词： CloudSat and CALIPSO cloud type cloud phase temporal and spatial distribution interannual variation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：