检索结果-南通市图书馆

A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol

引用

Journal of Geriatric Cardiology 2012年第3期9卷 228-236页

作者： xiao-Wei Ma xiao-hui guo Xin-Hua xiao Li-Xin guo xiao-Feng Lv Quan-Min Li Yan Gao Department of Endocrinology Peking University First Hospital No. 7 of Xishiku Street Xicheng District Beijing 100034 China Department of Endocrinology Peking Union Medical College Hospital No.1 Shuaifuyuan Dongcheng District Beijing 100005 China Department of Endocrinology Peking Hospital No. 1 Dahua Road Dongdan Dongcheng District Beijing 100730 China Department of Endocrinology Military General Hospital of Peking PLA No.5 Nanmencang Dongsishitiao Dongcheng District Beifing 100070 China Department of Endocrinology Second Artillery Forces General Hospital of Peking PLA No.16 Xinjiekouwai Street Xicheng District Beijing 100088 China

Objectives To evaluate the plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus （T2DM） and arteriosclerosis obliteran （ASO） when treated with Probucol plus Cilostazol in combination and individually. Methods In this open-label study, patients aged 40-75 years were randomized to receive conventional therapy alone, or with Cilostazol 100 mg bid, or with Probucol 250 mg bid, or with both in combination. Endpoints included changes in plasma biomarker and safety at 12 weeks. Results Of the 200 randomized pati- ents, 165 for per-protocol and 160 for the safety （QTc intervals） were set, respectively. Probucol significantly reduced total cholesterol （P 〈 0.001）, low-density lipoprotein cholesterol （LDL-C）, （P = 0.01）, and high-density lipoprotein cholesterol （HDL-C）（P 〈 0.001） compared with conventional therapy. Cilostazol was effective in increasing HDL-C （P = 0.002） and reducing triglycerides levels （P 〈 0.01） compared with conventional therapy. A trend towards significance was observed for the difference between conventional therapy alone and Probucol plus Cilostazol group for the change in oxidized low-density lipoprotein （Ox-LDL, P = 0.065）. No significant effects on the majority of the remaining biomarkers were found across the treatment groups. Conclusions We have confirmed that Ox-LDL could be a possible plasma atherosclerotic biomarker among the evaluated biomarkers, which reflected the synergetic effect of Cilostazol plus Probucol in patients with T2DM and ASO shown previously in preclinical studies.

关键词： Cilostazol Probucol Combination treatment Atherosclerosis Biomarkers Synergetic effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identifying a novel frameshift pathogenic variant in a Chinese family with neurofibromatosis type 1 and review of literature

引用

International Journal of Ophthalmology(English edition) 2023年第1期16卷 47-52页

作者： xiao-hui guo Xin Jin Bin Wang Zhao-Yan Wang Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100039China Department of Otolaryngology Peking Union Medical College HospitalBeijing 100730China

AIM:To detect the pathogenic gene variant in a family with neurofibromatosis type 1(NF1).METHODS:This patient with NF1 was sequenced using target sequence capture and high-throughput sequencing *** detecting the suspicious pathogenic variant type,the pathogenic variant sites of the patient and the patient’s family members were verified by multiple ligation dependent probe amplification and Sanger ***,polyphen-2,Mutation Taster and GERP++software were used to predict the pathogenicity of the unknown *** clinical data,diagnosis and treatment process of the patients were *** the keyword“NF1;frameshift pathogenic variant”,relevant literature was gathered for analysis from Chinese and international databases,with articles dating from the establishment of each database to April ***:A heterozygous frameshift pathogenic variant of NF1 in exon 33 was detected in the *** insertion of adenine in coding region 4486 resulted in the replacement of isoleucine with asparagine in protein *** sequencing validation and segregation analysis were performed,which demonstrated that the NF1 gene was cosegregated with the disease phenotype in this *** study identified a novel NF1 heterozygous frameshift mutation c.4486dupA(p.I1497Nfs*12).Relevant literature retrieval found 7 Chinese articles and 12 foreign *** NF1 gene mutation,mutation types are diverse,including point mutation,frameshift mutation,splice site mutation,exon mutation,chimeric mutation and de novo *** reports are based on autosomal dominant ***:This study’s results demonstrate that a novel deletion in exon 33 caused NF1 in this Chinese family,expanding the mutational spectrum of the NF1 gene.

关键词： neurofibromatosis type 1 frameshift pathogenic variant monozygotic twins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ace2, rather than ace1, is the major acetylcholinesterase in the silkworm, Bombyx moil

引用

Insect Science 2009年第4期16卷 297-303页

作者： hui-Juan Chen Zhen Liao xiao-Ming hui guo-Qing Li Fei Li Zhao-Jun Han Department of Entomology Nanjing Agricultural University Nanjing China

Two acetylcholinesterase （ace） genes have been reported in many insect species. In pests such as Helicoverpa assulta and Plutella xylostellas, acel gene encodes the predominant synaptic enzyme that is the main target of organophosphorus （OP） and carbamate pesticides. It has been reported that pesticide selection has an impact on the ace gene evolution. The domesticated silkworm, Bombyx mori, also has two ace genes. We studied ace gene expression and enzyme activities in silkworm as this has not faced pesticide selection over the past decades. The expression levels of two ace genes, Bm-acel and Bm-ace2, were estimated by quantitative real-time polymerase chain reaction. Bin-ace2 was expressed more highly than Bm-acel in all tested samples of different developmental stages or tissues, suggesting ace2, rather than acel, is the major type ofacetylcholinesterase （ACHE） in Bombyx mori. This is inconsistent with the aforementioned lepidopterons agricultural pests, partly be due to the widespread use of pesticides that may induce high expression of the acel gene in these pests. Besides high expression in the head, Bm-acel also expresses highly in the silk glands and Bm-ace2 is abundant in the germline, implying both ace genes may have potential non-hydrolytic roles in development. Furthermore, we found that the mRNA levels of two ace genes and their ratios （ace2/acel） change day to day in the first and third instars. This challenges the conventional method of estimating enzymatic activity using crude extract as an enzyme solution, as it is a mixture of ACHE 1 and ACHE2. An efficient and simple method for separating different ACHEs is necessary for reliable toxicological analyses.

关键词： acetylcholinesterase Bombyx mori expression Kin quantitative real-time polymerase chain reaction (qRT-PCR)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Overexpression of a Chloroplast-located Peroxiredoxin Q Gene, SsPrxQ, Increases the Salt and Low-temperature Tolerance of Arabidopsis

引用

Journal of Integrative Plant Biology 2006年第10期48卷 1244-1249页

作者： Li-Wen Jing Shi-Hua Chen xiao-Li guo hui Zhang Yan-Xiu Zhao Key Laboratory of Plant Stress Research College of Life Sciences Shandong Normal University Jinan 250014 China

Ablotlc stress, such as salt, drought and extreme temperature, can result in enhanced production of reactive oxygen species （ROS）. Plants have developed both enzymatic ROS-scavenging and non-enzymatic ROS-scavenging systems. The major ROS-scavenging enzymes of plants include superoxide dismutase （SOD）, ascorbate peroxldaae （APX）, catalaae （CAT）, glutathione peroxldaae （GPX） and peroxiredoxina （Prxa）. In the present work, we identified a gene encoding chloroplast-located peroxiredoxin Q, SsPrxQ, from Suaeda salsa L. located at chloroplast. Overexpression of SsPrxQ In Arabidopsis leads to an increase In salt and low-temperature tolerance.

关键词： overexpression peroxiredoxin Q salt and low-temperature tolerance suaeda salsa subcellular localization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Basaloid squamous carcinoma of esophagus:a clinicopathological,immunohistochemical and electron microscopic study of sixteen cases

引用

World Journal of Gastroenterology 1998年第5期4卷 34-40页

作者： ZHANG Xin Hua, SUN Gui Qin, ZHOU xiao Jun, guo hui Fang and ZHANG Tai He

AIM To further clarify the clinicopathological, immunohistochemical and electron microscopic features, and prognostic aspect of basaloid squamous carcinoma (BSC), a rare esophageal *** We reviewed 763 documented cases of esophageal malignancies from year (1977-1996) from our hospital, and discovered 16 (2.1%) cases of BSC. The clinicopathological features of these cases were evaluated. Immunohistochemistry (S-P method), histochemical stains, and electron microscopy were used to further characterize the *** The tumors were classified into stages Ⅰ (n=1), ⅡA (n=6), ⅡB (n=2), Ⅲ (n=5), and Ⅳ (n=2) according to the criteria of the UICC TNM classification system of malignant tumors (1987). Most neoplasms were located in the mid third of the esophagus. Grossly, they had a similar appearance of conventional esophageal carcinoma, but showed a typical cytoarchitectural pattern of BSC histologically. The most important histologic feature of this tumor is carcinoma with a basaloid pattern, intimately associated with squamous cell carcinoma, dysplasia, or focal squamous differentiation. The basaloid cells were round to oval in shape with scant cytoplasm, arranged mainly in the form of solid, smooth-contoured lobules with peripheral palisading. A panel of immunostains were used for the basaloid component of the tumor with the following results: CK(Pan) 14/16 (+); EMA 16/16 (+); Vimentin 4/16 (+); S-100 protein 7/16 (+). CEA and smooth muscle actin were negative. Electron microscopy (EM) revealed that the basaloid cells were poorly differentiated, with a few desmosomes and fibrils, and numerous free and polyribosome. Of the 11 patients with adequate follow-up 8 died within 2 years, with an average survival time of 16.2 months. No stage Ⅱ, Ⅲ or Ⅳ cases survived beyond 5 years. The one-year survival rate was 60% and two-year 20%.CONCLUSION The BSC of esophagus is a distinct clinicopathological entity with poor prognosis. The cellular differentiation and bi

关键词： esophageal neoplasms/pathology esophageal neoplasms/ultrastructure carcinoma, squamous cell/pathology carcinoma, squamous cell/ultrastructure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一种基于符号变换的描述逻辑ALC超协调推理算法

引用

计算机科学 2011年第3期38卷 206-212页

作者：张小旺肖国辉北京大学信息科学系北京100871 安徽大学数学科学学院合肥230039 维也纳技术大学信息系统研究所

语义万维网作为一个开放、不断更新而且相互协作的环境,经常会包含一些不协调的或不精确的信息。众所周知,描述逻辑是语义万维网重要的逻辑基础,然而描述逻辑缺乏处理不协调或不完全信息的能力。近来一些超协调方案通过限制或阻止使用... 详细信息

语义万维网作为一个开放、不断更新而且相互协作的环境,经常会包含一些不协调的或不精确的信息。众所周知,描述逻辑是语义万维网重要的逻辑基础,然而描述逻辑缺乏处理不协调或不完全信息的能力。近来一些超协调方案通过限制或阻止使用一些推理规则来避免推理的平凡化,从而容忍本体中出现的不协调。因为这些方法限制了描述逻辑系统的推理能力,所以推理能力弱于经典的描述逻辑推理能力,即使在处理协调的本体时。提出一种基于符号变换的具有强推理能力的超协调推理算法。证明了该算法是可判定的,而且在处理协调的本体时该推理系统与经典逻辑系统具有相等的推理能力。

关键词：语义互联网描述逻辑ALC 表演算超协调表演算不协调性处理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reversible renal infarctions associated with pheochromocytoma:a case report

引用

Chinese Medical Journal 2020年第12期133卷 1481-1482页

作者： Lu Liu Jian-Xing Qiu Ying Gao Jie Tian Zheng Zhang Jun-Qing Zhang xiao-hui guo Department of Endocrinology Peking University First HospitalBeijing 100034China Department of Radiology Peking University First HospitalBeijing 100034China Department of Urology Peking University First HospitalBeijing 100034China

To the Editor:The complications of pheochromocytoma caused by barely controlled hypertension and the overproduction of catecholamine can reduce patients’life expectancy and quality of ***,we report a case of bilateral multiple renal infarctions on computed tomography(CT)scan related to pheochromocytoma,which achieved complete relief on follow-up after tumor removal.A 47-year-old male with a 3-year history of uncontrolled hypertension(the highest value recorded was 210/160 mmHg)and intermittent severe headache,pallor,and sweating presented to our hospital on April 15,*** did not monitor his blood pressure regularly but occasionally took dihydropyridine calcium-channel blockers.

关键词： infarction cytoma hypertension

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

引用

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao Zhao Xuelin Wang hui guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thyroid function of twin-pregnant women in early pregnancy

引用

Chinese Medical Journal 2019年第17期132卷 2033-2038页

作者： Yan-Xin Jiang Wei-Jie Sun Yang Zhang Yu Huang You-Yuan Huang Gui-Zhi Lu Jun-Qing Zhang Ying Gao hui-Xia Yang xiao-hui guo Department of Endocrinology Peking University First Hospital Beijing 100034 China Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China National Engineering Research Center of Software Engineering Peking University Beijing 100871 China

Background: Serum human chorionic gonadotrophin (hCG) is higher in twin than that in singleton pregnancies. As hCG stimulates the thyroid to produce more free thyroxine (FT4), which may lead to decreased thyroid-stimulating hormone (TSH) levels, the reference ranges of thyroid-related indicators may differ between singleton and twin pregnancies in the first trimester. This study aimed to establish reference ranges for thyroid-related indicators in early twin pregnancies and to compare them with singleton pregnancies. Methods: Data of 820 twin-pregnant women were extracted from the established database of all pregnant women who delivered at Peking University First Hospital from October 2013 to May 2018;160 who met National Academy of Clinical Biochemistry criteria were included to establish TSH and FT4 reference ranges. We screened 480 (3:1 paired) women with singleton pregnancies from the same database as controls. The Mann-Whitney test for TSH and FT4 levels was applied for comparisons between singleton and twin pregnancies. Results: First-trimester reference ranges (4–12 gestational weeks) for twin pregnancies were: TSH 0.69 (0.01–3.35) mIU/L and FT4 16.38 (12.45–23.34) pmol/L. Median TSH was significantly lower at 7 to 12 gestational weeks than that at 4 to 6 gestational weeks (0.62 vs. 0.96 mIU/L, Z =-1.964, P = 0.049);FT4 was not significantly different between the two groups. Compared to singleton pregnancies, median TSH was significantly lower (0.69 vs. 1.27 mIU/L, Z =-6.538, P = 0.000), and FT4 was significantly higher (16.38 vs. 14.85 pmol/L, Z =-7.399, P = 0.000) in twin pregnancies in the first trimester. Conclusions: Specific reference ranges for thyroid-related indicators for twin pregnancies are needed to avoid a misdiagnosis of thyroid dysfunction. Moreover, establishment of separate reference ranges for 4 to 6 and 7 to 12 gestational weeks in twin pregnancies may be considered.

关键词： Twin pregnancy Reference ranges Thyroid-stimulating hormone Free thyroxine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

挤压铸造零件沿流程方向的成分偏析及组织偏聚

引用

工程科学学报 2017年第7期39卷 1041-1046页

作者：郭莉军邢书明敖晓辉郭洪钢北京交通大学机械与电子控制工程学院北京100044 长城汽车股份有限公司保定071000

采用挤压铸造(液态模锻)工艺制备了A357铝合金螺旋线试件,使用化学成分分析和金相分析方法研究了流程长度对合金成分偏析及组织偏聚的影响.结果表明:在沿流程方向上,流程的开始端和流程末端的Si元素和Mg元素含量大于流程中段的含量.合... 详细信息

采用挤压铸造(液态模锻)工艺制备了A357铝合金螺旋线试件,使用化学成分分析和金相分析方法研究了流程长度对合金成分偏析及组织偏聚的影响.结果表明:在沿流程方向上,流程的开始端和流程末端的Si元素和Mg元素含量大于流程中段的含量.合金的初始α晶粒尺寸随着流程长度的增加先增大后变小.初生固相率随着流程长度的增大呈现波动变化.造成流程成分偏析和组织变化的原因是在挤压铸造凝固阶段中补缩液相的强迫运动.

关键词：挤压铸造流程长度成分偏析组织偏聚

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：