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护理安全管理应用于心脏介入围手术期的临床效果

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临床医学研究与实践 2017年第14期2卷 174-175页

作者：李小花范惠咸阳市中心医院心血管内一科陕西咸阳712000 咸阳市中心医院护理部陕西咸阳712000

目的分析探讨护理安全管理对心脏介入围手术期患者的临床效果。方法选取本院在2014年11月至2016年11月收治的86例心脏介入手术患者,采用随机分组的方式将所有患者平均分为观察组和对照组,每组43例患者。对照组患者仅采用常规围手术期护... 详细信息

目的分析探讨护理安全管理对心脏介入围手术期患者的临床效果。方法选取本院在2014年11月至2016年11月收治的86例心脏介入手术患者,采用随机分组的方式将所有患者平均分为观察组和对照组,每组43例患者。对照组患者仅采用常规围手术期护理,观察组患者在常规围手术期护理基础上引入护理安全管理模式,比较两组患者的护理差错率、并发症发生率、患者护理满意度与护理质量评分等。结果护理后,观察组患者护理差错率、并发症发生率、护理满意度与护理质量评分都明显优于对照组,差异具有统计学意义(P<0.05)。结论对于心脏介入手术患者,采用护理安全管理模式具有确切的效果,能够减少术后并发症,提高患者护理满意度,值得临床推广使用。

关键词：护理安全管理心脏介入围手术期

Pronounced impact of size and shape effects on creep rupture life of a K439B superalloy combustion chamber casting simulator

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China Foundry 2025年

作者： Wen-tong Liu Yi-dong Wu Lei Gao Jing-yang Chen Cheng-bo xiao Xi-dong hui State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical Materials

The size and shape effect(SSE) of components has become a critical issue for mechanical properties, application reliability, and processing. In this study, the creep rupture life(CRL) of components with different wall thicknesses and positions in a combustion chamber casing simulator made of K439B superalloy was investigated. The intrinsic mechanisms of the SSE were explored from the dendrite structure, volume fraction and size of the γ' phase, and element segregation, etc. It is shown that this casting exhibits a strong SSE of creep rupture life, characterized by a significant difference in the CRL values up to 60% with the variation of wall thickness and position in the casing. In terms of casting technology, the influence of SSE on CRL is actually determined by the cooling rate. The SSE on the creep rupture life originates from the dendrite structure(such as the secondary dendrite arm spacing), volume fraction size of the γ' phase in the dendrite trunk, and elements segregation rate. This work may have implications for the design and application of engineering components with large sizes and complex structures.

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和谐号动车组悬挂设备及控制

铁道机车车辆 2011年第5期31卷 64-66页

作者：金哲韩晓辉范荣巍陈蓝中国铁道科学研究院机车车辆研究所

和谐号动车组悬挂控制设备由高度阀、平均阀、安全阀、电磁阀、压力开关、溢流阀、节流阀和塞门组成,可以根据载荷的变化自动控制空气弹簧压力,保证每节车或单车保持设定高度一致,同时检测出两个转向架上的空气弹簧压力平均值,并发送给... 详细信息

和谐号动车组悬挂控制设备由高度阀、平均阀、安全阀、电磁阀、压力开关、溢流阀、节流阀和塞门组成,可以根据载荷的变化自动控制空气弹簧压力,保证每节车或单车保持设定高度一致,同时检测出两个转向架上的空气弹簧压力平均值,并发送给制动控制系统。空气悬挂控制设备还采取各种安全控制措施,确保了和谐号动车组的安全运行。

关键词：空气悬挂控制空气弹簧制动系统安全控制

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin xiao fangqing Zhao Jing-Dong J.Han Qi Liu xiaohui fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Reaction mechanisms of low-grade molybdenum concentrate during calcification roasting process

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Transactions of Nonferrous Metals Society of China 2016年第11期26卷 3015-3023页

作者：甘敏范晓慧陈许玲吴程骞季志云王送荣汪国靖邱冠周姜涛中南大学资源加工与生物工程学院长沙410083

The effects of Ca-based additives on roasting properties of low-grade molybdenum concentrate were studied. The resultsshow that calcium-based additives can react with molybdenum concentrate to form CaSO4 and CaMoO4. The initial oxidationtemperature of MoS2 is 450℃, while the formation of CaMoO4 and CaSO4 occurs above 500℃. The whole calcification reactionsare nearly completed between 600 and 650℃. However, raising the temperature further helps for the formation of CaMoO4 but isdisadvantageous to sulfur fixing rate and molybdenum retention rate. Calcification efficiency of Ca-based additives follows theorder： Ca（OH）2〉CaO〉CaCO3. With increasing the dosage of Ca（OH）2, the molybdenum retention rate and sulfur-fixing rate rise, butexcessive dosages would consume more acid during leaching process. The appropriate mass ratio of Ca（OH）2 to molybdenumconcentrate is 1：1. When roasted at 650 ℃ for 90 min, the molybdenum retention rate and the sulfur-fixing rate of low-grademolybdenum concentrate reach 100% and 92.92%, respectively, and the dissolution rate of molybdenum achieves 99.12% withcalcines being leached by sulphuric acid.

关键词： molybdenum concentrate calcification roasting reaction mechanism thermodynamic analysis phase transformation

超重合并腹型肥胖的正常高值血压人群炎症因子变化及相关因素分析

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中国循环杂志 2018年第3期33卷 246-250页

作者：王鲁雁孙宁玲张晓辉杨帆吴云涛吴寿岭刘晓云北京大学人民医院心脏中心北京市100044 开滦总医院林西医院开滦总医院心内科

目的:探讨超重合并腹型肥胖正常高值血压人群血清炎症因子的变化特点及相关因素。方法:本研究入选189例正常高值血压伴超重及腹型肥胖[(体重指数(BMI)≥24.0 kg/m^2,同时腹围≥90 cm(男性)或≥85 cm(女性),收缩压(SBP)120~139 mm Hg或... 详细信息

目的:探讨超重合并腹型肥胖正常高值血压人群血清炎症因子的变化特点及相关因素。方法:本研究入选189例正常高值血压伴超重及腹型肥胖[(体重指数(BMI)≥24.0 kg/m^2,同时腹围≥90 cm(男性)或≥85 cm(女性),收缩压(SBP)120~139 mm Hg或舒张压(DBP)80~89 mm Hg]者作为腹型肥胖高值血压组,并纳入87例年龄匹配,BMI<24.0 kg/m^2、血压<120/80 mm Hg且无疾病者为健康对照组。所有入选者进行血脂等生化学检查并应用酶联免疫吸附法测定血清细胞间黏附分子1(ICMA1)、单核细胞趋化蛋白1(MCP1)、趋化因子配体(CXCL)-1、CXCL-2,氧化型低密度脂蛋白(oxLDL)。结果:腹型肥胖高值血压组的甘油三酯(TG)、空腹血糖及非高密度脂蛋白胆固醇(non-HDL-C)显著高于健康对照组(P均<0.05);腹型肥胖高值血压组的血清ICMA1和MCP1明显高于健康对照组(P均<0.05)。多因素相关分析显示,腹型肥胖高值血压组的ICMA1与BMI、SBP和低密度脂蛋白胆固醇(LDL-C)呈显著正相关,与年龄呈负相关,存在性别差异;MCP1与腹围、SBP、LDL-C和non-HDL-C呈显著正相关,与高密度脂蛋白胆固醇(HDL-C)呈显著负相关,同样存在性别差异(P均<0.05);oxLDL与SBP、LDL-C呈显著正相关(P均<0.05);未发现CXCL-1、CXCL-2与肥胖、血压、代谢指标相关。但健康对照组相关分析未发现炎症指标与其他指标具有相关性。炎症因子线性回归分析结果显示,在排除其他因素影响后,腹型肥胖高值血压组的ICAM1与BMI仍具有显著正相关(t值为2.901,P=0.005),男性中MCP1与SBP呈显著正相关(t值为5.076,P=0.000),与DBP呈显著负相关(t值为-3.369,P=0.001)。oxLDL与年龄、LDL-C正相关(t值分别为2.168、2.146,P值分别为0.032、0.034);CXCL-1与HDL-C呈负相关(t值为-2.013,P=0.047)。结论:超重合并腹型肥胖的正常高值血压者比正常人存在更多的糖脂代谢异常,且血清炎症指标升高,其血清炎症因子水平升高随体重指数和SBP水平升高而升高,提示该人群存在炎症反应异常且与超重及临界范围的血压升高有关。

关键词：肥胖症高血压前期炎症因子

Applications and recent advances of rare earth in solid oxide fuel cells

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Journal of Rare Earths 2022年第11期40卷 1668-1681,I0001页

作者： Qi Wang hui fan Yanfei xiao Yihe Zhang Bejing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes and School of Materials Science and Technology China University of Geosciences BeijingBejing100083China School of Metallurgy and Chemistry Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

Solid oxide fuel cells(SOFCs)are an all-solid energy conversion device from the chemical energy of fuels to electric energy at intermediate and high *** to now,massive efforts have been made in developing different components of solid oxide fuel cells,including electrolyte,anode,cathode and interconnect *** earth elements play an indispensable role in different components of SOFCs which have been extensively studied in the recent *** this review,we concentrate upon the rare earth application and recent advances in SOFCs and related *** structure involves perovskites,Ruddlesden-Popper,fluorite,spinel,pyrochlore,apatite and so ***,the effects of rare earth based oxides as matrix or dopants in different components are also *** and properties of the materials are related to the element type,valence,coordination and ion *** article will provide a comprehensive research direction towards SOFCs components for their composition,structural design and mechanisms research.

关键词： Solid oxide fuel cells Rare earths Anode Electrolyte Cathode Interconnect materials

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao xiao Yi-fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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糖尿病足患者多药耐药菌感染的危险因素logistic回归分析

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中华医院感染学杂志 2017年第4期27卷 815-818页

作者：杨雪孙晓菲范慧洁崔国敏于江红董其娟郑州人民医院内分泌科河南郑州450000

目的探讨糖尿病足患者多药耐药菌感染的危险因素,为制定临床防治措施提供理论依据。方法回顾性分析医院2014年1月-2016年6月收治192例糖尿病足患者的临床资料,分析多药耐药菌的分布情况,对比患者的各项临床资料,并通过多因素logistic回... 详细信息

目的探讨糖尿病足患者多药耐药菌感染的危险因素,为制定临床防治措施提供理论依据。方法回顾性分析医院2014年1月-2016年6月收治192例糖尿病足患者的临床资料,分析多药耐药菌的分布情况,对比患者的各项临床资料,并通过多因素logistic回归分析,探讨糖尿病足患者多药耐药菌感染的危险因素。结果 61例患者发生多药耐药菌感染,感染率为31.77%;93株多药耐药菌中,检出金黄色葡萄球菌41株(44.09%),检出铜绿假单胞菌20株(21.51%);使用抗菌药物、第三代头孢菌素类抗菌药物、有神经缺血性伤口、同一溃疡面住院>2次、发生骨髓炎的多药耐药感染率均显著高于无使用抗菌药物、无使用第三代头孢菌素类抗菌药物、无神经缺血性伤口、同一溃疡面住院≤2次、未发生骨髓炎的多药耐药感染率,差异有统计学意义(P2次以及骨髓炎是糖尿病足患者多药耐药菌感染的危险因素(P<0.05)。结论糖尿病足发生多药耐药菌感染的风险较高,临床应针对发生多药耐药菌感染的危险因素,制定有效的防治措施,以提高疾病的诊疗效果,改善患者预后。

关键词：糖尿病足多药耐药菌危险因素