检索结果-南通市图书馆

Analysis of risk factors leading to anxiety and depression in patients with prostate cancer after castration and the construction of a risk prediction model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第2期14卷 255-265页

作者： Rui-xiao Li xue-Lian Li Guo-Jun Wu Yong-Hua Lei xiao-Shun Li Bo Li Jian-Xin Ni Urology Hospital Xi'an People's Hospital(Xi'an Fourth Hospital)Xi'an 710199Shaanxi ProvinceChina Department of Surgery Xi'an Hospital of Traditional Chinese MedicineXi'an 710199Shaanxi ProvinceChina

BACKGROUND Cancer patients often suffer from severe stress reactions psychologically,such as anxiety and *** cancer(PC)is one of the common cancer types,with most patients diagnosed at advanced stages that cannot be treated by radical surgery and which are accompanied by complications such as bodily pain and bone ***,attention should be given to the mental health status of PC patients as well as physical adverse events in the course of clinical *** To analyze the risk factors leading to anxiety and depression in PC patients after castration and build a risk prediction *** A retrospective analysis was performed on the data of 120 PC cases treated in Xi'an People's Hospital between January 2019 and January *** patient cohort was divided into a training group(n=84)and a validation group(n=36)at a ratio of 7:*** patients’anxiety symptoms and depression levels were assessed 2 wk after surgery with the Self-Rating Anxiety Scale(SAS)and the Selfrating Depression Scale(SDS),*** regression was used to analyze the risk factors affecting negative mood,and a risk prediction model was *** In the training group,35 patients and 37 patients had an SAS score and an SDS score greater than or equal to 50,*** on the scores,we further subclassified patients into two groups:a bad mood group(n=35)and an emotional stability group(n=49).Multivariate logistic regression analysis showed that marital status,castration scheme,and postoperative Visual Analogue Scale(VAS)score were independent risk factors affecting a patient's bad mood(P<0.05).In the training and validation groups,patients with adverse emotions exhibited significantly higher risk scores than emotionally stable patients(P<0.0001).The area under the curve(AUC)of the risk prediction model for predicting bad mood in the training group was 0.743,the specificity was 70.96%,and the sensitivity was 66.03%,while in the validation

关键词： Prostate cancer Castration Anxiety and depression Risk factors Risk prediction model

A deep learning interatomic potential suitable for simulating radiation damage in bulk tungsten

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2024年第2期6卷 304-322页

作者： Chang-Jie Ding Ya-Wei Lei xiao-Yang Wang xiao-Lin Li Xiang-Yan Li Yan-Ge Zhang Yi-Chun Xu Chang-Song Liu xue-Bang Wu Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Science Island University of Science and Technology of ChinaHefei 230026China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China

So far, it has been a challenge for existing interatomic potentials to accurately describe a wide range of physical properties and maintain reasonable efficiency. In this work, we develop an interatomic potential for simulating radiation damage in body-centered cubic tungsten by employing deep potential, a neural network-based deep learning model for representing the potential energy surface. The resulting potential predicts a variety of physical properties consistent with first-principles calculations, including phonon spectrum, thermal expansion, generalized stacking fault energies, energetics of free surfaces, point defects, vacancy clusters, and prismatic dislocation loops. Specifically, we investigated the elasticity-related properties of prismatic dislocation loops, i.e., their dipole tensors, relaxation volumes, and elastic interaction energies. This potential is found to predict the maximal elastic interaction energy between two 1/2 loops better than previous potentials, with a relative error of only 7.6%. The predicted threshold displacement energies are in reasonable agreement with experimental results, with an average of 128 eV. The efficiency of the present potential is also comparable to the tabulated gaussian approximation potentials and modified embedded atom method potentials, meanwhile, can be further accelerated by graphical processing units. Extensive benchmark tests indicate that this potential has a relatively good balance between accuracy, transferability, and efficiency.

关键词： Machine learning Deep learning Interatomic potential Radiation damage Tungsten

维普期刊数据库

A simple and efficient CRISPR/Cas9 system permits ultra-multiplex genome editing in plants

在线全文

学校读者我要写书评

暂无评论

The Crop Journal 2024年第2期12卷 569-582页

作者： Suting Wu Htin Kyaw Zhijun Tong Yirong Yang Zhiwei Wang Liying Zhang Lihua Deng Zhiguo Zhang Bingguang xiao William Paul Quick Tiegang Lu Guoying xiao Guannan Qin xue'an Cui Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Biological Breeding for Fujian and Taiwan Crops Ministry of Agriculture and Rural AffairsCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina School of Biosciences The University of SheffieldFirth CourtWestern BankSheffield S102TNUK Key Laboratory of Tobacco Biotechnological Breeding National Tobacco Genetic Engineering Research CenterYunnan Academy of Tobacco Agricultural SciencesKunming 650021YunnanChina

The development and maturation of the CRISPR/Cas genome editing system provides a valuable tool for plant functional genomics and genetic *** available genome-editing tools have a limited number of targets,restricting their application in genetic *** this study,we developed a novel CRISPR/Cas9 plant ultra-multiplex genome editing system consisting of two template vectors,eight donor vectors,four destination vectors,and one primer-design software *** combining the advantages of Golden Gate cloning to assemble multiple repetitive fragments and Gateway recombination to assemble large fragments and by changing the structure of the amplicons used to assemble sg RNA expression cassettes,the plant ultra-multiplex genome editing system can assemble a single binary vector targeting more than 40 genomic loci.A rice knockout vector containing 49 sg RNA expression cassettes was assembled and a high co-editing efficiency was *** plant ultra-multiplex genome editing system advances synthetic biology and plant genetic engineering.

关键词： CRISPR/Cas9 Multiplex genome editing Assembly system Plant

维普期刊数据库

Activation and polarization of striatal microglia and astrocytes are involved in bradykinesia and allodynia in early-stage parkinsonian mice

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2024年第4期4卷 806-819页

作者： xue Zhang Zi-Lin Shen Ya-Wei Ji Cui Yin Cheng xiao Chunyi Zhou Jiangsu Province Key Laboratory of Anesthesiology School of AnesthesiologyXuzhou Medical UniversityXuzhou 221004China Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology Xuzhou Medical UniversityXuzhou 221004China NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs School of AnesthesiologyXuzhou Medical UniversityXuzhou 221004China

In addition to the cardinal motor symptoms,pain is a major non-motor symptom of Parkinson's disease(PD).Neuroinflammation in the substantia nigra pars compacta and dorsal striatum is involved in neurodegeneration in *** the polarization of microglia and astrocytes in the dorsal striatum and their contribution to motor deficits and hyperalgesia in PD have not been *** the present study,we observed that hemiparkinsonian mice established by unilateral 6-OHDA injection in the medial forebrain bundle exhibited motor deficits and mechanical *** these mice,both microglia and astrocytes in the dorsal striatum were activated and polarized to M1/M2 microglia and A1/A2 astrocytes as genes specific to these cells were *** effects peaked 7 days after 6-OHDA ***,striatal astrocytes in parkinsonian mice also displayed hyperpolarized membrane potentials,enhanced voltage-gated potassium currents,and dysfunction in inwardly rectifying potassium channels and glutamate *** administration of minocycline,a microglia inhibitor,attenuated the expression of genes specific to M1 microglia and A1 astrocytes in the dorsal striatum(but not those specific to M2 microglia and A2 astrocytes),attenuated the damage in the nigrostriatal dopaminergic system,and alleviated the motor deficits and mechanical allodynia in parkinsonian *** contrast,local administration of minocycline into the dorsal striatum of parkinsonian mice mitigated only *** study suggests that M1 microglia and A1 astrocytes in the dorsal striatum may play important roles in the development of pathophysiology underlying hyperalgesia in the early stages of PD.

关键词： Parkinson's disease Dopaminergic system Striatum Microglia Astrocytes Substantia nigra pars compacta

Investigations of methane adsorption characteristics on marine-continental transitional shales and gas storage capacity models considering pore evolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第4期21卷 2273-2286页

作者： Chen-Gang Lu Xian-Ming xiao Zhen-Qian xue Zhang-Xin Chen Yin-Tao Dong Yue Feng Gang Li School of Energy Resources China University of Geosciences (Beijing) School of Civil and Environmental Engineering Nanyang Technological University Chemical and Petroleum Engineering University of Calgary Eastern Institute of Technology (tentative) CNOOC Research Institute

Methane adsorption is a critical assessment of the gas storage capacity(GSC) of shales with geological conditions. Although the related research of marine shales has been well-illustrated, the methane adsorption of marine-continental transitional(MCT) shales is still ambiguous. In this study, a method of combining experimental data with analytical models was used to investigate the methane adsorption characteristics and GSC of MCT shales collected from the Qinshui Basin, China. The Ono-Kondo model was used to fit the adsorption data to obtain the adsorption parameters. Subsequently, the geological model of GSC based on pore evolution was constructed using a representative shale sample with a total organic carbon(TOC) content of 1.71%, and the effects of reservoir pressure coefficient and water saturation on GSC were explored. In experimental results, compared to the composition of the MCT shale, the pore structure dominates the methane adsorption, and meanwhile, the maturity mainly governs the pore structure. Besides, maturity in the middle-eastern region of the Qinshui Basin shows a strong positive correlation with burial depth. The two parameters, micropore pore volume and non-micropore surface area, induce a good fit for the adsorption capacity data of the shale. In simulation results, the depth,pressure coefficient, and water saturation of the shale all affect the GSC. It demonstrates a promising shale gas potential of the MCT shale in a deeper block, especially with low water saturation. Specifically,the economic feasibility of shale gas could be a major consideration for the shale with a depth of 60% in the Yushe-Wuxiang area. This study provides a valuable reference for the reservoir evaluation and favorable block search of MCT shale gas.

关键词： High-pressure methane adsorption Marine-continental transitional shale gas Ono-Kondo model Adsorption thermodynamics Gas storage capacity model

Optimal proportioning of iron ore in sintering process based on improved multi-objective beluga whale optimisation algorithm

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第7期31卷 1597-1609页

作者： Zong-ping Li Xu-dong Li xue-tong Yan Wu Wen xiao-xin Zeng Rong-jia Zhu Ya-hui Wang Ling-zhi Yi Zhongye Changtian International Engineering Co. Ltd.Changsha 410205HunanChina College of Automation and Electronic Information Xiangtan UniversityXiangtan 411105HunanChina College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina

Proportioning is an important part of sintering,as it affects the cost of sintering and the quality of sintered *** address the problems posed by the complex raw material information and numerous constraints in the sintering process,a multi-objective optimisation model for sintering proportioning was established,which takes the proportioning cost and TFe as the optimisation ***,an improved multi-objective beluga whale optimisation(IMOBWO)algorithm was proposed to solve the nonlinear,multi-constrained multi-objective optimisation *** algorithm uses the con-strained non-dominance criterion to deal with the constraint problem in the ***,the algorithm employs an opposite learning strategy and a population guidance mechanism based on angular competition and two-population competition strategy to enhance convergence and population *** actual proportioning of a steel plant indicates that the IMOBWO algorithm applied to the ore proportioning process has good convergence and obtains the uniformly distributed Pareto ***,compared with the actual proportioning scheme,the proportioning cost is reduced by 4.3361¥/t,and the TFe content in the mixture is increased by 0.0367%in the optimal compromise ***,the proposed method effectively balances the cost and total iron,facilitating the comprehensive utilisation of sintered iron ore resources while ensuring quality assurance.

关键词： Sintering process Proportioning Iron ore Multi-objective beluga whale optimisation algorithm Proportioning cost

Wild soybean(Glycine soja)transcription factor GsWRKY40 plays positive roles in plant salt tolerance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2024年第3期12卷 766-775页

作者： Minglong Li Man xue Huiying Ma Peng Feng Tong Chen xiaohuan Sun Qiang Li xiaodong Ding Shuzhen Zhang Jialei xiao Key Laboratory of Agricultural Biological Functional Genes Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Key Laboratory of Soybean Biology of Chinese Education Ministry Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Department of Plant Science School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China College of Life Science Leshan Normal UniversityLeshan 614000SichuanChina Mudanjiang Branch of Heilongjiang Academy of Agricultural Sciences Mudanjiang 157401HeilongjiangChina

Wild soybean(Glycine soja),a relative of cultivated soybean,shows high adaptability to adverse environmental *** identified and characterized a wild soybean transcription factor gene,GsWRKY40,that promotes plant salt ***40 was highly expressed in wild soybean roots and was up-regulated by salt ***40 was localized in nucleus and demonstrated DNA-binding activities but without transcriptional *** and overexpression of GsWRKY40 altered salt tolerance of Arabidopsis *** understand the molecular mechanism of GsWRKY40 in regulating plant salt resistance,we screened a cDNA library and identified a GsWRKY40 interacting protein GsbHLH92 by using yeast two-hybrid *** physical interaction of GsWRKY40 and GsbHLH92 was confirmed by co-immunoprecipitation(co-IP),GST pull-down,and bimolecular fluorescence complementation(BiFC)***,co-overexpression of GsWRKY40 and GsbHLH92 resulted in higher salt tolerance and lower ROS levels than overexpression of GsWRKY40 or GsbHLH92 in composite soybean plants,suggesting that GsWRKY40 and GsbHLH92 may synergistically regulate plant salt resistance through inhibiting ROS ***-PCR data indicated that the expression level of GmSPOD1 gene encoding peroxidase was cooperatively regulated by GsWRKY40 and GsbHLH92,which was confirmed by using a dual luciferase report system and yeast one-hybrid *** study reveals a pathway that GsWRKY40 and GsbHLH92 collaboratively up-regulate plant salt resistance through impeding GmSPOD1 expression and reducing ROS levels,providing a novel perspective on the regulatory mechanisms underlying plant tolerance to abiotic stresses.

关键词： Wild soybean Transcription factor Salt stress ROS

维普期刊数据库

Influencing factors analysis of hard limestone reformation and strength weakening under acidic effect

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2024年第7期31卷 2446-2466页

作者： HOU Ming-xiao HUANG Bing-xiang ZHAO Xing-long JIAO xue-jie ZHENG Chen-yang State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources China University of Mining and TechnologyXuzhou 221116China

Roof disaster has always been an important factor restricting coal mine safety *** effect can reform the rock mass structure to weaken the macroscopic strength characteristics,which is an effective way to control the hard limestone *** this study,the effects of various factors on the reaction characteristics and mechanical properties of limestone were *** results show that the acid with stronger hydrogen production capacity after ionization(pK_(a)<0)has more prominent damage to the mineral grains of *** pKa increases from−8.00 to 15.70,uniaxial compressive strength and elastic modulus of limestone increase by 117.22%and 75.98%.The influence of acid concentration is manifested in the dissolution behavior of mineral crystals,the crystal defects caused by large-scale acid action will lead to the deterioration of limestone strength,and the strength after 15%concentration reformation can be reduced by 59.42%.The effect of acidification time on limestone has stages and is the most obvious in the initial metathesis reaction stage(within 60 min).The key to the strength damage of acidified limestone is the participation of hydrogen ions in the reaction *** on the analytic hierarchy process method,the influence weights of acid type,acid concentration and acidification time on strength are 24.30%,59.54% and 16.16%,*** research results provide theoretical support for the acidification control of hard limestone roofs in coal mines.

关键词： hard roof acidic effect structural reformation strength weakening influencing factors

Distal-scanning common path probe for optical coherence tomography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2024年第3期17卷 84-92页

作者： Zhengyu Chen Bin He Zichen Yin Zhangwei Hu Yejiong Shi Chengming Wang xiao Zhang Ning Zhang Linkai Jing Guihuai Wang Ping xue State Key Laboratory of Low-dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijingChina Frontier Science Center for Quantum Information BeijingChina Jinsp Company Limited BeijingChina Beijing Institute of Technology BeijingChina Institute of Forensic Science Ministry of Public Security BeijingChina Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical Medicine and Institute of Precision MedicineTsinghua UniversityBeijingChina

In this paper,we present a distal-scanning common path probe for optical coherence tomography(OCT)equipped with a hollow ultrasonic motor and a simple and specially designed *** novel probe proves to be able to effectively circumvent polarization and dispersion mismatch caused by fiber motion and is more robust to a variety of interfering factors during the imaging process,experimentally compared to a conventional noncommon path ***,our design counteracts the attenuation of backscattering with depth and the fall-off of the signal,resulting in a more balanced signal range and greater imaging ***-domain OCT imaging of phantom and biological tissue is also demonstrated with a sensitivity of∼100dB and a lateral resolution of∼3μ*** low-cost probe offers simplified system configuration and excellent robustness,and is therefore particularly suitable for clinical diagnosis as one-off medical apparatus.

关键词： Common path optical coherence tomography endoscopic probe