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Quercetin Alleviates Lipopolysaccharide-induced Cardiac inflammation via inhibiting Autophagy and programmed Cell Death

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Biomedical and Environmental Sciences 2024年第1期37卷 54-70页

作者： YU Jin Hai HU Guo Liang GUO xiao Quan CAO hua Bin XiA Zhao Fei AMiN Buhe Jiangxi provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045JiangxiChina internal Medicine Laboratory Department of Veterinary Clinical MedicineCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100091China Department of Cancer Surgery Beijing Shijitan Hospital Affiliated with Capital Medical UniversityBeijing 100038China

Objective The aim of this study is to explore the potential modulatory role of quercetin against Endotoxin or lipopolysaccharide(LpS)induced sep.ic cardiac *** Specific pathogen-free chicken embryos(n=120)were allocated untreated control,phosphate buffer solution(pBS)vehicle,pBS with ethanol vehicle,LpS(500 ng/egg),LpS with quercetin treatment(10,20,or 40 nmol/egg,respectively),Quercetin groups(10,20,or 40 nmol/egg).Fifteenday-old embryonated eggs were inoculated with abovementioned solutions via the allantoic *** embryonic day 19,the hearts of the embryos were collected for histopathological examination,RNA extraction,real-time polymerase chain reaction,immunohistochemical investigations,and Western *** They demonstrated that the heart presented inflammatory responses after LpS *** LpS-induced higher mRNA expressions of inflammation-related factors(TLR4,TNFα,MYD88,NF-κB1,iFNγ,iL-1β,iL-8,iL-6,iL-10,p38,MMp3,and MMp9)were blocked by quercetin with three *** significantly decreased immunopositivity to TLR4 and MMp9 in the treatment group when compared with the LpS *** significantly decreased protein expressions of TLR4,iFNγ,MMp3,and MMp9 when compared with the LpS *** treatment prevented LpS-induced increase in the mRNA expression of Claudin 1 and ZO-1,and significantly decreased protein expression of claudin 1 when compared with the LpS *** significantly downregulated autophagyrelated gene expressions(ppARα,SGLT1,ApOA4,AMpKα1,AMpKα2,ATG5,ATG7,Beclin-1,and LC3B)and programmed cell death(Fas,Bcl-2,CASp1,CASp12,CASp3,and RipK1)after LpS *** significantly decreased immunopositivity to ApOA4,AMpKα2,and LC3-ii/LC3-i in the treatment group when compared with the LpS *** significantly decreased protein expressions of AMpKα1,LC3-i,and *** significantly decreased the protein expression to CASp1 and CASp3 by immunohistochemical investigation or

关键词： Quercetin Lipopolysaccharide inflammation Autophagy programmed cell death Myocardiocytes permeability

OsEiL1 and OsEiL2,two master regulators of rice ethylene signaling,promote the expression of ROS scavenging genes to facilitate coleop.ile elongation and seedling emergence from soil

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plant Communications 2024年第3期5卷 93-105页

作者： Jinzhu Qiao Ruidang Quan Juan Wang Yuxiang Li Dinglin xiao Zihan Zhao Rongfeng huang hua Qin Biotechnology Research institute Chinese Academy of Agricultural SciencesBeijing 100081China National Key Facility of Crop Gene Resources and Genetic improvement Beijing 100081China

Successful emergence from the soil is a prerequisite for survival of germinating seeds in their natural *** rice,coleop.ile elongation facilitates seedling emergence and establishment,and ethylene plays an important role in this ***,the underlying regulatory mechanism remains largely ***,we report that ethylene promotes cell elongation and inhibits cell expansion in rice coleop.iles,result-ing in longer and thinner coleop.iles that facilitate seedlings emergence from the *** analysis showed that genes related to reactive oxygen species(ROS)generation are upregulated and genes involved in ROS scavenging are downregulated in the coleop.iles of ethylene-signaling *** investiga-tions showed that soil coverage promotes accumulation of ETHYLENE iNSENSiTiVE 3-LiKE 1(OsEiL1)and OsEiL2 in the upper region of the coleop.ile,and both OsEiL1 and OsEiL2 can bind directly to the promoters of the GDp-mannose pyrophosphorylase(VTC1)gene OsVTC1-3 and the peroxidase(pRX)genes OspRX37,OspRX81,OspRX82,and OspRX88 to activate their *** leads to increased ascorbic acid content,greater peroxidase activity,and decreased ROS accumulation in the upper region of the *** of ROS accumulation promotes coleop.ile growth and seedling emergence from *** deepen our understanding of the roles of ethylene and ROS in controlling coleop.ile growth,and this information can be used by breeders to produce rice varieties suitable for direct seeding.

关键词： ethylene ROS coleop.ile growth emergence rate rice

Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome

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World Journal of Clinical Cases 2024年第5期12卷 942-950页

作者： Bao Qian Zhan-Jun Chen Yong-Sheng Wang xiao-Yan Hu xiao-Biao Hu Yong-hua Zheng pulmonary Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China Radiology Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China

BACKGROUND Obstructive sleep apnea-hypopnea syndrome(OSAHS)is p.imarily caused by airway obstruction due to narrowing and blockage in the nasal and nasopha-ryngeal,oropharyngeal,soft palate,and tongue base *** mid-frequency anti-snoring device is a new technology based on sublingual nerve *** p.inciple is to improve the degree of oropharyngeal airway stenosis in OSAHS patients under mid-frequency wave ***,there is a lack of clinical app.ication and imaging *** We selected 50 patients diagnosed with moderate OSAHS in our hospital between July 2022 and August *** underwent a 4-wk treatment regimen involving the mid-frequency anti-snoring device during nighttime *** the treatment,we monitored and assessed the sleep apnea quality of life index and Epworth Sleepiness Scale ***,we performed computed tomo-graphy scans of the oropharynx in the awake state,during snoring,and while using the mid-frequency anti-snoring ***-sectional area measurements in different states were taken at the narrowest airway p.int in the soft palate posterior and retrolingual *** Compared to pretreatment measurements,patients exhibited a significant reduction in the apnea-hypopnea index,the percentage of time with oxygen saturation below 90%,snoring frequency,and the duration of the most prolonged apnea *** lowest oxygen saturation showed a notable increase,and both sleep apnea quality of life index and Epworth Sleepiness Scale scores *** computed tomography scans revealed that in OSAHS patients cross-sectional areas of the oropharyngeal airway in the soft palate posterior area and retrolingual area decreased during snoring compared to the awake ***,during mid-frequency anti-snoring device treatment,these areas increased compared to *** The mid-frequency anti-snoring device demonstrates the potential to enhance various sleep parameters in pat

关键词： Mid-frequency anti-snoring device Obstructive sleep apnea-hypopnea syndrome Sleep monitoring Oropharyngeal computed tomography Curative effect

A novel approach based on a modified mask R-CNN for the weight prediction of live pigs

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Artificial intelligence in Agriculture 2024年第2期12卷 19-28页

作者： Chuanqi Xie Yuji Cang Xizhong Lou hua xiao Xing Xu Xiangjun Li Weidong Zhou State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Animal Husbandry and Veterinary ScienceZhejiang Academy of Agricultural SciencesHangzhou 310021China College of information Engineering China Jiliang UniversityHangzhou 310018China College of Hydraulic Engineering Zhejiang Tongji Vocational College of Science and TechnologyHangzhou 311231China

Since determining the weight of pigs during large-scale breeding and production is challenging,using non-contact estimation methods is *** study proposed a novel pig weight prediction method based on a mod-ified mask region-convolutional neural network(mask R-CNN).The modified approach used ResNeSt as the backbone feature extraction network to enhance the image feature extraction *** feature pyramid net-work(FpN)was added to the backbone feature extraction network for multi-scale feature *** channel at-tention mechanism(CAM)and spatial attention mechanism(SAM)were introduced in the region proposal network(RpN)for the adap.ive integration of local features and their global dependencies to capture global in-formation,ultimately improving image segmentation *** modified network obtained a precision rate(p),recall rate(R),and mean average precision(MAp)of 90.33%,89.85%,and 95.21%,respectively,effectively segmenting the pig regions in the *** image features,namely the back area,body length,body width,average depth,and eccentricity,were *** pig depth images were used to build five regression algo-rithms(ordinary least squares(OLS),AdaBoost,CatBoost,XGBoost,and random forest(RF))for weight value *** achieved the best prediction result with a coefficient of determination(R^(2))of 0.987,a mean absolute error(MAE)of 2.96 kg,a mean square error(MSE)of 12.87 kg^(2),and a mean absolute percentage error(MApE)of 8.45%.The results demonstrated that the machine learning models effectively predicted the weight values of the pigs,providing technical support for intelligent pig farm management.

关键词： Deep learning Modified mask R-CNN image processing pig weight prediction

Systematic bibliometric analysis of research hotspots and trends on the app.ication of premium iOLs in the past 2 decades

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international Journal of Ophthalmology(English edition) 2024年第4期17卷 736-747页

作者： Liang-pin Li Li-Yun Yuan De-Shen Mao Xia hua xiao-Yong Yuan Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China School of Medicine Nankai UniversityTianjin 300071China Anhui Medical University Hefei 230032Anhui ProvinceChina Tianjin Aier Eye Hospital Tianjin UniversityTianjin 300190China

AiM:To analysis of research hotspots and trends on the app.ication of premium intraocular lens(piOLs)in the past 2 ***:The literature search was performed on the Web of Science and included piOLs studies published between January 2000 and December *** retrieved literature was collated and analyzed by R-tool’s Bibliometrix package,CitNetExplorer,CiteSpace and other ***:A total of 1801 articles about piOLs were obtained,most of which were published in Sp.in and the United *** organization that published the most articles was the University of Valencia in ***ó JL,and Montés-Micó R,from Sp.in were the most influential authors in this *** Journal of Cataract and Refractive Surgery and Journal of Refractive Surgery were the core journals for this field;the top 10 cited articles mainly focus on postoperative satisfaction with multifocal intraocular lens(iOLs)and postoperative results of toric *** the keyword analysis,we found that trifocal iOLs,astigmatism and extended depth of focus(EDoF)iOLs are the most discussed topics at present,and the importance of astigmatism and the clinical app.ication of the new generation of piOLs are the emerging research ***:Bibliometric analysis can effectively help to identify multilevel concerns in piOLs research and the prevailing research trends in the realm of piOLs encompass the adop.ion of EDoF iOLs,trifocal iOLs,and their respective Toric models.

关键词： premium intraocular lens bibliometric H-index cataract surgery global trends

Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

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Rare Metals 2024年第1期43卷 175-185页

作者： Jin-xiao Zheng Zi-An Zhou Tiao Feng Hui Li Cheng-hua Sun NüWang Yang Tian Yong Zhao Shu-Yun Zhou Key Laboratory of photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Bioinspired Smart interfacial Science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaissance/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorp.ion and decomposition, and strict requirements for seamless packaging and ***, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic Scintillators Underwater X-ray imaging Underwater nondestructive testing technology

Global impact and Balancing Act:Deciphering the Effect of Fluorination on B 1s Binding Energies in Fluorinated h‑BN Nanosheets

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precision Chemistry 2024年第6期2卷 239-244页

作者： Yang xiao Jun-Rong Zhang Sheng-Yu Wang Weijie hua MiiT Key Laboratory of Semiconductor Microstructure and Quantum Sensing Department of Applied PhysicsSchool of PhysicsNanjing University of Science and Technology210094 NanjingChina

X-ray photoelectron spectroscopy(XpS)is an important characterization tool in the pursuit of controllable fluorination of two-dimensional hexagonal boron nitride(h-BN).However,there is a lack of clear spectral interpretation,and seemingly conflicting measurements *** discern the structure−spectroscopy relation,we performed a comprehensive first-p.inciples study on the boron 1s edge XpS of fluorinated h-BN(F-BN)*** gradually introducing 1−6 fluorine atoms into different boron or nitrogen sites,we created various F-BN structures with doping ratios ranging from 1 to 6%.Our calculations reveal that fluorines landed at boron or nitrogen sites exert competitive effects on the B 1s binding energies(BEs),leading to red or blue shifts in different *** calculations affirmed the hypothesis that fluorination affects 1s BEs of all borons in theπ-conjugated system,opposing the transferability from h-BN to ***,we observe that BE generally increases with higher fluorine concentration when both borons and nitrogens are nonexclusively *** findings provide critical insights into how fluorination affects boron’s 1s BEs,contributing to a better understanding of fluorination functionalization processes in h-BN and its potential app.ications in materials science.

关键词： X-ray photoelectron spectroscopy Core-electron binding energy Fluorination Hexagonal boron nitride Cluster-periodic method Born-Oppenheimer molecular dynamics

Effect of Ti particles on the Microstructure and Mechanical properties of AZ91 Magnesium Matrix Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 513-524页

作者： Lu xiao Ting-Ting Liu Yue Chu Bo Song Jie Zhao Xian-hua Chen Kai-Hong Zheng Fu-Sheng pan College of Materials Science and Engineering Chongqing UniversityChongqing 400044China lntelligent Manufacturing and Automobile School Chongqing College of Electronic EngineeringChongqing 401331China School of Materials and Energy Southwest UniversityChongqing 400715China Science and Technology Research institute of CNNC 404 Co.LTD Gansu 735100China institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

Spherical micro-Ti particle(Tip)-reinforced AZ91 magnesium alloy composites were fabricated by semi-solid stirring assisted ultrasonic vibration,which were then subjected to hot *** microstructure results showed that the addition of Ti particles refined the grain size and decreased the texture intensity of the as-extruded AZ91 *** Al3Ti phase with a thickness of 100 nm formed at the Ti/Mg interface,which had a non-coherent relationship with the magnesium *** as-extruded 1 vol.%Tip/AZ91 composite exhibited the best comprehensive mechanical properties,with yield strength,ultimate tensile strength,and elongation at break of 366 Mpa,456 Mpa,and 14.6%,respectively,which were significantly higher than those of the AZ91 ***,the addition of Ti particles can improve the strength and ductility of the AZ91 alloy,demonstrating the value of magnesium matrix composites for commercial app.ications.

关键词： Magnesium matrix composites Ti particles interface Mechanical properties

Catalytic asymmetric dearomative azo-Diels–Alder reaction of 2-vinlyindoles

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Chinese Chemical Letters 2024年第4期35卷 357-362页

作者： Yu-Hang Miao Zheng-Xu Zhang Xu-Yi huang Yuan-Zhao hua Shi-Kun Jia xiao xiao Min-Can Wang Li-ping Xu Guang-Jian Mei Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450052China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China institute of pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

Due to the high electrop.ilic nature of azo-dienop.iles, azo-Diels–Alder proceeds rapidly even without the need of a catalyst and is therefore regarded as the “click reaction”. This spontaneity causes strong background reaction and poses a daunting challenge to chemists for developing the catalytic asymmetric version. Reported herein is the first catalytic asymmetric dearomative azo-Diels–Alder reaction between2-vinylindoles and triazoledione. This protocol makes use of the high energy barrier of dearomatization to avert the strong background reaction of azo-Diels–Alder reaction, allowing the implementation of the projected reaction at ambient temperature. Density functional theory calculations have been performed to gain insights into the reaction mechanism and the origins of the enantioselectivity. By using this method,a variety of tetracyclic indole derivatives have been readily prepared in good to excellent yields and with excellent diastereo-and enantio–selectivities(33 examples, up to 97% yield and >99% ee, >20:1 dr).

关键词： Catalytic asymmetric dearomatization Azo-Diels–Alder reaction 2-Vinylindoles Chiral phosphoric acid Tetracyclic indole derivatives