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Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & pancreatic Diseases international 2024年第2期23卷 186-194页

作者： Meng-xiao Feng hua Zou Yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and physic-chemical injury Diseases of Zhejiang province Hangzhou 310003China Occupational Health and Radiation protection institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide p.isoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide p.isoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide p.isoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide p.isoning Clinical characteristics Liver injury

Cretaceous magmatic arc in Hainan and the peri-South China Sea asevidenced by geochemical fingerp.inting of granitoids in the region

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Geoscience Frontiers 2024年第5期15卷 355-371页

作者： xiao-Yan Jiang Yildirim Dilek Xian-hua Li State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Department of Geology and Environmental Earth Science Miami UniversityOxfordOH 45056USA

Mesozoic magmatic rocks occur widely in the South China Block and are generally interpreted as the manifestations of the subduction of the paleo-pacific oceanic lithosphere beneath *** magmatism in southeast(SE)China continued from the Late permian through the Late Cretaceous with an inferred lull between 125 Ma and 115 Ma that is known in the literature as the Cretaceous"magmatic quiescence".We report in-situ zircon U-pb ages,Hf-O and whole-rock Sr-Nd isotopes,and whole-rock geochemistry of Cretaceous granitoids on Hainan island and discuss their magmatic evolution within the framework of the Late Mesozoic geodynamics of SE *** recognize two main stages of the emplacement of Cretaceous granitoids on Hainan,first around 120 Ma and then around 100-95 Ma,displaying high-K calc-alkaline,i-type geochemical *** in both age groups are enriched in LiLE and LREE,but depleted in Nb,Ta,Ba,Sr,and *** 120 Ma granites have zircon ε_(Hf)(t)values of-2.6 to 2.3 corresponding to Hf crustal model ages,ranging from 0.79 Ga to 1.03 Ga,and δ^(18)O values ranging from 6.9‰to 7.7‰.Zircons from 100-95 Ma granites have ε_(Hf)(t)values of-4.2 to 1.1 corresponding to Hf crustal model ages of 1.08 Ga to 1.42 Ga,and δ^(18)O values ranging from 6.7‰to 8.4‰.increasing ε_(Hf)(t)values of the Cretaceous Hainan granites with younger crystallization ages indicate addition of more juvenile components and reworking of crustal material into their melt *** ε_(Nd)(t)values of the 120 Ma and 100-95 Ma granitoids range between-4.1 to-0.4 and-7.7 to-4.0,*** calculated two-stage model age of the 100-95 Ma granitoids clusters between 1.25 Ga and 1.53 *** isotopic data suggest that magmas of the Cretaceous granitoids were produced by partial melting of Mesoproterozoic metabasaltic rocks,which make up much of the crystalline basement of the southern Cathaysia *** geochemical and isotopic characteristics of the Cretaceous granitoids on H

关键词： i-type granites Cretaceous Hainan island Southeast China Magmatic arc peri-South China Sea region

Maximum p.inciple for Stochastic Control System with Elephant Memory and Jump Diffusion

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Journal of Systems Science & Complexity 2024年第4期37卷 1392-1412页

作者： FENG Siqi GAO Lei WANG Guangchen xiao hua School of Control Science and Engineering Shandong UniversityJinan 250061China School of Economics Shandong UniversityJinan 250100China School of Mathematics and Statistics Shandong UniversityWeihai 264209China

Motivated by a duopoly game problem,the authors study an op.imal control problem where the system is driven by Brownian motion and p.isson p.int process and has elephant memory for the control variable and the state ***,the authors establish the unique solvability of an anticipated backward stochastic differential equation,derive a stochastic maximum p.inciple,and prove a verification theorem for the aforementioned op.imal control ***,the authors generalize these results to nonzero-sum stochastic differential game ***,the authors apply the theoretical results to the duopoly game problem and obtain the corresponding Nash equilibrium solution.

关键词： Anticipated backward stochastic differential equation elephant memory Fréchet derivative maximum p.inciple stochastic delayed differential equation

Advances of biomarkers in nasopharyngeal carcinoma’s early detection

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Science Bulletin 2024年第2期69卷 141-145页

作者： xiao-Hui Zheng Allan Hildesheim Wei-hua Jia State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Costa Rican Agency for Biomedical investigation INCIENSA FoundationSan Jose 10108Costa Rica

Nasopharyngeal carcinoma(NpC),a highly invasive and metastatic cancer,is widely prevalent in South China,Southeast Asia,and North *** patients with stages i and ii are often ***,NpC patients are usually diagnosed with advanced-stage(stages iii and iV)at their first *** of NpC at early stage is the key to improve the survival of ***-Barr virus(EBV)plays an essential role in NpC occurrence in endemic ***-based biomarkers,including EBV antibody in serum and EBV DNA in plasma,have been specifically proposed for NpC early ***,we summarize recent advances in biomarkers for the early detection of NpC.

关键词： patients nasopharyngeal Nasopharyngeal

Creep-Resistant Covalent Adaptable Networks with Excellent SelfHealing and Reprocessing performance via phase-Locked Dynamic Covalent Benzopyrazole-Urea Bonds

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Chinese Journal of polymer Science 2024年第10期42卷 1545-1556,I0013页

作者： Miao Xie xiao-Rong Wang Zhan-hua Wang He-Sheng Xia State Key Laboratory of polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu610065China School of petrochemical Engineering Liaoning Petrochemical UniversityFushun113001China

Covalent adap.ive networks(CANs)are capable of undergoing segment rearrangement after being heated,which endows the materials with excellent self-healing and reprocessing performance,providing an efficient solution to the environment pollution caused by the plastic *** main challenge remains in developing CANs with both excellent reprocessing performance and creep-resistance *** this study,a series of CANs containing dynamic covalent benzopyrazole-urea bonds were developed based on the addition reaction between benzopyrazole and isocyanate *** calculation confirmed that relatively low dissociation energy is obtained through undergoing a five-member ring transition state,confirming excellent dynamic property of the benzopyrazole-urea *** verified by the FTiR results,this nice dynamic property can be well maintained after incorporating the benzopyrazole-urea bonds into polymer *** self-healing and reprocessing performance is observed by the 3-ABp/pDMS elastomers owing to the dynamic benzopyrazole-urea *** separation induced by the aggregation of the hard segments locked the benzopyrazole-urea bonds,which also makes the elastomers display excellent creep-resistance *** hard phase locking strategy provides an efficient approach to design CANs materials with both excellent reprocessing and creep-resistance performance.

关键词： Covalent adap.ive networks Self-healing polymer Dynamic covalent bond

pH-responsive metal nanoparticles as high contrast theranostic agents for selective imaging and synergistic cancer therapy

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Science China Chemistry 2024年第9期67卷 3063-3070页

作者： Sichao Tian xiaofeng He xiao Wu Dongxue Hu Qing-hua Xu Department of Chemistry National University of SingaporeSingapore 117543Singapore National University of Singapore(Suzhou)Research institute Suzhou 215123China institute of Medicinal plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore

The low signal-to-noise ratio(S/N)and single functionality of fluorescence imaging agents have limited their practical *** two-photon excitation(2pE)imaging probes are highly desirable in vivo with larger imaging depth,minor autofluorescence background,and less ***,we developed responsive aggregated gold nanoparticles(Au Nps)as high contrast 2pE imaging agents,capable of emitting red fluorescence upon excitation of near-infrared(NiR)laser and possessing a high signal-to-noise ratio(S/N of 2,475).By forming aggregates in situ inside tumor tissue,doxorubicin hydrochloride(DOX)-loaded mix-charged gold nanoparticles(DOX-MC-Au Nps)were utilized to act as selective fluorescence imaging probes and precise therapy *** high-contrast theranostic agents offer a promising potential for precise cancer imaging and therapy,which might open a new venue to multifunctional and noninvasive theranostics.

关键词： metal nanoparticles two-photon excitation high contrast imaging agents fluorescence imaging cancer therapy

Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2024年第4期21卷 421-430页

作者： Jing TAN Jin Si Ke-Ling xiao Ying-hua ZHANG Qi hua Jing Li Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Geriatric Medicine Xuanwu Hospital Capital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction(STEMi) are *** We analyzed 2313 patients admitted for acute STEMi between October 2013 and December 2020. in-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(ith the high prealbumin level(≥ 170 mg/L).RESULTS A total of 114 patients(4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, p = 0.034), cardiovascular death(8.4% vs. 3.4%, p = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, p = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(independent predictor of in-hospital major adverse cardiovascular events(odds ratio = 1.918, 95% Ci: 1.250–2.942, p = 0.003). The cutoff value of prealbumin level for predicting in-hospital death was 170 mg/L(area under the curve = 0.703, 95% Ci: 0.651–0.754, pitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level(170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent *** Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently assoc

关键词： patients admitted infarction

Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan Yang hua Yue Shuang Wang xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

Experimental investigation on using CO_(2)/H_(2)O emulsion with high water cut in enhanced oil recovery

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petroleum Science 2024年第2期21卷 974-986页

作者： Xi-Dao Wu peng xiao Bei Liu Guang-Jin Chen Jian-hua pang State Key Laboratory of Heavy Oil processing China University of PetroleumBeijing102249China Ocean intelligence Technology Center Shenzhen Institute of Guangdong Ocean UniversityShenzhen518120GuangdongChina

CO_(2) emulsions used for EOR have received a lot of interest because of its good performance on CO_(2)mobility ***,most of them have been focusing on the high quality CO_(2) emulsion(high CO_(2) fraction),while CO_(2) emulsion with high water cut has been rarely *** this paper,we carried out a comprehensive experimental study of using high water cut CO_(2)/H_(2)O emulsion for enhancing oil ***,a nonionic surfactant,alkyl glycosides(ApG),was selected to stabilize CO_(2)/H_(2)O emulsion,and the corresponding morphology and stability were evaluated with a transparent pVT ***,plugging capacity and apparent viscosity of CO_(2)/H_(2)O emulsion were measured systematically by a sand pack displacement apparatus connected with a 1.95-m long capillary ***,a high water cut(40 vol%) CO_(2)/H_(2)O emulsion was selected for flooding experiments in a long sand pack and a core sample,and the oil recovery,the rate of oil recovery,and the pressure gradients were *** results indicated that ApG had a good performance on emulsifying and stabilizing CO_(2) *** inversion from H_(2)O/CO_(2) emulsion to CO_(2)/H_(2)O emulsion with the increase in water cut was ***_(2)/H_(2)O emulsions with lower water cuts presented higher apparent viscosity,while the op.imal plugging capacity of CO_(2)/H_(2)O emulsion occurred at a certain water ***,the displacement using CO_(2)/H_(2)O emulsion provided 18.98% and 13.36% additional oil recovery than that using pure CO_(2) in long sand pack and core tests,*** work may provide guidelines for EOR using CO_(2) emulsions with high water cut.

关键词： CO_(2)/H_(2)O emulsion High water cut CO_(2) mobility control Enhanced oil recovery