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Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

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Asian Journal of Andrology 2024年第1期26卷 41-45页

作者： Shun Bai Ming-Zhen Li Yang-Yang Wan Xue-Chun Hu Yi-Xun Liu Xian-Hong Tong Tong-Hang Guo Lu Zong Ran Liu Yuan-Qi Zhao Ping Xiang Bo Xu xiao-hua jiang Department of Gynecology and Obstetrics Reproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Wannan Medical College Wuhu 241002China

Genetic risk factors have been shown to contribute to the development of sexual ***,the role of methylenetetrahydrofolate reductase(MTHFR)gene variants in the risk of erectile dysfunction(ED)remains *** this study,we recruited 1254 participants who underwent ED assessed by the International Index of Erectile *** MTHFR c.677C>T variant was also measured by fluorescence polymerase chain reaction(PCR).No significant difference in the genotypic frequency of the MTHFR C677T polymorphism(CC,CT,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic regression analysis,both crude and adjusted models showed that the risk of ED was not significantly associated with the C677T ***,a significantly higher frequency of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive correlation between the MTHFR 677TT polymorphism and severe ED was confirmed by logistic regression analysis,even after adjusting for potential confounders(odds ratio[OR]=2.46,95%confidence interval[CI]:1.15-5.50,P=0.02).These findings suggest a positive correlation between the MTHFR 677TT polymorphism and the risk of severe *** of MTHFR gene polymorphisms may provide complementary information for ED patients during routineclinicaldiagnosis.

关键词： erectile dysfunction gene variant genetic risk factors methylenetetrahydrofolate reductase sexual function

The molecular control of meiotic double-strand break (DSB) formation and its significance in human infertility

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Asian Journal of Andrology 2021年第6期23卷 555-561页

作者： Yang Li Yu-Fan Wu Han-Wei jiang Ranjha Khan Qi-Qi Han Furhan Iqbal xiao-hua jiang Qing-hua Shi Division of Reproduction and Genetics First Affiliated Hospital of USTCHefei National Laboratory for Physical Sciences at Microscalethe CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineCAS Center for Excellence in Molecular Cell ScienceCollaborative Innovation Center of Genetics and DevelopmentUniversity of Science and Technology of ChinaHefei 230027China Institute of Pure and Applied Biology Bahauddin Zakariya UniversityMultan 60000Pakistan

Meiosis is an essential step in gametogenesis which is the key process in sexually reproducing organisms as meiotic aberrations may result in infertility. In meiosis, programmed DNA double-strand break (DSB) formation is one of the fundamental processes that are essential for maintaining homolog interactions and correcting segregation of chromosomes. Although the number and distribution of meiotic DSBs are tightly regulated, still abnormalities in DSB formation are known to cause meiotic arrest and infertility. This review is a detailed account of molecular bases of meiotic DSB formation, its evolutionary conservation, and variations in different species. We further reviewed the mutations of DSB formation genes in association with human infertility and also proposed the future directions and strategies about the study of meiotic DSB formation.

关键词： DNA double-strand break(DSB) infertility meiosis mutation

Organic matter occurrence and pore-forming mechanisms in lacustrine shales in China

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Petroleum Science 2022年第4期19卷 1460-1472页

作者： Li-Chun Kuang Lian-hua Hou Song-Tao Wu Jing-Wei Cui hua Tian Li-Jun Zhang Zhong-Ying Zhao Xia Luo xiao-hua jiang Science and Technology R&D Department CNPCBeijing100000China Research Institute of Petroleum Exploration and Development CNPCBeijing100083China National Energy Tight Oil and Gas R&D Center Beijing100083China Key Laboratory of Oil and Gas Reservoirs CNPCBeijing100083China

The evolution of pore structure in shales is affected by both the thermal evolution of organic matter(OM)and by inorganic diagenesis,resulting in a wide variety of pore *** paper examines the OM distribution in lacustrine shales and its influence on pore structure,and describes the process of porosity *** principal findings are:(i)Three distribution patterns of OM in lacustrine shales are distinguished;laminated continuous distribution,clumped distribution,and stellate scattered *** differences in total organic carbon(TOC)content,free hydrocarbon content(S_(1)),and OM porosity among these distribution patterns are discussed.(ii)Porosity is negatively correlated with TOC and plagioclase content and positively correlated with quartz,dolomite,and clay mineral content.(iii)Pore evolution in lacustrine shales is characterized by a sequence of decreasing-increasing-decreasing porosity,followed by continuously increasing porosity until a relatively stable condition is reached.(iv)A new model for evaluating porosity in lacustrine shales is *** this model,the organic and inorganic porosity of shales in the Permian Lucaogou Formation are calculated to be 2.5%-5%and 1%-6.3%,respectively,which correlate closely with measured *** findings may provide a scientific basis and technical support for the sweet spotting in lacustrine shales in China.

关键词： Shale oil Unconventional oil and gas Organic matter Pore evolution Log interpretation model

Blood-testis barrier and spermatogenesis： lessons From genetically-modified mice

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Asian Journal of Andrology 2014年第4期16卷 572-580页

作者： xiao-hua jiang Ihtisham Bukhari Wei Zheng Shi Yin Zheng Wang Howard J Cooke Qing-hua Shi Hefei National Laboratory for Physical Sciences at Microscale School of Life Sciences University of Science and Technology of China Hefei China Medical Research Council Human Genetics Unit and Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh United Kingdom Institute of Physics Chinese Academy of Sciences Hefei China.

The blood-testis barrier （BTB） is found between adjacent Sertoli cells in the testis where it creates a unique microenvironment for the development and maturation of meiotic and postmeiotic germ cells in seminiferous tubes. It is a compound proteinous structure, composed of several types of cell junctions including tight junctions （TJs）, adhesion junctions and gap junctions （GJs）. Some of the junctional proteins function as structural proteins of BTB and some have regulatory roles. The deletion or functional silencing of genes encoding these proteins may disrupt the BTB, which may cause immunological or other damages to meiotic and postmeiotic cells and ultimately lead to spermatogenic arrest and infertility. In this review, we will summarize the findings on the BTB structure and function from genetically-modified mouse models and discuss the future perspectives.

关键词： blood-testis barrier genetically-modified mouse seminiferous tubule sertoli cells spermatogenesis

Ultrafine eutectic Ti_xSn_y/TiNi composites with high damping capacity

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Rare Metals 2013年第2期32卷 196-200页

作者： Jun-Song Zhang Li-Shan Cui Yang Shao Rui-Shi Li Shu-Jing Jiao xiao-hua jiang Department of Materials Science and Engineering China University of Petroleum

Three kinds of bulk-type ultrafine TixSny/TiNi （TixSny represents Ti3Sn, Ti2Sn, and TisSn3 or Ti6Sns） composites with homogeneous eutectic microstructure were prepared by arc melting. The composites exhibit high damping capacity （tan6 greater than 1 x 10-2） and enhanced mechanical strength （the highest fracture strength is 2.15 GPa）. The damping capacity originates from TiNi and Ti3Sn, while the eutectic contributes to the mechanical strength.

关键词： Eutectic Ti2Sn TisSn3 Ti6Sn5

Microscopic oil occurrence in high-maturity lacustrine shales:Qingshankou Formation,Gulong Sag,Songliao Basin

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Petroleum Science 2023年第5期20卷 2726-2746页

作者： Jing-Ya Zhang Ru-Kai Zhu Song-Tao Wu xiao-hua jiang Chang Liu Yi Cai Su-Rong Zhang Tian-Shu Zhang Research Institute of Petroleum Exploration and Development PetroChinaBeijing100083China

Occurrence and mobility of shale oil are prerequisites for evaluating shale oil reserves and prioritizing exploration targets,particularly for heterogeneous lacustrine *** Qingshankou Formation in the Gulong Sag,Songliao Basin is a classic lacustrine pure shale reservoir that contains abundant shale oil *** predicted geological reserves of the shale are 1.268×10^(9) *** this study,field emission scanning electron microscope(FE-SEM),the modular automated processing system(MAPS),pyrolysisgas chromatography(Py-GC),low-pressure nitrogen gas adsorption(LPNA),Soxhlet extraction,pyrolysis,and 2-D nuclear magnetic resonance(NMR)were integrated to describe the shale oil components,microscopic occurrence,mobility,and the effective pore size ***,the related controlling factors are *** shale oil in the Qingshankou Fm exists dominantly in the matrix pores of the clay minerals,with small amounts distributed in the intergranular pores of terrigenous clastic grains,intercrystalline pores of pyrite,intragranular pores of ostracod shells,and *** oil is distributed in the pore spaces of variable sizes in different *** clay mineral-laminated shales are characterized by the broadest range of pore size and largest volume of pore spaces with shale oil distribution,while the ostracod-laminated shales have limited pore spaces retaining ***,the proposed integrated analysis evaluates the shale oil molecules existing in two states:movable,and adsorbed oil,*** result illustrates that movable oil takes up 30.6%e79.4%of the total residual ***,mineral composition,and pore structures of the shale joint together to control the states and mobility of the shale *** values are positively correlated with the quantities of shale oil regardless of the state of *** mineral components significantly impact the state of shale *** differences in the states of oil were observed following

关键词： Shale oil content Occurrence states Micro-oil distribution Effective pore spaces Controlling factors Gulong sag

Hydrocarbon Accumulation Condition and Exploration Direction in the Deepwater Area of Qiongdongnan Basin,Northern South China Sea

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地学前缘 2009年第S1期16卷 147-148页

作者： Jun xiao,hua Wang,hua jiang Faculty of Earth Resources,China University of Geosciences(Wuhan),Wuhan 430074,China.

The deepwater area of southern Qiongdongnan Basin is a hydrocarbon exploration frontier and mainly located on the continental slope in the northwestern South China *** tectonic and depositional evolution is similar to the typical marginal deepwater areas abroad where oils have been *** hydrocarbon conditions in this area are as follows:(1) three sets of source rocks (including lacustrine mudstone of Eocene,coastal plain coal-bearing strata and semi-closed shallow sea mudstone of Oligocene,and marine mudstone

关键词： Qiongdongnan Basin deepwater area condition of hydrocarbon reservoir forming hydrocarbon exploration

FPGA-based plasma sterilization device for wound-edge recognition

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Nanotechnology and Precision Engineering 2024年第3期7卷 56-70页

作者： Huijuan Lu xiaorong Tang Minglei Li Xueping jiang Wenxiang xiao hua Li School of Life and Environmental Sciences Guilin University of Electronic TechnologyGuilin 541004People’s Republic of China Guilin URIT MEDICAL Electronic Sales Co. Ltd.Guilin 541004People’s Republic of China

There is a currently a lack of large-area plasma sterilization devices that can intelligently identify the shape of a wound for automatic *** this reason,in this work,a plasma sterilization device with wound-edge recognition was developed using aﬁeld-programmable gate array(FPGA)and a high-performance image-processing platform to realize intelligent and precise sterilization of *** was used to design the mechanical structure of the device,and it was manufactured using 3D *** device used an improvement of the traditional Sobel detection algorithm,which extends the detection of edges in only the x and y directions to eight directions(0○,45○,90○,135○,180○,225○,270○,and 315○),completing the wound-edge detection by adaptive *** device can be controlled according to different shapes of sterilization area to adjust the positioning of a single plasma-jet tube in the horizontal plane for two-dimensional move-ment;the distance between the plasma-jet tube and the surface of the object to be sterilized can be also adjusted in the vertical *** this way,motors are used to move the plasma jet and achieve automatic,efﬁcient,and accurate plasma *** was found that a good sterilization effect could be achieved at both the culture-medium level and the biological-tissue *** ideal sterilization parameters at the culture-medium level were a speed of 2 mm/s and aﬂow rate of 0.6 slm,while at the biological-tissue level,these values were 1 mm/s and 0.6 slm,respectively.

关键词： FPGA Wound-edge recognition Improvement of the Sobel algorithm Plasma Automatic and precise sterilization

Laparoendoscopic single-site distal pancreatectomy in pigs

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World Journal of Gastroenterology 2014年第22期20卷 6878-6883页

作者： Dong Wang Zhen-Ling Ji xiao-hua jiang Jing-Min Wang Yu-Yan Tan Yan Wang Ya-Zhou Wen Department of General Surgery Zhongda HospitalInstitute for Minimally Invasive SurgerySoutheast University Medical School Department of Obstetrics and Gynecology Zhongda HospitalSoutheast University Medical School Department of Anesthesiology Zhongda HospitalSoutheast University Medical School

AIM: To explore the technique for laparoendoscopic single-site distal pancreatectomy.

关键词： Laparoendoscopic single-site surgery LESS Pancreatectomy Fish hook retraction Curved laparoscopic multifunctional operative device