检索结果-南通市图书馆

Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2016年第14期8卷 616-624页

作者： Chang-Feng Dong Jia xiao Ling-Bo Shan Han-Ying Li Yong-Jia Xiong Gui-Lin Yang Jing Liu Si-Min Yao Sha-Xi Li xiao-hua le Jing Yuan Bo-Ping Zhou George L Tipoe Ying-Xia Liu Division of Ultrasound Shenzhen Third People’s Hospital National Key Disciplines for Infectious Diseases Shenzhen Third People’s Hospital Department of Immunobiology Institute of Tissue Transplantation and Immunology Jinan University Department of Pathology Shenzhen Third People’s Hospital School of Biomedical Sciences LKS Faculty of Medicine the University of Hong Kong

AIM: To investigate the combined diagnostic accuracy of acoustic radiation force impulse(ARFI), aspartate aminotransferase to platelet ratio index(APRI) and Forns index for a non-invasive assessment of liver fibrosis in patients with chronic hepatitis B(CHB). METHODS: In this prospective study, 206 patients had CHB with liver fibrosis stages F0-F4 classified by METAVIR and 40 were healthy volunteers were measured by ARFI, APRI and Forns index separately or combined as indicated. RESULTS: ARFI, APRI or Forns index demonstrated a significant correlation with the histological stage(all P < 0.001). According to the AUROC of ARFI and APRI for evaluating fibrotic stages more than F2, ARFI showed an enhanced diagnostic accuracy than APRI(P < 0.05). The combined measurement of ARFI and APRI exhibited better accuracy than ARFI alone when evaluating ≥ F2 fibrotic stage(Z = 2.77, P = 0.006). Combination of ARFI, APRI and Forns index did not obviously improve the diagnostic accuracy compared to the combination of ARFI and APRI(Z = 0.958, P = 0.338). CONCLUSION: ARFI + APRI showed enhanced diagnostic accuracy than ARFI or APRI alone for significant liver fibrosis and ARFI + APRI + Forns index shows the same effect with ARFI + APRI.

关键词： Acoustic radiation force impulse Aspartate aminotransferase to platelet ratio index Forns index Hepatitis B virus Non-invasive diagnosis

The relationship between the distribution of HBcAg in liver cells and the pathological manifestations of the liver in 429 HBeAg-positive chronic HBV-infected individuals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology & Hepatology Research 2024年第3期6卷 10-15页

作者： Fan Nie Chang-Chun Zeng Guang-Dong Tong Mu-Min Shao xiao-hua le Xin Deng Da-Qiao Zhou National Clinical Research Center for Infectious Diseases Shenzhen 518112China Central Laboratory of Shenzhen Longhua District Central Hospital Shenzhen 518112China Hepatology Department of Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518112China Pathology Department of Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518112China Pathology Department of Shenzhen Third People's Hospital Shenzhen 518112China Traditional Chinese Medicine Department of Shenzhen Third People's Hospital Shenzhen 518112China

Background:The natural history of chronic HBV infection is typically characterized by four stages:the immune tolerance period,the immune clearance period,the immune control period,and the immune escape *** stages are associated with the distribution of HBcAg in liver cells;however,this relationship remains a topic of broad debate within the field of liver *** objectively and quantitatively measure the intracellular distribution of HBcAg,this paper aims to design a method referred to as the“layered evaluation method”and to examine its ***:The distribution of HBcAg in liver cells is assessed using Image Pro Plus image processing software,along with calculations of cytoplasmic and nuclear positive staining ***:The findings indicate that the highest proportion of patients exhibited a positive cytoplasmic expression rate ranging from 0-2.5%.More than 40% of the total sample was categorized within the 0-2.5% positive nuclear expression *** HBcAg cytoplasmic positive staining rates were classified into five levels:a cytoplasmic HBcAg positive staining rate of less than 0.05% is designated as level 0,indicating negative expression;a staining rate between 0.05% and 5% is classified as level 1;a rate from 5% to less than 10% is classified as level 2;a rate from 10% to less than 20% is classified as level 3;and a nuclear positivity rate exceeding 20% is classified as level ***:The inflammatory activity grade in these patients was positively correlated with the cytoplasmic distribution of ***,the nuclear distribution rate of HBcAg was significantly higher in the G3 group compared to the other groups.

关键词： distribution of HBcAg pathological manifestations of the liver positive staining rate

Duodenal pseudolymphoma: A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第27期17卷 3267-3270页

作者： Yong-Heng huang, Tian-Zhu Long, Zhi-Yu xiao, hua Ye, Yun-le Wan, Jie Wang Yong-Heng huang, Tian-Zhu Long, Zhi-Yu xiao, hua Ye, Yun-le Wan, Jie Wang, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University Haizhu District, Guangzhou 510260, Guangdong Province, China Yong-Heng huang Tian-Zhu Long Zhi-Yu Xiao Hua Ye Yun-Le Wan Jie Wang Department of Hepatobiliary Surgery Sun Yat-sen Memorial Hospital Sun Yat-sen University Haizhu District Guangzhou 510260 Guangdong Province China

We report a rare case of duodenal pseudolymphoma without any symptoms. The lesion located in front of the head of the pancreas was found accidentally during a medical examination. The findings of computed tomography and positron emission tomography-computed tomography suggested a stromal tumor or malignant lymphoma. Surgical resection was performed. The lesions were patho- logically diagnosed as duodenal pseudolymphoma.

关键词： Pseudolymphoma Duodenum

Investigation on Factors Associated with Severe Hand, Foot and Mouth Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际感染病学（电子版） 2014年第2期3卷 82-91页

作者： Gui-lin Yang Ying-xia Liu Mu-tong Fang Yan-xia He John Nunnari Jing-jing Xie xiao-hua le Bo-ping Zhou Shenzhen Institute of Infectious Diseases Shenzhen Third People’s Hospital Department of Pediatrics ICU Shenzhen Children’s Hospital Department of Neurobiology the University of Massachusetts Medical School

Objective To analyze the clinical and laboratory features of patients with mild and severe HFMD to identify early predictive or diagnostic markers for severe cases. Methods Samples of feces, nasopharyngeal-swab specimens, peripheral blood, serum and cerebral spinal fluid were collected. Postmortem pathological examination was conducted on 2 dead patients with complication due to neurogenic pulmonary edema. Reverse transcription-polymerase chain-reaction(RT-PCR), culture and isolation of enterovirus 71(EV71) were performed to detect EV71 infection. Both univariate and multivariate logistic analysis were used to identify factors associated with severe cases. Results EV71 was mainly responsible for HFMD. In this study, 5 isolated EV71 strains belonged to C4 gene subtype. Compared with mild patients, EV71-RNA detection rate was higher and Cox A16 detection rate was lower among severe patients(P le for HFMD, particularly for severe cases. Vomiting and limb tremor were predictive markers for severe cases.

关键词： Hand,foot and mouth disease Enterovirus 71 Predictive marker Severe cases

The Relationship between Intrahepatic Distribution of Hepatitis B Virus Core Antigen and Serum ALT, HBV DNA levels and HBeAg Status

在线全文

学校读者我要写书评

暂无评论

国际感染病学（电子版） 2012年第2期1卷 84-90页

作者： Qing He Qi-yuan Tang xiao-hua le De-liang Lv Xiang-mei Zhang Fei-jian Ao Yi-min Tang Shan huang John Nunnari Gui-lin Yang Shenzhen Institute of Infectious Diseases Shenzhen Third People’s Hospital Shenzhen Hospital for Chronic Diseases Control and Prevention Department of Neurobiology University of Massachusetts Medical School

Objective The clinical significance of differential distribution of hepatitis B virus(HBV)nucleocapsid antigen in hepatocytes remains *** goal of this study is to determine the relationship between distinct HBV core antigen distribution pattern and alanine transaminase(ALT),liver histological inflammatory activity grades,serum HBeAg status and HBV DNA *** Total of 958 cases with chronic hepatitis B were recruited into this *** function tests,serum HBV DNA level,serological HBV markers and liver immunohistochemistry were examined according to the conventional *** Square tests were performed to analyze the differences among these *** It was found that 552(58%)cases were tested positive for HBV core antigen by immunohistochemical *** hepatitis B core antigen(HBcAg)expression correlated with ALT level and serum HBV DNA and liver inflammatory activity scores,however,nuclear HBcAg expression in hepatocytes was associated with normal ALT level,lower liver inflammatory activity score and higher serum HBV DNA level and rate of HBeAg *** nuclear and cytoplasmic HBcAg expression in hepatocytes associated with a middle ALT level and liver inflammatory activity score,higher rate of serum detectable HBeAg and a higher HBV DNA ***,undetectable core antigen was related to a lower ALT level and histological inflammatory activity grade,lower positive HBeAg rate and HBV DNA *** Undetectable liver HBcAg is associated with HBV clearance,ALT normalization and hepatitis B e antigen(HBeAg)seroconversion,and cytoplasmic HBcAg expression associated with higher hepatic inflammatory ***,nuclear HBcAg expression correlates with immune tolerance characterized with normal ALT and lower liver inflammatory activity,higher HBV replication level and higher rate of HBeAg positivity.

关键词： HBcAg distribution Immunohistochemistry HBV DNA Chronic hepatitis B HBeAg ALT

Quasispecies of Hepatitis B Virus

在线全文

学校读者我要写书评

暂无评论

国际感染病学（电子版） 2012年第4期1卷 177-182页

Hepatitis B virus(HBV) circulates in blood and replicates in the presence of quasispecies. During HBV replication, HBV DNA polymerase lacks fidelity and proofreading function partly because its exonuclease activity is either absent or deficient. Therefore, HBV genome is mutated with unusually high frequency. And these mutations can affect more than one open reading frame due to overlapping genes. Otherwise, natural substitutions, deletions or insertions involving the Cp/ENⅡ locus in the X gene can significantly alter the extent of viral replication activity. Particular selection pressures such as host immune system and antiviral therapy readily select out escape mutants from this pre-existing quasispecies pool. Antiviral drug resistance in chronic hepatitis B(CHB) can be caused by the viral mutation frequency, the intrinsic mutability of the antiviral target site, the selective pressure exerted by the drug, the magnitude and rate of virus replication, the overall replication fitness of the mutant, the genetic barrier of the compound and the availability of replication space. Potent inhibition of HBV replication could be able to prevent the development of drug resistance because mutagenesis is replication dependent. Viral load may decline to a point where the continued production of quasispecies with the potential to resist new drug treatments no longer occurs, if viral replication can be suppressed for a sufficient length of time.

关键词： Quasispecies Hepatitis B virus Mutation

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： hua Bai xiao-Feng Feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： xiao-Yi Wang Yao Hao Zi-Jian Wang Xiu-Liang Xu Jiang-hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

Machine learning Aided Key-Guessing Attack Paradigm Against Logic Block Encryption

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2021年第5期36卷 1102-1117页

作者： Yi Zhong Jian-hua Feng xiao-Xin Cui xiao-le Cui Institute of Microelectronics Peking UniversityBeijing 100871China Key Laboratory of Integrated Microsystems Peking University Shenzhen Graduate SchoolShenzhen 518055China

Hardware security remains as a major concern in the circuit design *** block based encryption has been widely adopted as a simple but effective protection *** this paper,the potential threat arising from the rapidly developing field,i.e.,machine learning,is *** illustrate the challenge,this work presents a standard attack paradigm,in which a three-layer neural network and a naive Bayes classifier are utilized to exemplify the key-guessing attack on logic *** with validation results obtained from both combinational and sequential benchmarks,the presented attack scheme can specifically accelerate the decryption process of partial keys,which may serve as a new perspective to reveal the potential vulnerability for current anti-attack designs.

关键词： hardware security logic encryption machine learning neural network naive Bayes classifier