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Non-linear relationship between combustion kinetic parameters and coal quality

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第5期13卷 344-352页

作者： Jian-guo YANG xiao-long ZHANG hong zhao Li SHEN State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

Combustion kinetic parameters(i.e.,activation energy and frequency factor) of coal have been proven to relate closely to coal properties;however,the quantitative relationship between them still requires further *** paper adopts a support vector regression machine(SVR) to generate the models of the non-linear relationship between combustion kinetic parameters and coal *** analyses on the thermo-gravimetry(TG) data of 80 coal samples were performed to prepare training data and testing data for the *** models developed were used in the estimation of the combustion kinetic parameters of ten testing *** predicted results showed that the root mean square errors(RMSEs) were 2.571 for the activation energy and 0.565 for the frequency factor in logarithmic form,*** curves defined by predicted kinetic parameters were fitted to the experimental data with a high degree of precision.

关键词： Kinetic parameter Coal property Thermo-gravimetry(TG) Support vector regression machine(SVR) Differential evolution

Different Features of Jets and Isotropic Fireballs in Gamma-ray Burst Phase

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Chinese Journal of Astronomy and Astrophysics 2006年第1期6卷 69-76页

作者： Yun-Ming Dong Lan-Wei Jia xiao-hong zhao Yunnan Astronomical Observatory/National Astronomical Observatories Chinese Academy ofSciences Kunming 650011 Graduate University of Chinese Academy of Sciences Beijing 100049

We investigated physical quantities including the spectrum, emission lines and pulse profiles expected from a uniform jet, a spherical fireball and the 1/Г region （the portion of the spherical fireball with opening angle 1/Г） in the prompt emission phase, after taking into consideration of the Doppler effect under the fireball framework. Our study shows that： a） for these physical quantities the spherical fireball and the uniform jets do not present obvious differences, so we cannot use these to distinguish a spherical fireball from a uniform jet; b） for the spherical fireball and a uniform jet, the observed quantities mainly come from the 1/Г region, so we can simply use the 1/Г region in approximate calculations; c） broadening of emission lines is a general phenomena, which mainly comes from the curvature effect; d） the 1/Г region plays different roles in different frequency ranges, and the radiation from the 1/Г region is greater in the higher than in the lower frequencies.

关键词： gamma-rays: bursts--gamma-rays: theory--radiation mechanisms: non-thermal --relativity

Role of serum β2-microglobulin, glycosylated hemoglobin, and vascular endothelial growth factor levels in diabetic nephropathy

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World Journal of Clinical Cases 2022年第23期10卷 8205-8211页

作者： Bing Yang xiao-hong zhao Guo-Bin Ma Department of Endocrinology and Metabolism 3201 HospitalXi’an Jiaotong University Health Science CenterHanzhong 723099Shaanxi ProvinceChina

BACKGROUND Diabetic nephropathy(DN)is a common complication of type 1 and type 2 diabetes that can lead to kidney damage and high blood *** evidence support the important roles of microproteins and cytokines,such asβ2-microglobulin(β2-MG),glycosylated hemoglobin(HbA1c),and vascular endothelial growth factor(VEGF),in the pathogenesis of this *** this study,we identified novel therapeutic options for this *** To analyze the guiding significance ofβ2-MG,HbA1c,and VEGF levels in patients with *** A total of 107 patients with type 2 diabetes mellitus complicated with nephropathy and treated in our hospital from May 2018 to February 2021 were included in the ***,107 healthy individuals and 107 patients with simple diabetes mellitus were selected as the control *** inβ2-MG,HbA1c,and VEGF levels in the three groups as well as the different proteinuria exhibited by the three groups were *** Changes inβ2-MG,HbA1c,and VEGF levels in the disease,healthy,and simple diabetes groups were significantly different(P<0.05).The expression of these factors from high to low were evaluated in different groups by pairwise *** the disease group,high to low changes inβ2-MG,HbA1c,and VEGF levels were noted in the massive proteinuria,microproteinuria,and normal urinary protein groups,*** in these factors were positively correlated with disease *** The expression of serumβ2-MG,HbA1c,and VEGF was closely correlated with DN progression,and disease progression could be evaluated by these factors.

关键词： Type 2 diabetic nephropathy β2-microglobulin Glycosylated hemoglobin Vascular endothelial growth factor Disease progression

The afterglow emission from a stratified jet in GRB 170817A

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Research in Astronomy and Astrophysics 2021年第7期21卷 223-233页

作者： Kang-Fa Cheng xiao-hong zhao Bin-Bin Zhang Jin-Ming Bai Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of the Chinese Academy of Sciences Beijing 100049China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210046China Department of Physics and Astronomy University of Nevada Las VegasNV 89154USA

The afterglow of GRB 170817 A has been detected for more than three years,but the origin of the multi-band afterglow light curves remains under debate.A classical top-hat jet model is faced with difficulties in producing a shallow rise of the afterglow light curves as observed(E_(v) ∝ T^(0.8)).Here we reconsider the model of stratified ejecta with an energy profile of E(> Γβ)=E_0(Γβ)^(-k) as the origin of the afterglow light curves of the burst,where Γ and β are the Lorentz factor and speed of the ejecta,respectively.k is the power-law slope of the energy *** consider that the ejecta are collimated into *** kinds of jet evolutions are investigated,including a lateral-spreading jet and a non-lateral-spreading *** fit the multi-band afterglow light curves,including the X-ray data at one thousand days post-burst,and find that both the models of the spreading and non-spreading jets can fit the light curves well,but the observed angular size of the source and the apparent velocity of the flux centroid for the spreading jet model are beyond the observation limits,while the non-spreading jet model meets the observation *** of the best-fit parameters for the non-spreading jet model,such as the number density of the circumburst medium~10^(-2) cm^(-3) and the total jet kinetic energy E ~ 4.8 × 10^(51) erg,also appear *** best-fit slope of the jet energy profile is k ~*** results suggest that the afterglow of GRB 170817 A may arise from the stratified jet and that the lateral spreading of the jet is not significant.

关键词： gamma-ray burst:general stars:jets relativistic processes

Effect of intensive multifactorial treatment on the intima-media thickness of large arteries in patients with new-onset type 2 diabetes mellitus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 378-385页

作者： xiao-hong zhao Zhe-rong XU Qin ZHANG Hai-feng GU Yun-mei YANG Department of Geriatrics the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Objective: To quantify the changes in blood glucose, blood lipids, blood pressure, and the intima-media thickness (IMT) of large arteries in patients with new-onset type 2 diabetes mellitus who received either intensive multifactorial treatment or conventional treatment. Methods: Two-hundred and ten patients with new-onset type 2 diabetes mellitus were randomly assigned to two groups: an intensive treatment group (n=110) and a conventional treatment group (n=100). Fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c), blood pressure, blood lipids [total cholesterol (TC), triglyceride (TG), low-density lipoprotein C (LDL-C), and high-density lipoprotein C (HDL-C)], and IMTs of large arteries (carotid, iliac, and femoral arteries) were determined before and at one and two years after starting treatment. The patients in the conventional treatment group received routine diabetes management in our outpatient department. Targets were established for patients in the intensive treatment group. Their blood glucose, blood lipids, and blood pressure levels were regularly monitored and therapeutic regimens were adjusted for those whose measurements did not meet the target values until all the parameters met the established targets. Within-group and between-group differences were evaluated. Results: A significantly greater percentage of patients in the intensive treatment group had LDL-C levels that reached the target value one year after starting treatment than those in the conventional treatment group (52.04% vs. 33.33%, P<0.05). No significant differences were found be- tween groups for FBG, HbA1c, blood pressure, TG, TC, or HDL-C. The percentages of patients with TG (51.02% vs. 34.48%), TC (52.04% vs. 33.33%), and LDL-C (61.22% vs. 43.67%) who met the respective target values in the in- tensive treatment group were all significantly higher than the corresponding percentages in the conventional treatment group two years after starting treatment (P<0.05). There were

关键词： Type 2 diabetes mellitus Intensive treatment Intima-media thickness (IMT) Large arteries

PM_(2.5) obtained from urban areas in Beijing induces apoptosis by activating nuclear factor-kappa B

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Military Medical Research 2017年第4期4卷 200-209页

作者： Hui Peng xiao-hong zhao Ting-Ting Bi xiao-Yan Yuan Jia-Bin Guo Shuang-Qing Peng Evaluation and Research Center for Toxicology Institute of Disease Control and Prevention Academy of Military Medical Sciences Beijing Key Laboratory of Bioactive Substances and Functional Foods Beijing Union University

Background: Particulate matter(PM), which has adverse effects on citizen health, is a major air pollutant in Beijing city. PM_(2.5) is an indicator of PM in urban areas and can cause serious damage to human health. Many epidemiological studies have shown that nuclear factor-kappa B(NF-κB) is involved in PM_(2.5)-induced cell injury, but the exact mechanisms are not well ***: The cytotoxic effects of PM_(2.5) at 25–1600μg/ml for 24 h were determined by MTT assay in Chinese hamster ovary cells(CHO) cells. Flow cytometry was used to determine the apoptosis rate induced by PM_(2.5). The destabilized enhanced green fluorescent protein(d2 EGFP) green fluorescent protein reporter system was used to determine the NF-κB activity induced by PM_(2.5). The expression of pro-apoptotic Bcl-2-associated death promoter(BAD) proteins induced by PM_(2.5) was determined by Western blotting to explore the relationship between PM_(2.5) and the NF-κB signaling pathway and to determine the toxicological mechanisms of PM_(2.5).Results: PM_(2.5) collected in Beijing urban districts induces cytotoxic effects in CHO cells according to MTT assay with 72.28% cell viability rates even at 200μg/ml PM_(2.5) and flow cytometry assays with 26.97% apoptosis rates at 200μg/ml PM_(2.5). PM_(2.5) increases the activation levels of NF-κB, which have maintained for 24 h. 200μg/ml PM_(2.5) cause activation of NF-κB after exposure for 4 h, the activation peak appears after 13.5 h with a peak value of 25.41%. The average percentage of NF-κB activation in whole 24 h is up to 12.90% by 200μg/ml PM_(2.5). In addition, PM_(2.5) decreases the expression level of the pro-apoptotic protein BAD in a concentration-dependent ***: PM_(2.5) induces NF-κB activation, which persists for 24 h. The expression of pro-apoptotic protein BAD decreased with increased concentrations of PM_(2.5). These findings suggest that PM_(2.5) plays a major role in apoptosis by activating the NF-κB signaling path

关键词： Particulate matter NF-κB pathway Apoptosis BAD protein

3D bioactive cell-free-scaffolds for in-vitro/in-vivo capture and directed osteoinduction of stem cells for bone tissue regeneration

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Bioactive Materials 2021年第11期6卷 4083-4095页

作者： Mamatali Rahman Xue-Liang Peng xiao-hong zhao Hai-Lun Gong xiao-Dan Sun Qiong Wu Dai-Xu Wei Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an710069China MOE Key Laboratory of Bioinformatics Center for Synthetic and System BiologyTsinghua UniversityBeijing100084China School of Life Sciences Tsinghua UniversityBeijing100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Hydrophilic bone morphogenetic protein 2(BMP2)is easily degraded and difficult to load onto hydrophobic carrier materials,which limits the application of polyester materials in bone tissue *** on soybean-lecithin as an adjuvant biosurfactant,we designed a novel cell-free-scaffold of polymer of poly(ε-caprolactone)and poly(lactide-co-glycolide)-co-polyetherimide with abundant entrapped and continuously released BMP2 for in vivo stem cell-capture and in situ osteogenic induction,avoiding the use of exogenous *** optimized bioactive osteo-polyester scaffold(BOPSC),***-10SC,had a high BMP2 entrapment efficiency of 95.35%.Due to its higher porosity of 83.42%,higher water uptake ratio of 850%,and sustained BMP2 release with polymer degradation,BOPSCs were demonstrated to support excellent in vitro capture,proliferation,migration and osteogenic differentiation of mouse adipose derived mesenchymal stem cells(mADSCs),and performed much better than traditional BMP-10SCs with unmodified BMP2 and single polyester scaffolds(10SCs).Furthermore,in vivo capture and migration of stem cells and differentiation into osteoblasts was observed in mice implanted with BOPSCs without exogenous cells,which enabled allogeneic bone formation with a high bone mineral density and ratios of new bone volume to existing tissue volume after 6 *** BOPSC is an advanced 3D cell-free platform with sustained BMP2 supply for in situ stem cell capture and osteoinduction in bone tissue engineering with potential for clinical translation.

关键词： Soybean lecithin Bioactive material Cell-free scaffold BMP2 Cell-capture Ossification

Association Between Polymorphisms of DNA Repair Gene XRCC1 and DNA Damage in Asbestos-Exposed Workers

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Biomedical and Environmental Sciences 2006年第3期19卷 232-238页

作者： xiao-hong zhao CUANG JIA YONG-QUAN LIU SHAO-WEI LIU LEI YAN YU JIN NIAN LIU Beijing Key Laboratory of Bioactive Substances and Functional Foods Be（jing Union University Beijing 100083 China Department of Occupational and Environmental Health Sciences School of Public Health Peking University Beijing 100083 China Institue of Haidian Health Inspection and Supervision Beijing 100080 China

Objective To compare the asbestos-induced DNA damage and repair capacities of DNA damage between 104 asbestosexposed workers and 101 control workers in Qingdao City of China and to investigate the possible association between polymorphisms in codon 399 of XRCC1 and susceptibility to asbestosis. Methods DNA damage levels in peripheral blood lymphocytes were determined by comet assay, and XRCC1 genetic polymorphisms of DNA samples from 51 asbestosis cases and 53 non-asbestosis workers with a similar asbestos exposure history were analyzed by PCR/RFLP. Results The basal comet scores （3.95±2.95） were significantly higher in asbestos-exposed workers than in control workers （0.10±0.28）. After 1 h H2O2 stimulation, DNA damage of lymphocytes exhibited different increases. After a 4 h repair period, the comet scores were 50.98±19.53 in asbestos-exposed workers and 18.32±12.04 in controls. The residual DNA damage （RD） was significantly greater （P〈0.01） in asbestos-exposed workers （35.62%） than in controls （27.75%）. XRCC1 genetic polymorphism in 104 asbestos-exposed workers was not associated with increased risk of asbestosis. But compared with polymorphisms in the DNA repair gene XRCC1 （polymorphisms in codon 399） and the DNA damage induced by asbestos, the comet scores in asbestosis cases with Gin/Gin, Gln/Arg, and Arg/Arg were 40.26±18.94, 38.03±28.22, and 32.01±11.65, respectively, which were higher than those in non-asbestosis workers with the same genotypes （25.58±11.08, 37.08±14.74, and 29.38±10.15）. There were significant differences in the comet scores between asbestosis cases and non-asbestosis workers with Gin/Gin by Student＇s t-test （P〈0.05 or 0.01）. The comet scores were higher in asbestosis workers with Gin/Gin than in those with Arg/Arg and in non-asbestosis workers exposed to asbestos, but without statistically significant difference. Conclusions Exposure to asbestos may be related to DNA damage or the capacity of cells to repair H2O2-induced DNA damage. DNA re

关键词： Asbestos Asbestosis DNA damage XRCC 1 DNA repair Polymorphisms Comet assays

A novel sensor of potassium ions based on mode-filtered light detection

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Chinese Chemical Letters 2010年第10期21卷 1243-1246页

作者： xiao hong zhao Li Ping Yang Suo Zhu Wu Wen Ping Cheng Shao Min Shuang Chuan Dong School of Chemistry and Chemical Engineering Research Center of Environmental Science and Engineering Shanxi University Taiyuan 030006 China Department of Applied Chemistry Taiyuan Institute of Technology Taiyuan 030008 China

A novel potassium ions sensor based on mode-filtered light detection was reported. The analyzer was consisting of an optical fiber immobilized with a dye of bromocresol green and a fused-silica capillary. It was found that mode-filtered light intensity decreased with the concentration of potassium ions and a linear detection range of 0.25-20 mmol/L （R^2 = 0.9977） was obtained with a detection limit of 9 ×10^-5 mol/L as well as fast response, good reproducibility and reversibility in the working concentration range.

关键词： Mode-filtered light Potassium ions Aqueous solution Bromocresol green