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Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

Science China Chemistry 2025年第1期 273-287页

作者： Shuguang Yang Lijun Hu hong xiao Zecong xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

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基于阻尼减振材料下拖拉机车身轻量化设计

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农机化研究 2025年第1期47卷 253-257页

作者：易小兰肖红吉利学院四川简阳641423 四川城市职业学院成都610101

由于农业生产环境恶劣,拖拉机在使用过程中振动和车内噪声对驾驶员的舒适性和工作效率产生负面影响,而阻尼材料能够将振动能量转化为其他形式的能量,从而减少振动的幅度和传递,同时也可以在不减少机械结构强度和稳定性的前提下减少结构... 详细信息

由于农业生产环境恶劣,拖拉机在使用过程中振动和车内噪声对驾驶员的舒适性和工作效率产生负面影响,而阻尼材料能够将振动能量转化为其他形式的能量,从而减少振动的幅度和传递,同时也可以在不减少机械结构强度和稳定性的前提下减少结构质量。为此,以拖拉机车身轻量化设计为研究对象,提出一种新兴液态可喷涂型阻尼隔音材料(Liquid Apply Sound Deadener,LASD),探讨了轻量化设计在减振性能和结构强度之间的平衡,并基于拖拉机车身静态刚度、动态刚度和侧面碰撞安全性能,采用近似模型优化方法进行轻量化设计。结果表明:采用阻尼减振材料可以显著降低拖拉机车身质量4.2%,显著降低拖拉机车身的振动幅度,并改善驾驶员的舒适性和工作效率。研究结果可为提高农业机械性能和驾驶员舒适性提供一种有效途径,具有实际应用前景。

关键词：拖拉机车身轻量化阻尼减振环保

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嵌入式系统的需求描述综述

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软件学报 2025年第1期36卷 27-46页

作者：陈小红刘少彬金芝上海市高可信计算重点实验室(华东师范大学) 高可信软件技术教育部重点实验室(北京大学) 北京大学计算机学院

随着嵌入式系统的广泛应用,其需求正变得越来越复杂,需求分析成为嵌入式系统开发的关键阶段,如何准确地建模和描述需求成为首要问题.系统地调研嵌入式系统的需求描述,并进行全面的比较分析,以便更深入地理解嵌入式系统需求的核心关注点... 详细信息

随着嵌入式系统的广泛应用,其需求正变得越来越复杂,需求分析成为嵌入式系统开发的关键阶段,如何准确地建模和描述需求成为首要问题.系统地调研嵌入式系统的需求描述,并进行全面的比较分析,以便更深入地理解嵌入式系统需求的核心关注点.首先采用系统化文献综述方法,对1979年1月–2023年11月间发表的相关文献进行识别、筛选、汇总和分析.通过自动检索和滚雪球等检索过程,筛选出150篇与主题密切相关的文献,力求文献综述的全面性.其次,从需求描述关注点、需求描述维度、需求分析要素等方面,分析现有嵌入式需求描述语言的表达能力.最后,总结现有嵌入式系统软件需求描述所面临的挑战,并针对嵌入式软件智能合成任务,提出对嵌入式系统需求描述方法表达能力的要求.

关键词：嵌入式系统需求描述需求描述语言需求分析系统需求

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新高考背景下深化高中教育教学改革应重视的几个问题

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教学与管理 2025年第1期 12-14页

作者：司晓宏马永昊陕西师范大学教育学部西安710062 陕西省社会科学院西安710061

自2014年新高考改革启动以来,已在全国29个省市逐步推进。调研发现,新高考在实际推进中给普通高中传统的教育、教学和管理带来了诸多压力与挑战,这突出表现为:“选课走班制”在实际推行中存在许多堵点;“学生综合素质评价”面临着评价... 详细信息

自2014年新高考改革启动以来,已在全国29个省市逐步推进。调研发现,新高考在实际推进中给普通高中传统的教育、教学和管理带来了诸多压力与挑战,这突出表现为:“选课走班制”在实际推行中存在许多堵点;“学生综合素质评价”面临着评价标准不一、结果应用受限等困境;“学生生涯规划教育”存在着专业性不强、效果不佳等问题;学生多样化自由选课凸显教师队伍结构性缺编等。针对上述问题,应加强普通高中选课走班制的资源条件支持,健全学生综合素质评价的体制机制,提高学生生涯规划教育的专业性和精准度,积极破解改革所导致的教师结构性缺编问题,以推动和确保新高考改革各项政策有效落地实施。

关键词：新高考改革选课走班制学生综合素质评价生涯规划教育教育教学改革

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A beam range monitor based on scintillator and multi-pixel photon counter arrays for heavy ions therapy

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Nuclear Science and Techniques 2022年第10期33卷 11-21页

作者： Wei Wang xiao-xiao Yuan xiao-hong Cai Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

Fast beam range measurements are required to maximize the time available for patient treatment, given that the beam range requires verification with respect to quality assurance to maintain accelerator commissioning standards and ensure patient safety. A novel beam range monitor based on a plastic scintillator and multi-pixel photon counter (MPPC) arrays is therefore proposed in this paper. The monitor was constructed using 128 plastic scintillator films with a thickness of 1 mm and an active area of 50 × 50 mm^(2). A customized MPPC array read the scintillation light of each film. The advantage of dividing the active detector volume into films is that it intercepts the particle beam and enables direct differential light yield measurement in each film, in addition to depth-light curve generation without the need for image analysis A GEANT4 simulation, including scintillator quenching effects, was implemented, and the results revealed that Birks’ law exhibited a slight little influence on the position of the beam range, only changing the shape and absolute normalization of the Bragg curve, which is appropriate for the calculation of the beam range using the depth-light curve. The performance of the monitor was evaluated using a heavy-ion medical machine in Wuwei City, Gansu Province, China. The beam range measurement accuracy of the monitor was 1 mm, and the maximum difference between the measured and reference ranges was less than0.2%, thus indicating that the monitor can meet clinica carbon ion therapy requirements.

关键词： Beam range Scintillator Multi-pixel photon counter(MPPC) Depth-light curve

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Influence of lateral displacement on strip shape during cold rolling

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Journal of Iron and Steel Research International 2018年第9期25卷 892-900页

作者： Zhong-kai Ren hong xiao hong-biao Xie xiao Liu College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004 Hebei China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004 Hebei China College of Mechanical Engineering Taiyuan University of Technology Taiyuan 030024 Shanxi China

The theory of metal plastic deformation is an important part of the strip shape control theories. In order to control the shape and gauge accurately during cold thin strip rolling, the mechanism of the metal lateral flow must be revealed clearly. Therefore, the lateral displacement of thin strip was studied by the grid method. Those grids with a line thickness of 10 μm and clear boundaries were successfully manufactured on the strip surface using lithography. Then, the effects of reduction, front and back tension, and taper angle of the first intermediate roll on the metal lateral flow were studied. The strip shape was calculated with and without considering the lateral displacement; furthermore, the calculations were compared with the measured results. The results show that the calculations with considering the lateral displacement are closer to the measured results. In addition, the comparison of finite element analysis results with the experimental results indicates that the test method was reliable.

关键词： Thin strip Lithography technology Lateral displacement Strip shape Experimental research Finite element simulation Cold rolling

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A-Browder's Theorem and Generalized a-Weyl's Theorem

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Acta Mathematica Sinica,English Series 2007年第5期23卷 951-960页

作者： xiao hong CAO College of Mathematics and Information Science Shaanxi Normal University

Two variants of the essential approximate point spectrum are discussed. We find for example that if one of them coincides with the left Drazin spectrum then the generalized a-Weyl＇s theorem holds, and conversely for ... 详细信息

关键词： a-Browder's theorem generalized a-Weyl's theorem spectrum

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Boundary Layer to a System of Viscous Hyperbolic Conservation Laws

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 523-528页

作者： xiao-hong Qin Department of Applied Mathematics Nanjing University of Science and Technology Nanjing 210094 China

In this paper, we investigate the large-time behavior of solutions to the initial-boundary value problem for n × n hyperbolic system of conservation laws with artificial viscosity in the half line （0, ∞）. We first show that a boundary layer exists if the corresponding hyperbolic part contains at least one characteristic field with negative propagation speed. We further show that such boundary layer is nonlinearly stable under small initial perturbation. The proofs are given by an elementary energy method.

关键词： Viscous hyperbolic conservation laws boundary layer asymptotic stability

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Weak Coupling in ^(143)Nd

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Chinese Physics Letters 2000年第4期17卷 264-266页

作者： ZHOU xiao-hong Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 E.Ideguchi T.KishidaM.Ishihara RIKENHirosawa 2-1WakoSaitama 351-01Japan H.Tsuchida Y.GonoT.MorikawaM.ShibataH.WatanabeM.MiyakeT.TsutsumiS.MotomuraS.Mitarai Department of Physics Kyushu UniversityHakozaki 6-10-1Fukuoka 812Japan

The high-spin states of ^(143)Nd have been studied in the ^(130)Te(^(18)O, 5n)^(143)Nd reaction at a beam energy of 80 MeV using techniques of in-beam γ-ray spectroscopy. Measurements of γ - γ - t coincidences, γ-ray angular distributions, and γ-ray linearpolarizations were performed. A level scheme of 143Nd with spin and parity assignments up to 53/2^(+) is proposed. While a weak coupling model can explain the level structure up to the J^(π)=39/2^(-)state,this model can not reproduce the higher-lying states. Additionally, a new low-lying non-yrast level sequence in ^(143)Nd was observed in the present work, which can be well described by the weak coupling of an i_(13/2) neutron to the ^(142)Nd core nucleus.

关键词： spectroscopy coupling

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Homogeneous and inhomogeneous magnetic oxide semiconductors

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Chinese Physics B 2019年第9期28卷 1-8页

作者： xiao-Li Li xiao-hong Xu Key Laboratory of Magnetic Molecules&Magnetic Information Materials of Ministry of Education and School of Chemistry and Materials Science Shanxi Normal UniversityLinfen 041004China Research Institute of Materials Science of Shanxi Normal University and Collaborative Innovation Center for Shanxi Advanced Permanent Magnetic Materials and Technology Linfen 041004China

Magnetic oxide semiconductors are significant spintronics *** this article, we review recent advances for homogeneous and inhomogeneous magnetic oxide *** the homogeneous magnetic oxide semiconductors,we focus on the various doping techniques including choosing different transition metals, codoping, non-magnetic doping,and even un-doping to realize homogeneous substitution and the clear magnetic *** the enhancement of the ferromagnetism is achieved by nanodot arrays engineering, which is accompanied by the tunable optical *** the inhomogeneous magnetic oxide semiconductors, we review some heterostructures and their magnetic and transport properties, especially magnetoresistance, which are dramatically modulated by electric field in the constructed *** the related mechanisms are discussed in ***, we provide an overview and possible potential applications of magnetic oxide semiconductors.

关键词： magnetic oxide semiconductors ferromagnetism magnetoresistance

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