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Effects of entecavir and lamivudine for hepatitis B decompensated cirrhosis: Meta-analysis

World Journal of Gastroenterology 2013年第39期19卷 6665-6678页

作者： xiao-guang ye Qi-Min Su Department of Infectious Diseases the SecondAffiliated Hospital of Guangzhou Medical University

AIM:To compare the effects of entecavir(ETV)and lamivudine(LAM)for the treatment of hepatitis B decompensated cirrhosis using a ***:We conducted a literature search for all eligible studies published prior to May 30,2013 using PUBMED,MEDLINE,EMBASE,the China National Knowledge Infrastructure(CNKI),the VIP database,the Wanfang database and the Cochrane Controlled Trial *** controlled trials(RCTs)comparing ETV with LAM for the treatment of hepatitis B decompensated cirrhosis were *** data were analyzed with Review Manager Software *** used RR as an effect measure,and reported its95%*** meta-analysis was performed using either a fixed-effect or random-effect model,based on the absence or presence of significant *** reviewers assessed the risk of bias and extracted data independently and in *** analysis was executed using the main outcome parameters including hepatitis B virus(HBV)DNA undetectability,HBV DNA level,hepatitis B e antigen(HBeAg)seroconversion,alanine aminotransferase(ALT)level,albumin level,total bilirubin(TBIL)level,prothrombin time activity(PTA)level,Child-Turcotte-Pugh(CTP)score,mortality,drugresistance,and adverse ***-analysis of the included trials and subgroup analyses were conducted to examine the association between pre-specified characteristics and the therapeutic effects of the two ***:Thirteen eligible trials(873 patients in total)were included and evaluated for methodological quality and *** these studies,all had baseline comparability,12 of them reported baseline values of the two treatment groups in *** various treatment durations(12,24,36,48 and>48 wk),both ETV and LAM significantly reduced HBV DNA level,however,reductions were greater in the ETV group(MD=-0.66,95%CI:-0.83-0.50,P<0.00001),(MD=-0.93,95%CI:-1.36-0.51,P<0.0001),(MD=-1.4,95%CI:-1.78-1.01,P<0.00001),(MD=-1.18,95%CI:-1.90-0.46,P=0.001),(MD=-0.14,95%CI:-0.17-0.

关键词： Hepatitis B Decompensated cirrhosis Entecavir Lamivudine Randomized controlled trial Metaanalysis.

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Effect of switching from treatment with nucleos(t)ide analogs to pegylated interferon α-2a on virological and serological responses in chronic hepatitis B patients

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World Journal of Gastroenterology 2016年第46期22卷 10210-10218页

作者： Li-Ting He xiao-guang ye xiao-Yuan Zho Department of Infectious Diseases The Second Affiliated Hospital of Guangzhou Medical University

AIM To investigate the efficacy of switching to pegylated interferon-α-2a(Peg IFNα-2a) treatment in nucleos(t)ide analog(NA)-treated chronic hepatitis B(CHB) responder patients. METHODS A 48-wk prospective and retrospective treatment trial of NA-treated CHB patients who had received entecavir(ETV) for at least 48 wk and had serum hepatitis B virus(HBV)-DNA < 500 IU/m L, serum hepatitis B envelope antigen(HBe Ag) < 100 S/CO, serum alanine aminotransferase, and aspartate aminotransferase levels < 2 × the upper limit of normal of 40 IU/L was performed. The effects on virological and serological responses and adverse reactions to 0.5 mg daily ETV for 48 wk vs switching to Peg IFNα-2a were compared. Forty-four patients were randomized to be switched from NA treatment to the Peg IFNα-2a group, and 44 patients were simultaneously randomized to the ETV group. RESULTS After 48 wk of therapy, the decrease in hepatitis B surface antigen(HBs Ag) levels was greater in the Peg IFNα-2a group than in the ETV group(3.1340 log10 IU/m L vs 3.6950 log10 IU/m L, P = 0.00). Seven patients who were anti-HBs-positive at baseline achieved HBs Ag loss when switched to Peg IFNα-2a(15.91% vs 0%,P = 0.018). The HBe Ag serological conversion rate was higher in the Peg IFNα-2a group than in the ETV group; however, the difference was not significant because of the small sample sizes(34.38% vs 21.88%, P = 0.232). In the Peg IFNα-2a group, patients with HBs Ag levels < 1500 IU/m L at baseline had higher HBe Ag seroconversion and HBs Ag loss rates at week 48 than those with HBs Ag levels ≥ 1500 IU/m L(HBe Ag seroconversion: 17.86% vs 62.5%, P = 0.007; HBs Ag loss: 41.67% vs 6.25%, P = 0.016). Moreover, patients with HBs Ag levels < 1500 IU/m L at week 24 had higher HBs Ag loss rates after therapy than those with HBs Ag levels ≥ 1500 IU/m L(36.84% vs 0%, P = 0.004). However, there were no statistically significant differences in HBe Ag seroconversion rates(47.06% vs 25.93%, P = 0.266). CONCLUSION NA-t

关键词： Chronic hepatitis B Entecavir pegylated interferon-α-2a Sequential therapy Effect

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Effects of telbivudine and entecavir for HBeAg-positive chronic hepatitis B: A meta-analysis

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World Journal of Gastroenterology 2012年第43期18卷 6290-6301页

作者： Qi-Min Su xiao-guang ye Department of Infectious Diseases the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina

AIM:To compare the effects of telbivudine (LDT) and entecavir (ETV) in treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B by meta-analysis. METHODS:We conducted a literature search using PubMed, MEDLINE, EMBASE, the China National Knowledge Infrastructure, the VIP database, the Wanfang database and the Cochrane Controlled Trial Register for all relevant articles published before April 1, 2012. Randomized controlled trials (RCTs) comparing LDT with ETV for treatment of HBeAg-positive chronic hepatitis B were included. The data was analyzed with Review Manager Software 5.0. We used relative risk (RR) as an effect measure, and reported its 95% CI. Meta-analysis was performed using either a fixedeffect or random-effect model, based on the absence or presence of significant heterogeneity. Two reviewers assessed the risk of bias and extracted data indepen- dently and in duplicate. The analysis was executed using the main outcome parameters including hepatitis B virus (HBV) DNA undetectability, alanine aminotransferase (ALT) normalization, HBeAg loss, HBeAg seroconversion, drug-resistance, and adverse reactions. Meta-analysis of the included trials and subgroup analyses were conducted to examine the association between pre-specified characteristics with the therapeutic effects of the two agents. RESULTS:Thirteen eligible trials (3925 patients in total) were included and evaluated for methodological quality and heterogeneity. In various treatment durations of 4 wk, 8 wk, 12 wk, 24 wk, 36 wk, 48 wk, 52 wk, 60 wk and 72 wk, the rates of HBV DNA undetectability and ALT normalization in the two groups were similar, without statistical significance. At 4 wk and 8 wk of the treatment, no statistical differences were found in the rate of HBeAg loss between the two groups, while the rate in the LDT group was higher than in the ETV group at 12 wk, 24 wk, 48 wk and 52 wk, respectively (RR 2.28, 95% CI 1.16, 7.03, P = 0.02; RR 1.45, 95% CI 1.16, 1.82, P = 0.001; R

关键词： Telbivudine Entecavir Hepatitis B e antigen-positive chronic hepatitis B Randomized controlled trials Meta-analysis

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Hepatitis C virus cure with direct acting antivirals: Clinical,economic, societal and patient value for China

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World Journal of Hepatology 2019年第5期11卷 421-441页

作者： Qing Xie Jian-Wei Xuan Hong Tang xiao-guang ye Peng Xu I-Heng Lee Shan-Lian Hu Department of Infectious Diseases Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Health Economic Research Institute School of PharmacySun Yat-Sen UniversityGuangzhou 510006Guangdong ProvinceChina Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Second Affiliated Hospital of guangzhou Medical University Guangzhou 510260Guangdong ProvinceChina Gilead Sciences Inc Shanghai 200122China Gilead Sciences Inc Foster CityCA 94404United States School of Public Health Fudan UniversityShanghai 200032China Shanghai Health Development Research Center Shanghai 200032China

About 10 million people in China are infected with hepatitis C virus(HCV),with the seroprevalence of anti-HCV in the general population estimated at 0.6%.Delaying effective treatment of chronic hepatitis C(CHC)is associated with liver disease progression,cirrhosis,hepatocellular carcinoma,and liver-related *** extrahepatic manifestations of CHC further add to the disease burden of *** CHC-related advanced liver diseases and systemic manifestations are costly for both the healthcare system and *** of work productivity due to reduced well-being and quality of life in CHC patients further compounds the economic burden of the ***,pegylatedinterferon plus ribavirin(PR)was the standard of ***,a substantial number of patients are ineligible for PR treatment,and only 40%–75%achieved sustained virologic ***,PR is associated with impairment of patient-reported outcomes(PROs),high rates of adverse events,and poor *** the advent of direct acting antivirals(DAAs),the treatment of CHC patients has been *** have broader eligible patient populations,higher efficacy,better PRO profiles,fewer adverse events,and better adherence rates,thereby making it possible to cure a large proportion of all CHC *** article aims to provide a comprehensive evaluation on the value of effective,curative hepatitis C treatment from the clinical,economic,societal,and patient experience perspectives,with a focus on recent data from China,supplemented with other Asian and international experiences where China data are not available.

关键词： Hepatitis C Value of cure Sustained virologic response End stage liver disease Prevention of transmission Cost-effectiveness Productivity Societal value Patient-reported outcomes

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Synthesis and Herbicidal Activity of 2-Benzo[b][1,4]oxazinylisoindoline-1,3-dione Derivatives

Synthesis and Herbicidal Activity of 2-Benzo[b][1,4]oxazinyl...

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中国化学会第四届有机化学学术会议

作者： HUANG, Ming-Zhi WANG, xiao-guang REN, ye-Guo LEI, Man-Xiang HUANG, Lu HOU,Zhong-Ke LIU, Ai-Ping OU, xiao-Ming (Hunan Research Institute of Chemical Industry, Changsha 410007)

＜正＞Herbicides inhibiting protoporphyrinogen oxidase （protox） have been commercialized for nearly 40 years. 2-（7-Fluoro-3-oxo-3,4-dihydro-2H-benzo-[b][1,4]oxazin-6-y1）-4,5,6,7-tetrahydro-2H-isoindoline-1,3-diones are a class of phenylimide protox inhibiting herbicides. The commercial product of this class is flumioxazin. In our previous work, we found a new compound B2055, which can be applied post-emergently as herbicide, and has better selectivity to crops than flumioxazin at the same dosage. However, the manufacturing cost for B2055 is higher

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基于本体的网络服务描述元模型的建立与分析

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上海交通大学学报 2005年第S1期39卷 113-117页

作者：刘晓光金烨上海交通大学机械与动力工程学院CIM研究所上海200030

为实现网络服务的自动匹配、集成及运行时的实时监控,提出了一个基于本体的网络服务描述元模型,该模型弥补了网络服务描述语言(WSDL)在语义描述方面的不足,为网络服务提供了一个比较完整、全面的描述,能够较好地支持网络服务自动匹配、... 详细信息

为实现网络服务的自动匹配、集成及运行时的实时监控,提出了一个基于本体的网络服务描述元模型,该模型弥补了网络服务描述语言(WSDL)在语义描述方面的不足,为网络服务提供了一个比较完整、全面的描述,能够较好地支持网络服务自动匹配、集成及运行时实时监控.

关键词：网络服务网络服务描述语言本体元模型

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超声造影定量分析在鉴别肝硬化背景下肝内胆管细胞癌与原发性肝细胞癌中的作用

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中国实用医药 2017年第7期12卷 1-3页

作者：杨思光欧阳晓光叶小楼广东省惠州市中大惠亚医院超声科 516081

目的探讨超声造影定量分析在鉴别肝硬化背景下肝内胆管细胞癌(ICC)与原发性肝细胞癌(HCC)中的作用。方法随机抽取接受超声造影检查并经临床或病理确诊具有肝硬化背景的20例ICC患者(ICC组)和35例HCC患者(HCC组),进行超声造影定量分析,比... 详细信息

目的探讨超声造影定量分析在鉴别肝硬化背景下肝内胆管细胞癌(ICC)与原发性肝细胞癌(HCC)中的作用。方法随机抽取接受超声造影检查并经临床或病理确诊具有肝硬化背景的20例ICC患者(ICC组)和35例HCC患者(HCC组),进行超声造影定量分析,比较两组相关参数,评价超声造影定量分析的鉴别价值。结果超声造影定量分析显示,两组患者上升时间(RT)、达峰时间(TTP)比较,差异均无统计学意义(t=0.546、0.967,P>0.05);ICC组平均渡越时间(mTT)少于HCC组,灌注指数(PI)小于HCC组,差异均具有统计学意义(t=2.073、2.460,P0.05),但定量分析的准确性高于主观判断。结论超声造影定量分析可直观地反映ICC和HCC的血流灌注情况,有助于肝硬化背景下ICC和HCC的鉴别,超声造影定量分析ICC的m TT少于HCC,PI小于HCC,有助于两种疾病的鉴别。

关键词：超声造影定量分析肝内胆管细胞癌原发性肝细胞癌

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世界创意农业模式在海南省全域旅游田园综合体建构中的应用研究

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江西农业学报 2017年第11期29卷 146-150页

作者：张海东徐小俊曾小红刘晓光叶露孙继华中国热带农业科学院科技信息研究所海南海口571101

阐述了美国、法国、荷兰等国创意农业的不同发展模式,从资源、技术和市场3个角度深入分析了文化创意产业和田园综合体建构在海南创建全域旅游示范省进程中的融合路径,探讨了农产品深度开发、区域品牌组合和创意农业园3种创意农业在全域... 详细信息

阐述了美国、法国、荷兰等国创意农业的不同发展模式,从资源、技术和市场3个角度深入分析了文化创意产业和田园综合体建构在海南创建全域旅游示范省进程中的融合路径,探讨了农产品深度开发、区域品牌组合和创意农业园3种创意农业在全域旅游田园综合体建构中的应用模式,最后提出了创意农业参与田园综合体建构的原则。

关键词：创意农业田园综合体全域旅游

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Pressure fluctuation characteristics in the pressurization unit of a multiphase pump

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Journal of Hydrodynamics 2021年第6期33卷 1230-1241页

作者： guang-tai Shi Zong-ku Liu ye-xiang xiao Xue-lin Tang xiao-bing Liu Key Laboratory of Fluid and Power Machinery Ministry of EducationXihua UniversityChengdu 610039China College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China State Key Laboratory of Hydroscience and Engineering and Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084China Beijing Engineering Research Centre of Safety and Energy Saving Technology for Water Supply Network System China Agricultural UniversityBeijing 100083China

The tip clearance induces the tip leakage vortex(TLV),which has a great impact on the pressure fluctuation characteristics of the multiphase *** investigate the effect of the tip clearance on the pressure fluctuations,based on the Reynolds time-averaged Navier-Stokes equation and the shear stress transfer(SST)k-ωturbulence model,the three-dimensional turbulent flow in the pump is numerically simulated for different tip clearances in the water and gas-liquid two-phase cases by using the ANSYS CFX software and the results are verified with experimental *** is shown the greater pressure fluctuation intensity corresponds with the TLV both in the water and gas-liquid two-phase *** the meantime,the location of the maximum pressure fluctuation intensity is related to the tip clearance *** addition,for different tip clearances,the pressure fluctuation intensity with the rotor and stator interaction(RSI)is relatively *** difference is that when R_(tc)=1.5 mm,the pressure fluctuation intensity near the impeller middle point is also relatively *** the whole,the pressure fluctuation intensity in the gas-liquid two-phase case is larger than that in the water ***,the gas causes the frequency of the high-amplitude pressure fluctuation in the impeller and the diffuser to be shifted from 7 f_(n)(f_(n) denotes impeller rotational frequency)and 3 f_(n) to the low-frequency region,*** pressure fluctuations at the blade-passing frequency(BPF)and the multiple BPFs gradually ***,the amplitude at the dominant frequency in the gas-liquid two-phase case is at least one order of magnitude smaller than that in the water case,and the peak-to-peak value of the pressure fluctuation is also much smaller.

关键词： Multiphase pump gas void faction pressure fluctuation intensity tip leakage vortex(TLV) numerical simulation

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Synthesis of porous aromatic framework with Friedel–Crafts alkylation reaction for CO_2 separation

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Chinese Chemical Letters 2016年第9期27卷 1479-1484页

作者： Peng Cui xiao-Fei Jing ye Yuan guang-Shan Zhu Key Laboratory of Polyoxometalate Science of Ministry of Education Department of Chemistry Northeast Normal University

A novel porous aromatic framework, PAF-8, derived from tetraphenylsilane as basic building unit, was successfully synthesized via Friedel-Crafts alkylation reaction. This PAF material had high thermal stability as well as high surface area （785 m^2 g^-1） calculated from the Brunauer-Emmett-Teller （BET） model. Meanwhile, PAF-8 possessed high performances in gas sorption and especially for CO2 separation.

关键词： Porous aromatic frameworks Friedel-Crafts alkylation Gas sorption CO2 separation Liquid vapor adsorption

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