检索结果-南通市图书馆

Role of tumor necrosis factor alpha-induced protein 6(TNFAIP6)in tumors:a pan-cancer analysis

Oncology and Translational Medicine 2024年第1期10卷 22-29页

作者： Yang Yang Zhi-gang Liu Yan-Qi Yang Zhi-gang Zhang xiao-Li Wang Yu-Long Li Rui-Fang Sun School of Public health Shaanxi University of Chinese MedicineXianyangChina Department of Thoracic Surgery Shaanxi Provincial Cancer HospitalXi'an Jiaotong UniversityXi'anChina Department of Pathology School of Basic Medical SciencesHealth Science CenterXi'an Jiaotong UniversityXi'anChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxiChina Department of Gastroenterology Shaanxi Provincial People's HospitalXi'anChina.

Background:There is growing evidence that the gene named tumor necrosis factorα–induced protein 6(TNFAIP6)has an important role in various ***,a systematic pan-cancer analysis of TNFAIP6 is *** we aimed to analyze the expression of TNFAIP6 across multiple cancers and verify its expression during the progression of colon ***:We performed a comprehensive bioinformatics analysis to examine the expression of TNFAIP6 across 27 tumor ***2 was used to evaluate the effect of TNFAIP6 on clinical cancer *** was used to assess TNFAIP6 *** correlation between TNFAIP6 and cancer immune infiltrates was explored using *** CancerSEA database was used to perform functional analysis of *** was used to identify TNFAIP6-related gene enrichment *** was performed to detect TNFAIP6 protein expression in the colon *** addition,the Comparative Toxicogenomics Database was searched for known and possible antitumor drugs that may be associated with ***:We found that,in most of the cancers included in this analysis,TNFAIP6 was highly expressed,and there is a distinct relationship between TNFAIP6 expression and cancer ***6 expression is associated with cancer-associated fibroblasts,neutrophils,and endothelial ***6 and similar genes may also be involved in the PID_VEGF_VEGFR_*** revealed an increasing trend of TNFAIP6 protein expression in normal,adenoma,and colon cancer *** known and possible antitumor drugs that may be associated with TNFAIP6 were identified in the Comparative Toxicogenomics *** results suggest that a number of drugsmay target TNFAIP6 during cancer treatment,including cisplatin,irinotecan,resveratrol,U 0126,NSC689534,genistein,NSC668394,oxaliplatin,plerixafor,topotecan,vincristine,flutamide,doxorubicin,MRK 003,folic acid,demecolcine,tunicamycin,zoledronic acid,and schizandrin B.

关键词： Cancer IHC Mutation Survival TNFAIP6

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

αExtractor: a system for automatic extraction of chemical information from biomedical literature

引用

Science China(Life Sciences) 2024年第3期67卷 618-621页

作者： Jiacheng Xiong xiaohong Liu Zhaojun Li Hongzhong xiao Guangchao Wang Zhenjiang Niu Chaoyuan Fei Feisheng Zhong gang Wang Wei Zhang Zunyun Fu Zhiguo Liu Kaixian Chen Hualiang Jiang Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215125China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China

Dear Editor,Great progress has been made using artificial intelligence(AI) techniques in learning knowledge from biomedical databases in recent years, revolutionizing the study of many fields, such as protein structure prediction and protein design(Madani et al., 2023). However, there is massive biomedical knowledge not curated in the form of structured data but hidden in primary scientific literature.

关键词： has such knowledge

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enabling an Inorganic-Rich Interface via Cationic Surfactant for High-Performance Lithium Metal Batteries

引用

Nano-Micro Letters 2024年第8期16卷 1-17页

作者： Zejun Sun Jinlin Yang Hongfei Xu Chonglai Jiang Yuxiang Niu Xu Lian Yuan Liu Ruiqi Su Dayu Liu Yu Long Meng Wang Jingyu Mao Haotian Yang Baihua Cui Yukun xiao Ganwen Chen Qi Zhang Zhenxiang Xing Jisheng Pan gang Wu Wei Chen Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore Agency for Science Technology and Research(A*STAR)Institute of High-Performance Computing1 Fusionopolis Way#16‑16 ConnexisSingapore 138632Singapore Department of Physics National University of Singapore2 Science Drive 3Singapore 117542Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207People’s Republic of China Agency for Science Technologyand Research(A*STAR)Institute of Materials Research and EngineeringInnovis2 Fusionopolis Way#08‑03Singapore 138634Singapore

An anion-rich electric double layer(EDL)region is favorable for fabricating an inorganic-rich solid-electrolyte interphase(SEI)towards stable lithium metal anode in ester ***,cetyltrimethylammonium bromide(CTAB),a cationic surfactant,is adopted to draw more anions into EDL by ionic interactions that shield the repelling force on anions during lithium *** situ electrochemical surface-enhanced Raman spectroscopy results combined with molecular dynamics simulations validate the enrichment of NO_(3)^(−)/FSI−anions in the EDL region due to the positively charged CTA^(+).In-depth analysis of SEI structure by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry results confirmed the formation of the inorganic-rich SEI,which helps improve the kinetics of Li^(+)transfer,lower the charge transfer activation energy,and homogenize Li *** a result,the Li||Li symmetric cell in the designed electrolyte displays a prolongated cycling time from 500 to 1300 h compared to that in the blank electrolyte at 0.5 mA cm^(-2) with a capacity of 1 mAh cm^(-2).Moreover,Li||LiFePO_(4) and Li||LiCoO_(2) with a high cathode mass loading of>10 mg cm^(-2) can be stably cycled over 180 cycles.

关键词： Cationic surfactant Lithium nitrate additive Solid-electrolyte interphase Electric double layer Lithium metal batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

谁为企业低效担责——家族管理者的堑壕行为与效应

引用

山西财经大学学报 2024年第2期46卷 112-126页

作者：吕蔚起贺小刚李婧文上海财经大学浙江学院浙江金华321013 上海财经大学商学院上海200433

通过分析高管离任过程中家族管理者的决策行为,提出“替罪羊”假说。基于2014—2020年家族管理者所经营的上市公司数据,实证检验高管离任中的“替罪羊”现象及其对企业绩效的影响。研究发现:(1)家族管理者在高管离任过程中存在堑壕行为... 详细信息

通过分析高管离任过程中家族管理者的决策行为,提出“替罪羊”假说。基于2014—2020年家族管理者所经营的上市公司数据,实证检验高管离任中的“替罪羊”现象及其对企业绩效的影响。研究发现:(1)家族管理者在高管离任过程中存在堑壕行为,即使企业经营绩效处于低下水平,家族管理者因独特权威和庇护型治理机制而赢得留任优势,其他高管则成为“替罪羊”离开企业;(2)高管离任中的“替罪羊”现象并不会损害家族企业整体价值,家族管理者留任而非家族成员型高管离任将在短期内有助于改进企业的市场价值。

关键词：家族管理者绩效下滑堑壕行为 “替罪羊” 市场价值

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Probing multi-physical process and deformation mechanism of a largescale landslide using integrated dual-source monitoring

引用

Geoscience Frontiers 2024年第2期15卷 417-432页

作者： Hong-Hu Zhu xiao Ye Hua-Fu Pei Wei Zhang gang Cheng Zi-Li Li School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China Department of Geotechnical Engineering Dalian University of TechnologyDalian 116024China Civil Structural&Environmental EngineeringSchool of Engineering and ArchitectureUniversity College CorkCorkIreland Department of Civil&Environmental Engineering Massachusetts Institute of TechnologyCambridgeMA 02139-4307United States

The implementation of isolated heterologous monitoring systems for spatially distant borehole deployments often comes with substantial equipment costs,which can limit the effectiveness of geohazard mitigation and georisk management *** address this,we have developed a novel monitoring system that integrates fiber Bragg grating(FBG)and microelectromechanical system(MEMS)techniques to capture soil moisture,temperature,sliding resistance,strain,surface tilt,and deep-seated *** system enables real-time,simultaneous data acquisition and cross-validation analyses,offering a costeffective solution for monitoring critical parameters in geohazard-prone *** successfully applied this integrated monitoring system to the Xinpu landslide,an active super-large landslide located in the Three Gorges Reservoir Area(TGRA)of *** resulting strain profile confirmed the presence of two shallow secondary sliding surfaces at depths of approximately 7 m and 12 m,respectively,in addition to the deep-seated sliding surface at a depth of28 *** lower secondary sliding surface was activated by extreme precipitation,while the upper one was primarily driven by significant changes in reservoir water levels and secondarily triggered by concentrated ***-slide piles have remarkably reinforced the upper moving masses but failed to control the lower *** gap between the pile heads and the soil amplified the rainwater erosion effect,creating a preferential channel for rainwater ***-physical measurements revealed a mixture of seepage-driven and buoyancy-driven behaviors within the *** study offers an integrated dual-source multi-physical monitoring paradigm that enables collaborative management of multiple crucial boreholes on a large-scale landslide,and contributes to the evaluation and improvement of engineering measures in similar geological settings.

关键词： Reservoir landslide Multi-physical process Integrated dual-source monitoring Fiber optic Extreme weather

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

引用

World Journal of Clinical Oncology 2024年第1期15卷 145-158页

作者： Lu Zhang Zu-Yuan Chen xiao-Xian Wei Jian-Di Li gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Emerging research suggests that microRNAs(miRNAs)play an important role in the development of hepatocellular carcinoma(HCC).A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further *** To make a comprehensive analysis of recent studies concerning miRNAs in *** All relevant publications were retrieved from the Web of Science Core Collection *** software,VOSviewer software and CiteSpace software were used to visually analyze the distribution by time,countries,institutions,journals,and authors,as well as the keywords,burst keywords and thematic *** A total of 9426 publications on this topic were found *** to the keywords analysis,we found that the studies of miRNAs focused on their expression level,effects,and mechanisms on the biological behaviour of *** bursting analysis showed that in the early years(2013–2017),“micro-RNA expression”,“gene expression”,“expression profile”,“functional polymorphism”,“circulating microRNA”,“susceptibility”and“mir 21”started to attract *** the latest phase(2018–2022),the hot topics turned to“sorafenib resistance”,“tumor microenvironment”and so *** This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric *** hotspots in this field focus on miRNAs expression level,effects,and mechanisms on the biological behavior of *** frontiers turned to sorafenib resistance,tumor microenvironment and so on.

关键词： miRNA hepatocellular carcinoma Bibliometric VOSviewer CiteSpace

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Receptor tyrosine kinase-like orphan receptor 1:A novel antitumor target in gastrointestinal cancers

引用

World Journal of Clinical Oncology 2024年第5期15卷 603-613页

作者： Zheng-Long Wu Ying Wang xiao-Yuan Jia Yi-gang Wang Hui Wang Xinyuan Institute of Medicine and Biotechnology College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina Department of Oncology Zhejiang Xiaoshan HospitalHangzhou 311201Zhejiang ProvinceChina

Receptor tyrosine kinase-like orphan receptor 1(ROR1)is a member of the type I receptor tyrosine kinase ***1 is pivotal in embryonic development and cancer,and serves as a biomarker and therapeutic *** has soluble and membrane-bound subtypes,with the latter highly expressed in ***1 is conserved throughout evolution and may play a role in the development of gastrointestinal cancer through multiple signaling pathways and molecular *** suggest that overexpression of ROR1 may increase tumor invasiveness and ***,ROR1 may regulate the cell cycle,stem cell characteristics,and interact with other signaling pathways to affect cancer *** review explores the structure,expression and role of ROR1 in the development of gastrointestinal *** discusses current antitumor strategies,outlining challenges and prospects for treatment.

关键词： Receptor tyrosine kinase-like orphan receptor 1 Gastrointestinal cancers Therapeutic target Molecular mechanisms Antitumor strategies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

3D自支撑钴基硫化物电极电催化还原硝酸盐特性研究

引用

环境科学学报 2024年第5期44卷 92-101页

作者：肖晓罗章奕何玮钰李安旎陈浩赵辉孙东潘纲广东海洋大学化学与环境学院湛江524088 海岸带环境保护与生态修复中心湛江524088 约克圣约翰大学人文学院英国YO317EX

针对水体硝酸盐污染严重的问题,本研究以泡沫镍(NF)为基底材料,采用恒电流沉积法制备了3D自支撑钴基硫化物电极—CoxS/NF,用于电催化还原硝酸盐.重点研究了CoxS/NF电极制备参数和电解工作条件对硝酸盐去除的影响规律及其硝酸盐还原机制... 详细信息

针对水体硝酸盐污染严重的问题,本研究以泡沫镍(NF)为基底材料,采用恒电流沉积法制备了3D自支撑钴基硫化物电极—CoxS/NF,用于电催化还原硝酸盐.重点研究了CoxS/NF电极制备参数和电解工作条件对硝酸盐去除的影响规律及其硝酸盐还原机制.研究结果表明,在硝酸盐初始浓度为50 mg·L^(-1)(以NO_(3)^(-)N计),工作电流为4.0 mA,反应时间为180 min的条件下,硫脲浓度为0.8 mol·L^(-1)和沉积电流为0.7 mA条件下制备的CoxS/NF电极(2 cm×2 cm)表现出最佳的硝酸盐去除效果,其硝酸盐去除率为79.0%,N2选择性高达93.6%.该过程符合伪一级动力学反应方程,反应速率常数为0.0077 min^(-1).CoxS/NF电极还表现出优异的Cl^(-)耐受性和重复使用性.循环伏安、计时电流和塔菲尔测试结果表明超薄纳米片CoxS的引入能有效增加电极与硝酸根离子的接触面积,改善了CoxS/NF电极的硝酸盐电催化活性和稳定性.

关键词：电催化还原电沉积钴基硫化物电极硝酸盐 N_(2)选择性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

钢筋混凝土柱的易损性函数研究

引用

工程力学 2024年第1期41卷 219-228页

作者：代旷宇于晓辉吕大刚郑州大学水利与土木工程学院郑州450001 哈尔滨工业大学土木工程学院哈尔滨150090 桂林理工大学土木建筑工程学院桂林541004

基于文献调研,建立了满足我国现行设计规范的钢筋混凝土(RC)框架柱的拟静力试验数据库。将RC柱的损伤状态分为六级,并给出了相应修复方法。基于FEMA P-58方法,以位移角为工程需求参数,建立了RC柱在各损伤状态下所对应的易损性函数。通过... 详细信息

基于文献调研,建立了满足我国现行设计规范的钢筋混凝土(RC)框架柱的拟静力试验数据库。将RC柱的损伤状态分为六级,并给出了相应修复方法。基于FEMA P-58方法,以位移角为工程需求参数,建立了RC柱在各损伤状态下所对应的易损性函数。通过与FEMA P-58的易损性函数对比,对所建立的易损性函数的质量进行了评定,并讨论了抗震设防等级和轴压比对易损性函数的影响。结果表明:该文所建立的易损性函数整体处于高质量水准。各极限状态下易损性函数中位值范围为0.764%~4.52%,对数标准差范围为0.339~0.425。三、四级框架柱与一级框架柱在各极限状态的易损性曲线的超越概率之差分别高达11.79%和15.39%。一级、二级及三、四级框架柱在高轴压比工况和低轴压比工况下各极限状态的易损性曲线的超越概率之差分别高达到42.61%、37.11%和43.37%。该文研究结果可辅助我国混凝土建筑结构的地震灾害损失评估及韧性分析。

关键词： RC柱易损性函数损伤状态修复方法抗震韧性

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolution of helium bubbles in FeCoNiCr-based high-entropy alloys containing γ′ nanoprecipitates

引用

Chinese Physics B 2024年第7期33卷 491-500页

作者：冯婷蒋胜明胡潇天张子骏黄子敬董士刚张建 College of Energy Xiamen UniversityXiamen 361005China16

A series of high-entropy alloys(heAs) containing nanoprecipitates of varying sizes is successfully prepared by a non-consuming vacuum arc melting *** order to study the irradiation evolution of helium bubbles in the FeCoNiCrbased he As with γ' precipitates,these samples are irradiated by 100-keV helium ions with a fluence of 5 × 10^(20) ions/m^(2) at 293 K and 673 K,*** the samples irradiated at room temperature are annealed at different temperatures to examine the diffusion behavior of helium *** electron microscope(TEM) is employed to characterize the structural morphology of precipitated nanoparticles and the evolution of helium *** results reveal that nanosized,spherical,dispersed,coherent,and ordered L1_(2)-type Ni_(3)Ti γ' precipitations are introduced into FeCoNiCr(Ni_(3)Ti)_(0.1) heAs by means of ageing treatments at temperatures between 1073 K and 1123 *** the ageing treatment conditions adopted in this work,γ' nanoparticles are precipitated in FeCoNiCr(Ni_(3)Ti)_(0.1) he As,with average diameters of 15.80 nm,37.09 nm,and 62.50 nm,*** average sizes of helium bubbles observed in samples after 673-K irradiation are 1.46 nm,1.65 nm,and 1.58 nm,*** improvement in the irradiation resistance of FeCoNiCr(Ni_(3)Ti)_(0.1) heAs is evidenced by the diminution in bubbles ***,the FeCoNiCr(Ni_(3)Ti)_(0.1) heAs containing γ' precipitates of 15.8 nm exhibits the minimum size and density of helium bubbles,which can be ascribed to the considerable helium trapping effects of heterogeneous coherent phase ***,annealing experiments conducted after 293-K irradiation indicate that heAs containing precipitated phases exhibits smaller apparent activation energy(E_(a)) for helium bubbles,resulting in larger helium bubble *** study provides guidance for improving the irradiation resistance of L1_(2)-strengthened high-entropy alloy.

关键词： high-entropy alloys irradiation resistance coherent precipitates helium bubbles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：