检索结果-南通市图书馆

Cu/Pd-catalyzed borocarbonylative trifunctionalization of alkynes and allenes:synthesis ofβ-geminal-diboryl ketones

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第12期64卷 2142-2153页

作者： Yang Yuan Fu-Peng wu Anke Spannenberg xiao-feng wu Leibniz-Institut für Katalyse e.V.an der Universität Rostock Albert-Einstein-Straβe 29a18059RostockGermany Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China

Functionalized bisboryl compounds have recently emerged as a new class of synthetically useful building blocks in organic ***,we report an efficient strategy to synthesizeβ-geminal-diboryl ketones enabled by a Cu/Pd-catalyzed borocarbonylative trifunctionalization of readily available alkynes and *** reaction promises to be a useful method for the synthesis of functionalizedβ-geminal-diboryl ketones with broad functional group *** studies suggest that the reaction proceeds through borocarbonylation/hydroboration cascade of both alkynes and allenes.

关键词： carbonylation copper/palladium alkynes/allenes trifunctionalization β-geminal-diboryl ketones

Palladium-catalysed efficient synthesis of primary alkyl halides from terminal and internal alkenes

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第12期9卷 63-65页

作者： Han-Jun Ai Matthias Beller xiao-feng wu Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Leibniz-Institut für Katalyse e.V.

The development of remote functionalization of alkenes has recently gained considerable attention as it offers the op-portunity to directly transform a mixture of unrefined olefin isomers into a single valuable fine c...

关键词：

Radical Carbonylation under Low CO Pressure:Synthesis of Esters from Activated Alkylamines at Transition Metal-Free Conditions

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第4期39卷 927-932页

作者： fengqian Zhao Han-Jun Ai xiao-feng wu Leibniz-Institut fur Katalyse e.V.an der Universitat Rostock Albert-Einstein-Straße 29a18059 RostockGermany Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China

Main observation and conclusion High CO pressure(>40 bar)is usually needed in radical carbonylation reactions in the absence of metal *** this communication,we developed a transition-metal-free radical carbonylation of activated alkylamines with phenols and alcohols under low CO pressure(1-6 bar).Various esters were obtained in moderate to excellent yields under simple reaction conditions with good functional group compatibility.

关键词： Carbonylation Radical Ester Alkylamine Katritzky salt

C–F bond activation under transition-metal-free conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第10期64卷 1630-1659页

作者： Han-Jun Ai Xingxing Ma Qiuling Song xiao-feng wu Leibniz-Institut fur Katalyse e.V.an der Universitat Rostock Rostock 18059Germany Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Key Laboratory of Molecule Synthesis and Function Discovery Fujian Province UniversityCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Next Generation Matter Transformation College of Material Sciences&EngineeringHuaqiao UniversityXiamen 361021China

The unique properties of fluorine-containing organic compounds make fluorine substitution attractive for the development of pharmaceuticals and various specialty materials,which have inspired the evolution of diverse C–F bond activation *** many advances have been made in functionalizations of activated C–F bonds utilizing transition metal complexes,there are fewer approaches available for nonactivated C–F bonds due to the difficulty in oxidative addition of transition metals to the inert C–F *** this regard,using Lewis acid to abstract the fluoride and light/radical initiator to generate the radical intermediate have emerged as powerful tools for activating those inert C–F ***,these transition-metal-free processes are greener,economical,and for the pharmaceutical industry,without heavy metal *** review provides an overview of recent C–F bond activations and functionalizations under transition-metal-free *** key mechanisms involved are demonstrated and discussed in ***,a brief discussion on the existing limitations of this field and our perspective are presented.

关键词： transition-metal-free fluorinated compounds C–F activation coupling

Palladium-catalyzed enantioselective carbonylation reactions

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2022年第3期65卷 441-461页

作者： Jin-Bao Peng Xin-Lian Liu Lin Li xiao-feng wu School of Biotechnology and Health Sciences Wuyi UniversityJiangmen 529020China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesLiaoning 116023China Leibniz-Institut für Katalyse e.V. Albert-Einstein-Straße 29aRostock 18059Germany

Carbonylation,one of the most powerful approaches to the preparation of carbonylated compounds,has received significant attention from researchers active in various ***,impressive progress has been made on this subject over the past few *** the various types of carbonylation reactions,asymmetric carbonylation is a straightforward methodology for constructing chiral *** rhodium-catalyzed enantioselective hydroformylations have been discussed in several elegant reviews,a general review on palladium-catalyzed asymmetric carbonylations is still *** this review,we summarize and discuss recent achievements in palladium-catalyzed asymmetric carbonylation ***,this review’s contents are categorized by reaction type.

关键词： palladium catalyst enantioselective carbonylation chiral

Difluoroalkylative carbonylation of alkenes to access carbonyl difluoro-containing heterocycles:convenient synthesis of gemigliptin

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2023年第1期66卷 139-146页

作者： Zhi-Peng Bao Youcan Zhang Le-Cheng Wang xiao-feng wu Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Leibniz-Institut für Katalyse e.V.Albert-Einstein-Straße 29a Rostock 18059Germany

Fluorinated heterocycles play a vital role in pharmaceutical and agrochemical ***,rapid and efficient construction of fluorinated heterocycles remains highly ***,a difluoroalkylative carbonylative cyclization of unactivated alkenes and ethylene gas enabled by palladium catalysis has been developed for the first time toward the synthesis ofα-carbonyl difluoro-modified *** procedure can also be applied to the synthesis of Ge Migliptin which is a medicine approved for the treatment of type 2 diabetes mellitus.

关键词： difluoroalkylative carbonylative unactivated alkenes ethylene gas heterocycles

Elemental Sulfur and Dimethyl Sulfoxide-Promoted Oxidative Cyclization of Trifluoroacetimidohydrazides with Methylheta-renes for the Synthesis of 3-Hetaryl-5-trifluoromethyl-1,2,4-triazoles

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第12期39卷 3443-3447页

作者： Jiajun Zhang Jianhua Tang Zhengkai Chen xiao-feng wu Department of Chemistry Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China Leibniz-lnstitutfurKatalysee.V. Albert-Einstein-Stra6e 29a18059 RostockGermany

A metal-free approach for the synthesis of 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles via sulfur/dimethyl sulfoxide-promoted oxidative cyclization of readily available trifluoroacetimidohydrazides with methylhetarenes has been *** transformation proceeds in cascade sulfur-mediated generation of thioaldehyde,condensation,intramolecular cyclization and oxidative aromatization sequence.

关键词： Heterocycles Oxidation Solvent effects Sulfur Trifluoroacetimidohydrazides

Palladium-catalyzed carbonylation of activated alkyl halides via radical intermediates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Industrial Chemistry & Materials

Industrial Chemistry & Materials 2024年第2期2卷 276-283页

作者： Zhi-Peng Bao xiao-feng wu Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of Sciences116023 DalianLiaoningChina Leibniz-Institut für Katalyse e.V Albert-Einstein-Straße 29a18059 RostockGermany

Palladium-catalyzed carbonylation is an efficient approach to prepare carbonyl-containing compounds with high atomic economy in synthetic organic ***,in comparison with aryl halides,carbonylation of alkyl halides is relatively challenging due to the decreased stability of the palladium *** of activated alkyl halides is even more difficult,as nucleophilic substitution reactions with nucleophiles occur more easily with *** this article,we summarize and discuss recent achievements in palladium-catalyzed carbonylative reactions of activated alkyl *** transformations proceed through radical intermediates which are generated in various *** a relatively high pressure of carbon monoxide,the corresponding aliphatic carboxylic acid derivates were effectively prepared with various nucleophiles as the reaction *** alcohols,amines and organoboron reagents,four-component reactions in combination with alkenes or alkynes were also ***-by-case reaction mechanisms are discussed as well and a personal outlook has also been provided.

关键词： Carbonyl group Palladium catalysis Carbonylation Activated alkyl halides Radical intermediates

Synthesis of 2-Trifluoromethyl-4-aminoquinolines via Heating-Promoted Multi-component Reaction of CF_(3)-Imidoyl Sulfoxonium Ylides and Amines with Difluorocarbene as a C1 Synthon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第23期41卷 3205-3210页

作者： Guangming Wei Chen Li Haoyuan Wang Zhengkai Chen xiao-feng wu School of Chemistry and Chemical Engineering Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhouZhejiang310018 China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China Leibniz-Institut für Katalyse e.V. Albert-Einstein-Straβe 29a18059RostockGermany

A thermally-induced multi-component reaction of CF_(3)-substituted imidoyl sulfoxonium ylides(TFISYs),amines and(triphenylphosphonio)difluoroacetate(PDFA)has been developed,allowing a facile access to 2-trifluoromethyl-4-aminoquinolines in high *** reaction proceeds smoothly with or without the addition of sulfur and utilizes difluorocarbene as a C1 synthon under simply heating *** study reveals that in-situ generated thiocarbonyl fluoride,isothiocyanate or gem-difluoroalkene might act as the key reaction intermediates.

关键词： CF_(3)-Imidoyl sulfoxonium ylides Difluorocarbene Multi-component reaction 2-Trifluoromethyl-4-aminoquinolines N-Heterocyclic compounds