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Psychosocial and spiritual needs of patients with chronic diseases: validation of the Chinese version of the Spiritual Needs Questionnaire

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Journal of Integrative Medicine 2013年第2期11卷 106-115页

作者： Arndt Büssing xiao-feng zhai Wen-bo Peng Chang-quan Ling Center for Integrative Medicine Faculty of Medicine University Witten/Herdecke Changhai Hospital of Traditional Chinese Medicine Second Military Medical University

OBJECTIVE： Even in secular societies, a small portion of patients find their spirituality to help cope with illness. But for the majority of patients, psychosocial and spiritual needs are neither addressed nor even considered a relevant factor by health care professionals. To measure such specific needs, the Spiritual Needs Questionnaire （SpNQ） was developed. The aim of this study was to validate the Chinese version of the SpNQ （SpNQ-Ch） and thus to measure psychosocial and spiritual needs of Chinese patients. METHODS： This was a cross-sectional study among 168 patients with chronic diseases who were recruited in the Changhai Hospital of Traditional Chinese Medicine, Shanghai, China using standardized questionnaires. We performed reliability and factor analyses, as well as analyses of variance, first order correlations and regression analyses. RESULTS： The 17-item SpNQ-Ch had a similar factorial structure as the original version with two main and three minor factors which accounted for 64% of variance, and internal consistency estimates （Cronbach＇s a） ranging from 0.51 to 0.81. Included were the 4-item scale Inner Peace Needs, the 5-item scale Giving/Generativity （with 2 sub-constructs, Praying and Sources）, and a Needs, the 5-item scale Religious Needs 3-item scale Reflection/Release Needs. In Chinese patients with cancer （63%）, pain affections （10%）, or other chronic conditions （23%）, the needs for Giving/Generativity （which refer to categories of Connectedness and Meaning） and Inner Peace Needs scored highest, while Religious Needs and the Reflection/Release Needs scored lower. CONCLUSION： The SpNQ-Ch is congruent with its primary version, and can be used in future studies with the mostly nonreligious patients from China. First findings indicate specific psychosocial and spiritual needs which should be addressed by health care professionals to support patients in their struggle with chronic illness in terms of psycho-emotional stabilization, finding hope and mean

关键词： spirituality chronic disease psychology adaptation, psychological questionnaires

Interpretation of illness in patients with chronic diseases from Shanghai and their associations with life satisfaction, escape from illness, and ability to reflect the implications of illness

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Journal of Integrative Medicine 2014年第5期12卷 409-416页

作者： Arndt Büssing Ariane von Bergh xiao-feng zhai Chang-quan Ling Institute of Integrative Medicine Faculty of Medicine Witten/Herdecke University Changhai Hospital of Traditional Chinese Medicine Second Military Medical University

The aim of this study is to analyze how patients with chronic diseases from Shanghai interpret their disease, and how these interpretations influence patients＇ life satisfaction, intention to escape from their illness and their ability to reflect on the implications of their illness. METHODS： A cross-sectional study enrolling 142 patients （mean age （50 ±16） years; 63% men, 37% women） with chronic diseases （60% cancer） was recruited in the Changhai Hospital of Traditional Chinese Medicine, Shanghai, China and surveyed using standardized questionnaires. RESULTS： Patients with chronic diseases from Shanghai interpreted their illness mostly as an Adverse Interruption of Life （55%）, as a Threat/Enemy （50%）, but also as a Challenge （49%）, and only rarely as a Call for Help （18%） or as a Punishment （13%）. Particularly fatalistic negative （i.e., Threat/Enemy, Adverse Interruption of Life） and strategy-associated disease interpretations （i.e., Relieving Break, Call for Help） were moderately associated with patients＇ intention to escape from illness. In contrast, positive interpretations （i.e., something of Value, Challenge） and also the guilt-associated negative interpretation Failure were moderately related with patients＇ ability to reflect on their illness. However, life satisfaction was weakly associated only with the view that illness might be a Challenge. Interestingly, 58% of those who would see their illness as an Adverse Interruption （AI＋） could see it also as a Challenge （Ch＋）. Detailed analyses showed that AI＋Ch＋ patients differ from their AI＋Chcounterparts significantly with respect to their ability to reflect life and implications of illness （F=9.1 ; P=-0.004）.

关键词： interpretation of illness chronic disease cancer self assessment personal satisfaction clinical trial

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World Journal of Gastroenterology 2012年第21期18卷 2689-2694页

作者： Cui-Xia Qiao xiao-feng zhai Chang-Quan Ling Qing-Bo Lang Hui-Juan Dong Qun Liu Mou-Duo Li Departmentof Traditional Chinese Medicine Changhai Hospital Affiliatedto the Second Military Medical University Shanghai 200433China Department of Graduate School Shanghai Uni-versity of Traditional Chinese Medicine Shanghai 201203China E-Institute of Traditional Chinese MedicineInternal Medicine Shanghai 200433 China

AIM: To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC). METHODS: A total of 140 patients diagnosed with HCC between June 2008 and April 2009 in our department were enrolled to this study. One hundred and thirty-five (96.5%) patients had liver cirrhosis secondary to hepatitis B virus (HBV) infection, 73 (54.07%) of them being HBV DNA positive; the other etiologies of liver cirrhosis were alcoholic liver disease (1.4%), hepatitis C (1.4%) or cryptogenic (0.7%). All subjects were fully aware of their diagnosis and provided informed consent. HRQoL was assessed before treatment using the functional assessment of cancer therapy-hepatobiliary (FACT-Hep) questionnaire. Descriptive statistics were used to evaluate demographics and disease-specific characteristics of the patients. One-way analysis of variance and independent samples t tests were used to compare the overall FACT-Hep scores and clinically distinct TNM stages. Scores for all FACT-Hep items were analyzed by frequency analyses. The mean scores obtained from the FACT-Hep in different Child-Pugh classes were also evaluated. RESULTS: The mean FACT-Hep scores were reduced significantly from TNM StageⅠto Stage Ⅱ, Stage ⅢA, Stage ⅢB group (687 ± 39.69 vs 547 ± 42.57 vs 387 ± 51.24 vs 177 ± 71.44, P = 0.001). Regarding the physical and emotional well-being subscales, scores decreased gradually from Stage Ⅰ to Stage ⅢB (P = 0.002 vs Stage Ⅰ; P = 0.032 vs Stage Ⅱ; P = 0.033 vs Stage ⅢA). Mean FACT-Hep scores varied by Child-Pugh class, especially in the subscales of physical well-being, functional well-being and the hepatobiliary cancer (P = 0.001 vs Stage I; P = 0.036 vs Stage Ⅱ; P = 0.032 vs Stage ⅢA). For the social and family well-being subscale, only Stage ⅢB scores were significantly lower as compared with Stage Ⅰ scores (P = 0.035). For the subscales of functional well-being and hepatobiliary c

关键词： Hepatocellular carcinoma Tumor node metastasis staging Functional assessment of cancer therapy-hepatobiliary Health-related quality of life Cross-sectional study

Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine

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Journal of Integrative Medicine 2018年第4期16卷 236-248页

作者： Chang-quan Ling Jia Fan Hong-sheng Lin feng Shen Zhen-ye Xu Li-zhu Lin Shu-kui Qin Wei-ping Zhou xiao-feng zhai Bai Li Qing-hui Zhou Department of Integrative Oncology Changhai Hospital of Traditional Chinese MedicineSecond Military Medical UniversityShanghai 200433China Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Hepatobiliary Surgery Eastern Hepatabiliary Surgery HospitalSecond Military Medical UniversityShanghai 200433China Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Oncology First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405China Cancer Center of Bayi Hospital Nanjing University of Chinese Medicine210002China Department of Rehabilitative Medicine Changhai Hospital of Traditional Chinese MedicineSecond Military Medical UniversityShanghai 200433China Department of Acupuncture-Moxihustion and Tuina Changhai Hospital of Traditional Chinese MedicineSecond Military Medical UniversityShanghai 200433China

Traditional Chinese medicine （TCM） is an important part of the treatment of primary liver cancer （PLC） in China; however, the current instructions for the integrative use of traditional Chinese and Western medicine for PLC are mostly based on expert opinion. There is no evidence-based guideline for clinical prac-tice in this field. Therefore, the Shanghai Association of Chinese Integrative Medicine has established a multidisciplinary working group to develop this guideline, which focuses on the most important questions about the use of TCM during PLC treatment. This guideline was developed following the method- ological process recommended by the World Health Organization Handbook for Guideline Development. Two rounds of questionnaire survey were performed to identify clinical questions; published evidence was searched; the Grading of Recommendations Assessment, Development and Evaluation approach was used to evaluate the body of evidence; and recommendations were formulated by combining the quality of evidence, patient preferences and values, and other risk factors. The guideline was written based on the Reporting Items for Practice Guidelines in Healthcare tool. This guideline contains 10 recommendations related to 8 questions, including recommendations for early treatment by TCM after surgery, TCM combined with transcatheter arterial chemoembolization for advanced PLC, TCM drugs for external use, and acupuncture and moxibustion therapy.

关键词： Primary liver cancerClinical practice guidelines Traditional Chinese medicineIntegrative medicine

A CELL-CENTERED GODUNOV METHOD BASED ON STAGGERED DATA DISTRIBUTION,PART Ⅰ:ONE-DIMENSIONAL CASE

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Journal of Computational Mathematics 2024年第4期42卷 1172-1196页

作者： Jiayin zhai xiao Li Zhijun Shen Institute of Applied Physics and Computational Mathematics LCPP.O.Box 8009-26Beijing 100088China College of Big Data and Internet Shenzhen Technology UniversityShenzhen 518118China Center for Applied Physics and Technology HEDPSPeking UniversityChina

This paper presents a cell-centered Godunov method based on staggered data distribu-tion in Eulerian *** motivation is to reduce the intrinsic entropy dissipation of classical Godunov methods in the calculation of an isentropic or rarefaction *** the same time,the property of accurate shock capturing is also *** analyzing the factors that cause nonphysical entropy in the conventional Godunov methods,we introduce two velocities rather than a single velocity in a cell to reduce kinetic energy dissipation.A series of redistribution strategies are adopted to update subcell quantities in order to improve *** examples validate that the present method can dramatically reduce nonphysical entropy *** subject classification:35Q35,76N15,76M12.

关键词： Godunov method Riemann solver Rarefaction wave Nonphysical entropy increase.

Resilience assessment and optimization method of city road network in the post-earthquake emergency period

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 765-779页

作者： Wang Haoran xiao Jia Li Shuang zhai Changhai Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information TechnologyHarbin Institute of TechnologyHarbin 150090China

The post-earthquake emergency period,which is a sensitive time segment just after an event,mainly focuses on saving life and restoring social *** improve the seismic resilience of city road networks,a resilience evaluation method used in the post-earthquake emergency period is *** road seismic damage index of a city road network can consider the influence of roads,bridges and buildings along the roads,*** road capacity after an earthquake.A function index for a city road network is developed,which reflects the connectivity,redundancy,traffic demand and traffic function of the *** optimization model for improving the road repair order in the post-earthquake emergency period is also developed according to the resilience evaluation,to enable decision support for city emergency management and achieve the best seismic resilience of the city road *** optimization model is applied to a city road network and the results illustrate the feasibility of the resilience evaluation and optimization method for a city road network in the post-earthquake emergency period.

关键词： city road network post-earthquake emergency period traffic demand resilience evaluation optimization model

Comparable effects of Jiedu Granule, a compound Chinese herbal medicine, and sorafenib for advanced hepatocellular carcinoma: A prospective multicenter cohort study

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Journal of Integrative Medicine 2020年第4期18卷 319-325页

作者： He-tong Zhao Yong-bin Meng xiao-feng zhai Bin-bin Cheng Sha-sha Yu Man Yao Hui-xia Yin Xu-ying Wan Yun-ke Yang Hui Liu feng Shen Chang-quan Ling School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Integrated Traditional Chinese and Western Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Integrative Medicine Zhongshan HospitalFudan UniversityShanghai 200032China The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China

Objective:Sorafenib has been extensively used for the treatment of advanced hepatocellular carcinoma(HCC),and Chinese herbal medicine has also been used to manage advanced *** present work evaluates the effectiveness and safety of Jiedu(JD)Granule,a compound of traditional Chinese herbal medicine,side-by-side with sorafenib for the treatment of advance ***:Patients with advanced HCC receiving treatment with JD Granule or sorafenib were enrolled from December 2014 to March *** primary endpoint was overall survival(OS).The secondary endpoints were progression-free survival(PFS)and *** score matching(PSM)analysis was used to control for possible selection bias from the study group allocation ***:Of the 325 patients included,161 received JD Granule and 164 received *** significant differences were found in OS or PFS among patients receiving JD Granule compared to sorafenib(P>0.05).Median OS of the two study groups was 6.83 months(95%confidence interval[CI]:5.83–9.47)in the group receiving JD Granule and 8 months(95%CI:6.67–9.80)in the group receiving sorafenib,with half-,1-and 2-year survival rates of 53.6%,31.2%and 13.2%vs 60.1%,35.5%and 14.2%,*** after PSM,the median survival time did not differ between the JD Granule group(9.03 months;95%CI:6.37–14.2)and the sorafenib group(7.93 months;95%CI:6.5–9.97),with comparable half-,1-and 2-year survival *** most common adverse events(AEs)were diarrhea(13.7%)and fatigue(5.6%)in the JD Granule group,and hand-foot skin reaction(46.3%)and diarrhea(36.6%)in the sorafenib *** JD Granule was more cost-effective than sorafenib treatment for advanced ***:Compared to sorafenib,JD Granule was more cost-effective and caused fewer AEs for the treatment of Chinese patients with advanced HCC.

关键词： Carcinoma,hepatocellular Jiedu Granule Sorafenib Chinese herbal medicine

Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: a multicenter randomized controlled trial

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Journal of Integrative Medicine 2013年第2期11卷 90-100页

作者： xiao-feng zhai Zhe Chen Bai Li feng Shen Jia Fan Wei-ping Zhou Yun-ke Yang Jing Xu xiao Qin Le-qun Li Chang-quan Ling Changhai Hospital of Traditional Chinese Medicine Second Military Medical University Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Liver Cancer Institute Fudan University Department of Traditional Chinese Medicine Zhongshan Hospital Fudan University Department of Hepatic Surgery the First Affiliated Hospital of Guangxi Medical University Department of Hepatobiliary Surgery Tumor Hospital of Guangxi Medical University

BACKGROUND： Disease recurrence is a main challenge in treatment of hepatocellular carcinoma （HCC）. There is no generally accepted method for preventing recurrence of HCC after resection. OBJECTIVE： To compare the efficacy of a traditional herbal medicine （THM） regimen and transarterial chemoembolization （TACE） in preventing recurrence in post-resection patients with small HCC. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This is a multicenter, open- label, randomized, controlled study, which was undertaken in five centers of China. A total of 379 patients who met the eligibility criteria and underwent randomization were enrolled in this trial. One hundred and eighty-eight patients were assigned to the THM group and received Cinobufacini injection and Jiedu Granule, and the other 191 patients were assigned to the TACE group and received one single course of TACE. MAIN OUTCOME MEASURES： Primary outcome measures were the annual recurrence rate and the time to recurrence. Incidence of adverse events was regarded as the secondary outcome measure. RESULTS： Among the 364 patients who were included in the intention-to-treat analysis, 67 patients of the THM group and 87 of the TACE group had recurrence, with a hazard ratio of 0.695 （P = 0.048）. Median recurrence-free survival of the patients in the THM and TACE groups was 46.89 and 34.49 months, respectively. Recurrence rates at 1, 2 and 3 years were 17.7%, 33.0% and 43.5% for the THM group, and 28.8%, 42.5% and 54.0% for the TACE group, respectively （P = 0.026）. Multivariate analysis indicated that the THM regimen had a big advantage for prolonging the recurrence-free survival. Adverse events were mild and abnormality of laboratory indices of the two groups were similar. CONCLUSION： In comparison with TACE therapy, the THM regimen was associated with diminished risk of recurrence of small-sized HCC after resection, with comparable adverse events. TRIAL REGISTRTION IDENTIFIER： This trial was registered in the Chinese Cli

关键词： hepatocellular carcinoma recurrence traditional Chinese medicine transarterial chemoembolization: randomized controlled trial

Prevalence of neutralizing antibodies against liver-tropic adeno-associated virus serotype vectors in 100 healthy Chinese and its potential relation to body constitutions

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Journal of Integrative Medicine 2015年第5期13卷 341-346页

作者： Chen Ling Yuan Wang Ying-lu feng Ya-ni Zhang Jun Li Xin-rui Hu Li-na Wang Mao-feng Zhong xiao-feng zhai Irene Zolotukhin Arun Srivastava Chang-quan Ling Division of Cellular and Molecular Therapy Department of Pediatrics University of Florida College of Medicine Shands Cancer Center University of Florida College of Medicine Changhai Hospital of Traditional Chinese Medicine Second Military Medical University Department of Traditional Chinese Medicine 401 Hospital of the Chinese People’s Liberation Army Shanghai University of Traditional Chinese Medicine E-Institute of TCM Internal Medicine Shanghai Municipal Education Commission

Recombinant adeno-associated virus （rAAV） serotype 2, 3 and 8 vectors are the most promising liver- tropic AAV serotype vectors. Liver diseases are significant problems in China. However, to date, few studies on AAV neutralizing antibodies （Nabs） were working with the Chinese population or with the rAAV3 vectors. The present study aimed to determine the prevalence of Nabs in Chinese population against wild-type AAV2, AAV3 and AAV8 capsids as well as additional two AAV3 variants. In addition, we performed a preliminary analysis to investigate the potential influence of traditional Chinese medicine body constitutions on AAV Nabs. Our work demonstrated that the majority of healthy Chinese subjects were positive for AAV Nabs, with the order of AAV2 〉 AAV3 = AAVLK03 〉 AAV8. There was no difference between： 1）AAV3 and its variants; 2） male and female subjects; and 3） different age cohorts （〈 35, 36- 50, and 〉 51 years old）. People in the Qi-deficiency constitution had significantly increased AAV8 Nabs than people in the Gentleness constitution. Our studies may have impact on the future clinical design of AAV-based gene therapy in the Chinese population.

关键词： medicine, Chinese traditional recombinant adeno-associated virus vector neutralizing antibodies body constitutions