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Chinese Medical Journal 2022年第3期135卷 261-267页

作者： Lixi Li Di Zhang Binliang Liu Dan Lv Jingtong Zhai Xiuwen Guan Zongbi Yi fei ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Antibody-drug conjugates(ADCs)combine the high specificity of monoclonal antibodies with the high anti-tumor activity of small molecular cytotoxic *** anti-tumor activity of ADCs is mainly achieved by the direct blocking of the receptor by monoclonal antibodies,direct action and bystander effect of cytotoxic drugs,and antibody-dependent cell-mediated cytotoxicity and complement-dependent *** have been used in adjuvant therapy and rescue treatment of human epidermal receptor 2(HER2)-positive breast cancer,greatly improving the prognosis of breast cancer *** ongoing clinical trials of ADC for breast cancer and other solid tumors proved the potential of ADCs will provide more promising treatment options for patients with malignant *** review introduces the mechanism and latest clinical progress of ADC drugs approved for HER2-positive breast cancer to guide clinical practice and conduct research.

关键词： Antibody-drug conjugate HER2-positive Breast cancer T-DM1 DS-8201

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目连戏成为百戏之祖的文学史演变

河北学刊 2019年第3期39卷 214-219页

作者：马小涵河南省文化艺术研究院河南郑州450000

目连戏是以目连救母故事为主要题材的剧目总称。自史料记载至今,已有近千年历史,仍演出不辍,被誉为"百戏之祖"和"中国戏剧的活化石"。其发展经历了五次文学史演变:目连救母故事源于晋代佛经《盂兰盆经》,唐代目连变文吸收、借鉴《地藏... 详细信息

目连戏是以目连救母故事为主要题材的剧目总称。自史料记载至今,已有近千年历史,仍演出不辍,被誉为"百戏之祖"和"中国戏剧的活化石"。其发展经历了五次文学史演变:目连救母故事源于晋代佛经《盂兰盆经》,唐代目连变文吸收、借鉴《地藏王菩萨本愿经》,丰富和扩展了故事情节与内容,为后世目连救母故事提供了相对完备的底本,但未脱离宣教主题;北宋《目连救母》以民间杂剧形式出现在东京汴梁(今河南开封)的勾栏瓦舍中,吸收了大量的杂技和百戏;金院本《打青提》将杂剧"艳段"(序幕)改编成独立的演出剧目,成为北方目连戏的发展方向;元明目连戏形成文人阶层和民间阶层两个演出倾向;清代目连救母故事依赖于宝卷和戏剧两种传播形式,戏剧演出开始进入宫廷,而民间目连戏盛演于南方,且打上地域文化的烙印。上述转变,是以目连救母故事为基础,在合适的契机下与其他艺术形式结合而成,也是不断中国化、世俗化、草根化、地域化及意识形态化的过程。

关键词：目连故事故事内容表演形式五次演变

分布式视频编码中量化失真和LDPC编解码失真的优化

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南京邮电大学学报（自然科学版） 2014年第5期34卷 67-73页

作者：胡晓飞南京邮电大学图像处理与图像通信江苏省重点实验室江苏南京210003 南京邮电大学地理与生物信息学院江苏南京210023

针对分布式视频编码中的量化失真和LDPC(Low Density Parity Check)编解码失真问题,提出了基于边缘分类的DCT(Discrete Cosine Transform)系数重组和基于边缘Hash的子块修复方案。首先根据子块边缘方向的不同,WZ(Wyner-Ziv)帧子块被分成... 详细信息

针对分布式视频编码中的量化失真和LDPC(Low Density Parity Check)编解码失真问题,提出了基于边缘分类的DCT(Discrete Cosine Transform)系数重组和基于边缘Hash的子块修复方案。首先根据子块边缘方向的不同,WZ(Wyner-Ziv)帧子块被分成3类,对不同类型的子块,其DCT系数采用不同的扫描方式并重组,使较大的DCT系数被组合在一起,减小了交流系数的量化步长。同时,把子块边缘信息作为Hash信息,指导WZ帧LDPC解码出错的子块的修复。最后,通过实验证实了提出的方法能使高量化等级下编码器的PSNR(Peak Signal to Noise Ratio)性能增益达到0.5 dB左右。

关键词：量化失真 LDPC编解码失真边缘Hash信息子块修复

Astragaloside Ⅳ inhibits pathological functions of gastric cancer-associated fibroblasts

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World Journal of Gastroenterology 2017年第48期23卷 8512-8525页

作者： Zhen-fei Wang Da-Guang ma Zhe Zhu Yong-Ping Mu Yong-Yan Yang Li Feng Hao Yang Jun-Qing Liang Yong-Yan Liu Li Liu Hai-Wen Lu Laboratory for Tumor Molecular Diagnosis Affiliated People’s Hospital of Inner Mongolia Medical UniversityHuhhot 010020Inner Mongolia Autonomous Region Department of cytotherapy for tumors Affiliated People’s Hospital of Inner Mongolia Medical University Department of Abdominal Tumor Surgery Affiliated People’s Hospital of Inner Mongolia Medical University Department of Radiotherapy Affiliated People’s Hospital of Inner Mongolia Medical University Central Laboratory People’s Hospital of Wuhai City Affiliated Hospital of Inner Mongolia Medical University Huhhot 010050Inner Mongolia Autonomous Region

AIM To investigate the inhibitory effect of astragaloside IV on the pathological functions of cancer-associated fibroblasts,and to explore the underlying *** Paired gastric normal fibroblast(GNF) and gastric cancer-associated fibroblast(GCAF) cultures were established from resected tissues. GCAFs were treated with vehicle control or different concentrations of astragaloside Ⅳ. Conditioned media were prepared from GNFs,GCAFs,control-treated GCAFs,and astragaloside Ⅳ-treated GCAFs,and used to culture BGC-823 human gastric cancer cells. Proliferation,migration and invasion capacities of BGC-823 cells were determined by MTT,wound healing,and Transwell invasion assays,respectively. The action mechanism of astragaloside Ⅳ was investigated by detecting the expression of micro RNAs and the expression and secretion of the oncogenic factor,macrophage colonystimulating factor(M-CSF),and the tumor suppressive factor,tissue inhibitor of metalloproteinase 2(TIMP2),in different groups of GCAFs. The expression of the oncogenic pluripotency factors SOX2 and NANOG in BGC-823 cells cultured with different conditioned media was also *** GCAFs displayed higher capacities to induce BGC-823 cell proliferation,migration,and invasion than GNFs(P < 0.01). Astragaloside Ⅳ treatment strongly inhibited the proliferation-,migration-and invasion-promoting capacities of GCAFs(P < 0.05 for 10 μmol/L,P < 0.01 for 20 μmol/L and 40 μmol/L). Compared with GNFs,GCAFs expressed a lower level of micro RNA-214(P < 0.01) and a higher level of micro RNA-301 a(P < 0.01). Astragaloside Ⅳ treatment significantly upregulated micro RNA-214 expression(P < 0.01) and down-regulated micro RNA-301 a expression(P < 0.01) in GCAFs. Reestablishing the micro RNA expression balance subsequently suppressed M-CSF production(P < 0.01) and secretion(P < 0.05),and elevated TIMP2 production(P < 0.01) and secretion(P < 0.05). Consequently,the ability of GCAFs to increase SOX2 and NANOG expression in BGC

关键词： Astragaloside Ⅳ Gastric cancer-associated fibroblasts Proliferation Migration Invasion Micro RNA

Method of evaluating interface traps in Al2O3/AlGaN/GaN high electron mobility transistors

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Chinese Physics B 2019年第6期28卷 378-383页

作者： Si-Qin-Gao-Wa Bao xiao-Hua ma Wei-Wei Chen Ling Yang Bin Hou Qing Zhu Jie-Jie Zhu Yue Hao School of Advanced materials and Nanotechnology Xidian UniversityXi’an 710071China Key Laboratory of Wide Band-Gap Semiconductor materials and Devices School of MicroelectronicsXidian UniversityXi’an 710071China School of Science Inner Mongolia University of TechnologyHohhot 010051China 4China Academy of Space Technology(Xi’an)Xi’an 710071China

In this paper, the interface states of the AlGaN/GaN metal–insulator–semiconductor(MIS) high electron mobility transistors(HEMTs) with an Al2 O3 gate dielectric are systematically evaluated. By frequency-dependent capacitance and conductance measurements, trap density and time constant at Al2 O3/AlGaN and AlGaN/GaN interface are *** experimental results reveal that the density of trap states and the activation energy at the Al2 O3/AlGaN interface are much higher than at the AlGaN/GaN interface. The photo-assisted capacitance-voltage measurements are performed to characterize the deep-level traps located near mid-gap at the Al2 O3/AlGaN interface, which indicates that a density of deep-level traps is lower than the density of the shallow-level states.

关键词： AlGaN/GaN HEMTs interface traps frequency-dependent C–V measurements photo-assisted C–V measurements

芳基四硫富瓦烯与碘电荷转移复合物的合成及其晶体结构

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无机化学学报 2023年第10期39卷 1869-1876页

作者：左琦马龙飞河南警察学院刑事科学技术系郑州450046

采用缓慢挥发溶剂的方法合成了硫原子桥联芳基取代四硫富瓦烯(Ar‑S‑TTF)与碘的3种电荷转移复合物(1+·)(I_(3))·I_(2)、(2^(+·))(I_(5))·I_(2)和(3^(2+))(I_(3))_(2),采用单晶X射线衍射、紫外可见光谱、循环伏安对其进行了表征。复合... 详细信息

采用缓慢挥发溶剂的方法合成了硫原子桥联芳基取代四硫富瓦烯(Ar‑S‑TTF)与碘的3种电荷转移复合物(1+·)(I_(3))·I_(2)、(2^(+·))(I_(5))·I_(2)和(3^(2+))(I_(3))_(2),采用单晶X射线衍射、紫外可见光谱、循环伏安对其进行了表征。复合物(1+·)(I_(3))·I_(2)为C2/c空间群,1+·呈椅式构型。化合物1与碘之间在溶液中和复合物中电荷转移一致。复合物(2^(+·))(I_(5))·I_(2)为P1空间群,2^(+·)呈椅式构型。复合物(3^(2+))(I_(3))_(2)为Pbca空间群,3^(2+)呈独特的平面构型。化合物2和3与碘之间在溶液中和复合物中呈现不同的电荷转移。复合物中聚碘阴离子呈现不同的堆积结构:由I_(3)^(-)或I_(5)^(-)/I_(2)组成的一维链状和I_(3)^(-)/I_(2)组成的二维网格状。

关键词：四硫富瓦烯碘晶体结构电荷转移复合物

Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer’s Disease

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Neuroscience Bulletin 2022年第11期38卷 1425-1430页

作者： Yun‑Long Xu Lin Zhu Zi‑Jun Chen xiao‑fei Deng Pei‑Dong Liu Shan Li Bing‑Chun Lin Chuan‑Zhong Yang Wei Xu Kui-Kui Zhou Ying‑Jie Zhu Shenzhen Key Laboratory of Drug Addiction Shenzhen Neher Neural Plasticity Laboratorythe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Neonatology Shenzhen Maternity&Child Healthcare HospitalThe First School of Clinical MedicineSouthern Medical UniversityShenzhen 518055China The First Afliated Hospital Sun Yat-sen UniversityGuangzhou 510080China Cheeloo College of Medicine Shandong UniversityJinan 250012China Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyCASShenzhen 518055China CAS Center for Excellence in Brain Science and Intelligence Technology CASShanghai 200031China CAS Key Laboratory of Brain Connectome and manipulation BCBDIShenzhen Institute of Advanced Technology(SIAT)CASShenzhen 518055China

Dear Editor,Alzheimer's disease(AD)is one of the most devastating neurodegenerative disorders and the most common form of *** loss is a hallmark of AD pathology and exacerbates cognitive impairment[1].Synaptic loss,un... 详细信息

关键词： Alzheimer pathology impairment

Improving outcomes in patients with heart failure:The contribution of cardiovascular specialist nurses

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South China Journal of Cardiology 2023年第4期24卷 182-187页

作者： WANG xiao-li LU xiao-ying ma Xiu-li QIN Ling-ling Heart Center Beijing Chaoyang Hospital Capital Medical UniversityBeijing 100020China

Background Heart failure(HF)is a chronic,impactful condition on individuals and healthcare systems,requiring management that goes beyond inpatient *** study investigated the impact of cardiovascular specialist nurses on long-term health outcomes and patient satisfaction in HF outpatient *** In a year-long observational study from July 2021 to July 2022,230 HF patients at our hospital were divided into an experimental group(n=115)receiving care from cardiovascular specialist nurses and a control group(n=115)managed by general nursing *** interventions included comprehensive care such as patient education,medication management,lifestyle guidance,symptom monitoring,and psychological *** major adverse cardiovascular events(maCEs)and rehospitalization rates were applied as the primary *** The experimental group demonstrated significantly fewer maCEs and lower rehospitalization rates compared to the control group(P<0.001).Higher patient satisfaction was observed in the experimental group,with 81.7%reporting high satisfaction vs.53.9%in the control group(P<0.001).Differences in incidence of myocardial infarction and death rates between the groups were not statistically *** The involvement of cardiovascular specialist nurses in HF outpatient care significantly enhances clinical outcomes and patient *** nurses play a key role in bridging the transition from hospital to home care,improving adherence to treatment regimens,and reducing healthcare system burdens.

关键词： Heart failure Cardiovascular specialist nurses Outpatient care Health outcomes Patient satisfaction Chronic disease management

New Families of Exact Excitations to （2＋1）-Dimensional Toda Lattice System via an Extended Projective Approach

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Communications in Theoretical Physics 2006年第5期45卷 864-868页

作者： FANG Jian-Ping fei Jin-Xi ZHENG Chun-Long College of Physics and mathematics Lishui University Lishui 323000 China Shanghai Institute of Applied mathematics and Mechanics Shanghai University Shanghai 200072China

In this paper, the extended projective approach, which was recently presented and successfully used in some continuous nonlinear physical systems, is generalized to nonlinear partial differential-difference systems （DDEs）, As a concrete example, new families of exact solutions to the （2＋1）-dimensional Toda lattice system are obtained by the extended projective approach.

关键词： extended projective approach DDEs Toda lattice exact solution