检索结果-南通市图书馆

Raf/MEK/ERK Signaling Pathway Is Involved in the Inhibition of Glioma Cell Proliferation and Invasion in the Ketogenic Microenvironment

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2023年第4期43卷 759-767页

作者： Wen-tao FAN xiao-fei liu liu Ri-chu LIANG Department of Neurosurgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421000China

Objective:A high-fat,low-carbohydrate ketogenic diet has been used to treat malignant glioma,in which the Raf/MEK/ERK signaling pathway is ***,whether the Raf/MEK/ERK signaling pathway is involved in the therapeutic effect of ketone bodies remains *** this study,we investigated the effects of a major ketone body,3-hydroxybutyric acid(3-HBA),on the proliferation and metastasis of malignant glioblastoma cells and the underlying ***:Two human malignant glioblastoma cell lines(U87 and U251)were treated with different concentrations of 3-HBA with or without the Raf inhibitor PAF C-16 for 24 *** proliferation,cell cycle,cell invasion,and phospholipase D1(PLD1)activity were *** and gene expression levels of Raf/MEK/ERK signaling pathway members were ***:3-HBA significantly decreased cell proliferation,invasion,and intracellular PLD1 activity in both U87 and U251 glioblastoma cell lines.3-HBA treatment significantly increased the proportion of cells in the G1 phase and decreased the proportion of cells in S phase in U87 *** the U251 line,the proportion of treated cells in S phase was increased and proportion of cells in G2 was decreased.3-HBA treatment also significantly decreased the protein expression levels of Raf,MEK,p-MEK,ERK,p-ERK,and PLD1 while increasing p53 expression;an effect that was similar to treatment with the Raf ***-treatment of 3-HBA with the Raf inhibitor further enhanced the effects of the 3-HBA in both cell ***:We confirmed that a ketogenic microenvironment can inhibit glioma cell proliferation and invasion by downregulating the expression of PLD1 through the Raf/MEK/ERK signaling pathway.

关键词： glioma ketogenic microenvironment Raf/MEK/ERK

Selective Synthesis of 2,6-Dimethylnaphthalene by Transalkylation in the Presence of Acid Ionic Liquids [C_nmim]Cl-AlCl_3

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2011年第6期27卷 1010-1013页

作者： WU Guang WU Wei xiao Lin-fei liu Dan Heilongjiang Province College Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion School of Chemistry and Material Sciences Heilongjiang University Harbin 150080 P. R. China

A highly selective synthesis of 2,6-dimethylnaphthanlene（2,6-DMN） by transalkylation between 2-methylnaphthanlene（2-MN） and 1,2,4,5-tetramethylbenzene（TeMB） was performed with 1-alkyl-3-methylimidazo- lium aluminum chloride（[Cnmim]Cl-AlCl3） ionic liquids（ILs） as catalysts. The influences of the alkyl group as the organic cation, the acidic strength of [C4mim]Cl-AlCl3 ILs as well as the reaction conditions on the catalytic performance were investigated. [C4mim]Cl-AlCl3 ILs[x（AlCl3）=71%] exhibited high activity and selectivity toward 2,6-DMN. The selectivity to 2,6-DMN and the 2,6-DMN/2,7-DMN ratio reached up to 68.2% and 3.7：1, respectively. The UV-Vis spectrum of TeMB treated by different ILs shows that the protonated degree of TeMB dependeds on the acidity strength of ILs, which has a significant impact on the reaction results. The high protonated degree of TeMB is advantageous to enhancing the conversion of transalkylation and the large stereo-hindrance effect of TeMB is favorable to improving the selecivity to 2,6-DMN.

关键词： Ionic liquid 2 6-Dimethylnaphthalene 1-Alkyl-3-methylimidazolium aluminum chloride Transalkylation

Conducting polymer-functionalized mesoporous metal-organic frameworks for high-performance Li-S battery

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第4期16卷 4867-4873页

作者： xiao-fei liu Ya-Rui Wang Hong Chen Bo Li Shuang-Quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001China Collaborative Innovation Center of Water Security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province College of Chemistry and Pharmacy EngineeringNanyang Normal UniversityNanyang 473061China

It was known that mesoporous metal-organic frameworks(MOFs)with hierarchical pores and unsaturated metal sites can effectively inhibit the shuttle effect of lithium polysulfides in lithium-sulfur battery,however,the unsatisfactory structural stability and electrical conductivity limit the application of mesoporous MOFs(MMOFs)in Li-S *** at sensible solutions,the conductive polyaniline(PANI)was incorporated into the MMOF to enhance the discharge capacity and the cycling stability of proposed Li-S batteries,as the stability and the conductivity of the MMOF cathode was improved *** activated MMOF-PANI provides physical and chemical adsorption of polysulfides against their shuttle ***,the introduction of PANI into the channels of MMOF effectively improves the conductivity of MMOF,thus improving the electrochemical performance of the MMOF-PANI-based *** from these synergetic effects,the S@MMOF-PANI cathode delivers improved electrochemical performance including excellent rate performance and cycling *** battery shows an initial capacity of 777.7 mAh·g^(−1)at 2.0 C and a low decay rate of 0.06%per cycle in 1,000 cycles and approximately a repeatable rate performance.

关键词： metal-organic framework conductivity mesoporous shuttle effect Li-S battery

Recent advances in electrochemical carboxylation reactions using carbon dioxide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Chemical Engineering 2022年第2期3卷 125-137页

作者： xiao-fei liu Ke Zhang Li Tao xiao-Bing Lu Wen-Zhen Zhang State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116024China

From the viewpoint of abundance,economy,non-toxicity,and renewability,CO_(2) is the ideal C1 synthon in organic synthetic *** CO_(2) for chemical conversion to synthesize highly value-added fine chem-icals is of great *** electrochemical synthesis that employs electrons as redox reagents to achieve selective oxidation or reduction has attracted much attention in the past *** this review,recent advances in the electrochemical carboxylations using CO_(2) from the perspective of organic synthesis will be *** give an overview about the research progress of electrocarboxylation reactions according to the classification of substrates,such as alkenes,organic(pseudo)halides,aldehydes,ketones,and *** carb-anions produced by cathodic reduction are important intermediates in the electrocarboxylation reactions using CO_(2).

关键词： Carbon dioxide Organic electrochemical synthesis Carboxylation Green chemistry Carboxylic acid

Rational designed isostructural MOF for the charge-discharge behavior study of super capacitors

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第7期15卷 6208-6212页

作者： Hong Chen xiao-fei liu Hai-Yang Li Peng Peng Shuang-Quan Zang Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

In recent years,the rapid charge-discharge property of super capacitors based on metal-organic frameworks(MOFs)has seen excellent applications in energy storage ***,the purposeful design of high-performance electrodes for MOFderived super capacitors is still an urgent problem that needs to be ***,we rationally design and prepare three MOFs with the same crystal configuration and controllable functional *** the combination of rigorous experiment and calculation,we have verified the effects of the specific surface area of the electrode material as well as the binding energy between the electrode material and the electrolyte ions on the performance of the super *** work not only extends the application of MOFs,but also provides a model-material platform for the study of charge–discharge behavior of MOF-based super capacitors,creating a way of thinking for the selection and design of MOF materials for energy storage applications.

关键词： Eu-metal-organic framework(Eu-MOF) super capacitor rational design controllable charge-discharge behavior

Rapid and high precision measurement of opto-thermal relaxation with pump-probe method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2018年第5期63卷 287-292页

作者： Tao Wang xiao-fei liu Yunqi Hu Guoqing Qin Dong Ruan Gui-Lu Long State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua University Beijing 100084 China School of Science and the State Key Laboratory of Information photonics and Optical communications Beijing University of Posts and Telecommunications Beijing 100876 China Collaborative Innovation Centre of Quantum Matter Beijing 100084 China Tsinghua National Laboratoly of Information Science and Technology Beijing 100084 China

Opto-thermal relaxation is one of the most important properties of nonlinear optical *** and high precision measurement of this parameter is vital in both fundamental research and *** measurement uses either complicated structure with poor precision or high power heating source with low ***,we propose a pump-probe method(PPM) to optically measure the thermal relaxation using whispering gallery mode(WGM) *** the pump laser shines on a microcavity,the materials absorb the input power resonantly and heat *** the heat dissipates from the cavities to the *** opto-thermal effect induces a refractive index change reflected in the signal light transmission *** analyzing the curve character of the transmission spectra of the signal response in the spontaneous relaxation process,the thermal relaxation time can be rapidly measured with high ***,we systematically verify the PPM using microtoroids under various pump powers and at various locking points of the signal laser *** small rate of refractive index changes($10à8) can be discerned with an input pump power as low as 11.816 l ***,the PPM can be used to detect refractive index perturbation,like gas or liquid sensing,temperature fluctuations with ultra-high sensitivity and be applied to optical materials analysis efficiently.

关键词： Microcavities Opto-thermal effect Optical materials Thermal relaxation Sensing Pump-probe

Thioxanthene-9-thione Mediated MMA Polymerization

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2018年第7期36卷 805-810页

作者： Xu Yan Guan Wang Li-Hua Zhang Li Wang xiao-fei liu Wan-Tai Yang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical and Technology Beijing Laboratory of Biomedical Materials Polymer Materials Beijing University of Chemical and Technology

In the ＂cycloketyl radical mediated living polymerization＂（CMP） process, a cycloketyl compound, [9,9＇]bixanthenyl-9,9＇ diol （BIXAN） was ultilized as initiator and mediator. The cycloketyl （CK） radical was used as the dormant radical to achieve the increase of molecular weight. Herein, a series of cycloketyl thioketones were synthesised by Lawesson＇s reagent by one step reaction with high yeild, and we found that, when a special cyeloketyl thioketone compound, thioxanthene-9-thione （TXT）, was added to a routine radical polymerization system, TXT could capture chain radical, and simultaneously formed an radical analogous to CK radical in structure, which could trigger the growth of polymer chains. This simple system was efficient to initiate the polymerization of methyl methacrylate （MMA） and in all cases the molecular weights increased with the increase of conversions. By the end-group analysis with 1H-NMR and MALDI-TOF MS, it was confirmed that the P-STXT radical was used to control the polymerization. The re-initiating reactions were achieved when PMMA was used as the macro-initiator.

关键词： Thioxanthene-9-thione Lawesson's reagent Methyl methacrylate Radical polymerization

Complexity responses of Rhododendron species to climate change in China reveal their urgent need for protection

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2023年第4期10卷 425-435页

作者： Kun-Ji Li xiao-fei liu Jin-Hong Zhang Xiong-Li Zhou liu Yang Shi-Kang Shen Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest ChinaInstitute of BiodiversitySchool of Ecology and Environmental ScienceYunnan UniversityKunming650504YunnanChina Institute of International River and Eco-security Yunnan UniversityKunming650504YunnanChina

Global climate change has been widely recognized as important factors that threaten *** species are not only famous woody ornamental plants worldwide but are also indispensable components in alpine and subalpine vegetation in southwest ***,the geographical distribution ranges response of this broad taxonomic group to future climate change remains not be fully ***,we studied the impact of climate change on the distribution of Rhododendron species in China by predicting the changes in their suitable habitats,centroid,and species richness under three climate change scenarios(SSP1-2.6,SSP2-4.5 and SSP5-8.5)in the *** species richness changes of Rhododendrons along altitude were also *** addition,we calculated the phylogenetic signals of distribution response to climate *** found that the distribution responses of Rhododendron to climate change have weak phylogenetic *** the 2090s,the suitable habitats of about 87%of Rhododendron species will be reduced,77%of Rhododendron species are manifested as northward *** high species richness of Rhododendrons tends to migrate to transboundary areas with high altitudes in *** Rhododendron species with no concern previously should be taken seriously for their high risk of habitat loss under climate ***,the urgent protection of Rhododendron species under climate change need to be paid more attention than previous *** recommend carrying out the reintroduction of endangered species in future suitable habitat,strengthening the protection of transboundary areas with high species richness,and focusing on species with few concerns previously.

关键词： Rescue Woody plant Alpine ecosystem Mountaintop Diversity

Different imaging findings of inflammatory myofibroblastic tumor of the liver

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第40期18卷 5821-5825页

作者： xiao-fei liu Bao-Ming He xiao-Hui Ou-Yang Zhi-Zhong Wang Jia-Gui Su Department of Nuclear Medicine The People's Liberation Army 309th HospitalBeijing 100091China

Inflammatory myofibroblastic tumor(IMT) in the liver is an uncommon lesion of uncertain *** most cases,symptomatological imaging and clinical studies suggest *** report a case of liver IMT with imaging findings from positron emission tomography/computed tomography(PET/CT),contrastenhanced computed tomography(CECT) and contrastenhanced ultrasonography(CEUS).This report was the first to depict a PET/CT scan of a liver IMT that revealed an inhomogeneous,intense(fluorine 18)-fluoro-2-deoxy-D-glucose *** CECT and CEUS images showed a hepatic artery supplying blood to the mass and *** characteristic histopathological features and the presence of spindle cells expressing smooth muscle actin,collagen fibers and lymphocytes allowed for the diagnosis of liver *** such findings will help to achieve a correct diagnosis and may prevent inappropriate treatment.

关键词： Inflammatory myofibroblastic tumor Liver Emission-computed tomography X-ray-computed to-mography