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甲状旁腺功能减退伴肌酶增高患者的治疗研究

中华内分泌代谢杂志 2013年第9期29卷 798-800页

作者：佟强李红方小正谭娟南京医科大学附属淮安第一医院老年医学科 223300

比较研究肌酶增高和肌酶正常的甲状旁腺功能减退症患者临床资料。结果显示，肌酶增高组与肌酶正常组在年龄、性别、病程、甲状旁腺素水平、病因方面均无差别，肌酶正常组血钙浓度均在正常范围，而肌酶增高组血钙浓度明显低于肌酶正常组... 详细信息

比较研究肌酶增高和肌酶正常的甲状旁腺功能减退症患者临床资料。结果显示，肌酶增高组与肌酶正常组在年龄、性别、病程、甲状旁腺素水平、病因方面均无差别，肌酶正常组血钙浓度均在正常范围，而肌酶增高组血钙浓度明显低于肌酶正常组；随着血钙水平是升，增高的肌酶逐渐降至正常．提示甲状旁腺功能减退症血钙浓度降低导致肌酶增高。

关键词：甲状旁腺功能减退症肌酶血钙

Generation and Selection of the Immunized Fab Phage Display Library from Human B Cell Lymphoma

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Generation and Selection of the Immunized Fab Phage Display ...

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

江苏省遗传学会第七届代表大会暨学术研讨会

作者： SHEN Yong-mei, YANG xiao-chun, XIE xiao-fang, DONG Ning-zheng, SHI Yi-zhen (Second Affiliated Hospital of Soochow University, Suzhou 215004, China)

＜正＞Background The approval of monoclonal antibodies as antibody-targeted therapy in the management of patients with B cell lymphoma has led to new treatment options for this group of patients. But the traditional h... 详细信息

关键词： B cell lymphoma Fab Phage display library pComb3H-SS vector

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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高校科研管理应增强的几种意识

宁德师专学报（自然科学版） 2006年第2期18卷 149-152页

作者：肖方峥莆田学院科研处福建莆田351100

科研工作是高校三大任务之一,在高校发展中具有重要的地位．如何有效地加强科研管理,推动科研工作不断上新台阶,成为众多科研管理工作者探索的焦点．在高校科研管理工作中,应注重增强创新意识、服务意识、激励意识、成果转化意识以及与... 详细信息

科研工作是高校三大任务之一,在高校发展中具有重要的地位．如何有效地加强科研管理,推动科研工作不断上新台阶,成为众多科研管理工作者探索的焦点．在高校科研管理工作中,应注重增强创新意识、服务意识、激励意识、成果转化意识以及与其他业务部门的协调意识,从而不断提高科研管理效率,促进科研管理水乎的逐步提升．

关键词：高校科研管理意识

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying fang xiao-Rui Pan Xin-Xing Zeng zheng-zheng Li Bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

森林地区PM2.5中氨基酸的水平、来源及转化

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中国环境科学 2021年第1期41卷 81-90页

作者：朱玉雯朱仁果方小珍潘媛媛温泽群东华理工大学地球科学学院江西南昌330013 东华理工大学江西省大气污染成因与控制重点实验室江西南昌330013 昆明理工大学国土资源学院地球科学系云南昆明650021

在春季采集了南昌森林地区(28.75°N,115.71°E)大气PM2.5样品,测定了其结合氨基酸(CAAs)和游离氨基酸(FAAs)的浓度以及甘氨酸(Gly)的氮同位素.结果表明,大气气溶胶中总CAAs的浓度为272.8~4761.5pmol/m^3,总FAAs浓度为56.4~494.0pmol/m^3.通过分析PM2.5中氨基酸的百分比组成,得出CAAs中Pro、Gly、Glu、Leu和Ala为主要氨基酸,分别占总CAAs的(19.5±12.0)%,(19.4±10.6)%,(15.3±4.9)%,(12.8±5.4)%和(9.1±1.6)%.在FAAs中,Gly为最丰富的氨基酸,占总FAAs的(71.1±9.2)%,其他单个FAAs的百分比却很小(占比范围为0.1%~14.3%).FAAs中的中性氨基酸百分占比明显高于其在CAAs中的百分占比,这可能与远距离传输过程中氨基酸的光化学反应有关.通过氨基酸浓度与O3、NO2和温度的相关性分析,发现森林地区气溶胶中FAAs形成与大气光化学过程和热反应有关.气溶胶中δ^15NC-Gly值(-1.0‰~+17.5‰)和δ^15NF-Gly值(-5.5‰~+13.0‰)均接近于土壤源的δ^15NGly值,说明森林地区PM2.5中氨基酸可能主要来源于土壤源.

关键词：结合氨基酸游离氨基酸 PM2.5 O3 δ^15NGly

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高血压对2型糖尿病认知功能的影响

中华内分泌代谢杂志 2013年第5期29卷 403-406页

作者：卢正红唐伟方小正陈敏朱永芳李雪琴谭娟南京医科大学附属淮安第一医院老年科南京223300 江苏省人民医院内分泌科

本研究观察了155例2型糖尿病患者认知功能与高血压情况的关系。2型糖尿病含合并高血压组和不合并高血压组，在高血压组中，血压控制不佳和控制良好亚组间认知功能间的差异有统计学意义（P＜0.05）。收缩压、脉压、平均动脉压、高血压病... 详细信息

本研究观察了155例2型糖尿病患者认知功能与高血压情况的关系。2型糖尿病含合并高血压组和不合并高血压组，在高血压组中，血压控制不佳和控制良好亚组间认知功能间的差异有统计学意义（P＜0.05）。收缩压、脉压、平均动脉压、高血压病程与多个认知域呈负相关。提示适度控制血压可能对2型糖尿病患者的认知功能有一定保护作用。

关键词：高血压认知糖尿病 2型

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long xiao Gao zhengwei Wang Zhizhong Guan xiaolan Qi Wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu xiao Shangru Zhai Chuang Xue Guangping zheng Deqing Zhang Renchao Che Junye Cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness