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GRU-integrated constrained soft actor-critic learning enabled fully distributed scheduling strategy for residential virtual power plant

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Global Energy Interconnection 2024年第2期7卷 117-129页

作者： xiaoyun Deng Yongdong Chen Dongchuan fan Youbo liu Chao Ma College of Electrical Engineering Sichuan UniversityChengdu 610065P.R.China State Grid Sichuan Comprehensive Energy Service Co.Ltd. Chengdu 610072P.R.China

In this study,a novel residential virtual power plant(RVPP)scheduling method that leverages a gate recurrent unit(GRU)-integrated deep reinforcement learning(DRL)algorithm is *** the proposed scheme,the GRU-integrated DRL algorithm guides the RVPP to participate effectively in both the day-ahead and real-time markets,lowering the electricity purchase costs and consumption risks for *** Lagrangian relaxation technique is introduced to transform the constrained Markov decision process(CMDP)into an unconstrained optimization problem,which guarantees that the constraints are strictly satisfied without determining the penalty ***,to enhance the scalability of the constrained soft actor-critic(CSAC)-based RVPP scheduling approach,a fully distributed scheduling architecture was designed to enable plug-and-play in the residential distributed energy resources(RDER).Case studies performed on the constructed RVPP scenario validated the performance of the proposed methodology in enhancing the responsiveness of the RDER to power tariffs,balancing the supply and demand of the power grid,and ensuring customer comfort.

关键词： Residential virtual power plant Residential distributed energy resource Constrained soft actor-critic Fully distributed scheduling strategy

Total Factor Productivity with Chinese Characteristics

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Social Sciences in China 2024年第1期45卷 54-70页

作者： fan Xin liu Wei School of Economics Renmin University of China

Although total factor productivity(TFP)is a common concept in mainstream Western economics,its origins are actually embedded in Marx's understanding of improving labor *** an important element of labor productivity under socialized production conditions,TFP is further reflected in the category of"socially necessary labor time"in two distinct ***-examining TFP from the perspective of Marxist political economy and incorporating it into the theoretical system of political economy of socialism with Chinese characteristics vividly illustrates the essence of"adhering to original principles,assimilating foreign concepts,and embracing a forward-looking vision"within political economy of socialism with Chinese *** practice,it is necessary to start with Marx's theory of productive labor and delineate the sectors involved in productive labor so that TFP and its fluctuations can be measured in a more relevant *** the context of the new era and the new journey,as the key to achieving high-quality economic development in China,efforts are needed to increase *** requires balancing economic factors such as the long term and short term,supply and demand,and gross quantity and structure,and promoting transformative changes in the quality,efficiency,and dynamism of economic development.

关键词： total factor productivity(TFP) technological progress technological effciency high-quality development

New Hybrid CHP System Integrating Solar Energy and Exhaust Heat Thermochemical Synergistic Conversion with Dual-Source Energy Storage

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Journal of Thermal Science 2024年第3期33卷 970-984页

作者： QIN Yuanlong liu Taixiu LI Peijing ZHAO Kai JIAO fan PEI Gang liu Qibin Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHefei230027China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

For the efficient use of solar and fuels and to improve the supply-demand matching performance in combined heat and power(CHP)systems,this paper proposes a hybrid solar/methanol energy system integrating solar/exhaust thermochemical and thermal energy *** proposed system includes parabolic trough solar collectors(PTSC),a thermochemical reactor,an internal combustion engine(ICE),and hybrid storage of thermal and chemical energy,which uses solar energy and methanol fuel as input and outputs power and *** methanol thermochemical decomposition reaction,mid-and-low temperature solar heat and exhaust heat are upgraded to chemical energy for efficient power *** thermal energy storage(TES)stores surplus thermal energy,acting as a backup source to produce heat without emitting CO_(2).Due to the energy storage,time-varying solar energy can be used steadily and efficiently;considerable supply-demand mismatches can be avoided,and the operational flexibility is *** the design condition,the overall energy efficiency,exergy efficiency,and net solar-to-electric efficiency achieve 72.09%,37.65%,and 24.63%,*** fuel saving rate(FSR)and the CO_(2) emission reduction(ER_(CO_(2)))achieve 32.97%and 25.33%,*** research findings provide a promising approach for the efficient and flexible use of solar energy and fuels for combined heat and power.

关键词： hybrid energy system solar thermochemical exhaust heat energy storage operational flexibility

Photo-controllable antifouling hydrogels embedded with AgNPs coated spiropyran functionalized mesoporous silica for long-term antibacterial activity

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Nano Research 2024年第9期17卷 8337-8349页

作者： Wei Su Fei Wang Bing Chen Ruoke Li Jindian liu Junjie Xu Jianhua fan Yueling liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Department of Applied Biology School of BiotechnologyEast China University of Science and TechnologyShanghai 200237China

Silver nanoparticles(AgNPs)are widely used in antimicrobial ***,its easy aggregation and rapid loss hinder the effective *** address this issue,a novel stimuli-responsive antibacterial nanocomposite(Ag@SP-MSN)was developed based on spiropyran covalently conjugated mesoporous silica nanoparticles(284.6 nm)and AgNPs(27.1 nm)via strong electrostatic *** transmission electron microscopy(TEM)and atomic force microscopy(AFM)images proved the successful modification of AgNPs onto *** light-induced maximum loading amount towards AgNPs was calculated to be 95.0 wt.%after ultraviolet irradiation,while the amount of AgNPs released from Ag@SP-MSN was 94.4 wt.%under visible light in the aid of ammonia(0.1%,v/v).Upon cycled light irradiation,Ag@SP-MSN could recover 84.5 wt.%of AgNPs even after four *** proposed Ag@SP-MSN exhibited better antibacterial activity against both *** and *** than Ag@MSN under visible light illumination,indicating the efficient photo-responsive isomerization of ***,the Ag@SP-MSN embedded gel demonstrated outstanding antifouling ability even after 21 days when compared to AgNPs *** long-term photo-controllable antifouling property proved the excellent reversible absorption and release of Ag@SP-MSN towards *** work provides new insights into the safe utilization of nanomaterials,offering promising advancements to meet clinical antibacterial requirements.

关键词： light-responsive silver nanoparticles spiropyran mesoporous silica nanoparticles antibacterial activity

Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2819-2834页

作者： Jikai Deng Shimin Yang Yingjian Li Xue Tan Jiejie liu Yanying Yu Qiang Ding Chengpeng fan Hongyun Wang Xianyin Chen Qianyun liu xiao Guo Feiyu Gong Li Zhou Yu Chen State Key Laboratory of Virology RNA InstituteCollege of Life Sciences and Frontier Science Center for Immunology and MetabolismWuhan UniversityWuhanChina School of Medicine Tsinghua UniversityBeijingChina School of Basic Medical Sciences Wuhan UniversityWuhanChina Animal Bio-Safety Level Ⅲ Laboratory/Institute for Vaccine Research Wuhan University School of MedicineWuhanChina

Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune ***,the K-D-K-E catalytic motif of 2′-O-MTase is highly conserved across numerous viruses,including flaviviruses,vaccinia viruses,coronaviruses,and extends even to ***,we observed a stronger 2′-O-MTase activity in SARS-CoV-2 compared to SARS-CoV,despite the presence of a consistently active catalytic *** further identified critical residues(Leu-36,Asn-138 and Ile-153)which served as determinants of discrepancy in 2′-O-MTase activity between SARS-CoV-2 and *** residues significantly enhanced the RNA binding affinity of 2′-O-MTase and boosted its versatility toward RNA *** interest,a triple substitution(Leu^(36)→Ile^(36),Asn^(138)→His^(138),Ile^(153)→Leu^(153),from SARS-CoV-2 to SARS-CoV)within nsp16 resulted in a proportional reduction in viral 2′-O-methylation and impaired viral ***,it led to a significant upregulation of type I interferon(IFN-I)and proinflammatory cytokines both in vitro and vivo,relying on the cooperative sensing of melanoma differentiation-associated protein 5(MDA5)and laboratory of genetics and physiology 2(LGP2).In conclusion,our findings demonstrated that alterations in residues other than K-D-K-E of 2′-O-MTase may affect viral replication and subsequently influence *** changes in nsp16 residues is crucial as it may aid in identifying and assessing future alteration in viral pathogenicity resulting from natural mutations occurring in nsp16.

关键词： pathogenesis impaired alterations

Generation and characterization of nanobodies targeting GPCR

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Biophysics Reports 2024年第1期10卷 22-30页

作者： Shenglan Zhang Zhiran fan Jianfeng liu Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Cellular Signaling laboratory International Research Center for Sensory Biology and Technology of MOST Key Laboratory of Molecular Biophysics of MOE College of Life Science and Technology Huazhong University of Science and Technology

G protein-coupled receptors(GPCRs) are a large family of cell membrane proteins that are important targets for drug discovery. Nanobodies, also known as VHH(variable domains of heavy chain-only antibodies, HcAbs) antibodies, are small antibody fragments derived from camelids that have gained significant attention as potential therapeutics for targeting GPCRs due to their advantages over conventional antibodies. However, there are challenges in developing nanobodies targeting GPCRs, among which epitope accessibility is the most significant because the cell membrane partially shields the GPCR surface. We developed a universal protocol for making nanobodies targeting GPCRs using the cell membrane extract of GPCR-overexpressing HEK293 cells as the llama/alpaca immunization antigen. We constructed an immune VHH library and identified nanobodies by phage display bio-panning. The monoclonal nanobodies were recombinantly expressed in Escherichia coli(E. coli) and purified to characterize their binding potency.

关键词： Nanobody Single domain antibody Heavy chain-only antibody GPCR G protein-coupled receptor

Stereoselectiveα-Glycosylation with GlcN_(3)Donors Enabled Collective Syntheses of Acinetobacter baumannii Capsular Polysaccharides K43,K47 and K88 Repeating Units

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Chinese Journal of Chemistry 2024年第14期42卷 1593-1598页

作者： Kunxiu Shou Shanshan liu Yunqin Zhang Guozhi xiao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyUniversity of Chinese Academy of SciencesChinese Academy of SciencesKunmingYunnan650201 China

Collective syntheses of *** CPS K43,K47 and K88 repeating units have been accomplished via a newα-glycosylation method with GlcN_(3) as donors,which features:1)mild reaction conditions,2)good to high yields,3)excellent *** synthetic route also highlights an orthogonal one-pot coupling strategy on the basis of glycosyl ortho-(1-phenylvinyl)benzoates for stereoselective constructions of both 1,2-trans and 1,2-cis glycosidic bonds,precluding the issues of aglycone transfer.

关键词： A baumanni CPS α-Glycosylation method One-pot glycosylation 1,2-GlcN bonds Glycosyl ortho-(1-phenylvinyl)benzoates Carbohydrates Oligosaccharides Total synthesis

Study on frictional behavior of SiC_(f)/SiC composite clad tube clamping condition under nuclear irradiation

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Friction 2024年第5期12卷 919-938页

作者： Chenglong xiao Liangliang SHEN Tianqi ZHU Jianbo TANG Ximing XIE Xinyu fan Jian XU Zhiying REN School of Mechanical Engineering Zhejiang University of TechnologyHangzhou310023China Engineering Laboratory of Advanced Energy Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China State Key Laboratory of Fine Chemicals Liaoning High-Performance Polymer Engineering Research CenterSchool of Chemical EngineeringDalian University of TechnologyDalian116024China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou350116China School of Computer Science and Technology Shandong UniversityQingdao266237China Aviation Industry Corporation of China Ltd.Beijing100028China

Silicon carbide fiber reinforced silicon carbide matrix(SiC_(f)/SiC)composite is the key cladding material of nuclear fuel,which determines the safety and reliability of nuclear fuel storage and *** replacement of its storage and transportation scenario needs to be completed by the manipulator,but the application of SiC_(f)/SiC wear,fracture,and nuclear leakage in the snatching process of brittle-flexible-rigid contact in the irradiation environment has been seriously restricted due to unclear understanding of the damage ***,the effects of irradiation dose and clamping load on the friction characteristics of the contact interface between SiC_(f)/SiC clad tube are studied in this paper,and the effects of irradiation parameters and clamping force on the static friction coefficient of the contact interface between the clad tube and flexible nitrile are *** on the Greenwood-Williamson tribological model,a numerical model of the shape and structure of the contact micro-convex at the micro-scale of the clamping interface is constructed by introducing the multi-surface integral,and finally verified by *** research results show that there is a unique“Irradiation suppression zone”under the clamping condition of SiC_(f)/SiC cladding tube under the nuclear irradiation environment,and the growth of static friction coefficient slows down until stagnates after irradiation reaches a certain extent(600 kGy),and there will be a decline when the irradiation dose continues to increase,among which the clamping force of 15.2 N within the irradiation interval of 1,000 kGy can meet the safety of nuclear environment *** results of this paper can provide an important theoretical basis and application guidance for the safe operation of SiC_(f)/SiC cladding tubes in the storage and transportation clamping process.

关键词： SiC_(f)/SiC Clad tube nuclear irradiation conditions Greenwood-Williamson tribological model multi-surface integral

Burning Numbers of Barbells

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 526-538页

作者： Hui-qing liu Rui-ting ZHANG xiao-lan HU Hubei Key Laboratory of Applied Mathematics&Faculty of Mathematics and Statistic Hubei UniversityWuhan 430062China Hubei Key Laboratory of Mathematical Sciences&School of Mathematics and Statistics Central China Normal UniversityWuhan 430079China

Motivated by a discrete-time process intended to measure the speed of the spread of contagion in a graph,the burning number b(G)of a graph G,is defined as the smallest integer k for which there are vertices x1,…xk su... 详细信息

关键词： burning number short/long barbell isometric subtree cycle