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Strip-oriented asynchronous prefetching for parallel disk systems

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第11期13卷 799-815页

作者： Yang LIU Jian-zhong HUANG xiao-dong shi Qiang CAO Chang-sheng XIE Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Sequential prefetching schemes are widely employed in storage servers to mask disk latency and improve system throughput. However, existing schemes cannot benefit parallel disk systems as expected due to the fact that they ignore the distinct internal characteristics of the parallel disk system, in particular, data striping. Moreover, their aggressive prefetching pattern suffers from premature evictions and prolonged request latencies. In this paper, we propose a strip-oriented asynchronous prefetching (SoAP) technique, which is dedicated to the parallel disk system. It settles the above-mentioned problems by providing multiple novel features, e.g., enhanced prediction accuracy, adaptive prefetching strength, physical data layout awareness, and timely prefetching. To validate SoAP, we implement a prototype by modifying the software redundant arrays of inexpensive disks (RAID) under Linux. Experimental results demonstrate that SoAP can consistently offer improved average response time and throughput to the parallel disk system under non-random workloads compared with STEP, SP, ASP, and Linux-like SEQPs.

关键词： Parallel disk system Strip Sequential prefetching Asynchronous scheduling

Topic-aware pivot language approach for statistical machine translation

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第4期15卷 241-253页

作者： Jin-song SU xiao-dong shi Yan-zhou HUANG Yang LIU Qing-qiang WU Yi-dong CHEN Huai-lin dong Software School Xiamen University Center for Digital Media Computing Xiamen University Cognitive Science Department Xiamen University Department of Computer Science and Technology Tsinghua University

The pivot language approach for statistical machine translation(SMT) is a good method to break the resource bottleneck for certain language pairs. However, in the implementation of conventional approaches, pivotside context information is far from fully utilized, resulting in erroneous estimations of translation probabilities. In this study, we propose two topic-aware pivot language approaches to use different levels of pivot-side context. The first method takes advantage of document-level context by assuming that the bridged phrase pairs should be similar in the document-level topic distributions. The second method focuses on the effect of local context. Central to this approach are that the phrase sense can be reflected by local context in the form of probabilistic topics, and that bridged phrase pairs should be compatible in the latent sense distributions. Then, we build an interpolated model bringing the above methods together to further enhance the system performance. Experimental results on French-Spanish and French-German translations using English as the pivot language demonstrate the effectiveness of topic-based context in pivot-based SMT.

关键词： Natural language processing Pivot-based statistical machine translation Topical context information

Deletion of Helicobacter pylori vacuolating cytotoxin gene by introduction of directed mutagenesis

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World Journal of Gastroenterology 2003年第10期9卷 2251-2257页

作者： Jian-Ping Yuan,Tao Li,xiao-dong shi,Bao-Yu Hu,Gui-Zhen Yang,Shan-Qing Tong,xiao-Kui Guo,Department of Microbiology and Parasitology,Shanghai Second Medical University,Shanghai 200025,China. Department of Microbiology and Parasitology Shanghai Second Medical University Shanghai 200025 China.

AIM: To construct a vacA-knockout Helicobacter pylori mutant strain, whose only difference from the wild strain is its disrupted vacA *** AND RESULTS: A clone containing kanamycin resistance gene used for homologous recombination was constructed in a directional cloning procedure into pBluescript ⅡSK, and then transformed into vacA+ H pylori by *** growing on the selective media containing kanamycin were harvested for chromosomal DNA extraction,and the allelic exchange was determined by polymerase chain reactions and sequencing. Loss of vacuolating activity of the vaci-knockout strain was confirmed by examining the gastric cells co-cultured with cell-free supernatants from H pylori wild strain or the ***: We constructed a vacA-knockout strain of H pylori through direct mutagenesis, which creates an important precondition for the future research on virulence comparison with gene expression analysis.

关键词： HP感染基因缺失基因突变细胞毒素克隆

SYNTHESIS OF 4,6-DISUBSTITUTED 5-THIOXO-1,2,4-TRIAZIN-3-ONE FROM BENZOTHIOFORMANILIDE

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Chinese Chemical Letters 1991年第7期2卷 525-526页

作者： Zhong E LU Tian Lin XU xiao dong shi Department of Chemistry,Suzhou University,Suzhou,215006

A method of synthesis of 4,6-disubstituted 5-thioxo-1,2,4-triazin- 3-ones from benzothioformanilides and semicarbazide is *** six new compounds were synthesized by this method.

关键词： SYNTHESIS OF 4 6-DISUBSTITUTED 5-THIOXO-1 2 4-TRIAZIN-3-ONE FROM BENZOTHIOFORMANILIDE

Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis

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Cell Research 2003年第3期13卷 171-177页

作者： SHENG WEI ZOU,JIAN CHAO ZHANG,xiao dong ZHANG,shi YING MIAO,SHU dong ZONG,QI SHENG,LIN FANG WANGNational Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Peking Union Medical College,5 dong Dan 3-tiao,Beijing 100005,ChinaNational B,esearch Institute for Family Planing,WHO Collaboration Center for B,esearch in Human Reproduction,12 Da Hui Si,Beijing 100081,China National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Peking Union Medical College Beijing China National Research Institute for Family Planing WHO Collaboration Center for Research in Human Reproduction Beijing China

Variable Charge X/Y(VCX/Y)is human testis-specific gene family that localized on X and Y *** this study,VCY protein was expressed in *** in the form of glutathione-S-transferase(GST)fusion *** the purified fusion protein as antigen,the anti-GST-VCY antibody was generated andthe localization of VCY protein in human testis was determined by *** the testisseminiferous epithelium,VCY proteins were highly expressed in nuclei of germ *** propidium io-dide staining and green fluorescent protein(GFP)tag technologies,VCY and VCX-8r proteins were mainlylocalized in the nucleoli of COS7 *** *** colocalization for VCY and VCX-8r in COS7 cellswas also *** VCY cDNA as bait,a cDNA fragment of acidic ribosomal protein PO was obtainedusing yeast two-hybrid *** the information above indicated that VCX/Y protein family might beinvolved in the regulation of ribosome assembly during spermatogenesis.

关键词： VCX/Y protein spermatogenesis nucleoli colocnlization.

NEW SYNTHETIC ROUTE TO ALKOXYPHOSPHORNES

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Chinese Chemical Letters 1994年第9期5卷 725-726页

作者： Lun Zu LIU Guo Wei LI Xing Zhong ZENG Ao ZHANNG xiao dong shi Zhong Biao ZHANG (Institute of elemento-Organic Chemistry, Nankai University, Tianjian, 30071)

A series of hydridophosphoranes reacted with benzenesulfenic esters to give the corresponding alkoxyphosphoranes in good fields.

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie shi Changle Hou Jingjing dong dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin xiao Fangqing Zhao Jing-dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

PVDF-HFP binder for advanced zinc−manganese batteries

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Transactions of Nonferrous Metals Society of China 2022年第9期32卷 3005-3014页

作者： Shu-ci MA xiao-dong shi Zhe-xuan LIU Yi-fan ZHOU Pin-ji WANG Jiang ZHOU Shu-quan LIANG Hunan Provincial Key Laboratory of Electronic Packaging and Advanced Functional Materials School of Materials Science and EngineeringCentral South UniversityChangsha 410083China

In order to optimize and select the appropriate binder to improve the electrochemical performance of aqueous zinc-manganese batteries,the influences of water-soluble binders and oil-based binders on the zinc storage performance of manganese-based cathode materials were systematically *** results show that the water-soluble binders with large numbers of hydroxyl and carboxyl groups are easily soluble in aqueous electrolytes,leading to poor electrochemical ***,the cathodes with polyvinylidene fluoride-hexafluoropropylene(PVDF-HFP)binder display high specific capacity of 264.9 mA·h/g and good capacity retention of 92%after 90 cycles at 100 mA/***,PVDF-HFP binder with plenty of hydrophobic groups presents excellent ability in inhibiting cracks on the surface of electrode,reducing voltage polarization and charge transfer resistance,as well as maintaining electrode integrity.

关键词： aqueous zinc−manganese batteries binders PVDF-HFP cycling stability