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复杂空间框架结构的自振特性分析

振动工程学报 2008年第3期21卷 261-267页

作者：郭永强陈伟球肖春文浙江大学土木工程学系浙江杭州310027 中铁七局郑州工程公司河南郑州450052

回传矩阵法自提出以来已被成功应用于平面桁架结构和层状介质的瞬态响应分析中。从编制统一的空间框架结构回传矩阵法动力计算程序的角度出发,给出回传矩阵法列式的统一推导过程,考虑材料阻尼、节点集中质量和弹簧阻尼支撑等因素,将原... 详细信息

回传矩阵法自提出以来已被成功应用于平面桁架结构和层状介质的瞬态响应分析中。从编制统一的空间框架结构回传矩阵法动力计算程序的角度出发,给出回传矩阵法列式的统一推导过程,考虑材料阻尼、节点集中质量和弹簧阻尼支撑等因素,将原回传矩阵法推广应用到复杂空间框架结构的自振特性分析中。数值算例表明该方法在求解自振特性时具有计算精度高、求解代价小等优点。

关键词：回传矩阵法空间框架结构自振特性

Thermodynamic model of lead oxide activity in PbO-CaO-SiO_2-FeO-Fe_2O_3 slag system

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Transactions of Nonferrous Metals Society of China 2015年第5期25卷 1633-1639页

作者：汪金良温小椿张传福江西理工大学冶金与化学工程学院赣州341000 中南大学冶金与环境学院长沙410083

According to the ion and molecule coexistence theory, a thermodynamic model of lead oxide activity in PbO-CaO-SiO2-FeO-Fe2O3 slag system was established at the temperature of 1273-1733 K. The activities of Pb O in slag were calculated, and their equal activity curves were plotted. The influences of slag basicity Q, iron oxide rate R and temperature T on activity NPb O and activity coefficient γPbO were also investigated. Results show that the calculated values of γPb O are in good agreement with the reported experimental data, showing that the model can wholly embody the slag structural characteristics. NPbO departures positively from Raoult values, and increases with increasing Pb O content in slag but changes little with T. γPbO increases with increasing Q, and goes through the maximum with increasing R for basic slag（Q0.3）. Results can be applied to the thermodynamic research and operational optimization of modern lead smelting technologies.

关键词： ion and molecule coexistence theory thermodynamic model lead oxide activity

The protective role of a novel human erythrocytederived depressing factor on blood vessels in rats

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The protective role of a novel human erythrocytederived depr...

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

2002全国青年药理学英文学术会议

作者： PANG Huan ZHANG xiao-chun wen Yun-yi (Department of Physiology, Institute of Basic Medical Sciences, CAMS, School of Basic Medicine, PUMC, Beijing 100005)

A human erythrocyte-derived depressing factor (EDDF) has been identified and extracted by our laboratory for the first time. EDDF had the advantages of a significant and long-lasting decreasing of blood pressure and t... 详细信息

关键词： erythrocyte-derived depressing factor (EDDF) calcium transport vasodilation hypertension

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang xiao-Qian Yang chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Study on induction of apoptosis by Fugongning in Endometriotic Cells

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Study on induction of apoptosis by Fugongning in Endometriot...

全国中青年中西医结合学术（英语）交流会议

作者： Yu yuefei, xiao chun wen bogui Huang guilin Department of biochmistry, Shantou University Medical College. Department of pathology, Jiangxi college of Traditional Chinese Medicine.

Objective: To explore the mechanism of Chinese drugs Fugongning on cures of Endometriosis at the molecular level, and to investigate whether apoptosis is induced in endometriosis by the ***: After making EMT animal model the rats were treated with *** and both medicines. Then apoptotic cells were detected by electron microscopy and flow cytometry(FCM).Result: 1 .On gross examination the size of transplant in treated groups was significantly decresed as compared with that of control(P < 0.05).The growth of Endometriotic cells were *** cells of treatment groups were found to have characteristic morphological changes of apoptosis by electron microsopy,such as extensive condensation of chromatin into dense masses,and it aggregated *** the nuclear *** apoptosis index in Fugongning,Danazol and the both medicines groups was( 8.04 ±4.88 )%, (6.17 ±3.22 ) % and (6.87 ±2.57) % respectively,which were significantly higher than that of control[( 2.53 ±1.35 )%,(P < 0.01 ).*** treatment with Fugongning,Danazol and both medicines,there were apoptotic peaks in cell cycle analysis on *** cells in S phase were obvionsly increased(P< 0.01),which indicated that cell cycles were hindered in S *** serum E2 level in Fugongning,Danazol and the both medicine group was 13.85 ±6.48, 14.2 ±6.13 and 14.23±6.04 respectively,which were significantly lower than that of control(l 8.87 ±2.31,P < 0.05 =Conclusion: This study indicates that Fugongning can induce apoptosis of Endometriotic *** possible mechanism is from decreasing the serum E2 level to suppress bcl-2 expression in endometriotic cells.

关键词： Fugongning Danazol Endometriotic cells apoptosis

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非线性光学位相共轭实时补偿大气湍流扰动

物理学报 1989年第3期38卷 466-470,T001页

作者：王晓春周定文张以谟天津大学精密仪器工程系

利用单色标量光波通过大气湍流的传输理论,在一级玻恩近似下,导出位相共轭波补偿气流扰动的理论,得出在无大气吸收及无限大共轭镜条件下,共轭波可完全补偿大气湍流的结论。实验结果表明,利用受激布里渊散射产生的位相共轭波可得到很好... 详细信息

利用单色标量光波通过大气湍流的传输理论,在一级玻恩近似下,导出位相共轭波补偿气流扰动的理论,得出在无大气吸收及无限大共轭镜条件下,共轭波可完全补偿大气湍流的结论。实验结果表明,利用受激布里渊散射产生的位相共轭波可得到很好的实时光场恢复。

关键词：非线性光学位相共轭大气湍流扰动

Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers

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World Journal of Clinical Oncology 2025年第1期16卷 59-64页

作者： chun-Han Cheng wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic *** et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term *** biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk *** PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer.

关键词： Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery Prognosis

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Radiomics and molecular analysis:Bridging the gap for predicting hepatocellular carcinoma prognosis

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World Journal of Clinical Cases 2025年第4期13卷 56-60页

作者： chun-Han Cheng wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404333TaiwanChina

This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the survival of patients with hepatocellular carcinoma(HCC).By integrating radiomics with molecular analysis,the study presented a strategy for accurately predicting the expression of EZH2 from CT *** findings demonstrated a strong link between the radiomics model,EZH2 expression,and patient *** noninvasive approach provides valuable insights into the therapeutic management of HCC.

关键词： Hepatocellular carcinoma Computed tomography Radiomics Enhancer of zeste homologue 2 expression Non-invasive imaging