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bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models

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World Journal of Stem Cells 2025年第1期17卷 22-39页

作者： Jing yang Jun Yuan yan-Qing Wen Li Wu Jiu-Jiang Liao Hong-bo Qi Women and Children’s Hospital of Chongqing Medical University Chongqing 401147China Chongqing Key Laboratory of Maternal and Fetal Medicine Chongqing Medical UniversityChongqing 400016China Obstetrics and Gynecology Guizhou Provincial People’s HospitalGuiyang 557300Guizhou ProvinceChina Research Laboratory of Reproduction and Development of Chinese Ministry of Education Chongqing Medical UniversityChongqing 400016China

BACKGROUND Uterine injury can cause uterine scarring,leading to a series of complications that threaten women’s *** healing is a complex process,and there are currently no effective *** our previous studies have shown that bone marrow mesenchymal stem cells(BMSCs)promote uterine damage repair,the underlying mechanisms remain ***,exploring the specific regulatory roles of BMSCs in uterine injury treatment is crucial for further understanding their functions and enhancing therapeutic *** To investigate the underlying mechanism by which BMSCs promote the process of uterine *** In in vivo experiments,we established a model of full-thickness uterine injury and injected BMSCs into the uterine *** sequencing was per-formed to determine the enrichment of differentially expressed genes at the wound *** in vitro experiments,we isolated rat uterine smooth muscle cells(USMCs)and cocultured them with BMSCs to observe the interaction between BMSCs and USMCs in the *** We found that the differentially expressed genes were mainly related to cell growth,tissue repair,and angiogenesis,while the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)pathway was highly *** reverse-transcription polymerase chain reaction was used to validate differentially expressed genes,and the results demonstrated that BMSCs can upregulate genes related to regeneration and downregulate genes related to *** BMSCs promoted the migration and proliferation of USMCs,and the USMC microenvironment promoted the myogenic differentiation of ***,we validated the PI3K/AKT pathway in tissues and cells and showed that BMSCs activate the PI3K/AKT pathway to promote the regeneration of uterine smooth muscle both in vivo and in *** BMSCs upregulated uterine wound regeneration and anti-inflammatory factors and enhanced uterine smooth muscle proliferation throu

关键词： Uterine injury bone marrow mesenchymal stem cells Uterine smooth muscle cells Phosphoinositide 3-kinase/protein kinase B pathway Cell-cell interactions Cell proliferation Immune regulation Wound regeneration

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口腔黏膜下纤维性变癌变的相关危险因素分析

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中国现代医学杂志 2011年第21期21卷 2648-2651页

作者：肖艳波尹晓敏高义军湖南中医药大学第一附属医院口腔科湖南长沙410007 中南大学湘雅医院口腔内科湖南长沙410078 中南大学湘雅二医院口腔医疗中心湖南长沙410011

目的通过对461例口腔黏膜下纤维性变(oral subm ucous fibrosis,O SF)及62例O SF癌变患者进行回顾性综合分析,探讨O SF癌变的相关危险因素。方法首先进行单因素检验,观察年龄、性别、职务、文化程度、咀嚼槟榔的时间和频率、吸烟量、饮... 详细信息

目的通过对461例口腔黏膜下纤维性变(oral subm ucous fibrosis,O SF)及62例O SF癌变患者进行回顾性综合分析,探讨O SF癌变的相关危险因素。方法首先进行单因素检验,观察年龄、性别、职务、文化程度、咀嚼槟榔的时间和频率、吸烟量、饮酒、是否伴发白斑或扁平苔藓、张口度等15个相关因素与O SF癌变的关系,筛选与O SF癌变相关的变量,进入多因素Logistic回归分析模型,计算这些因素的相对危险度(O R值)及95%的可信区间。结果单因素分析结果显示:年龄、文化程度、张口度、咀嚼槟榔、咀嚼槟榔的持续时间、吸烟、吸烟持续时间、吸烟量和饮酒被选入多因素Logistic回归分析模型;多因素Logistic回归结果显示年龄、咀嚼槟榔持续时间、吸烟及吸烟持续时间在O SF癌变过程中具有统计学意义(P<0.05)。结论年龄、咀嚼槟榔的持续时间、吸烟及吸烟持续时间是O SF癌变的危险因素。

关键词：口腔黏膜下纤维性变癌变危险因素回顾性研究

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I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

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Chinese Chemical Letters 2025年第1期36卷 277-282页

作者： You Zhou Li-Sheng Wang Shuang-Gui Lei bo-Cheng Tang Zhi-Cheng Yu Xing Li yan-Dong Wu Kai-Lu Zheng An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs The First Dongguan Affiliated HospitalSchool of PharmacyGuangdong Medical UniversityDongguan 523808China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction *** key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one ***,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关键词： Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission

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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou bo Ma yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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Five-year complete remission of super-giant hepatocellular carcinoma with hepatectomy followed by sorafenib plus camrelizumab:A case report

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 273-281页

作者： xiao-Qin Zheng Li-bo Sun Wen-Jie Jin Hui Liu Wen-yan Song Hui Xu Ju-Shan Wu xiao-Jun Wang Chun-yan Gou Hui-Guo Ding Integrated Traditional Chinese and Western Medicine Center Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Surgery Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Institute for Research in Biomedicine Universitàdella Svizzera italianaBellinzona 6500TicinoSwitzerland Department of Pathology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Radiology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Gastroenterology and Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND Cirrhotic patients with super-giant hepatocellular carcinoma(HCC)and portal vein invasion generally have a poor *** paper presents a patient with super-giant HCC and portal vein invasion,who underwent hepatectomy followed by a combination of sorafenib and camrelizumab,resulting in complete remission(CR)for 5 *** SUMMARY A 40-year-old male with compensated hepatitis B-related cirrhosis was diagnosed with HCC,Barcelona Clinic Liver Cancer stage *** computed tomography imaging revealed a 152 mm×171 mm tumor in the right liver,invading the portal vein and hepatic *** function was *** patient successfully underwent hepatectomy on July 18,***,by December 2019,HCC recurrence with lung metastases and portal vein invasion were *** started treatment with sorafenib(200 mg twice daily)and camrelizumab(200 mg every 3 weeks).By May 12,2020,the patient was confirmed to have *** was adjusted to 200 mg every 12 weeks from June 16,2021,with the last infusion on March 29,*** no further tumor recurrence was observed,he experienced two episodes of gastrointestinal bleeding due to esophagogastric varices,which were managed with endoscopic *** date,the patient has remained in CR for 5 *** The combination of hepatectomy with sorafenib and camrelizumab can achieve durable CR in patients with supergiant HCC and portal vein *** research is necessary to address these challenges and improve patient outcomes.

关键词： Hepatectomy Sorafenib Camrelizumab Super-giant hepatocellular carcinoma Complete remission Case report

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu yan-bo Li Qi Zhang Jun-Zhao xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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土壤重金属污染治理与修复方法研究进展

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长春工程学院学报（自然科学版） 2009年第3期10卷 73-78页

作者：刘磊肖艳波长春工程学院水利与环境工程学院长春130012

土壤重金属污染的治理和修复的基本原理是将重金属清除或改变其在土壤中的存在形态,降低迁移性和生物可利用性。根据土壤的性质和重金属在土壤中的赋存形态不同,目前重金属污染土壤治理和修复方法可分为工程物理化学法、土壤农化调控法... 详细信息

土壤重金属污染的治理和修复的基本原理是将重金属清除或改变其在土壤中的存在形态,降低迁移性和生物可利用性。根据土壤的性质和重金属在土壤中的赋存形态不同,目前重金属污染土壤治理和修复方法可分为工程物理化学法、土壤农化调控法和生物学修复法。通过对重金属污染治理与修复方法的综述,得出了各种方法的优缺点和适用范围,并对重金属治理的方法进行了展望。

关键词：重金属治理与修复污染

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boosting charge extraction and efficiency of inverted perovskite solar cells through coordinating group modification at the buffer layer/cathode interface

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Nano Research 2025年第1期18卷 415-423页

作者： Zhiqing Liang Ziqiu Ren Ziyu Wang Nan yan Ling Li bo Zhang yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

In inverted perovskite solar cells (PSCs),effective modification of the interface between the metalcathode and electron transport layer (ETL) is crucial forachieving high performance and stability. Herein, sulfonatedbathocuproine, commonly known as disodium bathocuproinedisulfonate (BCDS), was employed as a cathode buffer layerto address the interfacial issues at the [6,6]-phenyl-C61-butyricacid methyl ester (PCBM)/Ag interface. BCDS possesses theability to form coordinate bonds with Ag electrodes. Theutilization of the BCDS buffer layer enhanced the chargeextraction capability at the cathode interface whilesimultaneously achieving interfacial defect passivation,improving interfacial contact and increasing the built-in electricfield. Consequently, a power conversion efficiency (PCE) of25.06% was achieved. Furthermore, owing to the excellent filmforminguniformity of BCDS on PCBM, the stability of thedevice was also improved. After storage in dry air for morethan 2000 h, the device maintained 96% of its initial efficiency. This work underscores the remarkable potential of tailoringcoordination groups to enhance charge extraction efficiency at the ETL-cathode interface, unveiling a promising newfrontier in buffer layer development and performance optimization strategies for PSCs.

关键词： perovskite solar cells buffer layer bathocuproine disulfonate coordination group modification electron transport layer(ETL)-cathode interface

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Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-Xia Xu Jian-Dang Liu Bang-Jiao Ye Zi-Wen Pan Jun Lin Jin-Liang Song Jian-Qing Cao Chao yan Ying-Ping Hao Jin-Xing Cheng Qing-bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han bo yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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