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Chinese Journal of Natural Medicines 2017年第4期15卷 241-254页

作者： WANG xiao-Meng LI xiao-bo PENG Ying School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China

According to the theory of traditional Chinese medicine(TCM), Qi(vital energy) is regarded as a driving force of biological activities in human body, including both nutrient substances and organ functions. Qi-invigorating TCMs are widely used to treat various symptoms and disorders, such as fatigue, obesity, immunosuppression, intestinal flora imbalance, and gastrointestinal diseases, in which Qi is considered to be reduced or depleted. Interestingly, abundant clinical evidences suggest that these disorders are associated with the alternation of intestinal flora, which directly affects disease status. Herein we review the interaction between gut microbiota and Qi-invigorating TCMs under healthy and disease conditions and discuss the mechanisms of action and applications of Qi-invigorating TCMs in enhancing health status through microbial alternation. A better understanding of the role of Qi-invigorating TCMs in modulating microbial composition and the association between intestinal microbiota and diseases would help reveal the clinical consequences of microbiota alteration and explore opportunities to harness this symbiotic relationship to improve public health.

关键词： Gut microbiota Traditional Chinese medicine Qi

Synthetic Lethal Interactions Prediction Based on Multiple Similarity Measures Fusion

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Journal of Computer Science & Technology 2021年第2期36卷 261-275页

作者： Lian-Lian Wu Yu-Qi Wen xiao-Xi Yang bo-Wei Yan Song He xiao-Chen bo Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Department of Biotechnology Beijing Institute of Radiation MedicineBeijing 100850China Experimental Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100850China

The synthetic lethality(SL)relationship arises when a combination of deficiencies in two genes leads to cell death,whereas a deficiency in either one of the two genes does *** survival of the mutant tumor cells depends on the SL partners of the mutant gene,thereby the cancer cells could be selectively killed by inhibiting the SL partners of the oncogenic genes but normal cells could ***,there is an urgent need to develop more efficient computational methods of SL pairs identification for cancer targeted *** this paper,we propose a new approach based on similarity fusion to predict SL *** types of gene similarity measures are integrated and/c-nearest neighbors algorithm(k-NN)is applied to achieve the similarity-based classification task between gene *** a similarity-based method,our method demonstrated excellent performance in multiple *** the effectiveness of our method,the ease of use and expansibility can also make our method more widely used in practice.

关键词： synthetic lethality similarity measures fusion k-nearest neighbor multi-dimensional data

980 nm High Power Semiconductor Laser Stacked Arrays with Non-absorbing Window

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Journal of Materials Science & Technology 2007年第1期23卷 36-38页

作者： Xin GAO Baoxue bo Yi qu Jing ZHANG Hui LI National Key Lab on High Power Semiconductor Lasers Changchun University of Science and Technology Changchun130022 China

980 nm InGaAs/GaAs separate confinement heterostructure （SCH） strained quantum well （QW） laser with non-absorbing facets was fabricated by using thermal treatment. Microchannel coolers with a five-layer thin oxygen-free copper plate structure were designed and fabricated through thermal bonding in hydrogen ambient. The highest CW （continuous wave） output power of 200 W for 5-bar arrays packaged by microchannel coolers was presented.

关键词： High power Microchannel coolers Stacked arrays Non-absorbing facet

Perfect optomechanically induced transparency in two-cavity optomechanics

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Frontiers of physics 2023年第5期18卷 245-253页

作者： Lai-Bin Qian xiao-bo Yan School of Physics and Electronic Engineering Northeast Petroleum UniversityDaqing 163318China

Here,we study the controllable optical responses in a two-cavity optomechanical system,especially on the perfect optomechanically induced transparency(OMIT)in the model which has never been studied *** results show that the perfect OMIT can still occur even with a large mechanical damping rate,and at the perfect transparency window the long-lived slow light can be *** addition,we find that the conversion between the perfect OMIT and optomechanically induced absorption can be easily achieved just by adjusting the driving field strength of the second *** believe that the results can be used to control optical transmission in modern optical networks.

关键词： perfect optomechanically induced transparency slow light optomechanically induced absorption cavity optomechanics

siRNA targeting of Cdx2 inhibits growth of human gastric cancer MGC-803 cells

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World Journal of Gastroenterology 2012年第16期18卷 1903-1914页

作者： xiao-Tong Wang Yu-bo Xie Qiang xiao Department of Surgery The First Affiliated HospitalGuangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Anesthesiology The First Affiliated HospitalGuangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the effects of small interference RNA(siRNA) targeting of Cdx2 on human gastric cancer MGC-803 cells in vitro and in ***:The recombinant pSilencer 4.1-Cdx2 siRNA plasmids were constructed and transfected into gastric cancer MGC-803 cells in *** stable transfectants were *** effects of Cdx2 siRNA on growth,proliferation,cell cycle,apoptosis,migration and invasiveness of human gastric cancer MGC-803 cells were evaluated and the expression of phosphatase and tensin homolog(PTEN),caspase-9 and caspase-3 was observed in vitro by reverse transcription polymerase chain reaction(RT-PCR) and Western blotting *** also investigated the effect of Cdx2 siRNA on growth of MGC-803 cells in nude mice in ***:Cdx2 siRNA led to inhibition of endogenous Cdx2 mRNA and protein expression as determined by RT-PCR and Western blotting ***2 siRNA significantly inhibited cell growth and proliferation,blocked entry into the S-phase of the cell cycle,induced cell apoptosis,and reduced the motility and invasion of MGC-803 ***2 siRNA also increased PTEN expression,and activated caspase-9 and caspase-3 in MGC-803 cells in *** addition,siRNA targeting of Cdx2 inhibited the growth of MGC-803 cells and promoted tumor cell apoptosis in vivo in nude mice tumor ***:Cdx2 was involved in regulating progression of human gastric cancer cells *** of Cdx2 expression may be a potential therapeutic strategy for gastric cancer.

关键词： Cdx2 Gastric cancer Growth Small interference RNA

Removal effect on Mesocyclops leukarti and mutagenicity with chlorine dioxide

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Journal of Environmental Sciences 2006年第5期18卷 891-896页

作者： ZUO Jin-long CUI Fu-yi qu bo ZHU Gui-bing School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China Research Center for Eco-Environmental Sciences China Academy of Sciences Beijing 100085 China

Mesocyclops leukarti of zooplankton propagates excessively in eutrophic water body and it cannot be effectively inactivated by the conventional drinking water treatment process. In order to tackle this problem, a study of removal effect on Mesocylops leukarti with chlorine dioxide in a waterworks was performed. The results showed that Mesocyclops leukarti could be effectively removed from water by 1.0 mg/L chlorine dioxide prcoxidation combined with the conventional drinking water treatment process. Higher oxidizability and molecular state of chlorine dioxide in water is the key to the inactivation of Mesocyclops leukarti. The chlorite, disinfection by-products （DBPs） of chlorine dioxide, was stable at 0.45 mg/L, which is lower than that critical value of the USEPA. GC-MS examination showed that the quantity of organic substance in the water treated by chlorine dioxide obviously decreased. Ames test further revealed that the mutagenicity was reduced by chlorine dioxide with respect to prechlorine. The propagation ofMesocyclops leukorti can be inactivated effectively and safely by chlorine dioxide pre-oxidation.

关键词： chlorine dioxide disinfection by-products (DBPs) Mesocyclops leukarti preoxidation mutagenicity

Feasibility study of thermo-compensated resistance brazing welding of C/C composites and T2 copper with AgCuTi filler metal

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Chinese Journal of Aeronautics 2023年第5期36卷 534-548页

作者： Jiang YU Xinglin MIAO Hongtao ZHANG bo WANG Changming qu Peng HE State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Institute for Shipwelding Technology Shandong Institute of Shipbuilding TechnologyWeihai 264209China

The dissimilar materials joining of C/C composites to T2 copper were performed successfully by thermo-compensated Resistance Brazing Welding(RBW)with AgCuTi filler *** interfacial microstructure,phase composition,and shear strength of the resistance brazed joints were investigated by the relevant analysis *** results indicated that the order affecting the shear strength of the C/C-Cu joint was welding current,welding pressure,and welding time in *** shear strength of backward thermo-compensated RBW was higher than that of forward thermo-compensated RBW due to the Peltier *** maximum shear strength of the C/C-Cu joint was 11.56 MPa in the optimized welding parameter with welding current of 8.0 kA,welding time of 60 ms,and welding pressure of 0.10 MPa by backward thermo-compensated *** interface structure at the resistance brazed joint with this welding parameter was C/C composites/TiC/Cu(s.s)/T2 *** TiC phase was verified at the interface of the brazed joint by Scanning Electron Microscope(SEM),Energy-Dispersive X-ray Spectrometer(EDS),and X-ray Diffraction(XRD).Considerable fractures occurred in the C/C composites and partial fracture occurred at the interfacial reaction layer.

关键词： AgCuTi C/C composites Copper Resistance Brazing welding Shear strength

D-S Evidence Theory Based Trust Ant Colony Routing in WSN

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China Communications 2018年第3期15卷 27-41页

作者： Ziwen Sun Zhiwei Zhang Cheng xiao Gang qu School of Intemet of Things Engineering Jiangnan University Wu'xi 214122 China Engineering Research Center of Intemet of Things Technology Applications Ministry of Education Wu'xi 214122 China Department of Electrical & Computer Engineering and Institute for Systems Research University of Maryland College Park 20742 USA

This paper proposes a trust ant colony routing algorithm by introducing a node trust evaluation model based on the D-S evidence theory into the ant colony routing protocol to improve the security of wireless sensor networks. To reduce the influence of conflict evidences caused by malicious nods, the consistent intensity is introduced to preprocess conflict evidences before using the D-S combination rule to improve the reliability of the D-S based trust evaluation. The nodes with high trust values will be selected as the routing nodes to insure the routing security, and the trust values are used as heuristic functions of the ant colony routing algorithm. The simulation tests are conducted by using the network simulator NS2 to observe the outcomes of performance metrics of packets loss rate and average end-to-end delay etc. to indirectly evaluate the security issue under the attack of inside malicious nodes. The simulation results show that the proposed trust routing algorithm can efficiently resist malicious attacks in terms of keeping performances of the average end-to-end delay, the throughtput and the routing packet overhead under attacking from malicious nodes.

关键词： wireless sensor networks antcolony routing trust evaluation model D-Sevidence theory NS2 simulation

Microbial treatment in chronic constipation

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Science China(Life Sciences) 2018年第7期61卷 744-752页

作者： Linsheng Huang Qi Zhu xiao qu Huanlong Qin Department of General Surgery Shanghai Tenth People's Hospital Affiliated to Tongji UniversityShanghai 200072China Clinical Medical College of Shanghai Tenth People's Hospital of Anhui Medical University Shanghai 200072China

Chronic functional constipation is a kind of common intestinal disease that occurs in children, adults and elderly people. This disease not only causes great influence to physiological function, but also results in varying degrees of psychological barriers. At present, constipation treatments continue to rely on traditional methods such as purgative therapy and surgery. However, these approaches can disrupt intestinal function. Recent research between intestinal diseases and gut microbiota has gradually revealed a connection between constipation and intestinal flora disturbance, providing a theoretical basis for microbial treatment in chronic constipation. Microbial treatment mainly includes probiotic preparations such as probiotics, prebiotics, synbiotics and fecal microbiota transplantation(FMT). Due to its safety, convenience and curative effect, probiotic preparations have been widely accepted, especially gradually developed FMT with higher curative effects. Microbial treatment improves clinical symptoms, promotes the recovery of intestinal flora, and has no complications during the treatment process. Compared with traditional treatments, microbial treatment in chronic constipation has advantages, and is worthy of further promotion from clinical research to clinical application.

关键词： constipation probiotics prebiotics synbiotics FMT

Settled fast measurement of topological charge by direct extraction of plane wave from vortex beam

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Chinese Physics B 2021年第10期30卷 306-317页

作者： xiao-bo Yang Jin Hu School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China Institute of Information Engineering Chinese Academy of SciencesBeijing 100195China China Beijing Key Laboratory of Fractional Signals and Systems Beijing 100081China

A method of measuring the vortex beam topological charge(TC)is proposed based on a device that can directly extract the plane wave form from the vortex beam in which the different propagation angles of the plane waves are uniquely related to the different *** the TC can be obtained by simply comparing the energy values perceived by two fixed sensors in the detection location with the help of twin omnidirectional energy absorbers(OEAs).Because the settled detection relies only on the simple quantitative value at two fixed positions,neither pattern recognition nor field analysis procedure is applied,thus allowing faster *** features of the methodology are investigated,and the numerical simulations verify the feasibility and robustness of the system.

关键词： vortex beam topological charge settled measurement